Calidad de productos farmacéuticos y afines comercializados en el mercado Peruano:

Transcripción

1 UNIVERSIDAD NACIONAL MAYOR DE SAN MARCOS FACULTAD DE FARMACIA Y BIOQUÍMICA DEPARTAMENTO DE FARMACOTECNIA Y ADMINISTRACIÓN FARMACÉUTICA Calidad de productos farmacéuticos y afines comercializados en el mercado Peruano: pesquisados por DIGEMID, de TESIS para optar el título profesional de Químico farmacéutico AUTOR María Margarita Coral Monge ASESOR José Juárez Eyzaguirre Gustavo Bravo Orellana Lima Perú 2008

2 !"# $ %&% ' ( () )! "# $ *( +! *, + - ( ' ) # * '' -'. &,! "# '!"# (, %&% / &-0," #- *-0,10 ' ( %&% 2* # " '! "# ( 3 /&4 ) ( () 5# 6 ) ( () ( )' ( # ( () 8!&#0)0, & ( 8!&#0! 2 & # *

3 - ' #- (. * - - (, # () # & - (- # # # #9 -& #. ( ' -, ' ( %&%

4 !"#$ %&'!"#(() *+,*#(' $- &....*/!#0 %*#- &1 -$2 *3%(#(43/ #(! %& ( 5!#.# %#*./!# ::-$;91 < <'

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

10 3.#( G&. ( 3%/!#. &..( G* %, % *3 *# 3!#. /!#.#&#+(?. )%#*./!#(>3 F*. &*#!%#&. &)%#.3*!#&, &. & (. *%@. & /.*/!#?! %/.# - #*=. *# (!%3**=. &*&.. "#&3*%!. %!#.#(&#(() *!#(>3! %" &)%#* (#. &#%*=. 3 /.*/!# *&3? &A%&*&..? & /#.# &>3 ( % * &/! %)%/ 3 &#%!#%#@&#()%#* (#(. )%#.3**= >3 % (3&! 3 /.*/!#@&(*%*! %+(!*(. &#( ()*#(.#. ( && ". &! (#()%#* (#(@&#(/#.#( &#(>3 (. )#(!?!%! &#()%#.3*!#(3 " A! %/.#(@? &,3 *# /!#. &&#%!#%#. *#!%#&. *&... &)&! &#%.#%@!% #!%#( &..#!& (3 *# * )!#>3 "3 )(#/(&&)#%! (!#(*# * )!#( 3 (!%!. (!= &#&&%#)&A#?&)%!*)*=.!#.#(&#( / /%#(. &#% A*= )%,*#. &/(/@. (3(/ /%#(@(3( *&! (?. &(#*.. %& -#(*#(!#(. *&..(#.!% (!)#(D,&&#(@ () **=?)% " *= %(3 )&. ( 3%/!#. &*&..&*,%!#!&. &#(*#(! (. *&..( %.3* (,*!"/! #% 3 &.# 3/! &#( *#(!#(. )% " *=? 3!#/!*/! ( %.3* &#(,&&#(@?&#(% *3%(#(..*.#( () **= "%!.#/( )% " *= ( %.3* &"&#%!#!&. &#(*#(!#(. & *&... 3 (!%#()%#.3*!#(?( %"*#( /%# (!*&... *# ( %"%( &#&%#. &!%? *!#%>3 (3 & /.*/!#@ G(! & /#/!# >3 && 3 & 3(3%#, &. /! %.3%! &) %+#.#. ".E!&LG(!(3, *G. " */!#M@>3 &,%*! G (!& *.#@) %+#.# &*3&. *3/)&%*# &#(% >3(!#(. *&..@( 3%..?,** -#(,%*! ((# &#(% ()# (& ()%/%#(. &*&... &#(/.*/!#(?. *3/)&%*# (3*#/)%#/(#. *&..L'M Q-*&.. # (3 /! (+/(/( #3 */ #>3 3 *( *Q 8

