PROGRAMA GENERAL GENERAL PROGRAM

Transcripción

1 PROGRAMA GENERAL GENERAL PROGRAM 3 er SIMPOSIO INTERNACIONAL SOBRE FARMACOLOGIA DE LOS PRODUCTOS NATURALES 3 rd INTERNATIONAL SYMPOSIUM ON PHARMACOLOGY OF NATURAL PRODUCTS TOPES DE COLLANTES Sancti Spíritus, Cuba Junio / June, 6-10, 2012 Sitio web / Web site

2 2 Organizado por / Organized by Sociedad Cubana de Farmacología / Cuban Society of Pharmacology (SCF) Consejo Nacional de Sociedades Científicas de la Salud (CNSCS) / National Council of Scientific Societies of Health. Co-Auspiciado por / Co-Organized by: Centro de Investigación y Desarrollo de Medicamentos (CIDEM) / Drug Research and Development Centre. Dirección Nacional de Medicamentos y Tecnologias Sanitarias, Ministerio de Salud Pública (MINSAP) / National Direction of Drugs and Sanitary Technologies, Ministry of Public Health. Centro de Bioproductos Marinos / Center of Marine Bioproducts, (CEBIMAR) Centro para el Control Estatal de los Medicamentos (CECMED) / State Centre for the Quality Control of Drugs Instituto Finlay / Finlay Institute Instituto de Farmacia y Alimentos (IFAL), Universidad de La Habana / Pharmacy and Foods Institute, Havana University. Grupo Empresarial LABIOFAM / LABIOFAM Group Centro Nacional de Sanidad Agropecuaria / National Center for Animal and Plant Health. Centro Nacional Coordinador de Ensayos Clínicos / National Centre Coordinator of Clinical Trials. Laboratorio Central de Farmacología, Universidad Médica de La Habana, Facultad Salvador Allende (LCF-UMH) / Central Laboratory of Pharmacology, Havana Medical University, Faculty Salvador Allende. Organización Panamericana de la Salud (OPS) / Panamerican Association of Health Grupo Empresarial QUIMEFA / QUIMEFA Group Centro de Biopreparados (BIOCEN) / Bioproducts Centre Sociedad Italo-Latinoamericana de Etnomedicina (SILAE) / Italian Latinoamerican Society of Ethnomedicine (SILAE) Boletín Latinoamericano y Caribeño de Plantas Medicinales y Aromáticas (BLACPMA) / Latin- American and Caribbean Bulletin of Medicinal and Aromatic Plants. Asociación Latinoamericana de Farmacología (ALF) / Latin-American Association of Pharmacology,. Compañía Aérea Copa / Copa Airlines Empresa Los Portales S.A. / Los Portales S.A. Company Receptivo Oficial Oficial del Congreso / Official Incoming Agencia de Viajes / Travel Agency GAVIOTA TOURS. Web site: Professional Organizer: Mr. Juan Carlos Govea ( jefe.comercial.te@gaviotatours.cu) Telephone: (53-7) / Ext. 114, Fax: Ms. Zahily Delgado González, Esp. de Eventos e Incentivos, Gaviota Tours S.A. comercial1.te@gaviotatours.cu

3 3 Comité Organizador / Organizing Committee, Presidente / President: René Delgado Hernández, CIDEM, Cuba. Marlene Porto Verdecia CIDEM Celia Casado IFAL Omar Garcia CPHR Marian Hernandez IFAL Ricardo Castro CIDEM Gustavo Bracho FINLAY Carlos Rodriguez Ferrada CIDEM Maria Cristina Lara MINSAP Alicia Lagarto CIDEM Maylin Diaz CIDEM Carmen Portuondo CECMED Dulce María Calvo MINSAP Mariela Guevara LABIOFAM Alberto Hernandez CENCEC Mario Landys Chovel FINLAY Gledys Reynaldo IFAL Julian Rodriguez CENCEC José Herrera UH Ivones Hernandez CEBIMAR Maria Acelia Marrero CENCEC Roberto Vandama CIDEM Comité Científico / Scientific Committee, Presidente / President: Idania Rodeiro Guerra, CEBIMAR, Cuba Francisco Morón Laboratorio Central de Farmacologia, UMH, Cuba Beatriz Garrido CIDEM, Cuba Silvia Diaz IFAL, Cuba Cagatay Oktenli Turquía /Turkey Win Vanden Berghe Bélgica / Belgium Jorge Alonso Argentina Octavio Piñeros ALF, Colombia Jose Luis Martinez Chile Eva Marrero CENSA, Cuba Maria Eugenia Letelier Chile Andrea Zangara Reino Unido / United Kingdom (UK) Ed Okelo Reino Unido / United Kingdom (UK) Elisa Aznar BIOCEN, Cuba Adrian Llerena España / Spain Marcos Dehesa Ecuador Alberto Hernandez Cuba Roberto Menendez CEBIMAR, Cuba Diadelis Remirez CECMED, Cuba Angel Sanchez UH, Cuba Angela Malheiros Brasil Guy Haegeman Bélgica / Belgium Giset Jimenez MINSAP, Cuba Elisabeth Vila España / Spain Luca Rastrelli Italia / Italy

4 4 PROGRAMA GENERAL GENERAL PROGRAM

5 5 3 er SIMPOSIO INTERNACIONAL SOBRE FARMACOLOGIA DE LOS PRODUCTOS NATURALES / 3 rd INTERNATIONAL SYMPOSIUM ON PHARMACOLOGY OF NATURAL PRODUCTS PROGRAMA GENERAL / GENERAL PROGRAM ACTIVIDADES PRECONGRESO / PRE-CONGRESS ACTIVITIES LUNES 4 de Junio, 2012 / Monday, June 4, 2012 Taller Pre-Congreso (TPC). Comunicaciones Orales (CO) / Oral Communications. Precongress Workshop Taller de la Estación Experimental de Plantas Medicinales Juan Tomas Roig (EEPM). / Workshop of the Experimental Station of Medicinal Plants Juan Tomas Roig, CIDEM, Cuba. Coordinadores / Coordinators: MSc. Rosa Menéndez, CIDEM-Cuba / MSc. Roberto Vandama, CIDEM. 09:00-09:10 Palabras de Bienvenida y Apertura. / Welcome and Opening Words MSc. Marlene Porto Verdecia. Directora / Director, CIDEM. TPC CO-01 09:15-09:35 La Estación Experimental de Plantas Medicinales Juan Tomas Roig. Experiencias y resultados. / Experimental Centre of Medicinal Plants Juan Tomas Roig. Experience and Results. Carlos Rodriguez Ferradá, Director, EEPM-CIDEM, Artemisa, Cuba TPC CO-02 09:40-10:00 Estudio de la sostenibilidad del cultivo de plantas medicinales en la EEPM Dr. Juan Tomás Roig. / Sustainability study of medicinal plants crop in EEPM Dr. Juan Tomás Roig. MSc. Nayla Robaina Rodriguez, EEPM-CIDEM, Artemisa, Cuba TPC CO-03 10:00-10:20 Agroecología y sostenibilidad de las plantas medicinales en la EEPM. / Agroecology and sustainability of medicinal plant in the EEPM of CIDEM. MSc Roberto Vandama Ceballos, CIDEM. 10:25-11:00 Merienda / Snack. Degustación de frutas y jugos naturales. / Tasting of fruits and natural juices. TPC CO-04 11:00-11:20 Propagación in vitro de plantas medicinales en la Estación Experimental de Plantas Medicinales Dr. Juan Tomas Roig. / In vitro propagation of medicinal plants on experimental station of medicinal plants Dr. Juan Tomas Roig Rodríguez C, Echavarría I. EEPM-CIDEM, Artemisa, Cuba TPC CO-05 11:25-11:45 ALOE VERA. Desarrollo y perspectivas para la industria farmacéutica cubana. / ALOE VERA. Development and perspectives for Cuban pharmaceutical industry. DrC. Jorge Rodriguez Chanfrau. CIDEM. TPC CO-06 11:50-12:10 Producción de productos herbarios, homeopáticos y materias primas de origen vegetal. / Production of herbal medicinal products, homeopatic formulations and raw material from vegetal origen. Lic. Odalys Milián Valdés, EEPM-CIDEM, Artemisa, Cuba TPC CO-07 12:15-12:35 Proyecto mangiferina. Una nueva experiencia investigativa en la EEPM. Resultados preliminares y perspectivas de desarrollo. / Mangiferin Project. A new experience of research on EEPM. Preliminary result and future perspectives. DrC René Delgado Hernández, CIDEM. TPC CO-08 12:30-12:50 Sitio web de la EEPM Dr. Juan Tomás Roig./ Web site of EEPM Dr. Juan Tomas Roig. Lic. Beatriz Elizagaray, Ing Yosvaldy Rodriguez and Ricardo

