El Fe de la TF es eldeúnico que pueden utilizar las células.

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Tomás Soriano Sánchez
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2 I l F l TF s lú qu pu ulz ls éluls. s l ú qu s gul. l F ltf l F qu bs l TF s u s subss (s...) y fm l NTBI, p l ul s x- (PI) y pu ñ x éluls suspbls.

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8 Rguló l hp I

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10 I l 10% l pbló bls p l g 282Y. P bquíml 282Y +/+ l 36-76%. P l fm l 282Y +/+ l 2-38% y l 1-10%. l H63D s sbg fé sl s muó s (p. j.: H63D/282Y).

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13 Ñ D R F >200 g/ml mujs ó 300 g/ml s. %TF >45% + ó >50 s (más ssbl y spf). hp: p l fuu (m gé subg). ITION ONRT I F + %TF: Ds flmó, umus, plss, s. mból l %TF sul s R, hpps, lhlsm, ml ó bj (RFs). F+ %TF: s l l H. Fms ulplsmm y mus FP PF (pbbl/ s s). F + %TF + 282Y/282Y: H. F + %TF + 282Y/w, H63D/w, H63D/H63D, w/w R ó bóps.

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16 ss péus lmó F FBOTOI QNT I I ls NO lmó smls sfí y Blqu l F NO ñ x Nmlzó l Hp NO I I I NO Fuu: us quls, TF xóg, álgs hp...???

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18 l F l TF s l ú qu pu ulz ls éluls. l F l TF s l ú qu s gul. l F qu bs l TF s u s subss (s...) y fm l NTBI, p l ul s x- (PI) y pu ñ x éluls suspbls. I 2 lls gul h k f sf-bu by lg h xpss f suf sf p 1 (TfR1). I xs whh sf bms hghly su, l ls h ul s bu lw-mlul-wgh mpus (.g., ).11 Ths sf bu (NTBI) s ly k up by ll yps, lug hpys myys. Th xss upk f s NTBI bus x-m llul juy. f f h ulg NTBI s x- sg lbl plsm. xss jus lls pmly by lyzg h pu f xyg sps xss f h py f llul x sysms. Ths xyg sps us lp px, x f m s wh squ p p ss-lks, p fgm, DN mg. I ms ps, llul xss s squ f h upk f ulg NTBI.

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20 I 4 h pl f ulg sf mus lss h 3 mg, ulhll lls ps h ms ym mpm, ug bu 10 ms p y. Bus h f u by ulhll lls s qu hgh, hp-m hgs xp sul p mk hgs sum s.

21 xss hp y ls fy I -s yhpss, s s -fy -fy m (IRID) h m f h ss. Dmsh hp y ls h sl bsp l, whh ss wh hmhmss hlssm. 5

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23 xss hp y ls fy I -s yhpss, s s -fy -fy m (IRID) h m f h ss. Dmsh hp y ls h sl bsp l, whh ss wh hmhmss hlssm. 7

24 Rguló l hp I 8 Fu fully f hp guly phwys p: yhpss, sus, xyg s, flmm. Is yhpss s ss wh s hp xpss by mhsms h m b f. sglg mluls fm h mw lu gwh ff f 15 (GDF-15) ws gsul p hmlg 1 (TWG1). Is by sus ss hp xpss hugh w mhsms: ulg- sgl p by f-sf llul--ss sgl p by b mphg p 6 (BP-6). Th f-sf sgl s hugh sf ps 1 2 s mul by h hmhmss p HF. Th BP-6 sgl s hugh s p s mul by h BP p hmjul by g. Ds xyg s ls s hp xpss by sg h sp f w gs, mps-2 fu, h sps hypx-ubl f (HIF). ps-2 ls hm jul fm h ll suf, pg s fu s p. Fu ls hmjul ug pssg pu slubl fm h ss s BP-6 y. Ifs h fms f flmm s hp xpss by h yk luk-6. BPR s b mphg p p, HP hp g, JK-TT Jus-ss ks sgl sus s f sp, PO2 pl pssu f xyg.

25 Dss f h Hp Fp xs I 9 Of h sx ss hs gup, f h lss hy hmhmss phyp (l sf su, l sum f, ml hm, ssu l). Th phphyslgy f hs f s s sml:qu ff hp-m wgul f fp. s mus l FP GOF (p pé guló p l hp) s fpm smls l fm lás p l hp ml ó l. s mus FP OF (p fuó FP) qu fs l R, s ló l T, BI hppí. N s sb sus sus s s bf flbms. Fp mus (yp IV): us g g f fp (401) spsbl f w ff phyps (fgu 3). ( 'Fp mus' b.) phg yp: Ths "lss f fu" mus sul xss umul f mphgs, wh sulg hgh sum f, ml u sf su, ml m. Hp yp: Ths "g f fu" mus llw b bsb xss f, wh ps mfsg hgh lls f f hp, s sf sus, ypl ps f h hp phym. Dss f yh u Th w-gul f hp psss sp l.58 yhy sfuss bu subslly h bu ps wh hs ss. Dss f I Tsp suff ly f sf bu f h syhss f hm, sp ss. Th squ -s yhpss, m, bh bu lw hp lls hus l. O s g l TF (ulplsmm), fl l TF, l DT1 ( s g F s l m). l sul fl s l pé l sñl ftf, l sgu ss hp y bsó F.

26 l 10% l pbló bl s p l g 282Y. P bquím l 282Y +/+ l 36-76%. P l fm l 282Y +/+ l 2-38% y l 1-10%. l H63D s sbg fé sl s muó s (p. j.: H63D/282Y). I 10

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29 Ñ D R F >200 g/ml mujs ó 300 g/ml s. %TF >45% + ó >50 s (más ssbl y spf). hp: p l fuu (m gé subg). ITION ONRT F + %TF: Ds flmó, umus, plss, R, hpps, lhlsm, s. mból l %TF sul s ml ó bj (RF s). F + %TF: s l l H. Fms ulplsmm y mus FP PF (pbbl/ s s). F + %TF + 282Y/282Y: H. F + %TF + 282Y/w, H63D/w, H63D/H63D, w/w R ó bóps. 13 I

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32 ss péus FBOTOI QNT lmó F I lmó s mls ls NO I Blqu l F sfí y ñ x NO I Nmlzó l Hp NO NO Fuu: us quls, TF xóg, álgs hp...??? I I 16

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