11 %% $#$ %%&$#$$ &. *!3%. 1( *% # & (! %#. &3.?*!3&/! *3! *# ( ( =% #( (.# 3 #. &&#( & % **= $ %&..*/!#( (3/#(? %#( L$M@ *3?( )% *)& (,3 *# ( (# DL@'M!#%/!#. & (!%#!%#)%#.3*!#(,%/*53!*#(?, ( #!%#&?"& *!%. )%#.3*!#(,%/*53!*#(?, (@?. &#( (!& %*&A #%. & ** (#? 3(#. %*# &. /.*/!#( ( *& (?.()#(!"#(/5.*#( * (%#()%&)#&*= MINISTERIO DE SALUD DIGEMID I. Producto farmacéutico. II. Producto galénico. III. Productos naturales. IV. Producto cosmético y de higiene personal. V. Productos sanitarios y de limpieza domestica. VI. Productos dietéticos y edulcorantes. VII. Insumo, instrumental y equipo de uso médico, quirúrgico y odontológico. 93%ND;/!#(. *#/)! *. $ $'#$!' " 3()% *)& (,3 *# ((# D #%/%@ *#!%#&%? "&% & /)#%!*= *#/ )3&*...() (*=? F).#. )%#.3*!#(,%/*53!*#(?, ( )&*%&(( *# (?R#/..(. ( 3%.. (!& *.()#%&? & *3/)&/!#. & #%/!"..(!% 1

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ÓN DE AUTORIZACIONES SANITARIAS (DAS) EQUIPO DE CONTROL Y VIGILANCIA DE PRODUCTOS (ECVP) DIRECCIÓN GENERAL DIRECCIÓN DE CONTROL Y VIGILANCIA SANITARIA (DCVS) EQUIPO DE CONTROL Y VIGILANCIA DE ESTABLECIMIENTOS (ECVE) EQUIPO DE CONTROL PUBLICITARIO (ECPUB) DIRECCIÓN DE ACCESO Y USO DE MEDICAMENTOS (DAUM) EQUIPO CONTRA EL COMERCIO ILEGAL (ECCI)

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

22 ' $ 3.%#N!... %#.3*!#( (>3(.#( B C D E!F" 0 '@'0 1 8@' 8 0@' '8 1@18 ' 080 0@'8 $ $%,*N %#.3*!#( (>3(.#(.3%! &#(B#(U' CANTIDAD AÑOS

23 3.%#N!... %#.3*!#(*# $ ' ! D %3.(U$ $%,*N &*=!% &#()%#.3*!#(% (!%.#(?&#() (>3(.#( &B# Pesquisados % Registrados 93% Registrados Pesquisados $%,*N &*=!% &#()%#.3*!#(% (!%.#(?&#() (>3(.#( &B#' Pesquisados 9% Registrados 91% Registrados Pesquisados

24 3.%#N (3&!.#(. &#,#%/... &#(%#.3*!#( (>3(.#()#%B# $ C %66% %66 %66: %66G %66H $ 9 0 1' ' ' $ ' $%,*N (3&!.#. &#(%#.3*!#( (>3(.#()#%B# CANTIDAD CONFORME NO CONFORME AÑOS 3.%#N # (#&..#. &#( (3&!.#(. &( (>3((. &#(B#(&' $'$ E $!F" 9 8 ' 9 188

25 $%,*N #%*!. &#!&. (3&!.#(. &( (>3((. &&' 35% % CONFORME NO CONFORME

26 (3&!.#( #*#,#%/ ((.(% %#. &(3! / % &#((3! (*3.%#(D &4*+)-,,</ 3.%#N S-9V9 $ '$ 34 $ C %66% %66 %66: %66G %66H E 34 E 34 E 34 E 34 E!F" $!F" $!F" $!F" $!F" @ 8 '0@' 1 0@ 2 '@ @ 1@ - 0@ 1 0@ 8' 0@0 : @8 $ '8 080 W9X WW$

27 $%,*N' (3&!.#(%+!*#(. &( (>3((. &#(%#.3*!#(9%/*53!*#(?, (.3%! U' 9 8 6,3,5 6,99 PORCENTAJE (%) ,84 5, AÑOS $%,*N0 (3&!.#(,*! (. &( (>3((. &#(%#.3*!#(9%/*53!*#(?, (.3%! U' ,88 PORCENTAJE (%) ,2 12,1 9,15 3, AÑOS