6 Castro. CINFA-CIDEM. TPC CO-09 12:55-13:25 El desarrollo integral de fitomedicamentos en el CIDEM. Resultados y proyecciones futuras. / The integral development of phytodrugs in the CIDEM. Results and future projections. MSc. Marlene Porto Verdecia, Directora General / General Director, CIDEM. Carteles / POSTERS TPC P-01 Estudios agrícolas de la Salvia hispánica (Chia) en la Estación Experimental de Plantas Medicinales Juan Tomas Roig / Agricultural studies of Salvia Hispanica L. (Chia) in the Experimental Station of Medicinal Plants Dr. Juan Tomas Roig in Cuba. Rivera Amita MM, Milanes Figueredo M, Ramos SR, Hernández Martinez Y. EEPM-CIDEM, Artemisa, Cuba. TPC P-02 DISINFECTION OF MEDICINAL PLANTS IN EXPERIMENTAL STATION OF MEDICINAL PLANTS Dr. JUAN TOMAS ROIG Carballo C, Ramos R Experimental Station of Medicinal Plants Dr. Juan Tomas Roig. Drug Research and Development Center (CIDEM) La Habana, Cuba 13:30-14:00 Discusión General / General Discussion 14:00 Almuerzo (Comidas tradicionales cubanas) / Lunch (Traditional Cuban foods) 15:00 Actividad de Clausura / Closing activity 6 Vista de la casa principal de la Estación Experimental de Plantas Medicinales Juan Tomas Roig del CIDEM, Municipio San Antonio de los Baños, Provincia Artemisa, Cuba. /The main house of the Experimental Station of Medicinal Plants "Juan Tomas Roig", CIDEM, Municipality San Antonio de los Baños, Artemisa Province, Cuba.

7 7 Curso Precongreso (CPC) CIDEM, 26 y Boyeros, La Habana MARTES 5 de Junio / TUESDAY June 5 CURSO PRECONGRESO (CPC) / PRECONGRESS COURSE 09:00 14:00 APLICACIÓN DE FITOFÁRMACOS EN CLÍNICA MÉDICA. Dr. Jorge Alonso, Presidente de la Asociación Argentina de Fitoterapia. 08:30 ACREDITACION Y BIENVENIDA CPC C-01 09:00 1. Fitomedicina: Bases históricas en el desarrollo de fitomedicamentos. Remedios antiguos vs. remedios modernos. CPC C-02 10:00 2. Legislación sobre Fitomedicamentos en Latinoamérica. CPC C-03 11:00 3. Enfermedades reumáticas: Artrosis y Artritis Reumatoidea. Fisiopatología, métodos diagnósticos. Abordaje con fitomedicamentos. Diferencias vs tratamiento convencional. 11:00 11:30 Merienda / Snack CPC C-04 11:30 4. Patologías del SNC. Fitomedicamentos en ansiedad, depresión, enfermedad de Alzheimer, enfermedad de Parkinson. Diferencias con el tratamiento convencional. CPC C-05 12:30 5. Nutracéuticos, nutrigenómicos. Los nuevos hallazgos en principios activos de alimentos y su faz preventiva y terapéutica en procesos crónicos (incluyendo cáncer). CPC C-06 13:30 6. Fitodermatología: Principios activos de interés dermatológico. Fórmulas especiales en psoriasis, acné, vitiligo, eczema atópico. 14:30 Discusión General 15:00 Almuerzo Edificio principal del Centro de Investigación y Desarrollo de Medicamentos (CIDEM) / Main Building of Drug Research and Development Centre, Havana City, Cuba. Ave 26, No. 1605, Entre Ave 51 y Boyeros, Plaza de la Revolución, La Habana. / cidem@infomed.sld.cu Telephone:

8 8 MIÉRCOLES 6 de Junio / WEDNESDAY, June 6 08:00 Salida Delegados extranjeros de los Hoteles Kohly y El Bosque, Ciudad de La Habana hacia Hotel Los Helechos, Topes de Collantes, Cuba / Departure of Foreigners Delegates from Kohly and El Bosque Hotels, Havana to Los Helechos Hotel, Topes de Collantes, Cuba. 13:00 14:00 Recibimiento y Acreditación a Delegados. Ubicación en Habitaciones del Hotel Los Helechos / Welcome and Accreditation to Delegates. Location in Rooms at Los Helechos Hotel. 14:00 15:00 Almuerzo / Lunch 16:30 Inauguración y Conferencias de Apertura / Inauguration and Opening Lectures (L) 16:30 PALABRAS DE APERTURA / Opening words Coordinadores / Coordinators Dr. René Delgado-Hernández. Dra. Idania Rodeiro Guerra. 16:30-16:40 Bienvenida a los Delegados / Welcome remarks Dr. René Delgado-Hernández. Presidente Comité Organizador, Presidente Sociedad Cubana de Farmacología / President of Organizing Committee, President, Cuban Society of Pharmacology 16:45-16:55 Presentación del Programa del Congreso / Presentations the Program of the Symposium. Dra. Idania Rodeiro Guerra. Presidente del Comité Científico / President of Scientific Committee, Secretary, Cuban Society of Pharmacology. 16:50-17:00 Inauguración Oficial del Congreso / Official inauguration of the Congress Personalidad invitada / Invited personality L-01 17:00-17:45 Phytonutrients and Cancer. Prof. Jorge Alonso. Presidente Sociedad Argentina de Fitoterapia. Argentina. L-02 17:50-18:35 Phytochemicals in health and inflammatory disease: epigenetic friends or foe/ Prof. Wim Vanden Berghe University Antwerp, Bélgica / Belgium. 19:00 21:00 Cena / Dinner 21:30 Actividad Cultural de Bienvenida / Welcome Cultural Activity.

9 9 JUEVES, 7 Junio / Thursday, June 7 08:00-12:00 Recorrido por el Parque Natural Topes de Collantes, Visita al Salto del Caburni. / Traveled by the Natural Park, Visit to Salto del Caburni. 13:00-14:00 Almuerzo / Lunch Sala 1 / Teatro Room 1 / Theater Hotel Kurt, Topes Collantes Coordinador / Coordinator: Conferencias plenarias / Lectures Prof. Wim Vanden Berghe University Antwerp, Bélgica / Belgium. Dr. Diadelis Remirez, CECMED, Cuba. L-03 15:00-15:30 A desert plant-derived compound against inflammation. Prof. Guy Haegeman, LEGEST, University of Gent, Belgium. L-04 15:35-16:05 Trends in pharmacological research of natural therapeutic products. Dra. Evangelina Marrero Faz, National Center for Animal and Plant Health. Past President, Cuban Society of Pharmacology. / Centro Nacional de Sanidad Agropecuaria (CENSA), Pasada Presidente de la Sociedad Cubana de Farmacología, Cuba. Salas / Rooms 1,2,3,4 SALA 1 Teatro / ROOM 1 Theater Coordinadores / Coordinators: 16:10-16:25 RECESO / COFFEE BREAK 16:30-19:30 COMUNICACIONES ORALES / ORAL COMMUNICATIONS (OC) SIMPOSIOS / SYMPOSIA 16:30-19:30 SIMPOSIO: PRODUCTOS NATURALES INFLAMACION Y CANCER / SYMPOSIUM: NATURAL PRODUCTS, INFLAMMATION AND CANCER. Dr. Gilberto L. Pardo Andreu, IFAL, Cuba; Dr. Guy Haegeman, University of Gent, Belgium. OC-01 16:30-16:45 The permeabilizing effect of Guttiferone-A on mitochondrial membranes is a novel mechanism that explain its toxicity against cancer cells. Dr Gilberto L. Pardo, IFAL, Cuba. OC-02 16:50-17:05 Shikonin induces immunogenic cell death in tumor cells and enhances dendritic cell-based cancer vaccine. Dr. Hui-Ming Chen, Corea. OC-03 17:10-17:25 Xanthium Strumarium L as potential anticancer agent. MCs. Janet Piloto, CIDEM, Cuba. OC-04 17:30-17:45 Molecular characterization and valorization of Cuban natural products, in particular Vimang and its naturally glucosylxanthone mangiferin, for therapeutic applications against cancer and inflammation. Prof. Wim Vanden Berghe, University Antwerp, Belgium OC-05 17:50-18:05 Combination treatment with Cisplatin and mangiferin causes increased cell death in CT26.WT murine colon cancer cell line MSc. Julio C. Rodríguez, Rodeiro I, García L, Hernández I, Delgado R. Molecular Pharmacology Laboratory, CIDEM, Cuba. OC-06 18:10-18:30 Sesquiterpene lactone extract from native american herbs demonstrated antineoplastic activity against non Hodgkin lymphoma cells. Gustavo H. Marin 1 ; Eduardo Mansilla 1 ; Saulo Ciocchini 1 ; Nora Quiroga 1, Nancy Cardozo 1 ; Marilin Weiss 1 ; Hector Trebucq 1. Escuela Superior de Ciencias de la Salud; UNICEN. Av. Pringles

