CURRICULUM VITAE Antonio José Torres M.D., Ph.D., F.A.C.S. February 2013

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1 CURRICULUM VITAE Antonio José Torres M.D., Ph.D., F.A.C.S. February 2013 Dr. Antonio J. Torres was born in Coin (Málaga), Spain (17 December 1955). He received his M.D. degree from Málaga University School of Medicine in 1978 (License Number: He completed his training as a surgical intern and resident at the Carlos Haya University Hospital in Malaga (Spain) where he completed his residency in General and Digestive Surgery in Afterwards he completed his residency in Thoracic Surgery at the Complutense University School of Medicine (Clínico San Carlos Hospital) in Madrid in Dr. Torres is certified by the Spanish Board of General and Digestive Surgery (1981) and Spanish Board of Thoracic Surgery (1986). In 1983, he got his Ph Degree at the Complutense University School of Medicine in Madrid After completing his residencies, Dr. Torres became staff of the General, Digestive and Thoracic Service at the Clínico San Carlos Hospìtal, in Madrid (Spain). In 1986, Dr. Torres became Associate Professor of Surgery at the Complutense University of Madrid (Spain). In 2000, he became Professor of Surgery at the same University. At present time, he is Professor of Surgery at the Complutense University of Madrid, and Chief of the General, Digestive and Thoracic Surgery Service at the Clínico San Carlos Hospital. His main areas of interest have been: Bariatric Surgery, Obesity, Gatrointestinal Hormones, Intraabdominal Infections, Surgical Oncology and Video-Endoscopic Surgery (anti-reflux procedures, hepatobiliopancreatic surgery, and obesity surgery procedures) He is a member of 28 national and international professional associations including the International Federation for the Surgery of Obesity and metabolic disorders (IFSO), International Society of Digestive Surgery, the American College of Surgeons, the European Association of Endoscopic Surgery and the Spanish Society of Surgeons. At present time is the Past President of the International Federation for Surgery of Obesity and Metabolic related Diseases (IFSO) ( ) Dr. Torres has authored or co-authored over two hundred peer-reviewed journal articles and serves as principal investigator on numerous studies including several grants funded by officials institutions. 1

2 (ENCLOSED YOU CAN FIND A RELATION OF JOURNAL ARTICLES OF THE LAST 8 YEARS DIFFERENTIAL IMPACT OF P16 INACTIVATION BY PROMOTER METHYLATION IN NON-SMALL CELL LUNG AND COLORECTAL CANCER: CLINICAL IMPLICATIONS R González Quevedo, C García Aranda, A Morán, C de Juan, A Sánchez Pernaute, A Torres E Díaz Rubio, JL Balibrea, M Benito, P Iniesta. Internacional Journal of Oncology 24: , RELATIONSHIPS BETWEEN 3P DELETIONS AND TELOMERASE ACTIVITY IN NON-SMALL-CELL LUNG CANCER: PRONOSTIC