28 $%,*N8 (3&!.#()#%#!3&.#. &( (>3((. &#(%#.3*!#(9%/*53!*#(?, (.3%! U' 20 PORCENTAJE (%) ,2 1,2 16,26 13,3 13, AÑOS $%,*N1 (3&!.#()#%/#. () *,**=. &( (>3((. &#(%#.3*!#( 9%/*53!*#(?, (.3%! U' 8,56 PORCENTAJE (%) ,4 4,16 3,1 4, ' AÑOS

29 $%,*N (3/. &#( (3&!.#(##,#%/ (. &( (>3((. &#(%#.3*!#( 9%/*53!*#(?, (.3%! U' Cambio de Especificación 14% F.P.N.A.* 1% Sin Registro Sanitario 1% Obs. Críticas 1% Rotulado no autorizado 40% Prod. Deficiente 2% 0

30 %4 *,*+ *, * () +,-, +)- </A)-*<*,+()*),-+*%66%%66H 3.%#N' E/ %#. 3 (!%( (>3(.( E )#. %#.3*!# 3 C $ E %66% %66 %66: %66G %66H!F" ' ' $V ' ' 1 ' -V ' ' ' '' 81 V '0 ' 1 $-V 1 0 ' V ' 0 ' :-$ ' ' $ 0 $ ' $%,*N #%*!. ) (>3((( E!)#. )%#.3*!#,%/*53!*#?,+.3%! U ' GALÉNICO 1% MATERIAL MÉDICO 10% COSMETICO 9% PROD. DIETÉTICO BIOLÓGICO 2% 0% PROD. NATURAL 2% MED. GENÉRICO 30% PROD. SANITARIO 1% REACT. DIAGNÓSTICO 0% MED. MARCA 45% 8

31 3 3.%#N0 &*=. (3&!.#(. &"&3*= ( E!)#. %#.3*!#9%/*53!*#?, ( 0 C %66% %66 %66: 0 ' 1 0' ' $V 1 1' ' ' 1 1 ' - V 0 81 V 0 ' ' 1 ' $-V ' V :-$ ' 1 $ 1

32 $%,*N (3&!.#(. &"&3*=. &#(%#.3*!#(9%/*53!*#(?, ( CANTIDAD Medic. Marca Medic. Genérico 44 Prod. Natural Material Médico 11 4 Cosméticos CONFORME Galénico $%,*N Dietético Produc. Biológico NO CONFORME Produc. Sanitario (3&!.#(. &"&3*=. &#(%#.3*!#(9%/*53!*#(?, ( Otros CANTIDAD Medic. Marca Medic. Genérico Prod. Natural Material Médico Cosméticos Galénico Dietético Produc. Biológico Produc. Sanitario Otros CONFORME NO CONFORME

33 $%,*N (3&!.#(. &"&3*=. &#(%#.3*!#(9%/*53!*#(?, ( CANTIDAD Medic. Marca Medic. Genérico Prod. Natural Material Médico Cosméticos Galénico Dietético Produc. Biológico CONFORME NO CONFORME Produc. Sanitario $%,*N (3&!.#(. &"&3*=. &#(%#.3*!#(9%/*53!*#(?, ( Otros CANTIDAD Medic. Marca Medic. Genérico Prod. Natural Material Médico Cosméticos Galénico Dietético Produc. Biológico CONFORME NO CONFORME Produc. Sanitario Otros

34 $%,*N' (3&!.#(. &"&3*=. &#(%#.3*!#(9%/*53!*#(?, (' CANTIDAD Medic. Marca Medic. Genérico Prod. Natural Material Médico Cosméticos Galénico Dietético Produc. Biológico CONFORME NO CONFORME Produc. Sanitario Otros

35 $%,*N0 "#&3*=. &"&3*=. &#(.*/!#(. %*)#%B# CANTIDAD CONFORME AÑOS 3.%#N8 NO CONFORME (3/. &#(% (3&!.#(. &#(/.*/!#(. /%*.3%! U' $'$ 34 E $!F" 9 8'' 9 1 '1 $ ' $%,*N8 (3/. &#(% (3&!.#(. &#(/.*/!#(. /%*.3%! U' MEDICAMENTOS DE MARCA 31% 69% CONFORME NO CONFORME

