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2 0// INDEX Interactivity 1// All menus are interactive 2// In the bottom right of the pages there are hyperlinks to return to menus and sub-menus or to move to the next page Return to 0//INDEX 01// Introduction by Managing Director HULP and Scientific Director of IdiPAZ 2 02// EXECUTIVE SUMMARY // Global Analysis // Research Structure // Training Report and Teaching // Innovation and Transfer Activities // Quality Assurance Activities // Clinical Trials // Platforms // Scientific Production // CIBERs and RETICs // Institutional Projects // Impact upon Clinical Practice // Internationalisation 82 03// // Neuroscience Area // Cardiovascular Area // Infectious Diseases and Immunity Area // Large System Pathology Area // Cancer and Human Molecular Genetics Area // Surgery, Transplant and Health Technologies Area // ASSOCIATED CLINICS 304 1

3 01// Introduction by Managing Director HULP and Scientific Director of IdiPAZ Once again, the presentation of the annual Scientific Report of the Hospital La Paz Institute for Health Research (Instituto de Investigación Sanitaria del, IdiPAZ) provides an opportunity to acknowledge the achievements of each and every researcher. This report reflects the effort of the forty-eight consolidated and emerging research groups that constitute IdiPAZ, as well as their associated clinical groups. We congratulate all members for the magnificent work performed and the achieved results. Since its establishment in 2009, IdiPAZ has promoted the configuration of multidisciplinary teams capable of addressing several facets of translational research, taking into consideration the need to generate innovation and transfer the results to the healthcare system. Over the years, we have maintained a progressive growth of our scientific activity, which is structured into six research areas: neurosciences, cardiovascular, infectious diseases and immunity, large system pathology, human cancer and molecular genetics and surgery, and transplants and health technology. The increasing scientific contributions performed by our research groups over the last years have placed IdiPAZ among the top three health research institutes with the best scientific evaluation in Spain. Despite the difficult current economic situation, the joint efforts of all our members have allowed us to consolidate the achievements of previous years and maintain a good portion of the activity conducted. In, IdiPAZ s researchers published 931 articles from which 743 were original. In addition, the overall impact factor continued to increase, which in reached 4,060.46, representing a new record for our centre, it actually exceeded the 4,000-point threshold. There was also a consolidation in the quality of the source journals, with a mean impact factor of 4.36 for the third consecutive year and with more than 40% of the manuscripts published in journals in the first quartile of their subject area. Moreover, the activity of the six research areas that constitute IdiPAZ was extremely satisfactory, with a production of more than 100 documents in each area and a high impact factor. The current scientific report also shows data reflecting the commitment of IdiPAZ to training and transferring of biomedical research. The university involvement of most of the research groups as resulted in high participation in graduate programmes, generating 53 doctoral theses this year. The activities that have experienced the greatest increase in IdiPAZ over the last years are those related to innovation and transfer, which have placed us in a position of national leadership. 65 patents and 11 registered trademarks have been obtained, three of which started to generate important profits last year. In addition, our clinical research continues to be very active, placing us as one of the national centres with the largest number of conducted clinical trials. More specifically, 332 new contracts for clinical trials were signed in. We would like to express our admiration for all the professionals who enable the Hospital La Paz Institute for Health Research (IdiPAZ) to continue advancing, which allows us to be optimistic about the future. There have been many achievements and we are confident of achieving many more. Our human potential and determination to continue progressing represent the best guarantee of continued success. Dr. Eduardo López-Collazo Scientific Director of IdiPAZ Dr. Rafael Pérez-Santamarina Feijóo Managing Director HULP Advisory Board Chairman IdiPAZ 2 Return to 0//INDEX 3

4 02// EXECUTIVE SUMMARY 02.1// Global Analysis 02.2// Research Structure 02.3// Training Report and Teaching // Training Report and Teaching // Training courses conducted by IdiPAZ // IdiPAZ Doctoral Theses 02.4// Innovation and Transfer Activities // Innovation and Transfer Activities // Patents // Trademarks 02.5// Quality Assurance Activities // Quality Assurance Committee // Protocols and Clinical Pathways 02.6// Clinical Trials 02.7// Platforms // Biobank // UCICEC // Experimental Surgery Section // Cell Cultures Unit // Automatic Sequencing Laboratory // Image Laboratory // Flow Cytometry Laboratory // Radioisotope Laboratory // Biostatistics Section // Documentation Service // PAIN Platform 02.8// Scientific Production 02.9// CIBERs and RECTICs 02.10// Institutional Projects 02.11// Impact upon Clinical Practice 02.12// InternaTionalisation 4 Return to 0//INDEX 5

5 02// EXECUTIVE SUMMARY 02.1// Global Analysis The quality of the journals in which the articles were published has also experienced a marked improvement. In 2008, 11.8% of the articles were published in journals that were in the first decile of their subject area. In contrast, 22.55% of IdiPAZ articles were published in the first decile in. Moreover, 44.36% of the articles were published in journals in the first quartile of their field. DISTRIBUTION BY DECILE AND QUARTILE 1st DECILE 1st QUARTILE 2nd QUARTILE 3rd QUARTILE 4th QUARTILE NOT INDEXED Originals In, IdiPAZ research groups completed 931 publications, of which 743 were original articles. Fifty-one percent of the published articles belonged to IdiPAZ, which means that those documents, in which the first or last signatory or the author for correspondence, is a member of the Instituto de Investigación Sanitaria del Hospital Universitario La Paz (Hospital La Paz Institute for Health Research). NUMBER OF PUBLICATIONS NUMBER IF Mean IF 931 4, Owned 467 1, Un-owned 464 2, Originals 743 3, Owned Originals Un-owned Originals 420 2, These figures represent, compared with the previous year, similar data of the total number of pu- ImpACT FACTOR blished documents, and also in the originals. However, a significant increase of the impact of the published documents can be seen. The following figure shows the progress of the global Impact Factor (IF) for all IdiPAZ publications in recent years. In, the scientific production of IdiPAZ reached 2008 an IF of 4,060.46, which, an increase of over points compared with the previous year, shows the 2010 consolidation of the global impact of the published documents. Thus, for the first year, the IF of the publications exceeded the 4,000-point threshold This increase in scientific production was associated with an increase in the mean IF reached by each manuscript (or mean IF), which was 4.36 in. In any case, for the third consecutive year, the mean IF reached the threshold of Mean ImpACT FACTOR The evolution of the distribution by quartile of the articles published in the last five years has shown a sustained increase in the relevance of the source journals. As shown in the following figure, the percentage of articles published in first-quartile journals went from 8.96% in 2008 to 44.36% in. Moreover, the percentage of publications in the last quartile or notindexed journals has been very limited, despite the setbacks experienced by various national biomedical publications Distribution by quartile Quartile 1 (%) 2010 Quartile 2 (%) Quartile 3 (%) 2011 Quartile 4 (%) Non indexed (%) 2009 Quartile 1 (%) 2010 Quartile 2 (%) Quartile 3 (%) Quartile 4 (%) Non indexed (%) Quartile 1 (%) Quartile 2 (%) 20 Quartile 3 (%) journals of their subject area, and Quartile 4 (%) % were in first quartile journals Non indexed (%) 2012 ImpACT FACTOR for Mean ImpACT FACTOR for Original Papers 2008 Original Papers If we consider only the originals published by IdiPAZ researchers, we could also observe a continuous increase in IF. For the third consecutive year, the IF of the originals exceeded the 3,000-point threshold, reaching 3,291.94, which represents the highest value for this entire series. Moreover, 23.14% of the originals published in were in first-decile

6 Total 1 Original Papers // EXECUTIVE SUMMARY 02.1// Global Analysis The citation analysis shows that, by the time this scientific report was written, articles published in had received 1,868 citations, which represents a citation index over 2. For originals, the citation index was As shown in the following figure, the difference between the citation index reached by the originals and that achieved by the totality of the published manuscripts has increased over the years. Citation index Total In, 323 original IdiPAZ articles were published, with a mean impact factor of The growth rates achieved in previous years have been maintained, in the relative mean impact factor Total Original Papers Original Papers Total Original Papers The degree of integration of IdiPAZ researchers in national and international scientific networks is evidenced by the high number of articles published in collaboration, which accounts near 75% of the total documents published. For originals, 54.97% were completed in collaboration with other national institutions and 45.03% in collaboration with authors from international institutions. COLLABORATIVE NATIONAL 50 INTERNATIONAL PUBLICATIONS, % COLLABORATIONS, % COLLABORATIONS, % Owned Un-owned Originals Owned Originals Total Original Papers 1.5 Un-owned Originals Total 0 1 Original Papers 0.5 International collaboration Total Number Original Papers of articles Impact factor Collaboration among IdiPAZ research groups is also reflected by the percentage of intramural collaboration, which reached 18.05% in 400 for all manuscripts and 17.36% for originals. The upward trend in 350 scientific activity conducted by the forty-eight research groups that are part of IdiPAZ is also reinforced by the analysis 300 of IdiPAZ originals. For working purposes, IdiPAZ originals are those articles where the first or last signatory is a member of the IdiPAZ institute , Number of articles Impact factor Number of articles Likewise, since 2009, there was a consolidation in the quality of journals in which IdiPAZ originals were published, and Impact 200 currently, IdiPAZ original articles published in first-quartile journals of their subject area exceeds 100 documents. factor 0 Number of original papers in the first quartile , , ,000 9

7 02// EXECUTIVE SUMMARY 02.1// Global Analysis Analysis by Research Area The following chart summarises the main indicators of scientific activity performed by the six areas that make up IdiPAZ. ImpACT factor distribution for area Numbers of documents Neuroscience Area Cardiovascular Area 195 Infectious diseases and immunity Area Neuroscience Area 4 Total 5 Article Editorial Material Letter Review 2. Cardiovascular Area 3. Infectious diseases and immunity Area Distribution of manuscripts 1st DECILE, % 4. Large system pathology Area 1st QUARTILE, % 5. Cancer and human molecular genetics Area 2nd QUARTILE, % 6. Surgery, transplantation and health technology Area 3rd QUARTILE, % th QUARTILE, % NOT INDEXED, % 1. Neuroscience Area Cardiovascular Area Infectious diseases and immunity Area Large system pathology Area Cancer and human molecular genetics Area 6. Surgery, transplantation and health technology Area ImpACT factor and citation index Large system pathology Area Cancer and human molecular genetics Area Surgery, transplantation and health technology Area Collaboration analysis 18 Papers in Collaboration, % 17 National Collaboration, % 29 International Collaboration, % 1. Neuroscience Area Cardiovascular Area Infectious diseases and immunity Area Large system pathology Area Cancer and human molecular genetics Area 6. Surgery, transplantation and health technology Area Other activities Doctoral Theses Clinical Trials 1. Neuroscience Area Cardiovascular Area Infectious diseases and immunity Area Large system pathology Area Cancer and human molecular genetics Area 6. Surgery, transplantation and health technology Area Impact Factor Mean Impact Factor Number of Total Originals Total Originals Citations Citation Index 1. Neuroscience Area Cardiovascular Area 1, Infectious diseases and immunity Area Large system pathology Area Cancer and human molecular genetics Area 6. Surgery, transplantation and health technology Area Return to 02// EXECUTIVE SUMMARY INDEX 11