10 Olavarría, Buenos Aires, Argentina MR-01 18:35-19:20 Potentiality of use of scorpion Rophalurus juceus venom in the treatment of cancer. Drs Mariela Guevara, Alexis Diaz, José Ramón Cabrera. Grupo de Investigación, Desarrollo, Laboratorios LABIOFAM, Boyeros, Cuba. OC-07 19:20-19:35 Scientific theories to explain the action mechanisms that justify the use of scorpion venom as a natural product for the complementary treatment of cancer. Rodríguez JR, Rodríguez R, Cantalapiedra A, Soler D. Universidad de Ciencias Médicas de Guantánamo. Cuba. 19:35-19:45 DISCUSIÓN GENERAL / GENERAL DISCUSSION SALA 2 / ROOM 2 16:30-19:30 SIMPOSIO: FARMACOEPIDEMIOLOGIA Y PRODUCTOS NATURALES / SYMPOSIUM: PHARMACOEPIDEMIOLOGY AND NATURAL PRODUCTS. Coordinadores / Coordinators: Dra Giset Jimenez, MSc. Maria Cristina Lara Bastanzuri MINSAP, Cuba. MR-02 16:30-17:30 Roundtable Herbal Products: Inclusion in the basic drugs list and their safety. Cuban experience. Dra. Giset Jiménez, Dra. Ismary Alfonso, MSc. Cristina Lara, Dra Dulce Maria Clavo Barbado. MINSAP, Cuba. OC-08 17:35-17:55 Traditional treatment of various diseases by tribal and rural people of Madhya pradesh (India). Dr. Tahir Mahmood, India. OC-09 18:00-18:20 Vigilance of side effects associated to herbal medicines and natural medicines techniques. Matanzas Dr. Leydi Santos, Matanzas Medical University, Cuba. OC-10 18:25-18:45 Preventable adverse events reported by the consumption of herbal medicines. Cuba Drs Ana Karelia Ruiz Salvador, Ana Julia García Milian, Giset Jiménez López, Ismary Alfonso Orta, Bárbaro Pérez Hernández, Armando Carrazana Lee. Faculty of Medical Sciences "General Calixto Garcia." Havana. Cuba OC-11 18:50-19:10 Moringa oleífera. Uso popular vs evidencias. Dr. Leonardo Ramos, Santiago de Cuba Medical University, Cuba. 19:15-19:30 DISCUSIÓN GENERAL / GENERAL DISCUSSION SALA 3 / ROOM 3 16:30-19:30 SIMPOSIO: ORGANIZADO POR EL COMITÉ EDITORIAL DEL BOLETIN LATINOAMERICANO DE PLANTAS MEDICINALES Y AROMÁTICAS (BLACPMA) / SYMPOSIUM: ORGANIZED BY LATIN AMERICAN BULLETIN OF MEDICINAL AND AROMATIC PLANTS. Coordinadores / Coordinators: Dr. José Luis Martínez, Editor Jefe, BLACPMA, Chile; Dr. Alberto Hernández, CENCEC, Cuba. OC-12 16:30-16:50 Medicinal plants introduced in America during the Spanish conquer. Dr. José Luis Martínez, Chile OC-13 16:55-17:15 Medicinal plant research and education in the Medical University of Havana. Dr Francisco Morón, Central Laboratory of Pharmacology, Salvador Allende Faculty, Medical University of Havana, Cuba. OC-14 17:20-17:40 Studies of quantitative relationship structures antibacterial activity (QSAR) of synthetic naphtoquinones and furanonaphtoquinones.

11 Tatiana Alvarado, Mindy Sarabia, Ricardo Gaitán Luis Franco, Jairo Mercado, Harold Gómez. Universidad de Cartagena, Colombia. OC-15 17:45-18:05 Public Registration of Clinical Trials and herbal drugs. Role of BLACPMA. Dr. Alberto Hernández Rodríguez, CENCEC, Cuba. 18:05-18:30 DISCUSIÓN GENERAL / GENERAL DISCUSSION SALA 4 / ROOM 4 Coordinadores / Coordinators: 16:30-19:30 SIMPOSIO: EVALUACIÓN DEL POTENCIAL MUTAGÉNICO, CARCINOGÉNICO Y TERATOGENICO DE PRODUCTOS NATURALES. / SYMPOSIUM: EVALUATION OF MUTAGENIC, CARCINOGERNIC AND TERATOGENIC POTENTIALS OF NATURAL PRODUCTS. 11 Dr. Andrea Cabarkapa, University of Belgrade, Serbia. Dr. Angel Sánchez Lamar, Facultad de Biología, Universidad de La Habana. Faculty of Biology, Havana University, Cuba. OC-16 16:30-16:50 DNA protection: Theoretical approach to the mechanism of chemical interaction between the 2,4-di-terbutilfenol and three aromatic amines promutagenics. MSc. Junier Marrero, Faculty of Biology, Havana University, Cuba. OC-17 16:55-17:15 Effects of dry olive leaf extract against H 2 O 2 induced toxicity in human lymphocytes. Dr. Andrea Cabarkapa, University of Belgrade, Serbia. OC-18 17:20-17:45 Genotoxic potential the hidroalcoholic extract of marine plant Thalassia testudinum (BM-21), using in vitro and in vivo assays. MSc. Yadira Ansoar, IFAL, Cuba. OC-19 17:50-18:10 Clastogenic structure-activity relationship of benzoic acids with reported pro-oxidant activity. MSc. Estela Guardado, Camaguey University, Cuba. OC-20 18:15-18:35 Cymbopogon citratus extracts protect E. coli cells against the damage induced by UVC radiation. MSc. Mariolys Gonzalez, Faculty of Biology, Havana University, Cuba OC-21 18:35-18:55 Cymbopogon citratus essential oils fraction protective activity against UVC light in Caulobacter crecentus. MSc. Fabiana Fuentes, Faculty of Biology, Havana University, Cuba. 19:00-19:30 DISCUSIÓN GENERAL / GENERAL DISCUSSION Coordinadores / Coordinators: Carteles / Posters PPP-01-PPP-70 MR-03 OC-22 20:00-21:00 CENA / DINNER 21:00-23:30 SECCIÓN DE CARTELES / SECTION OF POSTERS Dres. Beatriz Garrido, Roberto Menéndez, Gilberto Pardo, Eva Marrero, Octavio Fernandez Limia, Alicia Lagarto, Cuba. 21:00-22:00 Discusión de carteles ( Carteles PPP-01-PPP-67) Farmacología preclínica. Intercambio científico. Presentación oral (5 min) de carteles seleccionados / Poster discusión (POSTERS PPP-01- PPP-67) PRECLINICAL PHARMACOLOGY. Scientific Exchange. Oral Presentation (5 min) of Selected Posters. 21:30-22:00 22:00-22:30 Roberto Vandama, Rosa Menéndez, Carlos Rodriguez, Alicia Lagarto, Saul Padrón, Ricardo Castro, Nicté González, René Delgado, Marlene Porto. Research and Development of Natural Products in the Drug Research and Development Centre (CIDEM). Present and Future. MSc. Ricardo Castro. Director of Center of Pharmaceutical

12 12 Information (CINFA), CIDEM. Presentation of Multimedia of Scientific Information related with natural products and herbal medicines. 22:30-23:30 Degustación de Rones Cubanos. Música y Karaoke. Demostraciones de Bailes tipicos por Fitofarmacólogos Cubanos / Tasting of Cuban Rums. Music and Karaoke. Performance of Cuban Phytopharmacologist that Showing Typical Dances. Montañas de Topes de Collantes, en la Cordillera del Escambray, al centro de la isla de Cuba. Una reserva natural de la biosfera de extraordinaria belleza. / Mountain of Topes de Collantes, in the Mountain range of the Escambray, to the center of the island of Cuba. A natural reservation of the biosphere of extraordinary beauty.