36 $%,*N1 "#&3*=. &"&3*=. &#(.*/!#($ 5%*#()#%B# CANTIDAD CONFORME AÑOS 3.%#N1 NO CONFORME (3/. &#(% (3&!.#(. &#(/.*/!#( 5%*#(.3%! U' $'$ 34 E $!F" 9 8 ' 9 1 ' $ 80 $%,*N (3/. &#(% (3&!.#(. &#(/.*/!#( 5%*#(.3%! U' MEDICAMENTO GENÉRICO 36% 64% CONFORME NO CONFORME

37 $%,*N "#&3*=. &"&3*=. &! %&5.*#3.#!#&=*#)#%B# CANTIDAD CONFORME AÑOS 23 3.%#N 2 NO CONFORME (3/. &#(% (3&!.#(. &! %&5.*#3.#!#&=*#.3%! U' $'$ 34 E $!F" 9 0 ' 9 $ 81 $%,*N (3/. &#(% (3&!.#(. &! %&5.*#3.#!#&=*#.3%! U' MATERIAL MÉDICO U ODONTOLÓGICO 40% 60% CONFORME NO CONFORME

38 CANTIDAD $%,*N "#&3*=. &"&3*=. &#(%#.3*!#(#(/5!*#( CONFORME AÑOS %#N NO CONFORME (3/. &#(% (3&!.#(. &#()%#.3*!#(*#(/5!*#(.3%! U' $'$ 34 E $!F" '8 $ ' $%,*N (3/. &#(% (3&!.#(. &#()%#.3*!#(*#(/5!*#(.3%! U' COSMÉTICO 32% 68% CONFORME NO CONFORME '

39 4)-</A)-*<*,,*,*.I,-*+ -*/*,-</A)-* 3.%#N E/ %#. %#.3*!#("&3.#()#%)#. (!& */!# C $3 # $ ' ' $ ' $%,*N #%*! ( E &!)#. (!& */!#9%/*53!*#. &#()%#.3*!#(,%/*53!*#(?, () (>3(.#(.3%! U' CANTIDAD AÑOS LABORATORIO DROGUERIA IMPORTADORA OTROS 0

40 3.%#N (3/. &#(% (3&!.#(( E &!)#. (!& */!#9%/*53!*#. &#( )%#.3*!#(,%/*53!*#(?, () (>3(.#(.3%! U' 3$ -: 1 $ ' 8 0 $ 8 $%,*N' (3/. &#()%#.3*!#() (>3(.#(( E &!)#. (!& */!# 9%/*53!*#.3%! U' IMPORTADORA 3% OTROS 0% DROGUERIA 58% LABORATORIO 39% 8

41 3.%#N &*=. (3&!.#(. &"&3*= ( E &!)#. (!& C %66% %66 %66: $ -: '0 '8 0 $ ' ' 8 1 ' ' 0 0 1

42 $%,*N0 E &!)#. (!& */!#9%/*53!*#U-#%!#%# CANTIDAD CONFORME AÑOS 3.%#N NO CONFORME (3/. &#(% (3&!.#(#!.#(.3%! &) %+#.#'-#%!#%# $'$ 34 E $!F" 9 00 '1 9 $ $%,*N8 (3/. &#(% (3&!.#(#!.#(.3%! &) %+#.#U' LABORATORIOS 31% 69% CONFORME NO CONFORME

43 $%,*N1 E &!)#. (!& */!#9%/*53!*#U%#3 % CANTIDAD AÑOS CONFORME NO CONFORME 3.%#N' (3/. &#(% (3&!.#(#!.#(.3%! &) %+#.#'%#3 %+ $'$ 34 E $!F" 9 ' 9 ' 8 $ ' $%,*N (3/. &#(% (3&!.#(#!.#(.3%! &) %+#.#U' DROGUERIAS 38% 62% CONFORME NO CONFORME

44 CANTIDAD $%,*N E &!)#. (!& */!#9%/*53!*#U/)#%!.#% AÑOS CONFORME NO CONFORME 3.%#N0 (3/. &#(% (3&!.#(#!.#(.3%! &) %+#.#'U/)#%!.#% $'$ 34 E $!F" 9 '0 9 $ 0 $%,*N E &!)#. (!& */!#9%/*53!*#U/)#%!.#% 3 14 IMPORTADORAS 33% 6% CONFORME NO CONFORME