8 02// EXECUTIVE SUMMARY 02.2// Research Structure José Luis López-Sendón Hentschel Leopoldo Martínez Martínez Jesús Mingorance Cruz Mercedes Salaices Sánchez Rafael Selgas Gutiérrez Fernando Rodríguez Artalejo Secretary: David Hardisson Hernáez Clinical Research Ethics ComitTee Governing Council Chairman: Javier Maldonado González. Deputy Minister of Health Care CAM Deputy Chairman: José María Sanz Martínez. Chancelor of UAM Members: Rafael Pérez-Santamarina Feijóo. Chairman of the Board of FIBHULP Rodolfo Álvarez-Sala Walther. FIBHULP Patron Ana Frank García. FIBHULP Patron Juan Antonio Vargas Núñez. UAM Representative for the Board of FIBHULP Executive Committee Eduardo López-Collazo. Scientific Director of IdiPAZ Paloma Martín Martín. FIBHULP Partron Almudena Castro Conde. FIBHULP Patron Exuperio Díez Tejedor. FIBHULP Patron Francisco Arnalich Fernández. UAM Representative Fernando Rodríguez Artalejo. UAM Representative Amparo Cano García. UAM Representative Pablo Lapunzina Badía. FIBHULP Patron Juan Julián González García. FIBHULP Patron Secretary: Ana Coloma Zapatero. Director of FIBHULP Chairwoman: Almudena Castro Conde Deputy Chairman Jesús Frías Iniesta Secretary Rosario Madero Jarabo Members Mario Arancón Monge Fernando Cabañas González Javier Arpa Gutiérrez Julia López Díaz Antonio Buño Soto Jaime Feliú Batlle Elena García Higuera Alejandro Balsa Criado Filiberto Chuliá Fernández Animal Welfare Ethics Committee Carmen Fernández Criado Fernando Carceller Benito Elena Villamañán Bueno Jaime Fernández-Bujarrabal Villoslada Luis Asensio Prianes Filomena Trocoli González Ramón Usandizaga Elío Ángel Robles Marhuenda José Ignacio Bernardino de la Serna Concepción Prados Sánchez Carlos Lahoz Rallo Miriam Romero Portales Member from outside the Institution Evangelina Garrido García Technical Secretary Paz Lavilla Uriol Emma Fernández de Uzquiano Sol de Gracia García Luis Álvarez García Carlota Largo Aramburu Chairman: Rafael Pérez-Santamarina Feijóo. Chairman of the Board of FIBHULP Members: Juan Antonio Vargas Núñez. Dean of UAM Medical School Eduardo López-Collazo. Scientific Director of IdiPAZ Ana Coloma Zapatero. Director of FIBHULP José Ramón Arribas López. HULP Representative Francisco Arnalich Fernández. UAM Representative Secretary: Ana Coloma Zapatero. Director of FIBHULP Quality Assurance Committee Coordinator: José Jonay Ojeda Feo Members: Blanca Fuentes Gimeno Alberto Martín Vega María Luisa Díaz Martínez Margarita Rodrigo Angulo Scientific Director Eduardo López-Collazo External Scientific Committee Juan Tamargo Menéndez - Institute of Pharmacology and Toxicology CSIC-UCM. Madrid Reiner Albert Veitia - Profesor de Génomique fonctionnelle. Université Denis Diderot, Paris VII. Group leader. Molecular Oncology and Ovarian Pathologies en el l Institut Jacques Monod, París Joaquín Arribas López - Vall d Hebron Hospital. Barcelona Jacinta Cecilia Bustamante - Associate Professor Paris Descartes University, Laboratory of Human Genetics of Infectious Diseases (INSERM U980), Imagine Institut. Center for the Study of Primary Immunodeficiencies, Necker Enfants-Malades Hospital, Paris Research Committee Chairman: Franciso Arnalich Fernández Members: Eduardo López-Collazo Isabel de Andrés de la Calle Alejandro Balsa Criado Carlos Belmonte Martínez - Institute of Neuroscienciences. Alicante Javier Defelipe Oroquieta - Research Professor at the Instituto Ramón y Cajal (CSIC). Co-director and Coordinator of the Molecular and Cellular Neuroscience. Isabel Fabregat Romero. IDIBELL- Bellvitge Biomedical Research Institute. Barcelona Carmen Maroto Vela - University of Granada María Teresa Miras Portugal - Complutense University Madrid Santiago Moreno Guillén - Ramón y Cajal Hospital. Madrid Amparo Cano García Javier de Castro Carpeño Ana Frank García Juan García Puig José Antonio Rodríguez Montes Pablo Lapunzina Badía Training Committee Coordinator Bárbara Martínez de Miguel Technical Secretary Marisa Tejedor Botello Documentation Service Raúl Román Cañizares Director: Ana Coloma Zapatero Human Resources Manager: Ana Gloria Herrera Puerta Private Projects Manager: Francisco Gil Gadea Clinical Trial Manager: Loreto Gordillo Medrano Public Projects Manager: Sara Moral Álamo Members: Ana Isabel de Cos Blanco Gema Moreno Bueno Mercedes Ruiz Balibrea Paloma Gómez Campelo FIBHULP (Foundation for Biomedical Research of La Paz University Hospital) Institutional Project Manager: José Luis Narro Villanueva Primary Health Care Projects Manager Silvia Arce Santamaría Contracting Manager: Sara Fernández Morata Accountants: Laura López Revuelta, Mónica García López Researcher Reception and Attention: Desirée Hernández López, Carmen García Artiaga 12 13

9 02 / / EX E C U TIV E SU M M AR Y 02.2 // Researc h Stru ct u r e Res earc h A re as 1 - N euroscience A rea 4 - L ar g e S yste m Pat h olo g y A rea Coordinator: Exuperio Díez Tejedor GROUP Coordinator: Francisco García Río NAME Psychiatry and Mental Health Neurology and Cerebrovascular Diseases Neurobiological Basis of Sleep and Sensory Processing Neuroprotective Strategies in Neurodegenerative Diseases Cellular Proteostasis and Conformational Diseases Structure, Neurochemistry and Plasticity of Neural Circuits of the Cerebral Cortex and Thalamus Neurobiology of the Inflammatory Response Involvement of Glycinergic and Glutamatergic Systems in Central Nervous System Pathologies DIRECTOR GROUP Consuelo de Dios Perrino Exuperio Díez Tejedor Isabel de Andrés de la Calle Antonio Cuadrado Pastor 17 Organic Dysfunction and Failure in the Aggression Respiratory Diseases Regulation of Gene Expression and by Hypoxia Nephrology Neonatology Aging and Fragility in the Elderly Molecular Hepatology Diagnosis and Treatment of Allergic Diseases Ophthalmology Gynecology and Obstetrics Emergency José González Castaño Francisco Clascá Cabré Francisco Arnalich Fernández Cecilio Giménez Martín NAME DIRECTOR Abelardo García de Lorenzo y Mateos Francisco García Río Luis del Peso Ovalle Rafael Selgas Gutiérrez Felix Omeñaca Terés Ángel Otero Puime Luis Álvarez García Santiago Quirce Gancedo Félix Armadá Maresca Ignacio Zapardiel Gutiérrez Manuel Quintana Díaz 2 - C ardio va S cular A rea Coordinator: Jose Luis López-Sendón Hentschel GROUP 5 - C ancer and Hu m an Molecular Genetics A rea NAME 08 Research on Invasive Clinical Cardiology - ICCI-Paz 09 Clinical Epidemiology and Cardiometabolic Disease Prevention Cardiovascular Epidemiology and Nutrition Metabolic-Vascular Unit Sex Hormones and Vascular Function Coagulopathies and Alterations of Haemostasis Vascular Physiology and Pharmacology DIRECTOR Jose Luis López-Sendón Hentschel Rafael Gabriel Sánchez Fernando Rodríguez Artalejo Juan García Puig Mercedes Ferrer Parra Víctor Jiménez Yuste Mercedes Salaices Sánchez Coordinator: Jaime Feliu Batlle GROUP Translational Oncology Experimental Therapies and Biomarkers in Cancer Oto-Neurosurgery Research Anatomopathology. Breast and Gynecological Cancer Mechanisms of Tumour Progression Animal and Cell Models for Detection and Characterization of Leukemic Stem Cells Research and Diagnosis of Inherited Metabolic Diseases 45 Coordinator: Eduardo López-Collazo GROUP AIDS and Infectious Diseases Molecular Microbiology Immuno-Rheumatology Innate Immune Response Diagnosis and Treatment of Diseases Associated with Abnormalities of the Complement System Lymphocyte Pathophysiology in Immunodeficiencies NAME DIRECTOR INGEMM - Institute of Medical and Molecular Genetics Pablo Lapunzina Badía Molecular Genetics of Dystroglycanopathies Jesús Cruces Pinto I nfectious D iseases and I n m unity A rea NAME Jaime Feliu Batlle María Inmaculada Ibáñez de Cáceres Luis Lassaletta Atienza David Hardisson Hernáez Amparo Cano García Carmela Calés Bourdet Magdalena Ugarte Pérez DIRECTOR José Ramón Arribas López Jesús Mingorance Cruz María Eugenia Miranda Carús Eduardo López-Collazo Margarita López Trascasa Eduardo López Granados 6 - S ur g ery, T rans p lant and Healt h T ec h nolo g ies A rea Coordinator: Leopoldo Martínez Martínez GROUP 12 NAME Research in Nutrition and Functional Foods NUTRINVEST Congenital Malformation Surgery Experimental Surgery Bone Pathophysiology and Biomaterials Cellular Engineering Clinical Pharmacology Osteoarticular Surgery Research GICOA DIRECTOR Carmen Gómez Candela Leopoldo Martínez Martínez Juan José Vázquez Estévez Nuria Vilaboa Díaz María Paz de Miguel González Jesús Frías Iniesta Enrique Gómez Barrena 15

