Ficha de investigador

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1 Ficha de investigador JOSEFA LEÓN LÓPEZ Grupo de Investigación: Estudio de las Enfermedades Hepáticas y Cáncer colorrectal. (Cod.: CTS227) Departamento: Sistema Sanitario Público de Andalucía. Hospital Universitario San Cecilio Mendeley: Correo electronico: pepileon@ugr.es Código: Ficha del Directorio Producción 63 Artículos (50) Libros (0) s de Libros (7) dirigidas (6) Evolución producción Capítu Libros Artículos Proyectos dirigidos Año Proyectos (4) Contratos (0) Convenios (0) Proyectos en curso por año Conve Contr Proye Año Actividades 0

2 Titulo publicación Fuente Tipo Fecha Influence of hla class i, hla class ii and kirs on vertical transmission and chronicity of hepatitis c virus in children Contribution of persistent organic pollutant exposure to the adipose tissue oxidative microenvironment in an adult cohort: a multipollutant approach. Relación entre los niveles de expresión de los receptores de membrana de la melatonina y las diferencias de género en la progresión del cáncer colorrectal Differential responses of two related neurosteroids to methylphenidate based on adhd subtype and the presence of depressive symptomatology Estudio en pacientes con obesidad mórbida de los factores relacionados con la señalización hepática de leptina, adiponectina e insulina y su relación con la progresión del hígado graso no alcohólico Estudio en pacientes con obesidad mórbida de los factores relacionados con la señalización hepática de leptina, adiponectina e insulina y su relación con la progresión del hígado graso no alcohólico Implicación de la endotelina- 1 en el mecanismo de inhibición del crecimiento del cáncer de colon por la melatonina Melatonin reduces endothelin-1 expression and secretion in colon cancer cells through the inactivation of foxo-1 and nf- ß Could radiotherapy effectiveness be enhanced by electromagnetic field treatment? Gender-related invasion differences associated with mrna expression levels of melatonin membrane receptors in colorectal cancer. Plasma ribavirin trough concentrations during treatment of chronic hepatitis c in genotype-1 patients. Factors associated with hepatic steatosis in obese children and adolescents. Genetic variation in il28b with respect to vertical transmission of hepatitis c virus and spontaneous clearance in hcv infected children. Genetic variation in interleukin 28b with respect to vertical transmission of hepatitis c virus and spontaneous clearance in hcvinfected children Hepatic expression of adiponectin receptors increases with non alcoholic fatty liver disease progression in morbid obesity in correlation with gpx1. Hepatic expression of adiponectin receptors increases with nonalcoholic fatty liver disease progression in morbid obesity in correlation with glutathione peroxidase 1. Gender-related invasion differences associated with mrna expression levels of melatonin membrane receptors in colorectal cancer Inhibition of poly (adp-ribose) polymerase-1 enhances doxorubicin activity against liver cancer cells Mutations in e2-pephd, ns5a-pkrbd, ns5a-isdr, and ns5a-v3 of hepatitis c virus genotype 1 and their relationships to pegylated interferon-ribavirin treatment responses. Quasispecies as predictive factor of rapid, early and sustained virological responses in chronic hepatitis c, genotype 1, treated with peginterferon-ribavirin. Identification of an inducible nitric oxide synthase in diaphragm mitochondria from septic mice: its relation with mitochondrial Plos one Articulo 2017 Environmental science & technology Articulo Psychopharmacology Articulo pineal research Articulo 2014 International journal of molecular sciences Articulo 2013 Molecular carcinogenesis Articulo 2012 clinical gastroenterology pediatric gastroenterology and nutrition Articulo 2012 Articulo 2011 Hepatology Articulo 2011 Hepatology Articulo 2011 Obesity surgery Articulo 2011 Obesity surgery Articulo 2011 Molecular carcinogenesis Articulo 2010 Cancer letters Articulo 2010 virology Articulo 2008 clinical virology Articulo 2008 The international journal of bio & cell Articulo 2006

