LABORATORY OF COGNITIVE AND COMPUTATIONAL NEUROSCIENCE (UCM-UPM) CENTER FOR BIOMEDICAL TECHNOLOGY ACTIVITY REPORT 2013

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1 LABORATORY OF COGNITIVE AND COMPUTATIONAL NEUROSCIENCE (UCM-UPM) CENTER FOR BIOMEDICAL TECHNOLOGY ACTIVITY REPORT 2013

2 Articles in scientific journals Aurtenetxe S, Castellanos NP, Moratti S, Bajo R, Gil P, Beitia G, Del-Pozo F, Maestú F. Dysfunctional and compensatory duality in mild cognitive impairment during a continuous recognition memory task. Int J Psychophysiol. Jan;87(1): doi:pii: S (12)00668-X /j.ijpsycho Impact Factor: Cela-Conde C, García-Prieto J, Ramasco J, Mirasso C, Bajo R, Munar E, Flexas A, Delpozo F, Maestú F.Dynamics of brain networks for aesthetic appreciation. Proceedings of the National Academy of Science of USA (PNAS). Impact Factor: Coullaut R, Arbaiza I, Bajo R, Arrúe R, López ME, Coullaut-Valera J, Correas A, Lopez-Sanz D, Maestu F, Papo D Drug polyconsumption is associated with hypersynchronized brain activity at rest and in a counting task. International Journal of Neural Systems 24 (1): 1-13, Impact Factor: Crespo A, Recuero M, Galvez G, Begtoña A. (2013). Effect of Binaural Stimulation on Attention and EEG. Archives Of Acoustics, 38(4), pp Impact Factor: Escudero J, Ifeachor E, Fernández A, López-Ibor JJ, Hornero R. Changes in the MEG background activity in patients with positive symptoms of schizophrenia: spectral analysis and impact of age. Physiological Measurement, 34, pp , Enero, Impact Factor: Fernández A, Gómez C, Hornero R, López-Ibor JJ. Complexity and Schizophrenia. Progress in Neuro-Psychopharmacology & Biological Psychiatry. vol 45, pp , 2013 Impact Factor: Fernández A, Turrero A, Zuluaga P, Gil-Gregorio P, del Pozo F, Maestu F, Moratti F. MEG delta mapping along the healthy aging-alzheimer s disease continuum: diagnostic implications. Journal of Alzheimer s Disease. vol. 35 pp Impact Factor: 4.17 Garcés P, Vicente R, Wibral M, Pineda Pardo JA, Lopez ME, Aurtenetxe S, Marcos A, de Andrés MA, Yus M, Sancho M, Maestú F, Fernández A. Brain-wide slowing of spontaneous alpha rhythms in mild cognitive impairment. Frontiers in Aging Neuroscience. DOI: /fnagi Impact Factor: 5.2 Gómez C, Pérez-Macías JM, Poza J, Fernández A, Hornero R. Spectral changes in spontaneous MEG activity across the life span. Journal of Neural Engineering, vol. 10, 6, pp , Octubre, Impact Factor: Gonzalez-Moreno A, Aurtenetxe S, Lopez-Garcia ME, Del Pozo F, Maestu F, Nevado A. Signal-to-noise ratio of the MEG signal after preprocessing. J Neurosci Methods Nov 4;222C: doi: /j.jneumeth [Epub ahead of print] PubMed PMID: Impact Factor: Jurado-Parras MT, Sánchez-Campusano R, Castellanos NP, del-pozo F, Gruart A, Delgado-García JM. Differential contribution of hippocampal circuits to appetitive and consummatory behaviors during operant conditioning of behaving mice. Journal of Neuroscience 6;33(6): Impact Factor: 7.115