10 02// EXECUTIVE SUMMARY 02.2// Research Structure Public Research Contracts RAMÓN Y CAJAL STABILISATION CONTRACTS (I3) (Autonomus Community of Madrid) Karen Elise Heath. Group 29. INGEMM - Institute of Medical and Molecular Genetics Jesús Mingorance Cruz. Group 18. Molecular Microbiology MIGUEL SERVET STABILISATION CONTRACTS (I2) (Carlos III Health Institute/Autonomus Community of Madrid) Juan Ángel Fresno Vara. Group 32. Translational Oncology Teresa Bellón Heredia. Group 44. Diagnosis and Treatment of Allergic Diseases Ángel Campos Barros. Group 29. INGEMM - Institute of Medical and Molecular Genetics María Paz de Miguel González. Group 42. Cellular Engineering Eduardo López-Collazo. Group 20. Innate Immune Response Juan Antonio Rey Herranz. Group 34. Oto-Neurosurgery Research Pilar Sánchez-Corral Gómez. Group 21. Diagnosis and Treatment of Diseases Associated with Abnormalities of the Complement System María Rosa Torres Jiménez. Group 11. Metabolic- Vascular Unit Nuria Vilaboa Díaz. Group 40. Bone Pathophysiology and Biomaterials Luis Álvarez García. Group 28. Molecular Hepatology Berta Rodés Soldevila. Group 16. Aids and Infectious Diseases David Vicent López. Group 28. Molecular Hepatology TECHNICAL SUPPORT STABILISATION CONTRACTS (Autonomus Community of Madrid) Francisco Gayá Moreno. Group 16. Aids and Infectious Diseases María Teresa Vallejo Cremades. Group 38. Congenital Malformation Surgery Beatriz Sanz Minguela. Cell Culture PTA CONTRACTS (Ministry of Economy and Competitiveness) Olga Pernía Arias. Group 33. Experimental Therapies and Biomarkers in Cancer Carolina Peña Granero. Group 34. Oto-Neurosurgery Research RAMÓN Y CAJAL CONTRACTS (Ministry of Economy and Competitiveness) Rebeca Pérez de Diego. Group 20. Innate Immune Response FPI CONTRACTS (Ministry of Economy and Competitiveness) Lara Crespo García. Group 40. Bone Pathophysiology and Biomaterials FPI CONTRACTS (Carlos III Health Institute) Alicia González Baeza. Group 16. Aids and Infectious Diseases Victoria María Heredia Soto. Group 35. Anatomopathology, Breast and Gynaecological Cancer Elena Álvarez Barco. Group 29. INGEMM - Institute of Medical and Molecular Genetics TECHNICAL SUPPORT CONTRACTS (Carlos III Health Institute) Víctor Manuel Toledano Real. Group 20. Innate Immune Response Mónica Barriuso Iglesias. Biobank Ángelo Gámez Pozo. Group 32. Translational Oncology Rocío López Vacas. Group 32. Translational Oncology Alicia de Pablo Olaiz. Group 16. Aids and Infectious Diseases SARA BORRELL POSTDOCTORAL CONTRACTS (Carlos III Health Institute) María Dolores Sánchez Niño. Group 25. Nephrology Laura Otero Ortega. Group 2. Neurology and Cerebrovascular Diseases Carolina Cubillos Zapata. Group 20. Innate Immune Response Pilar Valdecantos Jiménez. Group 4. Neuroprotective Strategies in Neurodegenerative Diseases RÍO HORTEGA CONTRACTS (Carlos III Health Institute) Alejandro Martín Quiros. Group 16. Aids and Infectious Diseases Borja Sanz Cuesta. Group 2. Neurology and Cerebrovascular Diseases MIGUEL SERVET CONTRACTS TYPE I (Carlos III Health Institute) María Fernández Velasco. Group 20. Innate Immune Response Laura Saldaña Quero. Group 40. Bone Pathophysiology and Biomaterials Nora Viviana Butta Coll. Group 14. Coagulopathies and Alterations of Haemostasis María Inmaculada Ibáñez de Cáceres. Group 33. Experimental Therapies and Biomarkers in Cancer MIGUEL SERVET CONTRACTS TYPE II (Carlos III Health Institute) Rosa María Rodríguez Pérez. Group 44. Diagnosis and Treatment of Allergic Diseases INTENSIFICATION CONTRACTS (Carlos III Health Institute) Javier de Castro Carpeño. Group 32. Translational Oncology Pablo Lapunzina Badía. Group 29. INGEMM - Institute of Medical and Molecular Genetics JUAN RODÉS CONTRACTS (Carlos III Health Institute) Ignacio Pérez Valero. Group 16. Aids and Infectious Diseases PREDOCTORAL FELLOWSHIP (Carlos III Health Institute) Enrique Hernández Jiménez. Group 20. Innate Immune Response DATA: HUMAN RESOURCES PREDOCTORAL CONTRACT (Autonomous Community of Basque Country) Alfonso Hisado Oliva. Group 29. INGEM-Institute of Medical and Molecular Genetics FPU CONTRACT (Ministry of Economy and Competitiveness) Scherezade Fuentes Julián. Group 42. Cellular Engineering Irene Francisco Recuero. Associated Clinics Daniel Ruiz Pérez. Group 23. Respiratory Diseases. No. OF PROGRAMME ORGANISATION CONTRACTS Established I3 Autonomous Community of Madrid 2 Estabilished I2 Carlos III Health Institute/ALE 12 Technical Support Stabilisation Contracts Autonomous Community of Madrid 3 TOTAL ESTABLISHED 17 PTA Contracts Ministry of Economy and Competitiveness 2 Ramón y Cajal Contracts Ministry of Economy and Competitiveness 1 FPI Contracts Ministry of Economy and Competitiveness 1 FPI Contracts Carlos III Health Institute 3 Technical Support Contracts (FIS) CA Carlos III Health Institute 5 Sara Borrell Contracts PD Carlos III Health Institute 4 Río Hortega Contracts CM Carlos III Health Institute 2 Miguel Servet Contracts CP Type 1 Carlos III Health Institute 4 Miguel Servet Contracts CP Type 1I Carlos III Health Institute 1 Intensification Contracts Carlos III Health Institute 2 Juan Rodés Contracts Carlos III Health Institute 1 TOTAL PROGRAMMES 26 Predoctoral Fellowship Carlos III Health Institute 1 Predoctoral Fellowship Autonomous Community of Basque Country 1 Predoctoral Fellowship Ministry of Economy and Competitiveness 3 TOTAL FELLOW 5 TOTAL ESTABLISHED + PROGRAMMES + FELLOWS 48 CAIBER CAIBER 4 FIS Proyects Carlos III Health Institute 13 European Proyects European Union 2 NETWORKS Themes Carlos III Health Institute 13 NETWORKS Autonomous Community of Madrid 5 SAF/MAT Ministry of Economy and Competitiveness 1 Biobank Carlos III Health Institute 2 Comercial Clinical Trials Clinical Trials Promoters 17 Private projects Pharmaceutical Industry 47 In-house Proyects FIBHULP 8 No Comercial Clinical Trials Carlos III Health Institute 2 TOTAL EMPLOYEES DEPENDET ON RESEARCH PROJECTS 114 Private projects Pharmaceutical Industry 21 TOTAL FELLOWS DEPENDET ON RESEARCH PROJECTS 21 TOTAL STAFF DEPENDENT ON RESEARCH PROJECTS 135 Technical Unit Staff FIBHULP 13 TOTAL TECHNICAL UNIT EMPLOYYES TOTAL TECHNICAL UNIT 13 TOTAL Return to 02// EXECUTIVE SUMMARY INDEX 17

11 02// EXECUTIVE SUMMARY 02.3// Training Report and Teaching // Training Courses Conducted by IdiPAZ in // Training Report and Teaching IdiPAZ s training committee is in charge of defining, elaborating and implementing the organization s training program. It must also ensure the proper development of the programs objectives. This committee is designed in such a way that all members of the IdiPAZ are represented. It is composed of a coordinator and a representative from La Paz University Hospital (HULP) and a representative of the Autonomous University of Madrid (UAM). IdiPAZ s training plan encompasses all studies la ongoing training (HULP) to postgraduate courses (UAM) which also includes IdiPAZ s own specialist courses. In order to design its own courses the committee annually consults via an online needs analysis survey IdiPAZ members on their area of interests regarding the training needs observed by group leaders. IdiPAZ s own courses are meant to complement HULP and UAM courses. These courses are coordinated by an IdiPAZ member who is not only the manager of these courses but also the person in charge of all the administrative documentation required by Spain s National Health System /Board. Thus IdiPAZ courses have the necessary state accreditation. The committee also is in charge of our professionals satisfaction follow up surveys. Our specialist courses are taught by researchers and professionals of related disciplines. TITLE HOURS CREDITS DATES HEAD ASSISTANTS How to write a research project report Training in animal experimentation procedures The ethics of research on humans and standards of good clinical practice European research programs Preparation and presentation of doctoral theses Research tools: statistics methods for beginners Data search and management of medical and research information. Planning for a systematic revision November May November May September May April // IdiPAZ Doctoral Theses Pablo Lapunzina Badía Carlota Largo Aramburu Rafael del Río Villegas Ana Tardón Ibáñez Juan José Arredondo Lamas Rosario Madero Jarabo María Luisa Maquedano Martínez CONTENT ASSESSMENT UTILISATION ASSESSMENT TEACHER ASSESSMENT Composition Coordinator: Bárbara Martínez de Miguel Members: Ana Isabel de Cos Blanco Gema Moreno Bueno IdiPAZ Demand Researh Areas Area Coordinators Research Groups Groups Director AUTHOR DIRECTOR GROUP TITLE UNIVERSITY RATING LECTURE DATE THESIS EUROPEAN Mireia Serra i Vila Javier Melero LLorca Beatriz Rodríguez-Vega Beatriz Rodríguez-Vega Carmen Bayón Pérez Group 1 Group 1 Comparison of the efficiency of music therapy of breast cancer patients during chemotherapy: a quantitative and qualitative analysis The effects of midnfulness training on attentional control and emotional adjustment in psychiatric and psychology residents Facultad de Psicología de la Universidad Ramón LLull Universidad de Alcalá de Henares Pass 21/03/ No Summa cum laude 11/06/ No Research Training Adapting to the Institute s strategic objectives IdiPAZ TRAINING PLAN IdiPAZ Opportunities HULP Continuing Education UAM Training Opportunities Institute Opportunities Research Area Training Aimed at basic and clinical researches Genny Lubrini Berta Rodríguez Frutos Blanca Lizarbe Serra José Antonio Periáñez Morales Ana Frank García Exuperio Díez Tejedor María Gutiérrez Fernández Exuperio Díez Tejedor Sebastián Cerdán García-Esteller Pilar López Larrubia Juan José Sáenz Group 2 Group 2 Group 2 Speed of information processing in multiple sclerosis patients Engineered mesenchymal stem cells treatments in cerebral infarction. The options of IV line and the source of adipose tissue Magnetic resonance imaging of appetiteinduced hypothalamic activity Universidad Complutense de Madrid Universidad Autónoma de Madrid Universidad Autónoma de Madrid Summa cum laude Summa cum laude Summa cum laude 09/07/ No 04/11/ No 25/10/ No 18 19