13 VIERNES, 8 Junio / FRIDAY, June 8 09:00-14:00 Visita a la Ciudad de Trinidad, Patrimonio de la Humanidad por la UNESCO. Visit to Trinidad City, Humanity Heritage by UNESCO/ Visita a la ciudad de Trinidad. Encuentro con el Historiador de la Villa. Visit to city of Trinidad. Encounter with the Historian of the Villa. 14:00-15:00 Almuerzo / Lunch Sala 1 / Teatro Room 1 / Theater Hotel Kurt, Topes Collantes Conferencias plenarias / Lectures Coordinadores / Coordinators: Dr. Hector Perez Saad, INNN, Cuba. Dr. Cagatay Oktenli, Turkia. / Turkey. L-05 15:00-15:30 Molecular mechanisms associated to new therapies for multiple sclerosis and stroke. Dr. Giselle Penton, CIGB, Cuba. L-06 15:35-16:05 Productos naturales en la enfermedad de Alzheimer. / Natural products in Alzheimer's disease. Dr. Huseyin Doruk, Gülhane Military Medical Academy, Department of Geriatrics, Etlik, Ankara, Turkey 16:10-16:25 RECESO / COFFEE BREAK Salas / Rooms 1,2,3 16:30-19:30 COMUNICACIONES ORALES / ORAL COMMUNICATIONS SIMPOSIOS / SYMPOSIA SALA 1 / ROOM 1 SIMPOSIO: PRODUCTOS NATURALES Y NEUROINMUNOMODULACION. / SYMPOSIUM: NATURAL PRODUCTS AND NEUROIMMUNOMODULATIONS. Coordinadores / Coordinators: Dr. Beatriz Garrido, CIDEM, Cuba, Dr. Roberto Menéndez, CEBIMAR, Cuba OC-23 16:30-16:50 Natural products, an alternate and complementary approach to treating neuropathic pain. Dr. Beatriz Garrido, CIDEM, Cuba. OC-24 16:55-17:15 C-Phycocyanin and phycocyanobilin are neuroprotective in models of brain ischemia. Dr. Javier Marin, IFAL, Cuba. OC-25 17:20-17:40 Isolation and identification of active metabolite in correspondence depressing effect of central nervous system obtained from extracts of pedilanthus tithymaloides (l.) poit. MSc. Hiran Cabrera, FCM Salvador Allende, UCM Habana, Cuba OC-26 17:45-18:05 Studies on the neuro-pharmacological profile of BM-21, an aqueous ethanolic extract from Thalassia testudinum in mice. MSc. Teydi Garcia, CEBIMAR, Cuba. OC-27 18:10-18:30 Neuroprotective effects of BM-21, an aqueous ethanolic extract from Thalassia testudinum, on acrylamide induced neurotoxicity in mice. MSc. Ruth Morales, CEBIMAR, Cuba. OC-28 18:35-18:55 One month oral administration of BM-21, an aqueous ethanolic extract from Thalassia testudinum, enhances cognitive performance in mice. Dr. Roberto Menéndez, CEBIMAR, Cuba. OC-29 19:00-19:20 Neuroprotection in brain ischemia and cerebrovascular disorders. Role of natural antioxidants and anti-inflammatory products. Experiences and results on laboratory of experimental neuropharmacology of CIDEM. DrC. René Delgado-Hernández et all. CIDEM, Cuba. 13

14 SALA 2 / ROOM 2 19:20-19:30 DISCUSIÓN GENERAL / GENERAL DISCUSSION 16:30-19:30 Coordinadores / Coordinators: 14 SIMPOSIO: ASPECTOS REGULATORIOS PARA EL DESARROLLO DE PRODUCTOS NATURALES / REGULATORY ASPECTS ON NATURAL PRODUCTS DEVELOPMENT. Dr. Ana Cecilia Bezerra Carvalho, Brazil; Dr. Diadelis Remirez, Cuba. OC-30 16:30-16:50 National policy and regulatory framework of homeopathic and natural products in Cuba. MSc Maritza González, CECMED, Cuba. OC-31 16:50-17:10 Situation of herbal medicines in Brazil. Dr. Ana Cecilia Bezerra, Brazil. OC-32 17:10-17:30 Legislation of natural products in Paraguay. Dra Nelida Soria, Paraguay. OC-33 17:30-17:50 Regulations and expectations of natural products in Ecuador. Dr. Francisco Hernández, Ecuador. OC-34 17:50-18:10 Use of natural products in Paraguay. Pharmacovigilance. Dra. Ninfa Colman, Paraguay. OC-35 18:10-18:30 Regulatory framework of homeopathics products in Cuba. Is it a necessity? MSc. Carmen Beatriz de la Cruz, MSc. Niovis Ceballos Rodriguez, CECMED, Cuba OC-36 18:30-18:50 Update in preclinical and clinical regulatory requirements of natural products in Cuba. Dr. Diadelis Remirez Figueredo, CECMED, Cuba. OC-37 18:50-19:10 Regulatory Considerations for the clinical development of natural products MSc. Julian Rodriguez Alvarez. National Coordinator Center of Clinical Trials. CENCEC, Cuba. 19:10-19:30 DISCUSIÓN GENERAL / GENERAL DISCUSSION 20:00-21:00 CENA / DINNER SALA 3 / ROOM 3 16:30-19:30 SIMPOSIO: ANTI-INFECCIOSOS NATURALES. / SYMPOSIUM: NATURALS ANTI-INFECTIOUS. Coordinadores / Coordinators: Dr. Eliza Aznar, Cuba; Dr. Marco Dehesa, Ecuador. OC-38 16:30-16:45 Inhibitory activity of polyphenols from Chilean propolis on the cariogenic bacteria Streptococcus mutans. MSc. Jorge Veloz, Chile. OC-39 16:50-17:05 Anacardic acids as inhibitors of virulence factors regulated by systems quorum sensing in bacterial pathogens. Dr. Norma Velazquez, Mexico. OC-40 17:10-17:25 Anthelmintic activity of Albizia lebbeck (l.) bark and Cassia fistula (l.) fruit against Trichostrongylid nematodes of sheep. Dr. Rao Abbas, Pakistan. OC-41 17:30-17:45 Antileishmanial evaluation of natural products extracts. MSc Marley Garcia, IPK, Cuba. OC-42 17:50-18:05 Anthelmintic activity of Azadirachta indica seeds against trichostrongylid nematodes of sheep. Dr. Wasim Baber, Pakistan. OC-43 18:10-18:25 In vitro antimicrobial assessment of Cuban propolis extracts. MSc. Lianet Monzote, IPK, Cuba. OC-44 18:30-18:45 Antiparasitic activity of tannin extracts from bolivian timber plants. Dr Gloria Saavedra, Bolivia. OC-45 18:50-19:05 Advances in anthelmintic medicinal plants prospecting, aiming the

15 further development of a veterinary phytopharmaceutical. Dr. Veronica Cesio, Uruguay OC-46 19:10-19:25 Antipsoriatic topical effect of three Vimang formulations in the mouse tail model. Dr. Nelson Merino, CIDEM, Cuba. OC-47 19: Methodologies that improve antiviral activity evaluation of natural and non natural molecules against dengue virus. Fleitas Salazar N, Pupo-Gómez D, Huerta V, Díaz CE and Chinea G. Center for Genetic Engineering and Biotechnology, Havana, Cuba. 19:45-20:00 DISCUSION GENERAL / GENERAL DISCUSION 20:00-21:00 CENA / DINNER 15 Coordinadores / Coordinators: PCP PEP PBI-01 PIR PTS PAP PPT PAE :00-23:30 SECCIÓN DE CARTELES / SECTION OF POSTERS Dres. Beatriz Garrido, Roberto Menéndez, Gilberto Pardo, Eva Marrero, Octavio Fernández Limia, Alicia Lagarto, Cuba. 21:30-22:00 Discusión de carteles / Poster Discussion. Farmacología clínica Clinical Pharmacology / (PCP -01-PCP-14), Etnofarmacología. / Ethnopharmacology (PEP-01-PEP-10), Informática / Informatics sciences (PBI-01), Información Científica / Scientific Information (PIR-01-PIR-03), Toxicología / Toxicology (PTS-01-PTS-11), Analítica y fotoquímica / Analytical and Phytochemistry (PAP-01- PAP-12), Tecnologías farmacéuticas / Pharmaceuticals Tecnologies (PPT-01-PPT-05) y Agroecología / Agroecology (PAE-01-PAE-06). Intercambio científico. Presentación oral (5 min) de carteles seleccionados / Scientific Exchange. Oral Presentation (5 min) of Selected Posters. OC-48 21:30-22:00 Presentación del Trabajo que realizan en el desarrollo de Productos Naturales los Laboratorios LABIOFAM. / Presentation of LABIOFAM laboratories and its activity in the field of natural products. 21:30 22:30 PRESENTACIÓN, COMERCIALIZACIÓN DE COMPENDIOS INFORMATIVOS SOBRE PRODUCTOS NATURALES / Presentation and Commercialization books and Compendium of Natural Products. OC-49 Dr. Marcos Dehesa González, Asociación de Fabricantes de Productos Naturales del Ecuador, AFAPRONAT, Ecuador. Presentación Lab. CATALYSIS, España. 22:30-23:30 Degustación de Rones Cubanos. Música y Karaoke. Demostraciones de Bailes típicos por Fitofarmacólogos Cubanos / Tasting of Cuban Rums. Music and Karaoke. Performance of Cuban Phytopharmacologist that Showing Typical Dances.