3 mitochondria from septic mice: its relation with mitochondrial dysfunction and prevention by melatonin Inhibition of neuronal nitric oxide synthase activity by n-1-acetyl-5- methoxykynuramine, a brain metabolite of melatonin Pharmacological utility of melatonin in the treatment of septic shock: experimental and clinical evidence. Anti-inflammatory actions of melatonin and its metabolites, n1-acetyln2-formyl-5-methoxykynurenamine (afmk) and n1-acetyl-5- methoxykynurenamine (amk), in macrophages Interactions between melatonin and nicotinamide nucleotide: nadh preservation in cells and in cell-free systems by melatonin Kynurenamines as neural nitric oxide synthase inhibitors Melatonina y parkinson: implicación del poro mitocondrial de transición en la fisiopatología del parkinson y papel de la melatonina como neuroproetctor Selective cck-a but not cck-b receptor antagonists inhibit ht-29 cell proliferation: synergism with pharmacological levels of melatonin 4,5-dihydro-1h-pyrazole derivatives with inhibitory nnos activity in rat brain: synthesis and structure-activity relationships Changes in inos activity, oxidative stress and melatonin levels in hypertensive patients treated with lacidipine Effects of some synthetic kynurenines on brain amino acids and nitric oxide after pentylenetetrazole administration to rats Mechanisms of n-methyl-d-aspartate receptor inhibition by melatonin in the rat striatum Melatonina, ritmos biológicos y estrés oxidativo Synthesis and inos/nnos inhibitory activities of new benzoylpyrazoline derivatives Calreticulin-melatonin Changes in brain amino acids and nitric oxide after melatonin administration in rats with pentylenetetrazole-induced seizures Characterization of melatonin high-affinity binding sites in purified cell nuclei of the hamster (mesocricetus auratus) harderian gland Evaluación de la melatonina y kinureninas sintéticas sobre la actividad de la kinurenina 3-hidroxilasa en el cerebro de rata Melatonin counteracts lipopolysaccharide-induced expression and activity of mitochondrial nitric oxide synthase in rats Mitochondrial regulation by melatonin and its metabolites Papel de la melatonina en la protección frente al envejecimiento y enfermedades neurodegenerativas Specific binding of melatonin to purified cell nuclei from mammary gland of swiss mice: day-night variations and effect of continuous light Synergistic effects of melatonin and deprenyl against mptp-induced mitochondrial damage and da depletion. Bioquímica pineal bio & cell biology Articulo 2006 neuro Articulo 2006 pharmacy and pharmacology neuroimmunology Articulo 2006 Articulo 2005 pineal research Articulo 2005 Universidad de granada. fisiología Articulo pineal research Articulo 2005 Articulo 2004 hypertension Articulo 2004 pineal research Articulo 2004 neuroendocrinology Longevidad. tratado integral sobre salud en la segunda mitad de la vida Articulo Tetrahedron Articulo 2004 European journal of bio (print) Articulo 2003 pineal research Articulo 2003 pineal research Articulo 2003 Universidad de granada. cirugía y sus especialidades 2003 The faseb journal Articulo 2003 Advances in experimental medicine and biology El envejecimiento. aspectos básicos, clínicos y sociales Articulo pineal research Articulo 2003 Neurobiology of aging Articulo 2003 Melatonina: realidad actual y posibilidades