12 02// EXECUTIVE SUMMARY 02.3// Training Report and Teaching AUTHOR DIRECTOR GROUP TITLE UNIVERSITY RATING LECTURE DATE THESIS EUROPEAN Jesús Pacheco Torres Cristina Bódalo Tejedor Maysa Ahmed Abd El-Hamid Mobasher Carolina Navarro San Francisco Rocío Cózar León Carlos de Diego Rus Eduardo Ramón Armada Romero Maritza Muñoz Pareja Dora Elia Cortés Hernández José Miguel Carrasco Gimeno Sebastián Cerdán García-Esteller Paloma Ballesteros García Pilar López Larrubia Isabel de Andrés de la Calle Ángela Martínez Valverde Juan Julián González García Francisco Arnalich Fernández Rafael Peinado Peinado Ernesto Díaz Infante Rafael Peinado Peinado Ernesto Díaz Infante José Luis López- Sendón Herschel Rodolfo Álvarez- Sala Walter Elena Villamañán Bueno Fernando Rodríguez Artalejo Pilar Guallar Castillón José Javier Sánchez Hernández José Ramón Banegas Banegas Marina Pollán Fernando Rodríguez Artalejo Group 2 Group 3 Group 4 Group 16 Group 7 Group 8 Group 8 Group 8 Group 23 Pharmacy Group 10 Group 10 Group 10 Novel approaches for the measurement of tumoral po2 by magnetic resonance methods Effect of the sleep-wake cycle produced by histamines administered in cholinoceptive regions of the pontine tegment. An experimental study on a cat in a laboratory Protection against paracetamol-induced adverse effects in the liver by the inhibition of the protein tyrosine phosphatase 1b Evolution of the clinical and epidemiological characteristics of coinfection with human immunodeficiency virus and hepatitis C virus in Spanish population 2010 A comparative study of the efficiency and safety of two ant tachycardia stimulus algorithms of fast ventricular tachycardia in carriers of an implantable automatic cardioverter-defibrillator Electrophysiological changes during acute artery ischemia and reperfusion injury in a two-dimensional cardiac model Effects of electronic prescriptions, assistance in a critical care unit an assessment of medication errors Eating behavior related weight excess, and in agreement with the main nutrition recommendations among Spain s high cardiovascular risk Control of arterial hypertension and cardiovascular mortality attributed to hypertension in Mexico Health problems associated with the prestige s spill on coastline of Cantabria Universidad Autónoma de Madrid Universidad Autónoma Madrid Universidad Autónoma de Madrid Universidad Autónoma de Madrid Universidad de Sevilla Universidad Autónoma de Madrid Universidad Autónoma de Madrid Universidad Autónoma de Madrid Universidad Autónoma de Madrid Universidad Autónoma de Madrid Summa cum laude Unanimous summa cum laude Summa cum laude Pass with honors Summa cum laude Summa cum laude Pass with honors Summa cum laude Summa cum laude Summa cum laude 13/12/ Yes 21/03/ No 26/07/ No 19/07/ No 02/05/ No 16/05/ No 17/06/ No 30/10/ No 04/11/ No 25/04/ No AUTHOR DIRECTOR GROUP TITLE UNIVERSITY RATING LECTURE DATE THESIS EUROPEAN Alicia Padrón Monedero Leyre Teresa Díez Porres Luis Matías Beltrán Romero María Soledad Avendaño Herrador Alberto Hernández Tejedor Sergio Álvarez García-Peñuela Elena González Higueras David Trejo Cervantes Carlos Javier Carpio Segura Laura Gómez Maldonado Sara Romero Pérez Iñaki Galán Labaca Fernando Rodríguez Artalejo Group 10 Risk factor of psychological distress among the adolescent population estimated through the General Health Questionnaire (GHQ-12) Juan García Puig Group 11 The efficacy of a team of palliative care during the last days of a patient s life José Villar Ortiz Salvador García Morillo Mercedes Salaices Sánchez Ana María Briones Alonso Lluis María Cabré Abelardo García de Lorenzo y Mateos Abelardo García de Lorenzo y Mateos César Casado Pérez Vicente de Paz Varea José Manuel Añón Elizalde Abelardo García de Lorenzo y Mateos Abelardo García de Lorenzo y Mateos César Casado Pérez Francisco García Río Rodolfo Álvarez-Sala Walther Luis del Peso Ovalle Rafael Selgas Gutiérrez Juan José Díez Gómez Group 11 Group 15 Group 17 Group 17 Group 17 Group 17 Group 23 Group 24 Group 25 Influence of antiretroviral in inflammatory markers and the activation of monocyte macrophages via stweak and scd163 HIV naive population COX-2 derived prostanoids, reactive oxygen species and GRK2 underlie the functional, structural and mechanical vascular alterations in hypertension The limits of therapeutic efforts in ICUs. Evolution and prognosis of long term ICU patients with worsening conditions Mortality determinants in critical patients with necrotizing soft tissue infections An anatomic study of the digestive system s failure in the multiple organ dysfunction Allogenic transplants of composed tissues The effects of continuous positive airway pressure (cpap) on recurring acute coronary episodes in obstructive sleep apnea (osa) and in myocardial infarction Regulation of EFNA3 expression by hypoxia through a novel lncrnamediated mechanism. A potential role in cancer metastasis Thyroid function in patients on peritoneal dialysis: associated with cardiovascular disease, survival and some emerging factors of cardiovascular risk Universidad Autónoma de Madrid Universidad Autónoma de Madrid Universidad de Sevilla Universidad Autónoma de Madrid Universidad Autónoma de Madrid Universidad Autónoma de Madrid Universidad Autónoma de Madrid Universidad Autónoma de Madrid Universidad Autónoma de Madrid Universidad Autónoma de Madrid Universidad Autónoma de Madrid Summa cum laude Summa cum laude Summa cum laude Summa cum laude Unanimous summa cum laude Unanimous summa cum laude Unanimous summa cum laude Unanimous summa cum laude Unanimous summa cum laude Summa cum laude Summa cum laude 01/02/ No 01/10/ No 14/11/ No 13/12/ Yes 21/05/ No 18/06/ No 27/06/ No 16/12/ Yes 18/12/ No 19/12/ Yes 15/11/ No 20 21