16 16 Sala 1 / Teatro Room 1 / Theater Hotel Kurt, Topes Collantes Coordinadores / Coordinators: SABADO 9 Junio / SATURDAY, June 9 CONFERENCIAS PLENARIAS / LECTURES Dr. Giselle Penton Rol, CIGB, Cuba DrSc Evangelina Marrero, CENSA, Cuba L-07 09:00-9:30 Apigenin inhibits human melanoma cell growth, migration and invasion by blocking the STAT3 pathway. Dr. Zhi-Ling YU. Center for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China. L-08 09:35-10:05 Association of cardiomyocyte apoptosis with metabolic syndrome in type 2 diabetic rats with obesity: potential of gymnemic acidphospholipid complex (GPC). Dr. Uma Bhandary, Department of Pharmacology, Faculty of Pharmacy, Hamdard University, New Delhi, India. Salas / Rooms 1,2,3 10:10-10:30 RECESO / COFFEE BREAK 10:30-14:00 COMUNICACIONES ORALES / ORAL COMMUNICATIONS SIMPOSIOS / SYMPOSIA SALA 1 / ROOM 1 10:30-14:00 SIMPOSIO: EVALUACIÓN FARMACOLÓGICA Y POTENCIALIDADES TERAPÉUTICAS DE PRODUCTOS NATURALES. / SYMPOSIUM: PHARMACOLOGICAL EVALUATION AND THERAPEUTICS POTENTIALITIES OF NATURAL PRODUCTS. Coordinadores / Coordinators: Dr. Horacio Heinzen, Uruguay; Dr. Francisco Morón, Cuba. OC-50 10:30-10:50 Phytochemistry, antiproliferative and antioxidant effect of vegetables. Dr. Horacio Heinzen, Uruguay. OC-51 10:50-11:10 Cuban plants evaluation for obtain secondary metabolites with pharmacological activity: anti- inflammatory and antitumoral. Dra. Luz Maria Sánchez Perera y colectivo de Autores. CENSA. San José de las Lajas, Cuba OC-52 11:10-11:30 Challenges and opportunities of herbal technology: an ethic analysis. Dr. Martha Carralero, QUIMEFA, Cuba. OC-53 11:30-11:50 Immunomodulator of natural origin: Biomodulina T. Dr. Elisa Aznar, BIOCEN, Cuba. OC-54 11:50-12:10 Hepatoprotective and antioxidant effect of Geranium schideanum following thioacetamide-induced necrosis in rats. Dr. Mirandeli Bautista, Mexico. OC-55 12:10-12:30 Anti-inflamatory activity of low polarity extract and isolated compounds from Maytenus elaeodendroides, an endemic specie. Dr Iraida Splenger, Faculty of Chemistry, Havana University, Cuba. OC-56 12:30-12:50 The importance of the assessment of antiplatelet potential of medicinal plants. Dr. Milagros Garcia, Instituto Nacional de Angiología, Cuba. OC-57 12:50-13:10 Phytochemical study of Jatropha curcas leaf. Dr. Tahir Mahmood, Barkatullah University, Bhopal, India.

17 OC-58 13:10-13:30 Antioxidant capacity of poliphenolic and thiol herbal compounds. Dr. Maria Eugenia Letelier, Universidad de Chile, Chile. OC-59 13:30-13:50 Preclínical evaluation of the effectiveness of Croton lechleri and some medicinal preparations from the latex and the leaves of this specie. Dr. Marco Dehesa Gonzaléz, Laboratorio RENASE, Quito, Ecuador. OC-60 14:10-14:30 Tropical medicinal and toxic plants: Experimental pharmacological effects vs natural intoxications in animals. Research carried out at CENSA, Havana, Cuba. DrCs Evangelina, Marrero Faz, Centro Nacional de Sanidad Agropecuaria, CENSA, San José de Las Lajas, Mayabeque, Cuba. 14:30-15:00 GENERAL DISCUSION / DISCUSION GENERAL SALA 2 / ROOM 2 10:30-14:00 SIMPOSIO: ENSAYOS CLÍNICOS CON PRODUCTOS NATURALES. / SYMPOSIUM CLINICAL TRIALS WITH NATURAL PRODUCTS. Coordinadores / Coordinators: Dr. Adrian Llerena, España / Spain Dra. Maria Acelia Marrero, Cuba. OC-61 10:30-10:45 Quality standards in clinical trials a natural product: ISO 9001-Good Clinical Practice. MSc. Sandra Alvarez, CENCEC, Cuba OC-62 10:50-11:05 Pharmacogenetics of Herbal Medicine: Potential Relevance for Vulnerability to Depression and Antidepressant Drug Effect. Dr Adrian LLerena, Clinical Research Centre. Extremadura University Hospital and Medical School. Hospital Infanta Cristina, Badajoz, Spain. OC-63 11:10-11:25 CUMIN-250 capsules and CUMIN-50 topical cream: A new phytomedicine from Cúrcuma longa L. Experiences in HIV, dislipidemic, hepatitis and pharmacological results in skin diseases. Dr. Juan J Garcia, SAL PLANT Laboratory, MINSAP, Pinar del Rio, Cuba. OC-64 11:30-11:45 Two natural's products in migraine prevention. Clinical trial phase III. Dr. Maria Acelia Marrero, CENCEC, Cuba. OC-65 11:50-12:05 Risk Analysis for of early use of SURFACEN in children with NRDS. Preliminary results. Dr. Octavio Fernández Limia, CENSA, Cuba. OC-66 12:10-12:25 Attention deficit disorder and hyperactivity in children is reviewed from the literature to identify the causes and possible ways to take control. Dr. Pierre Marchand, Canada. OC-67 12:30-12:45 Nutritional Supplements: The Health of Nature. Pérez MR 1, I. Guevara O 1, Rodríguez C 1, Fraga JA 1, Merino N 2, Álvarez D 3 1 Group LABIOFAM. Ave Independencia Km 16½ Mulgoba, Boyeros, La Habana, Cuba. 2 CIDEM, 3 IFAL, Pharmacy Institute, University of Havana. Ave 222 La Coronela, La Lisa, La Habana, Cuba. MSc. Maria Regla Pérez Capote. OC-68 12:50-13:05 The Cuban Health care Revolution: Tradition and Technology forging a new social model. Dr Chiara Stella Cochetti, United Kingdom (UK). 13:10-13:30 DISCUSION GENERAL / GENERAL DISCUSION 17