IMPLICATIONS. P Iniesta, R González Quevedo, A Morán, C García Aranda, C de Juan, A Sánchez Pernaute, A Torres, E Díaz Rubio, JL Balibrea and M Benito. British Journal of Cancer (2004) SURGICAL SITE INFECTION A EUROPEAN PERSPECTIVE OF INCIDENCE AND ECONOMIC BURDEN. David J Leaper, Harry van Goor, Jacqueline Reilly, Nicola Petrosillo, Heinrich K Geiss, Antonio Torres, Anne Berger. Int Wound J 2004;1: BIPULMONARY TRANSPLANTS WITH LUNGS OBTAINED FROM TWO NON- HEART-BEATING DONORS WHO DIED OUT OF HOSPITAL. J Ramón Nuñez, A Varela, F del Rio, P Gámez, J Calatayud, M Córdoba, F Hernando, P Usseti, A Gómez, MC Carreño, A Torres, J Gómez. JL Balibrea, A Lopez. J Thoracic Cardiovasc Surg 2004:127: CHARACTERIZATION OF MDGA1, A NOVEL HUMAN GLYCOSYLPHOSPHATIDYLUINOSITOL-ANCHORED PROTEIN LOCALIZED IN LIPID RAFTS. a. Díaz-López, C. Rivas, P. Iniesta, A, Morán C. García-Aranda, D. Megías, A. Sánchez- Pernaute, A. Torres, E. Díaz-Rubio, M. Benito, D. De Juan. Experimental Cell Research 307 (2005) TYPE OF RESECTION AND PROGNOSIS IN LUNG CANCER. EXPERIENCE OF A MULTICENTRE STUDY. R, Rami-Porta, M, Mateu-Navarro, J, Freixinet, M de la Torre, AJ, Torres García, Yat-Wah Pun, A, Cantó Armengol, on the behalf of The Bronchogenic Carcinoma Cooperative Group of the Spanish Society of Pneumology and Thoracic Surgery (GCCB-S). European Journal of Cardio-Thoracic Surgery 28 (2005)

3 THE DEVELOPMENT OF LAPAROSCOPIC SURGERY IN SPAIN. Xavier Feliu, Eduardo Mª Taragona, Ana García-Agustí, Albert Pey, Angel Carrillo, Antonio Mª Lacy, Salvador Morales, José Luis Salvador, Antonio Torres, Enrique Veloso. Di Surgery 587. DIFFERENTIAL GENE EXPRESION PROFILE BETWEEN RER + AND RER SPORADIC COLORECTAL TUMOURS Manuel benito, J. Rodríguez, P. Iniesta, C. de Juan, C. García-Aranda, A. Sánchez Pernaute, A. Torres, E Díaz- Rubio, J.L. Balibrea and M. Benito. Familial Cancer 2005: P 19. OVEREXPRESSION OF C-MYC AND LOSS OF HETEROZIGOSITY ON 2P, 3P, 5Q, 17P AND 18Q IN SOPORADIC COLORECTAL CARCINOMA. A Sánchez Pernuate, E, Pérez Aguirre, FJ Cerdán, P. Iniesta, L. Díez Valladares, C. de Juan, A, Morán A, García Botella, C. García Aranda, M. Benito, A.J. Torres and J.L. Balibrea. Rev Esp Enferm Dig Vol 97, Nº 3, pp (2005). RIGHT-ANGLED STAPED LATERO-LATERAL DUODENO-JEJUNAL ANASTOMOSIS IN THE DUODENAL SWITCH. A.Sánchez Pernaute, E. Pérez Aguirre, L. Díez Valladares, A. Robin, P. Talavera, M.A. Rubio, A. Torres García. Obesity Surgery, DEMORA EN EL TRATAMIENTO QUIRUGICO DEL CANCER DE PULMON A.J. Torres García An Med Interna 2005;22, CLINICAL RELEVANCE OF MMP-9, MMP-2, TIMP-1 AND TIMP-2 IN COLORECTAL CANCER. Morán A, Iniesta P, García-Aranda C, de Juan C, Sánchez Pernaute A, Torres AJ, Díaz Rubio E, Balibrea JL, Benito M. Oncology Reports 2005,13(1) ADYUVANT VINORELBINE PLUS CISPLATIN VERSUS OBSERVATION IN PATIENTS WITH COMPLETELY RESECT STAGE IB-IIIA NON-SMALL-CELL LUNG CANCER (ADJUVANT NAVELBINE INTERNATIONAL TRIALIST ASSOCIATION (ANITA)): A RANDOMISED CONTROLLED TRIAL. Dovillard JY, Rosell R, De Lena M, Carpagnano R, Gonzáles-Larriba JL, Grozki T, Rodrigues Pereira J, Le Groumellec A, Lorusso V, Clary C, Torres AJ, Dahabreh J, Bouquet, PJ, Astudillo J, Fournel P, Artal-Cortes A, Jassem J, Koubkova L, His P, Riggi M, Hurteloup P. Lancet Oncol 2006;7:

