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28

29 CONFERENCIAS PLENARIAS

30

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38

39 COMUNICACIONES ORALES

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59 % 2R9 C < 1. * < % 1 *. % 52. #. 4 :?- 94-;4-#$ ;9-9 -&EJN@A /&259(;-& 5 97"-( #( 9 ; &(& MSE '& <N<NA 97>/& 7 A J

60

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64 &+(&- %'M. ' 03$ 0 3P+/4"$ ( IK 3 I5K + ISK IµEK 9>B±C JM@9±<R@ B9R=±=R9 J "D< C<M±M J=@=±C9 F9C±;; <=W<9 "D-7< CB@±; J=B=±FC ;==±CB M<F±F9 "D<B-7< =<>±> JMC9±9M F@;±MM 9>99±9=M "D<B-7< =9<±; J=MF±=B FBF±M; BB=±9<9 A B PTX concentration PTX HPCD NP PTX CD NP 5000 PTX NHCD NP Taxol PTX-NP Time (h Taxol i.v PTX concentration (ng/ml C CDCD ( 0 ' 3' ;'$ $. 0 β' 3' ;'$ ' ' 3' 6';'$ +. 0 ;6 ' 3' ;6;'$ 'K U&". L 4A "D L / L L& &. L"D -7B-7B-7@ &LA 8 & L& A & "D K&@4A6& "D<-7< "D<B-7< L <K && &"D L& "D<B-7< ( &L & < M ". & Time (h (53$'=0@..." 2K.' 0 3$ 0 34X$ 38$ ' 0= = 34X$ % 5'K I1EK ' IK ' I1K # I1K 9EC( I1 J9 K N MMNK M M KJK "D< "D<-7< MJMJbb KM K N KS N "D<B-7< MNNbb SK MN S "D<B-7< KM KN KMM N S N bb0n"d<8bβ<-7< "D<β<-7<@"D<Bβ<-7< "<9U& 6 & &I &L & LI & A. & &. "D<-7< "D<B-7< L&& & Sa UD F4 4GF G F2 A 6/- F9 - "%G@/4S<JSA? [\ 4 ;- 3 SS@Ae [\ Y& ('-&Ke [\/=&3@AeM@KA JS

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66 &+(&- E. #e 5<.5 +. e Y<. 9&9 4E A %*6 C.%-< & *5Y43< Y43< E E E E E E E E E % 1%88 53\ ]$3^$ 1.40E E E E E E E E Concentration Micromolar Concentration Micromolar 110%< ]^$ 3\$ C ' ' # % ' * % # Y43< + 5 & '.$ * < & 2% Y43<. * 9 Y43< + 5 2% K & & $ $ * % % $ # % &. 6 <9 -E/4M< NK<e4N<J <-% E 4-89NRSe4-89MRJM <- E LI. (68/69E C/B(<-"<K<JN U K J <&& - # U J M

67 %# 8/#"%5"#"#%548/ /4% ;159; 2$+$C$/+&$4 "%# / C 9# $RNN <E] *6 C + % + * %# + # R * $ ' J<a % ' El presente estudio tiene por objeto caracterizar la disposición de vancomicina en pulmón cuando se administra en forma de liposomas por vía pulmonar. # #6 9 C<w< & & 4A -& & (A 5A ( (A & & 9 A BmNKD<@9I4A %% C%% # + & % / % $ C$ A " J`- K& & K`- M " $ J 4 & $ U & 2 % % 2 %% FL&<G 2 /$*% +* G9 A$ $ *% m M A 6 + # % % % * $ * # * $ # + * / 6 666A #@266A % $* ''&$ 7# ' * 38 J / 6A J9 BmNKRa " D< C M