18 18 SALA 3 / ROOM 3 10:30-14:00 SIMPOSIO: BIODIVERSIDAD MARINA CARIBEÑA COMO FUENTE DE NUEVOS COMPUESTOS DE INTERÉS BIOMÉDICO Y OTRAS APLICACIONES INDUSTRIALES. / SYMPOSIUM: CARIBBEAN MARINE BIODIVERSITY AS A SOURCE OF NEW COMPOUNDS OF BIOMEDICAL INTEREST AND OTHERS INDUSTRIAL APPLICATIONS. Coordinadores / Coordinators: Dr. Roberto Núñez, CEBIMAR, Cuba. MCs. Miguel David Fernández, CEBIMAR, Cuba. OC-69 10:30-10:50 Production of natural products from marine bacteria. Dr. Roberto Núñez, Director, CEBIMAR, Cuba OC-70 10:55-11:15 New compounds obtained from sponges from Pandaros acanthifolium with promissory pharmacological activity. Dr Abilio Laguna, CEBIMAR, Cuba. OC-71 11:20-11:40 Identification and purification of a trypsin inhibitor from the hemolymph of the spiny lobster Panulirus argus. Dr. Rolando Perdomo, CIDEM, Cuba. OC-72 11:45-12:05 Anti-inflammatory and antinociceptive potentialities of methanol extract from the red seaweed Dichotomaria obtusata. MSc. Neyvis Garcia, CEBIMAR, Cuba. OC-73 12:10-12:30 Inhibition of LDL-oxidation and antioxidant properties related to polyphenols content of hydrophilic fractions from seaweed Alimeda incrassata (ellis) lamouroux. MSc. Aridana Costa- Mugica, Faculty of Biology, University of Havana, Cuba. OC-74 12:35-12:55 Toxicological assessments of aqueous extracts from seaweeds Bryothamnion triquetrum (GMELIN) M.A.Howe in vitro and models animal studies. Dr. Alexis Vidal, Faculty of Biology, Havana University, Cuba. OC-75 13:00-13:20 Isolation and identification of marine Actinomycetes and its potential antimicrobial activity. MSc Milagros R. Garcia, Centro de Bioactivos Químicos. Universidad Central de las Villas, Cuba. OC-76 13:25-13:45 Cytotoxicity activity and potential of pharmacological interactions of BM-21, a new product obtained from Thalassia testudinum marine plant. DrC Idania Rodeiro Guerra, CEBIMAR, Cuba. 13:50-14:00 GENERAL DISCUSION / DISCUSION GENERAL 14:30-15:30 ALMUERZO / LUNCH 15:30 18:30 TIEMPO LIBRE. Recorrido por el Parque Natural Topes de Collantes. / FREE TIME. Visit to Natural Park Topes de Collantes. 19:00 20:00 CEREMONIA DE CLAUSURA / CLOSING CEREMONY L-09 19:00 19:30 Conferencia de Clausura / Closing Lecture Management Development of Natural Products in Cuba. Experience of the Drug Research and Development Center. MSc. Marlene Porto Verdecia, Directora General, CIDEM, Cuba 19:35 20:00 RELATORÍA DE LAS PRINCIPALES ACTIVIDADES DESARROLLADAS DURANTE FAPRONATURA / Summary of Principal Activities Developed During Fapronatura MSc. Gledys Reynaldo, IFAL, Cuba. 20:00 20:30 PREMIOS Y RECONOCIMIENTOS DE LA SOCIEDAD CUBANA DE FARMACOLOGÍA A LOS MEJORES TRABAJOS PRESENTADOS EN FAPRONATURA 2012 / Awards and

19 19 Recognitions of the Cuban Society of Pharmacology to the Best Works Presented in Fapronatura Dres. Diadelis Remirez, Mario Landys Chovel, Maria Acelia Marrero, Idania Rodeiro, Maria Cristina Lara and René Delgado, Cuban Society of Pharmacology, Cuba. 20:30 21:30 CENA DE DESPEDIDA / FAREWELL DINNER 22:00 24:00 FIESTA DE DESPEDIDA / FAREWELL PARTY DOMINGO, 10 Junio / SUNDAY, June 10 08:00-11:00 Desayuno. / Breakfast Entrega de habitaciones / Check out the room DESPEDIDAS / FAREWELLS 11:00 SALIDA / DEPARTURE Regreso de delegados a sus países y provincias / Return of delegates to their countries and provinces. Topes de Collantes, Cordillera del Escambray, Sancti / Spíritus, Cuba

20 20 CARTELES / POSTERS JUEVES, 7 Junio / Thursday, June 7 21:00-23:30 SECCIÓN DE CARTELES / SECTION OF POSTERS Coordinadores / Coordinators: Dres. Beatriz Garrido, Roberto Menéndez, Gilberto Pardo, Eva Marrero, Octavio Fernández Limia, Alicia Lagarto, Cuba. PPP-01 CARTELES FARMACOLOGÍA PRECLÍNICA / POSTERS PRECLINICAL PHARMACOLOGY PPP-67 PPP-01 IN VITRO ANTIBACTERIAL PRECLINIC OF TOTAL EXTRACTS OF THE LEAVES OF Petiveria alliacea L. (ANAMÚ) Pacheco A, Morán J, Escalante K. Department of Pharmacy, Faculty of Natural Science, Universidad de Oriente, Patricio Lumumba and Avenida de Las Américas s/n, Santiago de Cuba City, Cuba, aochoa@cnt.uo.edu.cu PPP-02 EFFECTS OF MANGIFERA INDICA L. EXTRACT AND MANGIFERIN ON THE PHARMACOKINETICS OF THE THEOPHYLLINE IN RATS. Alejandro S. Padrón 1, Pedro Alejo 1, Ivones Hernandez 2, Roberto Menendez 2, Jose Herrera 3, Teidy Garcia 2, Julio Cesar Rodriguez 1, Jesus Dominguez 1, Tatiana Gabilondo 1, Maria Elena Garcia 1, Idania Rodeiro 2. 1 Centro de Investigaciones y Desarrollo de Medicamentos, CIDEM, 26 y 51, Vedado, Plaza de la Revolución, Habana, Cuba. 2 Centro de Bioproductos Marinos, CEBIMAR, Lomay 37, Nuevo Vedado, Habana, Cuba. 3 INRE, Universidad de La Habana, Cuba. PPP-03 PPP-04 PPP-05 PPP-06 PPP-07 PPP-08 PPP-09 DIURETIC EFFECT OF THE PEPEROMIA PELLUCIDA IN RATS WISTAR Dranguet Y, Soler D, Silva J. UNIVERSITY OF MEDICAL SCIENCES GUANTÁNAMO. dayamisc@infosol.gtm.sld.cu COX-2 AND SPLA-2 IN VITRO INHIBITORY ACTIVITY STUDY FROM ORGANIC EXTRACT OBTAINED FROM Allophylus cominia (L) sw. Oliva Y, Sánchez J, Abad MJ*, Bermejo P*, Marrero E. National Center for Animal and Plant Health, CENSA, Apdo 10, San José de las Lajas, Mayabeque, Cuba. * Department of Pharmacology, Faculty of Pharmacy, Madrid Complutense University, Spain. yuleivys@censa.edu.cu HEALING EFFECTS AND IRRITANT ASSAYS OF A 1% CALENDULA OFFICINALIS CREAM. Bellma A, Lagarto A, Bueno V, Carrillo C, Valdéz O, Guerra I, Muñoz A. Centro de Investigación y Desarrollo de Medicamentos (CIDEM), Unidad de Ciencia y Técnica Control Biológico. 17 Nº 6208 e/ 62 y 64 Playa, Ciudad de La Habana, Cuba. addisbm@infomed.sld.cu; addis.bellma@cidem.sld.cu PRECLINICAL VALIDATION OF THE TRADITIONAL USES OF THE PHANIA MATRICARIOIDES (SPRENG) GRISEB FRESH AERIAL PARTS DECOCTION. García AI, Victoria MC, Morón FJ, Frías AI, López M, Boucourt E, Morejón Z, Acosta L. Central Laboratory of Pharmacology, Dr. Salvador Allende School of Medical Sciences. Carvajal entre Agua Dulce y A, Cerro, Ciudad de La Habana, CP 12000, Cuba. anaibisgar@infomed.sld.cu PRECLINICAL VALIDATION OF SAFE OF TWO MEDICINAL PLANTS FROM CUBA AND THE CARIBBEAN. López M 1, Morejon Z 1, Garcia AI 1, Boucourt E 1, Martinez MJ 1, Bacallao Y 1, Fuentes V 2, Acosta L 1. 1 Central Laboratory of Pharmacology, Faculty of Medical Sciences Dr. Salvador Allende. " Carvajal s / n e / A and Agua Dulce. Cerro. Ciudad de La Habana, CP 12000, Cuba. 2 Fruit Station. Guira de Melena. Havana Province. marisolb@infomed.sld.cu ANTIMICROBIAL ACTIVITY OF DIFFERENT PLANT EXTRACTS. Boucourt E, Martinez MJ, Lopez M, Morejon Z, Garcia AI, F. Morón Central Laboratory of Pharmacology, Faculty of Medical Sciences "Dr. Salvador Allende, "Carvajal s/n e/ A y Agua Dulce, Cerro, Havana, CP 12000, Cuba. elisa@infomed.sld.cu ANTIOXIDANT PROPERTIES OF DICHROSTACHYS CINEREA (MIMOSACEA) LEAVES AND