4 MUCOCELE OF THE GASTRIC TUBE AFTER CONVERSION OF VERTICAL BANDED GASTROPLASTY TO DUODENAL SWITCH: NOT JUST A RADIOLOGICAL IMAGE. Sánchez Pernaute A, Pérez Aguirre E, Talavera P, Robin A, Díez Valladares L, Cabrerizo L, Rubio MA, Méndez R, Santos E, Torres A. Obesity Surgery, 16,2006, CUIDADOS DEL PACIENTE COLOSTOMIZADO Cerdán J, Esteban F, García M, Jiménez F, Palencia N, Cerdán C, Torres AJ. Rev. Cáncer, Vol. 20, Nº 2, 85-91, DOLOR ANAL POST-HEMORROIDECTOMÍA F. Esteban, M, García, N. Palencia, F, Jiménez, A. Torres, J, Cerdán. Algia 2006; 1:7-15. CUIDADOS DEL PACIENTE COLOSTOMIZADO Cerdán J, Esteban F, García M, Jiménez F, Palencia N, Cerdán C, Torres AJ. Rev Cáncer 2006; 20 (2); ISSN MUCOCELE OF THE GASTRIC TUBE AFTER CONVERSION OF VERTICAL BANDED GASTROPLASTY TO DUODENAL SWITCH: NOT JUS A RADIOGICAL IMAGE Sánchez-Pernaute A, Pérez-Aguirre E, Talavera P, Robin A, Díez-Valladares L, Cabrerizo L, Rubio MA, Méndez R, Santos E, Torres AJ. Obesity Surgery 2006; 16: ISNN CORRELATIONS OT TELOMERE LENGTH, TELOMERASE ACTIVITY, AND TELOMERIC-REPEAT BINDING FACTOR 1 EXPRESSION IN COLORECTAL CARCINOMA Garcia-Aranda C, de Juan C, Diaz-López A, Sánchez-Pernaute A, Torres AJ, Diaz-Rubio E, Balibrea JL, Benito M, Iniesta P. Cancer 2006;106: DOI: /cncr CRITICAL ASSESSMENT OF THE CURRENT GUIDELINES FOR THE MANAGEMENT AND TREATMENT OF OBESITY Burguera B, Agusti A, Arner P, Baltasar A, Barbe F, Barcelo A, Bretón I, Cabanes T, Casanueva FF, Couce ME, Dieguez C, Fiol M, Fernadez-Real JM, Formiguera X, Fruhbeck G, Garcia-Romero M, Garcia-Sanz M, Ghigo E, Gomis R, Higa K, Ibarra O, Lacy A, Larrad A, Masmiquel L, Moizé V, Moreno B, Moreiro J, Ricart W, Riesco M, Salinas R, Salvador J, Pi-Sunyer FX, Scopinaro N, Sjostrom L, Pagan A, Pereg V, Sánchez-Pernaute A, Torres A, Urgeles JR, Vidal-Puig A, Vidal J, Vila M J Endocrinol Invest 2007;30(10): PMID:

5 PROXIMAL DUODENAL-ILEAL END-TO-SIDE BYPASS WITH SLEEVE GASTRECTOMY: PROPOSED TECHNIQUE A.Sánchez-Pernaute, M. A. Rubio, E. Pérez-Aguirre. J.C. García Pérez, L. Cabrerizo, L. Díez-Valladares, C. Fernández, P. Talavera,Torres AJ. Obesity Surgery 2007;17: INSS EARLY COLONIC TRANSHIATAL HERNIATION AND ANASTOMOTIC LEAK AFTER IVOR LEWIS ESOPHAGECTOMY A.Sánchez-Pernaute, E. Pérez-Aguirre, P. Talavera, F. Hernando, L. Díez- Valladares,Torres AJ Esophagus 2007;4: INSS LONG-TERM SURVIVAL ASSOCIATED WITH COMPLETE RESECTION AFTER INDUCTION CHEMOTHERAPY IN STAGE IIIA (N2) AND IIIB (T4N0-1) NON- SMALL-CELL