13 02// EXECUTIVE SUMMARY 02.3// Training Report and Teaching AUTHOR DIRECTOR GROUP TITLE UNIVERSITY RATING LECTURE DATE THESIS EUROPEAN Érika de Sousa Amorin Oriana Ramírez Rubio Jaime de Juan Sanz Víctor Moreno García Elena Hernández Agudo Blanca Díes López Jorge Oliver de la Cruz Lorena Sanz López Raúl Jiménez Pérez Rafael Selgas Gutiérrez María Auxiliadora Bajo Rubio Ángel Otero Puime Daniel Brook Carmen Aragón Rueda Enrique Casado Sáenz Paloma Cejas Guerrero Jaime Feliu Batlle Javier de Castro Carpeño Paloma Cejas Guerrero Jaime Feliu Batlle Rosario Perona Abellón Leandro Sastre Garzón Ángel Ayuso Sacido Rosario Perona Abellón Teresa Rivera Rodríguez Isabel Valera Nieto Carlos Avendaño Trueba Miguel Ramón Campanero Group 25 Group 27 Group 30 Group 32 Group 32 Group 33 Group 33 Group 34 Group 6 Group 37 The evolution of peritoneal function on long term patients treated with peritoneal dialysis. The development of new strategies to improve the membrane s viability and to minimize the consequences associated with that technique Epidemic of chronic kidney disease of unknown causes in Nicaragua: epidemiology, causal hypotheses, and public health intervention A study of the intracellular traffic of the neuronal glycine conveyor: modulated by glyt2: modulation by lipid rafts, ubiquitin and interaction Na/KATPase Modification of the gene therapy in rectum cancer treated with chemio-radiotherapy neoadjuvant: the role of trefoil factor 3 as potential therapeutic target A study of gene profiles expression in patients with advanced non-small-cell lung cancer value of a non directed study of transcriptone involved in a massive response to cisplatin-based chemotherapy in lung cancer The role of tumor stem cells therapeutic response to cisplatinbased chemotherapy non- micro lithic lung cancer The identification and isolation of a subpopulation of supporting glial cells SOX2+ in the white matter of the adult human brain Characterization cochlear implant in a CBA mouse in a model of noise induced ototoxicity Functional identification and characterization of genes involved in the malignant shift of lymphocyte behavior Universidad Autónoma de Madrid Universidad Autónoma de Madrid Universidad Autónoma de Madrid Universidad Autónoma de Madrid Universidad Autónoma de Madrid Universidad Autónoma de Madrid Universidad Autónoma de Madrid Universidad de Alcalá de Henares Universidad Autónoma de Madrid Summa cum laude Summa cum laude Summa cum laude Summa cum laude Summa cum laude Pass with honors Pass with honors Summa cum laude Summa cum laude 12/12/ No 14/10/ Yes 13/04/ No 25/04/ No 15/11/ No 26/02/ No 13/03/ No 20/12/ No 31/10/ No AUTHOR DIRECTOR GROUP TITLE UNIVERSITY RATING LECTURE DATE THESIS EUROPEAN Ana Lourdes Luis Huertas José Miguel Sánchez Márquez Juan Antonio Tovar Larrucea Leopoldo Martínez Martínez Enrique Gil Garay Samuel Antuña Antuña Eugenio-Miguel Enrique Gil Garay Ferrer Santacreu Eduardo J. Ortiz Cruz Yago Alcaína de la Iglesia Salvador Argudo Garijo Alberto Borobia Pérez Sandra Dolores Arduim Brasil Fernando Magdaleno Dans Sara Iacoponi Estibaliz Alsina Marcos Maria Paz de Miguel González Maria Paz de Miguel González María Ángeles Aller Reyero Isabel Prieto Nieto Antonio Carcas Sanjuán María Belén Pérez González Antonio González González Ignacio Zapardiel Gutiérrez Javier de Santiago García Fernando Gilsanz Rodríguez Group 38 Group 40 Group 46 Group 40 Clinical and experimental study of new components of neurocrystal dysfunction in congenital diaphragmatic hernia Experimental contributions to the study of progressive correction of scoliosis through the use of metals with memory shape Encondroma versus condrosarcoma low grade in long bones of the appendicular akeleton. Clinical and radiological criteria Group 42 A study of induction mechanisms of pluripotency using an experimental model of mouse s primordial germ cells Group 42 Adipociticas stem cell therapy of mesenchymal origin on an experimental model of secondary liver insufficiency: microsurgical extra hepatic cholestasis Group 43 The influence of demographic clinic and pharmaco genetic in stable dosage of an acenocumarol and the development dosage algorithm Group 45 New targets and therapeutics approaches in inherited metabolic disorders Group 48 The evaluation of the efficiency and safety of atosiban as a maintenance tocolytic upon the threat of a preterm labour Group 48 Group 35 Anesthesiology An analysis of the factors associated with recurrent local vulva cancer Effects of induction anesthesia with sevoflurane or intravenous anesthesia with remifentanil in neuroendocrine and inflammatory and postop in Hyperalgesia Universidad Autónoma de Madrid Universidad Autónoma de Madrid Universidad Autónoma de Madrid Universidad Autónoma de Madrid Universidad Complutense de Madrid Universidad Autónoma de Madrid Universidad de Lisboa Universidad Autónoma de Madrid Universidad Autónoma de Madrid Universidad Autónoma de Madrid Unanimous summa cum laude Pass with honors Pass with honors Unanimous summa cum laude Unanimous summa cum laude Unanimous pass with honors. Extraordinary award Summa cum laude Pass with honors Summa cum laude Summa cum laude 21/11/ No 01/07/ No 08/07/ No 20/02/ No 11/10/ No 17/01/ No 03/10/ Yes 26/02/ No 30/11/ No 03/07/ No 22 23

14 02// EXECUTIVE SUMMARY 02.3// Training Report and Teaching AUTHOR DIRECTOR GROUP TITLE UNIVERSITY RATING LECTURE DATE THESIS EUROPEAN Concepción Pérez Hernández Fernando Gilsanz Rodríguez Azahara Arturo Soriano Sancho de Ávila Benítez de Lugo Javier Arranz Durán Luis Riera del Moral Covadonga Mendieta Azcona José Antonio Blázquez González Belén Rodríguez Doñate María Martín Fuentes Fátima Martín Muñoz Mariano García Arranz Damián García Alonso Julia Bujan Varela Gemma Pascual Gonzalez Marcelo Fernando Jiménez López Ana Isabel de Cos Blanco Lucrecia Herranz de la Morena Luis Felipe Pallardo Sánchez Joaquín de Nova García Laura Espinosa Román Luis Albajara Velasco Angiology and Vascular Surgery Angiology and Vascular Surgery Cardiac Surgery Anesthesiology Anesthesiology Endocrinology Endocrinology Group 9 Pediatric Nephrology An epidemiological, observational and transversal study to evaluate the prevalence of Neuropathic Pain and the diagnostic value of scales of neuropathic pain in oncology patients on active chemotherapy The predictive value of cytokines in the evaluation of graphs, in orthotopic liver transplants Coadyuvant treatment via mesenchymal stem cells from abdominal aorta aneurysms The age of the vein wall: inflammation and alterations in the elastic component of the vein wall ease the early development vein insufficiency similarly to the ageing process Hemodynamic and clinic effectivity of lung thromboendarterectomy, in patients with chronic pulmonary hypertension thromboembolic An evaluation of a multidisciplinary group strategy to change lifestyles in obesity Doppler ultrasound of supraaortic trunks ankle-brachial and the ankle/brachialiindex, or abi index-, with macrovascular complications in diabetes patients type 2 and ischemic heart disease Oral health a kidney transplant child Universidad Autónoma de Madrid Universidad de la Laguna Universidad Autónoma de Madrid Universidad de Alcalá de Henares Universidad de Salamanca Universidad Complutense de Madrid Universidad Autónoma de Madrid Universidad Complutense de Madrid Summa cum laude Summa cum laude Pass with honors Pass with honors Pass with honors Summa cum laude Summa cum laude Pass with honors 12/11/ No 07/06/ No 14/04/ No 15/04/ No 17/05/ No 24/06/ No 01/03/ No 25/10/ No 02.4// Innovation and Transfer Activities // Innovation and Transfer Activities The Innovation Node of FIBHULP was created in June 2010 within the framework of the ITEMAS Network -currently called ITEMAS Platform- of the Carlos III Institute of Health. Since its creation, the Innovation Node has contributed to promoting and protecting innovative/ground breaking research conducted in IdiPAZ. The node also intends to harness our center s considerable innovative potential generated, as a step prior to its subsequent transfer to society. Therefore, one of the main commitments of the Innovation Node is that researchers and health personnel perceive it as a resource at their service, to provide support and advice in all that relates to the identification, management, protection, transfer, marketing and dissemination of their research results. ACTIVITIES The main task of the Innovation Node is to identify the potential transferable research results generated within our centre and to accompany and support the researcher throughout the whole innovation process: from the birth of the idea to its placement on the market. Since the Node has been in operation, we have managed projects sponsored by the centre itself and have signed collaboration agreements with important private institutions and organisations to promote innovation. Our main objectives are: Promotion of a culture of innovation protection within the various sectors that constitute IdiPAZ and its Hospital through seminars on subjects related to the protection of research results and technology transfer. Active search and identification of innovation throughout the medical setting of our centre. Provision of institutional support for groups that generate innovation. Localisation of new technologies for daily use. Active search for partners required for the development of projects, including technological companies as well as industrial and financial partners. Organisation of seminars with other centres from which potential collaborations might arise to our technological and training needs. Preparation and consultancy for any type of collaboration agreement with the industrial sector or other research centres, including attendance bids for funding. Evaluation of research results in terms of their protection and transfer. Protection of research results and management and promotion of the IdiPAZ technology portfolio. Search for licensees for the transfer of results, including existing and yet-to-be-created companies. Achievement of the greatest possible impact on society and financial return for the institution itself. Over the last year the Innovation Node has achieved the following accomplishments: This last year has been crucial for the Innovation Node because they have managed to overcome almost all procedures aimed at the establishment of the first technology-based company of the Hospital (and also of the region of Madrid) according to the regulations established by the Department of Health of the Community of Madrid will be the year of the establishment of the company Biomedica Molecular Medicine, spin-off that will exploit the research results in oncology specifically, a genomic test to determine whether breast cancer patients should have chemotherapy - designed by some members of IdiPAZ. 24 Return to 02// EXECUTIVE SUMMARY INDEX 25