21 PPP-10 PPP-11 PPP-12 PPP-13 PPP-14 BARK. Ribalta V. 1, Hernández E. 1, Torres L. 1, Sueiro M. 1, Armas Y. 1 Pharmacy Department, Chemistry and Pharmacy Faculty. Central University of Las Villas. Santa Clara, Villa Clara. Road to Camajuaní km 5 ½. Cuba. venancior@uclv.edu.cu ORAL ANTIPYRETIC EFFECT OF TRADITIONAL MEDICINAL PLANTS. Martínez I, Morón FJ, Victoria MC, Brito G, Nossin E y Acosta L. Medical Science University of Havana. Central Research Unit of Pharmacology. Carvajal esq. Agua Dulce, Cerro, La Habana, Cuba. ioanna@infomed.sld.cu TOPICAL ANTIINFLAMMATORY EFFECT OF TRADITIONAL HERBAL USES. Brito G, Frías AI, Morón FJ, García N, Cabrera H, Morejón Z. Medical Science University of Havana. Central Research Unit of Pharmacology. Carvajal Esq. Agua Dulce, Cerro, La Habana, Cuba. gisellebrito@infomed.sld.cu PHARMACOLOGICAL VALIDATION OF FRESH LEAVES AND FLOWERS DECOCTIONS OF HIBISCUS ROSA-SINENSIS (MAR PACÍFICO). Victoria MC, Morón FJ, Martínez I, Brito G, Morejón Z, Fuentes V. Medical Science University of Havana. Central Research Unit of Pharmacology. Carvajal Esq. Agua Dulce, Cerro, La Habana, Cuba. mcvictoria@infomed.sld.cu SCREENIG OF ANTIMUTAGENICITY VIA ANTIOXIDANT ACTIVITY IN CUBAN MEDICINAL PLANTS. Ramos A, Piloto J*, Vizoso A, García A, Rodríguez C. Drug Research and Development Center (CIDEM). Ave 26 # 1605 e/ Puentes Grandes and Boyeros. Havana. Cuba. E mail: janet.piloto@cidem.sld.cu POTENT AND VERSATILE FREE RADICAL SCAVENGING AND ANTIOXIDANT PROPERTIES OF KIGELIA PINNATA FLOWERS EXTRACT ON CELL-FREE SYSTEMS. Hernández-Barreto E. *, Ruz V., Ribalta V., Sueiro M., Armas Y., Pérez-Donato J. A. *Pharmacy Department, Chemistry and Pharmacy Faculty. Central University of Las Villas. Santa Clara, Villa Clara. Road to camajuaní km 5 ½. Cuba. enoelh@uclv.edu.cu PPP-15 ANTI-HYPERALGESIC EFFECT OF MANGIFERA INDICA L. EXTRACT AFTER CHRONIC CONSTRICTION INJURY OF THE SCIATIC NERVE IN RATS. Castro M, Garrido-Suárez B, García M, Merino N, Valdés O, Delgado R. Center of Research and Drug Development, Ave 26, No Boyeros y Puentes Grandes CP 10600, Plaza de la Revolucion, Habana City, Cuba. PPP-16 PPP-17 PPP-18 PPP-19 PPP-20 ANTI-INFLAMMATORY ACTION TO THE DECOCTION OF THE SOLANUM TORVUM. Pérez L, Puente E, Larramendi D, Jackson E, González Y. Centro de Toxicología y Biomedicina (TOXIMED). Address Autopista Nacional, Km 11/2, Apartado postal 4033, Santiago de Cuba, CUBA. . bebe@toxi.scu.sld.cu, antídotos@toxi.scu.sld.cu ANTIULCEROUS ACTIVITY OF THE DECOCTION OF ZUELANIA GUIDONIA (GUAGUASÍ) Puente E, Pérez L, Larramendi D, Salas H, Pileta Y. Centro de Toxicología y Biomedicina (TOXIMED). Autopista Nacional, Km 11/2, Apartado postal 4033, Santiago de Cuba, CUBA. . edgar@toxi.scu.sld.cu zapata.puente@medired.scu.sld.cu ASSESSMENT OF THE CONTENT OF PHENOLICS AND ANTIOXIDANT ACTIONS OF NEEM (AZADIRACHTA INDICA A. JUSS). Fong O, De la Vega JE, Berenguer CA, Wawoe N, Puente E. Centro de Toxicología y Biomedicina (TOXIMED). Autopista Nacional, Km 11/2, Apartado postal 4033, Santiago de Cuba, CUBA. . fong@toxi.scu.sld.cu PHARMACOLOGICAL ACTIVITIES OF AQUEOUS EXTRACT AND FRACTIONS OF GREEN VARIETY OF Sechium edule (Jacq.) Sw. LEAVES. Sánchez J 1, Oliva Y 1, Young L 2, Harvey A 2, Marrero E 1 1 Chemistry, Pharmacology and Toxicology Department, National Centre for Animal and Plant Health, (CENSA). Apdo. #10, San José de las Lajas, Mayabeque, Cuba. 2 Strathclyde Institute for Pharmaceutical and Biomedical Science (SIPBS), University of Strathclyde, Glasgow, Scotland, UK. jsanchez@censa.edu.cu NPCI, A NEW CARBOXYPEPTIDASE INHIBITOR ABLE TO INHIBIT THE GROWTH OF PLASMODIUM FALCIPARUM IN INTRA-ERYTHROCYTIC PHASE. Sierra-Gómez Y 1, González Y 1,Díaz J 1, Delfín J 1, French L 2, Reytor M 1, Trejo, S 3 ; Avilés, F 3 and Alonso del Rivero, M 1. 1 Center for Protein Studies, 25 Street, #455, Vedado, Plaza de la Revolución, Havana, Cuba 21