LUNG CANCER PATIENTS: THE SPANISH LUNG CANCER GROUP TRIAL 9901 P. Garrido, J.L. González-Larriba, A. Insa, M. Provencio, Torres AJ, D. Isla, J. M. Sánchez, F. Cardenal, M. Domine, J. R. Barceló, V. Tarrazona, A. Varela, R. Aguilo, J. Astudillo, I. Muguruza, A. Artal, F. Hernando-Trancho, B. Massuti, M. Sánchez-Ronco, R. Rosell. Journal of Clínical Oncology 2007;25(30): INSS X THE SIDE OF PNEUMONECTOMY INFLUENCES LONG-TERM SURVIVAL IN STAGE I AND II NON-SMALL CELL LUNG CANCER Simón C, Moreno N, Peñalver R, González G, Alvarez-Fernández E, González-Aragoneses F, José-L Duque, Angel López-Encuentra, Ramón Rami, Julio Astudillo, Pedro López de Castro, Josep-María Gimferrer, Antonio Cantó, Antonio Arnau, Juan Casanova, Manuel Mariñán, Manuel Castanedo, Antonio Fernández de Rota, Jorge Freixinet, Nicolás Llobregat, Nuria Mañes, Mireia Serra, José Belda, José-L Martín de Nicolás, Nuria Novoa, Jesu s Rodríguez, Antonio-Jose Torres-Garci a, Ana Gómez, Mercedes de la Torre, Abel Sánchez-Palencia, Javier Ruíz-Zafra, Andrés Varela-Ugarte, Francisco-J Moradiellos, Yat Wah Pun. Annals of Thoracic Surgery 2007;84(3): ISSN: EXPRESSION OF MMP-9 AND TIMP-1 AS PROGNOSTIC MARKERS IN GASTRIC CARCINOMA De Mingo M, Morán A, Sánchez-Pernaute A, Iniesta P, Diez-Valladares L, Pérez-Aguirre E, de Juan C, García-Aranda C, Diaz-López A, García-Botella A, Martín-Antona E, Benito M, Torres A, Balibrea JL Hepatogastroenterol 2007; 5

6 DIFFERENTIAL TRANSCRIPTIONAL PROFILE OF Wnt PATHWAY AND E- CADHERIN INACTIVATION IN SPORADIC COLORECTAL CANCERS WITH AND WITHOUT MICORSATELLITE INSTABILITY P. Ortega, A. Morán, C. de Juan, C. Frías, S. Hernández, J. A. López-Asenjo, A. Sánchez- Pernaute, Torres AJ, P. Iniesta, M Benito. Clinical Cancer Research 2008;14(4): INSS PROPHYLACTIC CLOSURE OF TROCAR ORIFICES WITH AN INTRAPERITONEAL MESH (VENTRALEX ) IN LAPAROSCOPIC BARIATRIC SURGERY A.Sánchez-Pernaute, E. Pérez-Aguirre, A. García-Botella, L. Rodriguez, E. Martín Antona, J. Cabeza, D. Jimenez Valladollid, M. A. Rubio, I. Delgado, Torres AJ. Obesity Surgery 2008;18: INSS TELOMERE SHORTENING IS ASSOCIATED WITH POOR PROGNOSIS AND TELOMERASE ACTIVITY CORRELATES WITH DNA REPAIR IMPAIRMENT IN NON-SMALL CELL LUNG CANCER C. Frías, C García-Aranda, C. de Juan, A. Morán, P. Ortega, A. Gómez, F. Hernando, J. A. López-Asenjo, AJ Torres, M. Benito, P. Iniesta. Lung Cancer 2008;60: INSS CIRUGÍA METABÓLICA A.Sánchez-Pernaute, Torres AJ. Cirugía Española 2008;84(1):1-2 INSS X EFFECTS OF WEIGHT LOSS AFTER BARIATRIC SURGERY FOR MORBID OBESITY ON VASCULAR ENDOTHELIAL GROWTH FACTOR-A, ADIPOCYTOKINES, AND INSULIN N. García de la Torre, M. A. Rubio, E. Bordiu, L. Cabrerizo, E. Aparicio, C. Hernández, A. Sánchez-Pernaute, L. Díez-Valladares, Torres AJ, M. Puente, A. L. Charro. Journal of Clinical Endocrinology and Metabolism 2008; 93(11): INSS X RECIDIVA LOCAL TRAS CIRUGÍA DEL CÁNCER DE PULMÓN Jarabo JR, Torres AJ An Med Interna (Madrid) 2008;25:53-4 MORGAGNI-LARREY PARASTERNAL DIAPHRAGMATIC HERNIA IN ADULT Torres AJ, Arráez-Aibar LA, González C. Revista Española de Enfermedades Digestivas 2009;101(5): INSS