4 Inhibition of nnos activity in rat brain by synthetic kinurenines: structure-activity dependence Inhibition of nnos activity in rat brain by synthetic kynurenines: structure-activity dependence La glándula pineal y los mecanismos de inhibición en el sistema nervioso central Melatonin increases the activity of the oxidative phosphorylation enzymes and the production of atp in rat brain and liver mitochondria Melatonin, mitochondrial homeostasis and mitochondrial-related diseases Melatonina, ritmos circadianos y psiquiatría Melatonin increases the activity of the oxidative phosphorylation enzymes and the production of atp in rat brain and liver mitochondria Papel antiexcitotóxico de la melatonina en el cerebro Calcium-dependent effects of melatonin inhibition of glutamatergic response in rat striatum Melatonina: realidad actual y posibilidades The international journal of bio & cell biology Current topics in medicinal Depresión: estado actual The international journal of bio & cell biology Melatonina: realidad actual y posibilidades neuroendocrinology Articulo 2001 Melatonin, mitochondria, and cellular bioenergetics pineal research Articulo 2001 Comparative effects of melatonin, l-deprenyl, trolox and ascorbate in the suppression of hydroxyl radical formation during dopamine autoxidation in vitro Melatonin but not vitamins c and e maintains glutathione homeostasis in t-butyl hydroperoxide-induced mitochondrial oxidative stress Papel protector de la melatonina frente al estrés oxidativo en enfermedades neurodegenerativas Structure-related inhibition of calmodulin-dependent neuronal nitricoxide synthase activity by melatonin and synthetic kynurenines Cartilage and serum levels of nitric oxide in patients with hip osteoarthritis Melatonin interaction with magnesium and zinc in the response of the striatum to sensorimotor cortical stimulation in the rat Modification of nitric oxide synthase activity and neuronal response in rat striatum by melatonin and kynurenine derivatives Modulation of rat striatal glutamatergic response in search for new neuroprotective agents: evaluation of melatonin and some kynurenine derivatives Synthesis of 1,3-dioxolanes catalysed by alpo4 and alpo4-al2o3: kinetic and mechanistic studies pineal research Articulo 2000 The faseb journal Articulo 2000 Radicales libres y estres oxidativo en biomedicina 2000 Molecular pharmacology Articulo 2000 rheumatology Articulo 1999 pineal research Articulo 1998 neuroendocrinology Articulo 1998 Brain research bulletin Articulo 1998 the chemical society perkin transactions 2 Articulo 1995

5 1 Caracterizacion de la hemo oxigenesa-1 en el cancer de colon:antioxidantes naturales como tratamientos alternativos Actividades 0 Proyecto 1/1/10 1/1/13 2 Desarrollo de nuevas terapias para el tratamiento del cáncer de colon Proyecto 1/1/08 1/1/10 3 Titulo proyecto Tipo Inicio Fin Implicacion de la hemoxigenasa-1 en el proceso de angiogénesis mediado por óxido nítrico: interés del uso de melatonina y otros antioxidantes naturales Proyecto 1/1/07 12/31/08 4 Cáncer de cólon y melatonina Proyecto 1/1/05 12/31/07 Titulo actividad Fuente Tipo Fecha Colaboradores DARIO ACUÑA CASTROVIEJO (40) GERMAINE ESCAMES ROSA (38) FRANCISCO JAVIER SALMERON ESCOBAR (17) ANGEL CARAZO GALLEGO (15) ANGELES RUIZ EXTREMERA (13) JORGE CASADO RUIZ (12) ROSA QUILES PEREZ (11) MIGUEL ANGEL GALLO MEZO (10) Mª ENCARNACIÓN CAMACHO QUESADA (10) ANA GILA MEDINA (9) PALOMA MUÑOZ DE RUEDA (9) ANA BELÉN MARTIN ÁLVAREZ (7) FRANCISCO DE PAULA VIVES MONTERO (7) LAURA SANJUAN NÚÑEZ (7) JOSÉ ANTONIO MUÑOZ GÁMEZ (6) ANTONIO JOSÉ ENTRENA GUADIX (5) MARÍA DORA CARRIÓN PEREGRINA (5) ESTHER OCETE HITA (4) LUIS CARLOS LÓPEZ GARCÍA (4) MIGUEL MARTÍN HERNÁNDEZ (4) JUAN DE DIOS LUNA DEL CASTILLO (3) Sergio Manuel Jiménez Ruiz (3) ANGEL PALACIOS PEREZ (2) DOLORES QUINTERO FUENTES (2) JOSE MANUEL RODRIGUEZ FERRER (2) NICOLAS OLEA SERRANO (2) ANTONIO MOLINA CARBALLO (1) ANTONIO MUÑOZ HOYOS (1) ANTONIO OSUNA CARRILLO DE ALBORNOZ (1) FRANCISCO JAVIER OLIVER POZO (1) JOSE LUIS MUNDI SANCHEZ-RAMADE (1) JOSÉ UBEROS FERNÁNDEZ (1) JUAN PEDRO ARREBOLA MORENO (1) LUISA CARLOTA LOPEZ CARA (1) MARIA ISABEL NUÑEZ TORRES (1)

6 MARIANA FATIMA FERNANDEZ CABRERA (1) Mª PILAR UTRILLA NAVARRO (1) PALOMA DE LA CUEVA BATANERO (1) PEDRO HERNÁNDEZ CORTÉS (1)