15 02// EXECUTIVE SUMMARY 02.4// Innovation and Transfer Activities In addition to the four license agreements signed over the past three years, two new licenses were signed in. One of them is based on a patent related with a composition to reduce inflammatory processes, in particular, processes associated with the menopause. The other one is based on a computer application (called TIMI) intended for the management of antibiotic treatments. The Institute s technology portfolio has continued to grow, not only at the patent level but also in the area of intellectual property, mainly through the registry of computer programmes, quality of life questionnaires, etc. A catalogue of technological offers -based on specification sheets- has been completed, which includes the complete portfolio of exploitable IdiPAZ results. This catalogue aims to promote the transference of IdiPAZ s technology portfolio to the industrial sector, generate collaborative projects for technological development and foster the exploitation of research results. Those sheets that have been already validated are published on the IdiPAZ website. The catalogue will be updated as the Institute s technology portfolio grows. By virtue of its membership in the ITEMAS Platform, the Unit has continued to strengthen ties and creating synergies with the members of this Platform in order to achieve its established objectives. The Unit has participated in various forums and round tables organised by various participants of the biomedical sector. We are in the advanced phases of signing at least three more licenses that are based on technologies developed in our centre. ORGANISATION Since its implementation, the Innovation Node has been integrated into the organisational structure of FIBHULP, as one of the Support Platforms for IdiPAZ research. The Node is directed by Dr. Javier de Castro Carpeño, Bachelor of Medicine and a member of the Medical Oncology Department of the La Paz University Hospital/Universidad Autónoma de Madrid and of the Transnational Oncology Unit of IdiPAZ. The Node also consists of four other professionals experts in fostering innovation and protect research results and technology transfer: Estela Sánchez Simón, Law Graduate; Natalia Moreno Sánchez, PhD. in Genetics and Molecular Biology; Marisa Tejedor Botello, Bachelor of Economic Sciences; and María Dolores Pérez Garre, Bachelor of Chemical Sciences. CONTACT Coordinator: Javier de Castro Carpeño Phone: (+34) Members: Estela Sánchez Simón Phone: (+34) Marisa Tejedor Botello Phone: (+34) Natalia Moreno Sánchez Phone: (+34) María Dolores Pérez Garre Phone: (+34) // Patents INVENTORS GROUP OWNER(S) TITLE REGISTRATION NUMBER Segovia Iñigo, C. Group 26 FIBHULP Positioning device for neonates U30102 Montes Bueno, M. T (Utility model) Castell Gómez, J. T. Surgery FIBHULP System of partial or total openings and buttonholes for patient pyjama or nightgown P Castell Gómez, J. T. Carrascal Morillo, T. de la Oliva Senovilla, P. Surgery Pediatric Intensive Care Unit FIBHULP UNED FIBHULP INSTITUTO SALUD CARLOS III Synthetic surgical mesh Shut-off valve for the interruption technique used in the analysis of respiratory mechanics P31453 PCT/ES2005/ EP García Fernández, J. Anaesthesiology FIBHULP Anaesthesia machine simulator P PCT/ES2008/ US12/228,712 Espinosa Arranz, E. Fresno Vara, J. A. Gámez Pozo, A. Sánchez Navarro, I. Cejas Guerrero, P. González Barón, M. Casado Saenz, E. Sánchez Hernández, J. J. Perona Abellón, R. Cejas Guerrero, P. Belda Iniesta, C. Feliu Batlle, J. González Barón, M. de Castro Carpeño, J. Casado Saenz, E. Sánchez Hernández, J. J. Redondo Sánchez, A. Hardisson Hernaéz, D. Barriuso Feijoo, J. Mendiola Sabio, M. Redondo Sánchez, A. Hardisson Hernaéz, D. Barriuso Feijoo, J. Mendiola Sabio, M. Vilaboa Díaz, N. E. Gónzalez Carrasco, J. L. Multigner Domínguez, M. Lieblich Rodríguez, M. Muñoz Hernández, M. Frutos Torres, E. Saldaña Quero, L. Vilaboa Díaz, N. E. González Carrasco, J. L. Saldaña Quero, L. Frutos Torres, E. Vilaboa Diaz, N. E. Calzado-Martín, A Crespo García, L. Saldaña Quero, L. Martín-Saavedra, F. M. Vilaboa Díaz, N. Cebrián Hernando, V. Arruebo Gordo, M. Santamaría Ramiro, J. Gómez Navascués, L. Goldman Tarlovky, L. Group 32 FIBHULP Method for tumor subclassification P PCT/ES2009/ Group 32 Group 33 Group 32 Group 33 Group 32 Group 35 Group 32 Group 35 Group 40 Group 40 Group 40 Group 40 Pediatric Anaesthesiology FIBHULP UAM CSIC FIBHULP UAM FIBHULP FIBHULP FIBHULP CSIC CIBER-BBN FUAX FIBHULP CSIC CIBER-BBN FIBHULP CIBER-BBN FIBHULP CIBER-BBN Unizar FIBHULP Use of trefoil factor family 3 (TFF3) in the prognosis of patients diagnosed with colorectal cancer Genomic fingerprint for the prognosis of the evolution of colorectal adenocarcinoma Method to obtain data useful for the prediction of a patient s clinical response to an anticancer treatment Method to obtain data useful for the prediction of a patient s pathological response to an anticancer treatment Magnesium/polymer composite biomaterial for biomedical applications Method to obtain a metallic-coated biomaterial Chamber device for dynamic cell culture on biomaterials Fibrin hydrogel with plasmonic nanoparticles System and method to obtain data on a patient s breathing cycle P PCT/ES2008/ EP P PCT/ES2008/ EP P P P PCT/ES2011/ P PCT/ES2011/ P30040 PCT/ES/ P30894 P PCT/ES2011/

16 02// EXECUTIVE SUMMARY 02.4// Innovation and Transfer Activities INVENTORS GROUP OWNER(S) TITLE REGISTRATION NUMBER Group 39 FIBHULP P UAM PCT/ES2011/ de Miguel del Campo, E. Reglero Rada, G. Largo Aramburu, C. Fornari Reale, T.; Rodríguez García-Risco, M. Jaime de Pablo, L. Santoyo Díez, S. Señorans Rodríguez, F. J. García Grande, A. Merino Martín, J. Caz Bonillo, J. V. Posadas Mañanes, S. J. de Miguel del Campo, E. Posadas Mañanes, S. J. Reglero Rada, G. Largo Aramburu, C. García Grande, A. Merino Martín, J. J. Caz Bonillo, V. Fornari Reale, T. Rodríguez García-Risco, M. Señorans Rodríguez, F. J. Álvarez Gallego, M. Group 39 General and Digestive System Surgery FIBHULP UAM FIBHULP Composition for the reduction of symptoms associated with menopause Composition for the protection of tissues from the digestive tract and the nervous system of radiotherapy patients Device for the extraction of surgical specimens by insufflation and suction Castell Gómez, J. T. Surgery FIBHULP Surgical device for interrupted suture Glaria Enríquez, A. Mañas Rueda, A. Velázquez Soto, R. de Miguel del Campo, E. Largo Aramburu, C. Tabernero Urbieta, M. Reglero Rada, G. Marín Martín, F. Fornari Reale, T. Prodanov Prodanov, M. Ruiz Rodríguez, A. Ibáñez Ezequiel, E. Jaime de Pablo, L. Soler Rivas, C. Rodríguez García-Risco, M. Santoyo Díez, S. González Lorente, M. Arranz Gutiérrez, E. Gil Ramírez, A. de Miguel del Campo, E. Largo Aramburu, C. Tabernero Urbieta, M. Reglero Rada, G. Marín Martín, F. Fornari Reale, T. Prodanov Prodanov, M. Ruiz Rodríguez, A. Ibáñez Ezequiel, E. Jaime de Pablo, L. Soler Rivas, C. Rodríguez García-Risco, M. Santoyo Díez, S. González Lorente, M. Arranz Gutiérrez, E. Gil Ramírez, A. Radiotherapy Oncology Group 39 Group 39 FIBHULP FIBHULP UAM CSIC FIBHULP UAM CSIC Isolation and immobilization device for test animals Functional heart-healthy beverage containing wine and extracts of hops Method to obtain extract of hop and the extract obtained P P PCT/ES2011/ P PCT/ES2011/ EP US13/ P PCT/ES2011/ P PCT/ES2012/ P INVENTORS GROUP OWNER(S) TITLE REGISTRATION NUMBER Cejas Guerrero, P. Belda Iniesta, C. Feliu Batlle, J. de Castro Carpeño, J. Moreno García, V. Burgos, E. Casado Saenz, E. Sánchez Hernández, J. J. de Miguel González, M. P. Arnalich Montiel, F. Royuela, M. M. Zapardiel Gutiérrez, I.; de Santiago García, J. Zapardiel Gutiérrez, I. de Santiago García, J. Moreno Rubio, J. Cejas Casado, P. Feliu Batlle, J. Ramírez de Molina, A. Reglero, G. Vargas Alonso, T. Molina Arranaz, S. González-Vallinas, M. Group 32 Group 33 FIBHULP UAM HOSPITAL INFANTA SOFIA Genomic fingerprint for predicting the clinical response to an antitumor therapy in colorectal cancer Group 42 FIBHULP UAH FIBIOHRC Corneal endothelium injector Group 48 FIBHULP New single-port device for laparoscopic surgery P PCT/ES2012/ P PCT/ES2012/ P30532 Group 48 FIBHULP Laparoscopic surgical instrument P PCTES/ Group 32 Group 39 FIBHULP IMDEA ALIMENTACION Methods and kits for the prognosis of colorectal cancer Riera del Moral, L. F. Vascular Surgery FIBHULP Aortic endoprosthesis for the treatment of aneurysm Vergés Milano, J. García García, A. Ruhí Roura, R. Montell Buenaventura, E. García López, M. Aláez Versón, C. R. Escaich Ferrer, J. Egea Máiquez, J. Negredo Madrigal, P. Lorrio González, S. Valdivielso Amate, F. Bullido Gómez-Heras, M. J. Martínez García, A. Valdivielso Amate, F. Santos Burgos Muñoz, J. Ramírez Moreno, C. Sastre Merlín, I. Valdivielso Amate, F. Montoliú, J. L. Pozueta Larios, J. Ballesteros García, P. López Larrubia, P. Domínguez Mateo, L. Marco Contelles, J. L. Cerdán García-Esteller, S. Innamorato, N. G. Cuadrado Pastor, A. León, R. Egea, J. Buendía, I. Parada, E. Navarro, E. Rada, P. Cuadrado, A. García, A. G. López, M. G. Group 2 BIOIBÉRICA S.A. UAM Sulphated disaccharides for the treatment of neurodegenerative and/or neurovascular diseases Group 2 UAM Method of identifying compounds that induce or inhibit endoplasmic reticulum stress or oxidative stress Group 2 Group 2 Group 2 Group 4 Group 4 CSIC UAM CSIC UAM CSIC UNED UAM CSIC FUNDACIÓN PARA LA INVESTIGACIÓN BIOMÉDICA DEL HOSPITAL UNIVERSITARIO DE LA PRINCESA Method of identifying therapeutic compounds which can be used for the treatment and/or prevention of infections and diseases caused by human herpesviruses Alzheimer's disease animal model, method for obtaining same and uses thereof Set of magnetic resonance imaging and spectroscopy cell acidity extrinsic indicators comprise polyol derivatives based on alditols Use of sulforaphane as supplementary therapy for early-stage neurodegenerative disease Use of 3-(2-isothiocyanatoethyl)-5- methoxy-1h-indole for the treatment of neurodegenerative diseases P PCTES/ P PCTES/ P PCT/EP2010/ P PCT/ES2008/ US P PCT/ES2005/ EP US AT AU CA JP PCT/ES2006/ EP US P P P