22 PPP-21 PPP-22 PPP Instituto de Medicina Tropical Pedro Kouri, Havana, Cuba. 3 Institut de Biotecnologia i Biomedicina and Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Spain. ISOLATION AND EVALUATION OF SOME BIOLOGICAL PROPERTIES THE LECTIN FROM DICHROSTACHYS CINEREA (L). Morales Diaz M. Universidad Central de Las Villas km11 Carretera a Camajuani Santa Clara.Villa Clara. mirtha@ uclv.edu.cu CONTRIBUTION OF RUTINE AND QUERCETINE FLAVONOIDS AND DIURETIC ACTIVITY. Sueiro-Oyarzun M 1, Machín-Pérez M 2, Siverio-Mota D 1, Herrera-Pis Y 1, Boffill-Cárdenas M 2, Morón- Rodríguez F 3 1 Pharmacy Department, Chemistry and Pharmacy Faculty, Central University of Las Villas, Santa Clara City, Cuba. 2 Medical Sciences University of Villa Clara, Santa Clara City, Villa Clara, Cuba. 3 Medical Science University of Havana, Havana City, Cuba. msueiro@uclv.edu.cu ANTIBACTERIAL ACTIVITY OF PERICARPS OF THREE CLONES OF COCOA AGAINST PYOGENAL BACTERIA. Viera Y a*, Fajardo L a, Morales G a, Rosabal U b. a Universidad de Granma, Carretera a Manzanillo, km 17½, CP:85100, Bayamo, Granma, Cuba. b Medilip, Quimefa, CP:85100, Bayamo, Granma, Cuba. yvierat@udg.co.cu PPP-24 COMPOSITION AND BIOLOGICAL PROPERTIES OF THE VOLATILE OIL OF ARTEMISIA GORGONUM WEBB. Fernandez Miguel D., Erik L. Regalado, Risoleta Orteta, Olivier P. Thomasa, Jorge A. Pino, Jean- Jacques Filippia. 1 Center of Marine Bioproducts, Loma y 37, C.P , La Habana, Cuba. 2 Université de Nice- Sophia Antipolis, Laboratoire de Chimie des Molécules Bioactives et des Aromes (LCMBA), UMR 6001 CNRS, Faculté des Sciences, 28 Avenue Valrose, F Nice Cedex 2. 3 Instituto de Investigaciones para la Industria Alimenticia, Carretera al Guatao km 31_2, La Habana, CP 19200, Cuba. migueldavid@cebimar.cu PPP-25 HEPATOPROTECTIVE PROPERTIES OF BM-21, AN EXTRACT FROM THALASSIA TESTUDINUM MARINE PLANT: IN VITRO AND IN VIVO ASSAYS. Hernández I a, I. Rodeiro a, M. T. Donato a, R. A. Morales a, J. C. Rodríguez a, T. del Vallín a, D. Martinez a, Fernandez MD a, J. V. Castell a, M. J. Gómez-Lechón a, R. Menéndez a. a Departamento de Farmacología, Centro de Bioproductos Marinos, (CEBIMAR), Loma 37, Vedado, P.O. Box 10400, Havana, Cuba. b Unidad de Hepatología Experimental, Centro de Investigación, Hospital La Fe, Avda Campanar 21, Valencia, Spain. c Departamento de Bioquímica y Biología Molecular, Facultad de Medicina y Odontología, Universitat de València, Avda. Blasco Ibáñez 15, Valencia, Spain. PPP-26 PPP-27 PPP-28 PPP-29 INCREASE OF POLYPHENOLIC, FLAVONOIDS AND TOTAL ANTIOXIDANT CAPACITY IN EXTRACTS OF SOLANUM LYCOPERSICUM IRRIGATED WITH STATIC MAGNETIC FIELDS. Ferrer A a, Fung Y a, Oliveira G b, Gómez L a, Rocha J c a National Center of Applied Electromagnetism. Universidad de Oriente Ave. The Americas s/n. Santiago of Cuba City. Cuba. CP GP albys@cnea.uo.edu.cu. b Dpt. Quimica Biologica,Univ. Regional do Cariri, Crato-CE, Brazil. c Dpt. Quimica, Bioquimica Toxicologica, (CCNE) Univ. Federal de Santa Maria, RS, Brazil EVALUATION OF THE ANTI-PLATELET ACTIVITY OF THE ETHANOL 80% EXTRACT OF THE SPECIES BOLDOA PURPURASCENS. Hernández Y 1, González D 1, Morales Y 2. 1 Central University Marta Abreu of Las Villas, Road to Camajuaní Km 5 ½. Santa Clara, Villa Clara. yannarys@uclv.edu.cu. 2 Hospital Arnaldo Milián Castro, Hospital Avenue. Santa Clara, Villa Clara. EVALUATION OF AN ANTIFUNGAL ACTIVITY OF THE FLAVONOIDS CRUDE OBTAINED FROM THE LEAVES OF BOLDOA PURPURASCENS. González D, Hernández Y, Palenzuela Y, Sosa R. Central University Marta Abreu of Las Villas, Road to Camajuaní Km 5 ½. Santa Clara, Villa Clara. dulcem@uclv.edu.cu. FZ (A NATURAL PRODUCT) EFFECT ON GLUCEMIC CONTROL OF DIBETIC RATS. Fleitas AS, Concepción Rosabal B, Rodriguez-Fuentes G. * 22

23 Instituto Nacional de Angiología y Cirugía Vascular (INACV). UCT. MINSAP. Calzada del Cerro Ciudad Habana. *IMRE, Universidad de La Habana. E_mail: bionuel@infomed.sld.cu PPP-30 IN VITRO ACTIVITY OF SURFACEN AND SURFACTANT PROTEIN A AGAINST LEISHMANIA AMAZONENSIS. Lugones Y, Blanco O, Faure R, Díaz E, Monzote L*. National Center for Animal and Plant Health, CENSA, Apdo 10, San José de las Lajas, Mayabeque, Cuba. *Department of Parasitology, Medicine Tropical Institute, Pedro Kourí. Havana. Cuba. PPP-31 ANTI-INFLAMMATORY AND ANTIOXIDANT POTENCIALITIES OF Phyllanthus orbicularis HBK. Gutiérrez Y 1, Echavarría M 1. Martínez M 2, Miranda M 1, Figueroa JL 3, Bello A 1 1 Farmacy and Food Institute, University of Havana, Ave 23 e/ 214 y 222 # 21425, C.P , La Coronela, La Lisa, Havana, Cuba. mercedepd@infomed.sld.cu, midalysep@ifal.uh.cu. 2 Chemistry Institute. National Autonomy University of México, Exterior circuit, University City, Coyoacón, C.P , México, D.F. 3 Medicine Faculty. Pharmacology Department. National Autonomy University of México, Exterior circuit, University City, Coyoacón, C.P , México, D.F. PPP-32 CHEMICAL ANALYSIS AND ANTIOXIDANT ACTIVITY OF VOLATILE OILS OF THREE SPECIES OF PIPERACEAS GROWN IN CUBA. Elisa Jorge Rodríguez 1, Guillermo Ramis-Ramos 2, Yvan Vander Heyden 3, Yanelis Saucedo- Hernández 1, Urbano Monteagudo 1, Ernesto F. Simó-Alfonso 2, María Jesús Lerma 4, Luis Bravo 1 Mildred Medinilla 1 and José Manuel Herrero-Martínez 2. 1 Pharmacy Department, Faculty of Chemistry, Central University Marta Abreu of Las Villas, C Santa Clara, Cuba. 2 Department of Analytical Chemistry, Faculty of Chemistry, University of Valencia, E Burjassot (Valencia), Spain. 3 Department of Analytical Chemistry and Pharmaceutical Technology, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel-VUB, Belgium. 4 Departamento de Química Analítica y Tecnología de los Alimentos, Universidad de Castilla La Mancha, Avda. Camilo José Cela 10, E-13004, Ciudad Real, Spain PPP-33 ANTI-INFLAMMATORY ACTIVITY OF FLAVONOIDS ISOLATED FROM BOLDOA PURPURASCENS CAV. Siverio-Mota D 1, Gonzáles-Mosquera DM 1, Rodríguez-Pérez L 1, Vicet-Muro L 1, Sueiro-Oyarzun ML 1, Giner RM 2. 1 Department of Pharmacy, Faculty of Chemistry-Pharmacy, Central University Marta Abreu of Las Villas, Santa Clara, Villa Clara, Cuba. danys@uclv.edu.cu 2 Department of Pharmacology, Faculty of Pharmacy. University of Valencia, Spain. PPP-34 MULTI-CLASSIFIER SYSTEMS FOR THE SEARCH OF NEW NATURAL ANTI-INFLAMMATORY COMPOUNDS. Siverio-Mota D 12, Marrero-Ponce Y 12, Herrera-Pis Y 1, Vicet-Muro L 1, Sueiro-Oyarzun ML 1. 1 Department of Pharmacy, Faculty of Chemistry-Pharmacy, Central University Marta Abreu of Las Villas, Santa Clara, Villa Clara, Cuba. danys@uclv.edu.cu. 2 Unit of Computer-Aided Molecular Biosilico Discovery and Bioinformatic Research (CAMD-BIR Unit), Faculty of Chemistry-Pharmacy, Central University Marta Abreu of Las Villas, Santa Clara, Villa Clara, Cuba. PPP-35 EVALUACIÓN DE LA PROPIEDAD CICATRIZANTE DE LA TINTURA AL 20% DE PEDILANTHUS TITHYMALOIDES (L.) POIT. Lic. Anay Vera Ayala (Departamento de Química), M.Sc. Tania López González, M.Sc. Carlos Manuel Dutok Sánchez (Departamento de Farmacia).Santiago de Cuba. Correo: anay@cnt.uo.edu.cu, tlopez@cnt.uo.edu.cu, cmdutok@cnt.uo.edu.cu. PPP-36 ACUTE TOXICITY AND ANTIOXIDANT ACTIVITIES OF PULP AND PEEL GARCINIA TINCTORIA FRUITS Arazo M.*, Bello A.*, Montelier M.*, Delgado L.*, Al-Shagdari A.** * Department of Chemistry, Institute of Pharmacy and Food, Havana University, Cuba. Ave 25 #21425 entre 214 y 222. La Coronela. La Lisa. ** Yemen Economic Corporation (YEC0). Sanaa. República de Yemen. qfarmaceutica@infomed.sld.cu PPP-37 IDENTIFICATION AND PURIFICATION OF ANTIMICROBIAL PEPTIDES FROM HEMOCYTES OF SPINY LOBSTER PANULIRUS ARGUS. Montero-Alejo V, Pacios-Michelena A, Perdomo-Morales R, Vega-Hurtado Y. Biochemistry Department. Center for Pharmaceuticals Research and Development (CIDEM) Ave 26 No. 1605, Plaza de la Revolución, CP La Habana. Cuba. vivian.montero@fq.uh.cu 23