45 :4,*.I,+;*.,J+)-</A)-*<*,, /*,* 3.%#N8 %#*. *. &#(%#.3*!#("&3.#( C $ '$ %66% %66 %66: %66G %66H $ ' <Y '0 $ ' $%,*N %#*. *. &#(%#.3*!#("&3.#( CANTIDAD NACIONALAÑOS IMPORTADO

46 3.%#N1 (3/. &)%#*. *. &#(%#.3*!#("&3.#(.3%! U' $ '$ E!F" - 0' <Y '0 $ 8 $%,*N (3/. &)%#*. *. &#(%#.3*!#("&3.#(.3%! U' PROCEDENCIA EXTRANJERO 45% NACIONAL 55%

47 3.%#N &*=. (3&!.#(. &"&3*= ( E &)+(. #% $ '$ C %66% %66 %66: $ ' <Y '0 '8 ' ' '0

48 $%,*N %#*. **# &. &#(%#.3*!#("&3.#( CANTIDAD AÑOS CONFORMES 3.%#N NO CONFORMES (3/. &(#( %"*# (&#()%#.3*!#(. #% *# &.3%! U' $'$ 34 E $!F" '0 1 $ 0' $%,*N' (3/. &(#( %"*# (&#()%#.3*!#(. #% *# &.3%! U' 29% NACIONAL 1% CONFORME NO CONFORME '

49 $%,*N0 %#*. *F!% %. &#(%#.3*!#("&3.#( CANTIDAD AÑOS CONFORME 3.%#N NO CONFORME (3/. &(#( %"*# (&#()%#.3*!#(. #% F!% %#.3%! U ' $'$ 34 E $!F" $ '0 $%,*N8 (3/. &(#( %"*# (&#()%#.3*!#(. #% F!% %#.3%! U ' EXTRANJERO 41% 59% CONFORME NO CONFORME 0

50 3.%#N E/ %#. %#.3*!#(#,#%/ (( E )+(. )%#*. * %66% %66 %66: %66G %66H E E E E E!F"!F"!F"!F"!F" ' 8 ' 1 1 0' -: 08 ' ' ' '0 :- ' 1 ' ' ' ' $ ' ' ' ' 8 Z 8 0 '0 ' 0 00 ' 8 ' %#N E/ %#. %#.3*!#(##,#%/ (( E )+(. )%#*. * %66% %66 %66: %66G %66H E E E E E!F"!F"!F"!F"!F" 1 0 ' ' : ' ' ' ' ' :- 1 0 ' $ 8 ' 8 ' ' '0 ' ' 4 1 ' '1 ' ' Z 0 '0 ' 8 ' 8

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

58 *# & " &. F *( /! %(!& ( *#/# :@ () *,**# (? *#!%#& (. /! %)%/?)%#".#% ( /%#@3 >3 (! )& *# * *. &/)#%! *?3% *. /)& /!% &% >3 %/!#. &. /#(!%*=. >3"& *! %)53!*@ &/?#%+. &#()+( (E # F(! #%/!"(. # >3"& *@*#/# ( 3 (!%#*(#-R@ (3,3 *=.% *!%A /! %. *#!%&#%+(!%@G*# *..# () *& /)#%! * &.! %/ *=. # >3"& * L'@ 0M 3 >3 *#(!#(# *#!%3%+3 / #%#, %!. &*&... &#()%#.3*!#(#,% *.#( '

59 ' $ &#()%#.3*!#(,%/*53!*#(?, () (>3(.#(*# #( %"*# ( & *&.. ( *#!%%# D #!3&.# # 3!#%A.# C@ %#.3*!#,*! 0C@ %+!*# 0C@ /#. () *,**= C@ (!%#!%#C?9#%/. % (!*= #3!#%A.C &#(!)#(. )%#.3*!#(,%/*53!*#(?, () (>3(.#( &C. /.*/!#. /%*@ &'C. /.*/!# 5%*#@ &C. & /! %&/5.*#? &C. &#(*#(/5!*#()% (! % (3&!.#(. # *#,#%/.. -#(!)#(. (!& */!#(. &#( *3& ( )%#*. &#( )%#.3*!#(,%/*53!*#(?, () (>3(.#(*# #( %"*# (&*&..(# D -#%!#%#(C@%#3 %+(8C /)#%!.#%(C!% &#()%#.3*!#(,%/*53!*#(?, () (>3(.#( #*#,#%/ (@ & 1C(#. )%#*. * *# &?C F!% %I(.# &)+(*# /(#( %"*# (&. 0