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73 PÓSTERS

74

75 TECNOLOGÍA FARMACÉUTICA

76

77 ?( /8+//"O #"/"#"#%"%/%% %/#"""JC+"%#/%% -42$$<4$695 ('95 7 "%# 5 *:L A %* C C $ % ' C >A #@A * & % '# $ ' %* ' ' C =L C= & $ *# + $ % +. $ # # # C $ 4"--R-< "-NR-< C # & $ < %/ C =L@RA C < C $ % %* C %-< C= 9 * "-N * 9. A $ C= * -. 9@A Pemeabilidad LY (cm/s 6e-7 5e-7 4e-7 3e-7 2e-7 1e-7 0 LY LY + AAS 1mM LY + PC 1mM ATCC/Caco-2 ('% 7` % 003$ 5 Permeabilidad LY (cm/s 3.0e-7 2.5e-7 2.0e-7 1.5e-7 1.0e-7 5.0e TC7/Caco-2 LY LY + AAS 1mM LY + PC 1mM ( 5'% 7` % 003$ T N

78 &+(&- Permeabilidad LY (cm/s 1.8e-7 1.6e-7 1.4e-7 1.2e-7 1.0e-7 8.0e-8 6.0e-8 4.0e-8 2.0e TC7/Caco-2 LY LY + AAS 0.1mM LY + PC 0.1mM (#'% 7` % 0 0 3"$ T / C=% -<%"-N1 $ + + B* * $ C= $ % C. $ 6 / 3 6A. -44/ C + C=L. * % # C =L % 1 ' & 9 -@42CJ<M<-< R4C6A B--KKDA :?- /& 3/ Y"I "& " B& 4 & = 4 = - L& & ' -< & & & & & & 3& Ke5JENK<NJJ Y& = BL Y /&$ 9 "& -< ( (& (&emm@akk<kjn /IBB /B89Y ;Y&& &' -< L $ ( & ( Se@AEM<MM K"I$I 9/ B 9 4/< Y& = /&$ 9 & -< (& (& 3& - KeJE<N N

79 ?( / %/#$"%"""/"8%"%/%%% N#"6%""#/%8/&8# 84 ;(C#9 7 6%P%"%# CCSCC" * 4 $ %< *% + C # $.* # * + # 1 + # 9- # F(G #. +. C + $ *.+ $ + * $+ % %@A ' ' +@-A $ a A # # $ & + # # 9 /$ & + " + % 9# % / $ * % U@9 94/4A <I-<S 5<5 * + $$ 9 C$J9 + #K9 C<R@MEK RA' CRC S JµC # % 2%6-B@A # / $ (3MA * # 3/ C % * #$$ - " f K4% `- N`- J`-R& 4+ # + 4& %3 # +4-% $ Ja $ $ %* " + -4 $ $ J`- & Tabla 1. Valores estimados y sus respectivos intervalos de confianza del 95% bootstrap para los parámetros cinéticos y el plazo de validez. 0 0 ISK K < MN / I1 J9 K I.EK B<S I-K NK K KS< K KM< J K< SM K< M KKK< JM JN< J NM< K< M KK< JM JM< J N< N C % + a@ja $ $ # K % * #@ %A@JA * S % + N

80 & + (&- $ C % + % * + + % Histogram of t90% Normal Q-Q Plot # E- + " & % Histogram of Ln A Normal Q-Q Plot 6000 Sample Quantiles Theoretical Quantiles. 6 * 3 0? * 3. $ # $ $ 3 aa & * * & * < $ # YYYY 0 % % * : * 0. ( * $ A % A % 1 6 % % NK -4 Theoretical Quantiles 0 ' # $ # 4.0 * # C 3.8 YYYY % 0 * 1 < 3.6 t90% Frequency S a m p le Q u a n tile s Normal Q-Q Plot 2 Sample Quantiles Histogram of Ea 2 Normal Q-Q Plot Theoretical Quantiles Ln A Ea. -2 Theoretical Quantiles Histogram of t90% % t90% F requenc y S a m p le Q u a n tile s F requenc y 0 Theoretical Quantiles Co % Frequency S a m p le Q u a n tile s Normal Q-Q Plot 0 F re qu enc y Histogram of Co % $ QB " & ( 3 ; 4 A 6-B 5 4 E 9 (A A = & I / 4 = & 9 ; & / NME N K<N S / N 4 I /4 ERRLLL3< ' 8 4 ;( CC # 9 6 ; & K E M < N M