7 TRATAMIENTO QUIRÚRGICO DEL CÁNCER DE PULMÓN Fernández E, Jarabo JR, Hernando F, Gómez AM, Calatayud J, Sánchez R, Milla L, Torres AJ. Rev Cáncer 2009;23(4): INSS METABOLIC SURGERY Torres AJ, Sánchez-Pernaute A, Cabrerizo L, Gortazar A, Dominguez I, Matía P, García de la Torre N, Rubio MA. Obesity and Metabolism 2009;5(2):80-85 ISSN LAPAROSCOPIC APPROACH TO ESOPHAGEAL PERFORATION SECONDARY TO PNEUMATIC DILATION FOR ACHALASIA A.Sánchez-Pernaute, E. Perez-Aguirre, P. Talavera, L. Díez-Valladares, J. Pérez de la Serna, C. Sevilla Mantilla, A. Ruíz de León, Torres AJ. Surgical Endoscopy 2009;23: INSS THE FTO OBESITY GENE. GENOTYPING AND GENE EXPRESSION ANALYSIS IN MORBIDLY OBESE PATIENTS C. Zabena, J. L. González-Sánchez. M. T. Martinez-Larrad, Torres AJ, J. Álvarez- Fernández-Represa, A. Corbatón-Anchuelo, M. Pérez-Barba, M. Serrano-Ríos. Obesity Surgery 2009;19:87-95 INSS SHORT- AND MID-TERM OUTCOMES OF SLEEVE GASTRECTOMY FOR MORBID OBESITY: THE EXPERIENCE OF THE SPANISH NATIONAL REGISTRY Sánchez-Santos R, Masdevall C, Baltasar A, Martínez-Blazquez C, García Ruiz de Gordejuela A, Ponsi E, Bombuy E, Durán-Escribano C, Ortega L, Ruiz de Adana JC, Baltar J, Maruri I, García-Blázquez, Torres AJ. Obesity Surgery 2009;19: INSS TELOMERE FUNCTION IN COLORECTAL CANCER Frias C, Morán A, de Juan C, Ortega P, Fernández-Marc elo T, Sánchez-Pernaute A, Torres AJ, Díaz-Rubio E, Benito M, Iniesta P World Journal of Gastrointestinal Oncology 2009; COST-EFFECTIVENESS AND BUDGET IMPACT OF OBESITY SURGERY IN PATIENTS WITH TYPE 2 DIABETES IN THREE EUROPEAN COUNTRIES (II) Anselmino M, Bammer T, Fernández-Cebrián JM, Daoud F, Romagnoli G, Torres A Obes Surg 2009;19(11): PMID: DOI: /s z 7

8 ABDOMINAL PSEUDOCYST COMPLICATING INCISIONAL HERNIA REPAIR: OUR EXPERIENCE AND LITERATURE REVIEW Ielpo B, Cabeza j, Jimenez D, Delgado I, Torres AJ. Hernia 2010; INSS DIFFERENTIAL COLORECTAL CARCINOGENESIS: MOLECULAR BASIS AND CLINICAL RELEVANCE Morán A, Ortega P, de Juan C, Fernández-Marcelo T, Frías C, Sánchez-Pernaute A, Torres AJ, Díaz-Rubio E, Iniesta P, Benito M. World Journal of Gastrointestinal Oncology 2010;2(3): INSS MMP-7 AND SGCE AS DISTINCTIVE MOLECULAR FACTORS IN SPORADIC COLORECTAL CANCERS FROM THE MUTATOR PHENOTYPE PATHWAY Ortega P, Morán A, Fernández-Marcelo T, de Juan C, Frias C, Lopéz-Asenjo JA, Sánchez- Pernaute A, Torres AJ, Díaz-Rubio E, Iniesta P, Benito M Int J Oncology 2010; THE ENDOCRINE SOCIETY S CLINICAL PRACTICE GUIDELINE ON ENDOCRINE AND NUTRITIONAL MANAGEMENT OF THE POST-BARIATRIC SURGERY PATIENT: COMMENTARY FROM EUROPEAN PERSPECTIVE Torres AJ, M. A. Rubio. European Journal