17 02// EXECUTIVE SUMMARY 02.4// Innovation and Transfer Activities INVENTORS GROUP OWNER(S) TITLE REGISTRATION NUMBER Pérez Girón, J. V. Group 15 NANOATE SL Method for producing biosensors P Ruiz-Castellanos, M. J. de Luis Jiménez, O. Pérez Boto, V. Sanz González, R. Hernández Vélez, M. C. Mas Gutiérrez, J. A. Alonso Gordo, M. J. Salaíces Sánchez, M. Ros Pérez, M. Coloma Jerez, A. Asenjo Barahona, A. Sanz Montaña, J. L. Puente Prieto, J. Jensen, J. Romero Gómez, M. Solá Lamoglia, R. González García, J. J. Group 16 SERVICIO ANDALUZ DE SALUD UNIVERSIDAD DE SEVILLA FUNDACIÓ INSTITUT MAR D`NVESTIGACIONS MEDIQUES FIBHULP Kit for decision making in patients with Hepatitis C genotypes 1 and 4 P Mingorance Cruz, J. Castán García, P. Franco de Sarabia Rosado, P. M. Mingorance Cruz, J. Vicente Muñoz, M. Rueda González, M. S. Mingorance Cruz, J. Castán García, P. Franco de Sarabia Rosado, P. M. Llamas Matías, M. A. López-Collazo, E. Selgas Gutiérrez, R. Bellón Heredia, T. Rodríguez Sanz, A. I. Álvarez Builla, J.; Vaquero López, J. J. Sánchez Alonso, P. Alajarín Fernández, R. Friedman, S. Li, D. Narla, G. Martignetti, J. Heath, K. Ibáñez de Cáceres, I. Belda Iniesta, C. Pernía, O. Perona Abellón, R. Cortes Sempere, M. Perona Abellón, R. Sánchez Pérez, I. Machado Pinilla, R. Sastre Garzón, L. Murguía, J. R. Group 18 FIBHULP BIOTOOLS S.L. Composition, method and kit for detecting bacteria by means of sequencing Group 18 CSIC Method for determining state of growth and viability of bacterial FtsZ population, whether natural or cultivated, is based on determining existence of FTsZ rings in actively growing individual cells Group 18 Group 20 Group 25 Group 44 Group 29 Group 33 Group 33 FIBHULP BLACKBIO S.L. MIGUEL ÁNGEL LLAMAS MATÍAS FIBHULP UNIVERSIDAD DE ALCALÁ FIBHULP SINAI SCHOOL OF MEDICINE FIBHULP CSIC UAM HOSPITAL DE MADRID CSIC UAM UPV Composition, method and kit for detecting fungi and yeasts by means of sequencing Method to determine the risk of developing an infectious disease Use of compounds derived from salts of pyridazine [1,6 :1,2] pyrido[3,4-b]indol-5-inium and piridazine[3,2-b] benzimidazol-5-ium as anti-inflammatory agents Kruppel-like factor 6 (klf6), a tumor suppressor protein, and diagnostics, therapeutics, and screening based on this protein Method for predicting the response to a treatment consisting of radiotherapy combined with cisplatin-based chemotherapy Sequence of nucleotides and peptides GSE 24.2 of dyskerin, which can induce telomerase activity, method for obtaining same, therapeutic compositions and applications thereof PCT/ES2009/ EP MX CA P PCT/ES2010/ P30768 P31143 PCT/US2001/ EP CA P30783 P PCT/ES2006/ EP US AT CA DK JP PT INVENTORS GROUP OWNER(S) TITLE REGISTRATION NUMBER Group 33 CSIC UAM Perona Abellón, R. Sastre Garzón, L. Machado Pinilla, R. Sánchez Pérez, I. Martínez Máñez, R. Murguía, R. Perona Abellón, R. Agostini, A. Mondragón Martínez, L. Moreno Torres, M. Manguán García, C. Marcos Rodríguez, M. D. Soto Camino, J. Sacedón Galarza, F. Perona, R. Sastre, L. Pintado Berninches, L. Carrillo García, J. Molina Pachón, A. Iarriccio Silva, L. Manguán García, C. Polak, M. Roca-Ribas Serdá, F. Gavilán Bouzas, J. Lassaletta Atienza, L. Miró Castillo, N. Rodrigo Dacosta, J. Cobo Parra, P. Varela-Nieto, I. Murillo-Cuesta, S. Navares Zaera, R. Martínez Vega, R. Cediel-Algovia, R. Cobo Parra, P. Varela Nieto, I. Murillo Cuesta, S. Cediel Algovia, R. Hergueta-Redondo, M. Sanz, P. G. Rojo, A. García, J. F. Moreno-Bueno, G. Garcia García, J. F. Martín Moreno, A. M. Roncador, G. Martinez Torrecuadra, J. L. Moreno-Bueno, G. Pivel Ranieri, J. P. Ferrer Cuesta, J. M. Gidekel, M. Molina Carlevarino, M. L. Cabrera Barjas, G. Sunkel Letelier, C. Gutiérrez Moraga, A. Juarranz de la Fuente, A. Espada Regalado, J. Sanz Rodríguez, F. Espada Regalado, J. Carrasco Cerro, E. Calvo Sánchez, M. I. Juarranz de la Fuente, A. Group 33 CSIC UPV CIBERNED CIBERER Use of inductor agents GSE24.2 for producing pharmaceutical compositions for treating illnesses relating to cellular senescence Release of substances into senescent cells Group 33 CSIC Peptides derived from GSE24.2 for treating diseases caused by oxidative stress and DNA damage Group 34 Group 34 Group 34 Group 36 Group 36 Group 36 Group 36 MED-EL ELEKTRO- MEDIZINISCHE GERAETE GMBH CSIC UCM CIBERER CSIC UCM UAM CSIC FUNDACIÓN MD ANDERSON FUNDACIÓN MD ANDERSON CNIO APOTEKNOS PARA LA PIEL Y UXMAL UAM CSIC Hearing treatment in patients with questionable cochlear nerve functionality Anechoic acoustic chamber for evaluating the auditory function in laboratory animals Method for designing a reverberating acoustic chamber for hearing tests with animals Gasdermin B2 as a new biomarker of malignance and resistance of Trastuzumab inhibitor in Her2+ tumors Using specific antibody in the diagnosis and prognosis of lymphoma Use of a composition containing an extract of a gramineous plant for the prevention of cutaneous lesions caused by ultraviolet radiation Use of a photosensitive agent capable of producing reactive oxygen species in the production of a drug for the photodynamic therapy of a disease related to stem cells, in vitro use, and pharmaceutical composition P PCT/ES2008/ EP US JP CA P PCT/ES/ P31573 PCT/US2011/ US P P PCT/ES2009/ P P P PCT/ES2010/ P PCT/ES/

18 02// EXECUTIVE SUMMARY 02.4// Innovation and Transfer Activities INVENTORS GROUP OWNER(S) TITLE REGISTRATION NUMBER Group 36 INDUSTRIAL P FARMACÉUTICA PCT/ES2010/ CANTABRIA S.A. US Domínguez Valdés-Hevia, M. Brieva Delgado, A. González Rodríguez, S. Reyes Martín, E. Carballeira Morado, J. Quintana González, E. Pivel Ranieri, J. P. Guerrero Gómez-Pamo, A. Juarranz de la Fuente, A. Espada Regalado, J. Sanz Rodríguez, F. Olmeda Casadomé, D. Moreno Bueno, G. Portillo Pérez, F. Cano García, A. Olmeda Casadomé, D. Peinado Selgas, H. Portillo Pérez, F. Nieto Toledano, M. A. Cano García, A. Campanero, M. R. Molina Privado, I. Rodríguez Martínez, M. Zapata, J. M. Pérez Chacón, G. Fabiilli, M. Wilson, C. Padilla, F. Martín-Saavedra, F. M. Valenta, R. Constantin, C. Quirce Gancedo, S. Pérez, B. Jorge-Finnigan, A. Desviat, L. R. Martínez, A. Underhaug, J. Ugarte, M. Arenas, M. A. Conde, A. Damborenea, J. J. Matykina, E. Esteban Moreno, J. Gómez Barrena, E. Pérez- Jorge Permarch, C. Pérez Tanoira, R. Brian Gahan, P. Stroun, M. García del Olmo, D. García Arranz, M. Vega Clemente, M. L. Group 36 UAM CSIC Product for the preparation of dermatological, cosmetic or cosmeceutical compositions intended for skin treatment Method for the diagnosis and/or prognosis of breast cancer Group 36 UAM Materials and methods for the derepression of the E-cadherin promoter Group 37 Group 37 Group 40 CSIC UAM CSIC UAM UNIVERSITY OF MICHIGAN Method for the differential diagnosis between Burkitt lymphoma and diffuse large B-cell lymphoma Use of an indolic compound with nucleophilic substituents at C3 and its dimeric variants in the preparation of a pharmaceutical composition useful for treating B-lymphoid neoplasias Ultrasound-Triggerable agents for tissue engineering Group 44 PHADIA AB Novel wheat allergens. (Nuevos alérgenos del trigo) Group 45 Group 46 Cell Therapy UAM UNIVERSIDAD DE BERGEN UNIVERSIDAD DE MICHIGAN CSIC IIS-FJD PETER BRIAN GAHAN MAURICE STROUN FIBHULP Compounds useful for the treatment of methylmalonic aciduria Titanium materials anodised with fluoriner Method for blocking tumour growth P PCT/ES2008/ US P P P PCT/SE2008/ EP AU CA CN JP RU US P30171 P PCT/ES2011/ EP // Trademarks BRAND NAME OWNER AUTHOR APPLICATION NUMBER LOGO KARYOARRAY FIBHULP INGEMM USA no Europe no METABOLARRAY FIBHULP INGEMM Spain no USA no Europe no ONCOHEMATOARRAY FIBHULP INGEMM Spain no USA no Europe no OVER GROWTH ARRAY FIBHULP INGEMM Spain no USA no Europe no ONCOARRAY FIBHULP INGEMM Spain no USA no Europe no ONCOSEC FIBHULP INGEMM USA no Europe no INGEMM FIBHULP INGEMM Spain no USA no Europe no THYROARRAY FIBHULP INGEMM USA no Europe no COMPLEMENTEST FIBHULP Margarita López Trascasa Europe no IdiPAZ FIBHULP FIBHULP USA no Europe no PHARMARRAY FIBHULP INGEMM UAM EEUU no Europe no Return to 02// EXECUTIVE SUMMARY INDEX 33