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

61 33$#2@ :%%#( Y@ -( )#&+!*(,%/*53!*(.*# F*#/%A#ILMD0 %"&Y@9&#% (@ (?#(. *&..(#% /.*/!#( F(!! ( &/ %*.# *# &D3 (!% # &)%/ %!%/ (!% 11[ (()% #)!% &!!3&#. S3+/*#9%/*53!*#\-/D9*3&!.. 9%/*? :#>3+/*@ " %(.. *# &?#%. %*#(I11 #% #Y (E()#%!3.. (. #*# %E-!+ G%/[ &+ \ [, *G. ** (#. 3 #. 0\ -.()# & D G!!)DRRHHH&! )G%/!R F)#R)%#%/(G!/& * 3%#)..*/!#( $%3)#.!%# (#% *#!%#& () **=. &#(/.*/!#(. &#/(= #%/(. *#%% *!,%**=. &I %. $3+D8 (! %#. &3..*/!#(?*&..[ &+ \[, *G. ** (#. 3 #. 0\ -.()# & D G!!)DRRHHH/(&#"%RG!/R(! R$ %*#(R(! R*&..() ' % A*= 3.&. &&3. 3%... &#(.*/!#([ &+ \[, *G. ** (#. 3 #. 0\-.()# & D G!!)DRRHHHHG#!R/.*!% R,*!(G!(R,(1R (R. FG!/ 0 % A*= 3.&. &&3.-! (,*(3&3*G*#!%&#( /.*/!#(,&(,*.#([ &+ \#" /% [, *G. ** (#. 3 #. 0\ -.()# & D G!!)DRRHHHHG#!R/.*!% R H(R% & ( (RR)%8R (R. F 8 %G3 &%/ &... &#(.*/!#(9#%#&3.[ &+ \ [, *G. ** (#. 3 #. 0\-.()# & D G!!)DRRH%%*)!) R9R,#%#(&3.R9-R).,(R &].)., 1

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

63 8 1 -?N81.. *!3% -?. % *=. & (! %#. &3. L#%/!".. (!!3*# &. E/ 1M *%!# 3)% /# N 8.. Y3&# (!& * ()#(*# ()% &#!%#&. &..?3/ (!%#(.,#%/*= (#%.*/!#(L#%/!".. (!!3*# &. &$@ E/ %# '@. 0M -./ (!%*=..*/!#(@&/!#(? * #&#+5.* LM[ &+ \[, *G. ** (#. #" /%. 0\ -.()# & ( D G!!)DRRHHH /!#"%R G!!)DRRHHH /!#"%R- (&*# R.*/!#(R()#(*# & (!!3!#. 6& *..*/!#(?&/!#(L6M[ &+ \[, *G. ** (#. #" /%. 0\-.()# & ( D G!!)DRRHHH "/#"*#&R G!!)DRRHHH/ *#/ %*##"*#R #!!R.#*3/!#(R*#/)!!"..R * 3!%#(R<R.!R&%#R*)!3&#R0G!/ - **# &. 6& *!%L6M[ &+ \ [, *G. ** (#. #" /%. 0\-.()# & ( D G!!)DRRHHH "(#"%R."3&R #!*(R0R10]G!/ G!!)DRRHHH "(#"%R ()R& (R% (#&R']%.*G!/ G!!)DRRHHH "(#"%R ()R. FG!/ G!!)DRRHHH "(#"%R,>. /*R. F() - *%!%. &3.. 5F*#[ &+ \[, *G. ** (#. #" /%. 0\-.()# & D G!!)DRRHHH( *%!%. (&3.#"/F -% A*= 3.&. &&3.LM[ &+ \[, *G. ** (#. #" /%. 0\-.()# & D '

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

71 ANEXO Nº 3 Estériles 25 días No Estériles 15 días Falsificados 15 días SI NO '1