of Endocrinology 2011;165: INSS CÁNCER COLORRECTAL: RETRASO DIAGNÓSTICO. HEMOS MEJORADO ALGO EN LOS ÚLTIMOS 25 AÑOS C. Cerdán, Ó. Cano, S. Cárdenas, Torres AJ, J. Cerdán. Revista Española de Enfermedades Digestivas 2011;103(9): ISSN ** PREOPERATIVE CHEMOTHERAPY PLUS SURGERY VERSUS SURGERY VERSUS SURGERY PLUS ADJUVANT CHEMOTHERAPY VERSUS SYRGERY ALONE IN EARLY-STAGE NON-SMALL CELL LUNG CANCER. Enriqueta Felip, Rafael Rosell, José Antonio Maestre, José Manuel Rodríguez-Paniagua, Julio Astudillo, Guillermo Alonso, José Manuel Borro, José Luis González-Larriba, Antonio Torres, Carlos Camps, Ricardo Guijarro, Dolores Isla, Rafael Aguiló Vicente Alberola, José Padilla, Abel Sánchez-Palencia, José Javier Sánchez, Eduardo Hermosilla and Bartomeu Massuti Journal of Clinical Oncology. 2010; : ChREBP EXPRESSION IN LIVER, ADIPOSE TISSUE AND DIFFERENTIATED PREADIPOCYTES IN HUMAN OBESITY Calvo RM, Hurtado C, Vesperinas-García G, Rubio MA, Corripio-Sánchez R, Torres AJ, Obregón MJ. Molecular and Cell Biology of Lipids 2011; 8

9 HERNIA INGUINAL Y QUISTE DE CORDÓN ESPERMÁTICO EN UNA PACIENTE SOMETIDA PREVIAMENTE A UNA CIRUGÍA DE REASIGNACIÓN DE SEXO Cano-Valderrama O, Cabeza J, Jiménez-Valladolid D, Delgado I, Torres AJ. Cirugía Española 2011; INSS EXPRESSION OF HUMAN MDGA1 INCREASES CELL MOTILITY AND CELL- CELL ADHESION AND REDUCES ADHESION TO EXTRACELLULAR MATRIX PROTEINS IN MDCK CELLS Díaz-López A, Inisesta P, Morán A, Ortega P, Fernández-Marcelo T, Sánchez-Pernaute A, Torres AJ, Benito M, de Juan C. Cancer Microenvironment 2011;4(1):23-32 INSS AGENESIA DE LA VESÍCULA BILIAR. A PROPÓSITO DE UN CASO Cano-Valderrama O, Talavera P, Domínguez-Serrano I, Sánchez-Pernaute A, Torres AJ. Cirugía Española 2011; INSS SUPERVIVENCIA PROLONGADA TRAS LA RESECCIÓN DE UNA METÁSTASIS HEPÁTICA DE UN TUMOR NEUROENDOCRINO DE PÁNCREAS Cano-Valderrama O, Díez-Valladares L, Domínguez-Serrano I, Cerdán C, Torres AJ. Cirugía Española 2011; INSS MORE THAN ONE PULMONARY RESECTIONS OR COMBINED LUNG-LIVER RESECTION IN 79 PATIENTS WITH METASTATIC COLORECTAL CARCINOMA Jarabo JR, Fernández E, Calatayud J, Gómez AM, Fernández C, Torres AJ, Hernando F. J Surg Oncol. 2011;104(7): DOI: /jso METHYLATION PROFILING IN NON-SMALL CELL LUNG CANCER: CLINICAL IMPLICATIONS Morán A, Fernández-Marcelo T, Carro J, de Juan C, Pascua I, Head J, Gómez A, Hernando F, Torres AJ, Benito M, Iniesta P. International Journal of Oncology 2012; 40: INSS TRAINING PROGRAMS INFLUENCE IN THE LEARNING CURVE OF LAPAROSCOPIC GASTRIC BYPASS FOR MORBID OBESITY: A SYSTEMATIC REVIEW Sánchez-Santos R, Estévez S, Tomé C, González S, Brox A, Nicolas R, Crego R, Piñón M, Masdeval C, Torres A Obes Surg 2012; 22:

10 DIFFERENTIAL EXPRESSION OF SENESCENCE AND CELL DEATH FACTORS IN NON-SMALL CELL LUNG AND COLORECTAL TUMOURS SHOWING TELOMERE ATTRITION Iniesta P, Torres AJ Oncology 2012 (in press) 10