19 02// EXECUTIVE SUMMARY 02.5// Quality Assurance Activities // Protocols and Clinical Pathways Name of Protocol Status Name of Protocol Status // Quality Assurance Committee IdiPAZ s vision is to be a national and European reference centre for multidisciplinary translational biomedical research. To achieve this objective, the institution combines its efforts to ensure the quality of all its processes, thus ensuring the best service, research and teaching. IdiPAZ is committed to a comprehensive quality model backed by the maturity and quality of the managing team of the IdiPAZ institutions. In order to support and facilitate quality, the institution has a permanent Quality Committee. During, the Quality Committee developed its principles and achieved specific quality objectives. In July the Quality Committee obtained the ISO 9001:2008 standard certification for its quality management. The scope of this certification includes the three main processes assigned to the Quality committee: monitoring technical and scientific quality; support and development of initiatives for the improvement of IdiPA; and, the analysis of complaints, suggestions and acknowledgements received from the IdiPAZ researchers. In these settings, the Quality Committee maintains a close relationship with the Technical Secretary of IdiPAZ. This achievement is a starting point for the future certification of other areas of IdiPAZ, thus spreading the ISO Quality Management culture throughout the organisation. Moreover, considering that IdiPAZ is a continuously evolving organisation, our ISO Quality activities have been enriched by the different achievements made by and Universidad Autónoma de Madrid. The hospital, with its accumulative experience of quality of care improvement, has continued its intensive work during. Protocols, clinical pathways and participation in clinical practice guidelines has been developed and reviewed. The attached tables show the clinical pathways reviewed in as well as the protocols developed or updated in the same period. In addition, staff members collaborate continuously in the institution s improvement by participating in clinical committees and creating improvement groups, as well as implementing satisfaction surveys for patients and professionals. Also during, 16 departments maintained the standard ISO 9001:2008 of their quality management system. In addition to these certificates, the hospital is one of the main Spanish centres of accreditation of reference centres, services and units of the Spanish National Health System. In fact, in the hospital had 18 accredited units. The centre also has departments that are preparing their accreditation at other scientific-technological levels, humanization, etc. Finally, in, the quality management at IdiPAZ was maintained with the primary objective of facilitating activities for all the professionals that are part of IdiPAZ and at the same time offering an overall and common reference framework for the achievement of excellence. Actuación en el ingreso pre y postquirúrgico del niño con cardiopatía congénita Actuación en Neonatología con el postoperatorio del paciente con cardiopatía congénita Actuación en Reanimación infantil con el postoperatorio del paciente con cardiopatía congénita Actuación multidisciplinar en el estudio y diagnóstico de las reacciones adversas a los medios de contraste radiológico Actuación Multidisciplinar para diagnóstico y tratamiento de pacientes con Síndrome de Stevens-Johnson/ Necrolisis Epidérmica Tóxica, pacientes con DRESS y Pustulosis Exantemática Aguda Generalizada ACV agudo Adecuación en diálisis peritoneal Amenaza de parto prematuro. Actualización en su manejo Anemia en Enfermedad Renal Crónica Avanzada (ERCA) Anestesia en trasplante renal Asepsia/antisepsia en los quirófanos de cirugía cardiaca de adultos Asistencia ventricular Atención a la trombosis venosa superficial Atención a Pacientes con Angioedema Hereditario por déficit de C1 inhibidor Atención al paciente con TCE anticoagulado/ antiagregado Atención al paciente con urgencia reumatológica Atención al paciente con urgencia reumatológica Atención Nutricional en Fibrosis Quística Atención Nutricional en Trastornos de la Conducta Alimentaria Calidad de prescripción de antibióticos ("Programa PROA" de prescripción optimizada de antibióticos) Calidad de prescripción de tratamientos biológicos en enfermedades autoinmunes sistémicas Carta de duelo y seguimiento telefónico Cartas de condolencia a familiares de pacientes fallecidos New New New New New New New New New Cateterismo de venas pancreáticas y vena hepática derecha para detección preoperatorio de insulinomas Cateterización de senos petrosos para determinación de ACTH Cateterización de venas cervicales y torácicas para toma de muestras de PTH Cateterización de venas suprarrenales en el hiperaldosteronismo Colelitiasis Colestasis neonatal Comprobación y seguridad inicio administración biológicos (vacunas) Control de la integridad de la piel y tejidos blandos de los pacientes sometidos a cirugía cardiaca Derivación de pacientes a ERCA Derivación desde primaria de pacientes a Nefrología Desensibilización a PLV en niños con respuesta anafiláctica Diagnóstico y tratamiento de Cáncer de mama Diagnóstico y tratamiento de la toxoplasmosis congénita Disfunción del catéter en diálisis peritoneal Distocia de hombros Dolor torácico Duelo a familiares Educación nutricional y seguimiento grupal Enfermedad Inflamatoria pélvica Estudio de las Miopatías Metábolicas Estudio de riesgo cardiovascular en pacientes con artritis de inicio Estudio del donante vivo Estudio en pacientes con Conectivopatías Estudio Enfermedad Paget Estudio preoperatorio de pacientes con carcinoma broncogénico Evaluación clínica pie diabético Evaluación de la membrana peritoneal Evaluación hipotálamo-hipofisaria en los traumatismos craneoencefálicos Evaluación y seguimiento de pacientes coronarios con cardiopatía isquémica New New New New New New New New 34 35

20 02// EXECUTIVE SUMMARY 02.5// Quality Assurance Activities Name of Protocol Status Name of Protocol Status Name of Protocol Status Clinical Pathway Status Fallo hepático agudo Fiebre del viajero Fisioterapia respiratoria pre y postoperatoria Formación en higiene de manos Golpe de calor Hemofiltración de cadenas ligeras Hepatitis autoinmune Hepatitis viral Hipertensión arterial en el periodo neonatal Hipertensión portal Historia clínica, seguimiento de diabetes y control médico de educación diabetológica Indicaciones quirúrgicas y manejo postoperatorio del ductus arterioso Infarto Cerebral Neonatal Infección de catéter central permanente en hemodiálisis Inmovilización terapéutica Inmunosupresión en el trasplante renal Inmusosupresión en el trasplante Intervención intensiva en obesidad (Programa EGO) Intoxicación por litio Intoxicación por metanol Líquido turbio en diálisis peritoneal Malnutrición Hospitalaria Manejo de enfermedad tromboembólica venosa Manejo de la vía aérea Manejo de las deformidades congénitas en la pared torácica (pectus excavatum y carinatum) Manejo de terapias biológicas Manejo del VHC en la Unidad de Agudos de Hospitalización Manejo del VHC en la Unidad de Crónicos de Hemodiálisis Manejo multidisciplinar de la estenosis carotídea Manejo quirúrgico del derrame pleural maligno Manejo, medidas de aislamiento y trípticos de información a los familiares para prevenir la extensión de microorganismos patógenos en los pacientes ingresados Manejo/visitas del feto con cardiopatía Metabolopatías New New New New New New New New New Modelo proforma de declaración médica para solicitud por parte de los familiares de cuidado del menor afectado de enfermedad grave Modelo proforma de justificante de acompañamiento a familiares Nefropatía por contraste Nuevos modos de ventilación no invasiva en neonatología. Cánulas RAM Nutrición Artificial Domiciliaria Nutrición en Enfermedad Renal Crónica Avanzada (ERCA) Nutrición en hemodiálisis Nutrición parenteral durante la hemodiálisis Obesidad en el embarazo Optimización de antirretrovirales Osteodistrofia en Enfermedad Renal Crónica Avanzada (ERCA) Precauciones de contacto en pacientes con gérmenes multirresistentes Preparación para la colonoscopia en paciente ERCA Pretrasplante en Enfermedad Renal Crónica Avanzada (ERCA) Prevención de lesiones de piel y tejidos blandos en pacientes sometidos a cirugía cardiaca Prevención del riesgo suicida en la Unidad de Hospitalización psiquiátrica Profilaxis antibiótica en cirugía de mama Profilaxis de osteoporosis corticoidea Protocolo antiestrés de la enfermedad renal Prueba de estimulación del cortisol con comida Realización de la exploración funcional nasal con rinomanometría Rechazo agudo tras trasplante renal Recirculación en hemodiálisis Recogida de muestra para las pruebas de catecolaminas, ácido vanilmandélico, hidroxiindolacético, metanefrinas y dopamina. Recogida y envío de muestras al Servicio de Microbiología Registro de morbimortalidad Revisión de la anticoagulación Screening de S. aureus en hemodiálisis Seguimiento del riñón único Seguridad inmunógena en terapias biológicas New New New New New New New New New New New Síndrome de hiperestimulación ovárica Supresión salina para confirmación de hiperaldosteronismo primario Suspensión de terapia biológica Talleres de actividad física para el paciente con obesidad Talleres de dietética para el paciente con obesidad Talleres de psicología para el paciente con obesidad Test de ayuno prolongado Test de restricción hídrica Toxoplasmosis y embarazo Transplante cardíaco infantil Transplante de Miembro Superior Transfusión segura: unidad de quemados críticos Trasplante hepático Trasplante hepático de donante vivo, en niños no residentes Trastornos de conducta alimentaria Tratamiento de hiperglucemia en pacientes con Ictus Tratamiento de la Hipertensión Pulmonar Tratamiento de la insuficiencia cardiaca en el anciano Tratamiento de la Leucemia Mieloide Crónica Tratamiento del sangrado de quistes en la poloiquistosis renal Tratamiento médico del aborto espontáneo del primer trimestre Tratamiento médico del embarazo ectópico Tromboprofilaxis del embarazo Trombosis de la vena renal en el trasplante Utilización de anti-tnfs en Reumatología, Digestivo y Dermatología Utilización de Bortezomib y Lenalidomida Utilización de inhibidores de la tirosín kinasa en carcinoma renal Utilización de Omalizumab Vacunación del VHB Vacunación en Enfermedad Renal Crónica Avanzada (ERCA) Valoración funcional en Enfermedad Renal Crónica Avanzada (ERCA) Valoración y manejo del dolor en el recién nacido Vuelta a diálisis tras fallo de trasplante renal New New New New New New Agitación psicomotriz Ataxias y paraparesias espásticas degenerativas Atención de las neuropatías hereditarias Braquiterapia Cirugía de la obesidad Control metabólico de la diabetes gestacional Diagnóstico precoz de carcinoma broncogénico Enfermedad respiratoria exacerbada por aspirina (EREA) Extracción de sangre preoperatoria en reanimación en pacientes cianóticos Fístulas arterio-venosas Hiperhidrosis esencial palmar y axilar Ictus agudo Ictus en edad pediátrica Limitación del esfuerzo terapéutico en neonatología Manejo ambulatorio del debut de diabetes tipo 1 Manejo de enfermedad tromboembólica venosa Manejo de insuficiencia cardiaca Manejo de neumonía Neumotórax espontáneo primario Nutrición enteral Nutrición parenteral Pacientes con bombas de infusión subcutánea continua de insulina (ISCI) Proceso asistencial del embarazo, parto y puerperio normal Síndrome de abstinencia alcohólica Unidad de patología mamaria Varices New New New New New New 36 Return to 02// EXECUTIVE SUMMARY INDEX 37

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