3 Kort, N.S., Cuesta, P., Nagarajan, S.S., and Houde, J.F., High gamma cortical responses to voice pitch feedback reveals network driving error correction. (to be submitted). Maestú C, Blanco M, Nevado A, Romero J, Rodríguez-Rubio P, Galindo J, Bautista Lorite J, de Las Morenas F, Fernández-Argüelles P. Reduction of pain thresholds in fibromyalgia after very low-intensity magnetic stimulation: A double-blinded, randomized placebo-controlled clinical trial. Pain Res Manag Nov-Dec;18(6):e PubMed PMID: Impact Factor: Maestu C, Cortes A, Vazquez JM, del Rio D, Gomez-Arguelles JM, del Pozo F, Nevado A. Increased brain responses during subjectively-matched mechanical pain stimulation in fibromyalgia patients as evidenced by MEG. Clin Neurophysiol Apr;124(4): doi: /j.clinph Epub 2012 Oct 31. PubMed PMID: Impact Factor: Martínez-Zarzuela M, Gómez C, Díaz-Pernas FJ, Fernández A, Hornero R. Crossapproximate entropy parallel computation on GPUs for biomedical signal analysis. Application to MEG recordings. Computer Methods and Programs in Biomedicine. vol. 112, 1, pp , Octubre, 2013 Impact Factor: Montejo P, Montenegro M, Fernandez MA, Turrero A, Yubero R, Huertas E, Maestu F. European Journal of Aging. In press, Impact Factor: Moratti S, Méndez-Bértolo C, Del-Pozo F, Strange BA. Dynamic gamma frequency feedback coupling between higher and lower order visual cortices underlies perceptual completion in humans. Neuroimage Nov 1. pii: S (13) doi: /j.neuroimage Impact Factor: Navas A, Papo D, Bocaletti S, Del Pozo F, Bajo R, Maestú F, Gil P Sendiña I, Buldu J. Funtional hubs in Mild Cognitive Impairment. International Journal of Bifurcation and Chaos, in press Impact Factor: 0.92 Niso G, Bruña R, Pereda E, Gutiérrez R, Bajo R, Maestú F, del-pozo F. HERMES: towards an integrated toolbox to characterize functional and effective brain connectivity. NeuroInformatics Oct;11(4): Impact Factor: Pacios J, Gutierrez R, Solesio-Jofre E, Moratti S, Ruiz-Vargas JM, López-Frutos JM, Lorenzo-López L, del Pozo F, Maestú F. Early prefrontal activation as a mechanism to prevent forgetting in the context of interferente. American Journal of Geriatric Psychiatry in press. Impact Factor: Pascual T, García-Pacios, J. The effect of motivation in retrieval suppression of unwanted memories. Edupsykhé (1) Impact Factor: 0.5 Verdura Vizcaino EJ, Fernandez-Navarro P, Blanco C, Ponce G, Navio M, Moratti S, Rubio G. Maintenance of Attention and Pathological Gambling. Psychol Addict Behav May 27. Impact Factor: Total Impact Factor 2013:

4 Book Chapters Maestú F, Solesio E and Bajo R. Towards the understanding of healthy and pathological aging trough MEG. In Supek S and Aine C (editors), MEG: from signals to Dynamic Cortical Networks. Springer-Berlag in press Niso G., Pereda E., Maestú F., Gudín M., Carrasco S., del-pozo F. Causal Relationships and Network Parameters in Effective Brain Connectivity, Functional Brain Mapping and the Endeavor to Understand the Working Brain, Dr. Francesco Signorelli (Ed.), InTech 2013, ISBN: , DOI: /56499 Posters and abstracts at scientific congress Bajo R, López ME, Aurtentxe S, Garcés P, Castellanos NP, Barabash A, Montejo P, Yubero R, Delgado M, Marcos A, Cabranes JA, Maestú F. Cognitive reserve benefits brain efficiency in healthy aging. An MEG study. AAIC. Boston, 2013 (USA). García-Pacios J, Del Río D, Maestú F. Olvido por interferencia emocional. Diferencias en el control cognitivo de distractores agradables y desagradables. En I Congreso Avances en Investigación Científica. Madrid (España) Junio 2013 Jimenez Fernandez T; Mingote Adan JC; De Vicente F; Moratti S. Visual Cortex Activity Modulation by Fear Conditioning in Post-Traumatic Stress Disorder. 53rd Annual Meeting of the Society for Psychophysiological Research. Florencia, Italia, 02/10/2013 López ME, Cuesta P, Castellanos NP, Garcés P, Aurtenexte S, Bajo R, Cabranes JA, Delgado ML, Montenegro M, Marcos A, Barabash A, Maestú F, Fernández A. Mild cognitive impairment subtypes. An MEG study. AAIC. Boston, 2013 (Estados Unidos). Mateos P, Correas A, Porras C, Corral M, García Moreno LM, Maestú F, Cadaveira F. Atención y activida cerebral en Jóvenes con consumo de alcohol. FANPSE, Málaga 8-9 Noviembre, Mendez Bertolo C; Moratti S; Toledano R; Gil-Nagel A; Yebra M; Martinez Alvarez R; Lopes Sosa F; Strange BA. The Fast Pathway for Fear. 53rd Annual Meeting of the Society for Psychophysiological Research<br> Florencia, Italia02/10/2013 Niso G., Pereda E., Carrasco S., Gudín M., Canuet L., del Pozo F., Maestú F. Characterizing functional connectivity of interictal MEG activity in epileptic patients using graph theoretical analysis. International Society for the Advancement of Clinical Magnetoencephalography (ISACM 2013). From to Sapporo, Japan Niso G., Bruña R., Pereda E., Gutiérrez R., Bajo R., del-pozo F., Maestú F. HERMES: towards an integrated toolbox to characterize functional and effective brain

5 connectivity. International Society for the Advancement of Clinical Magnetoencephalography (ISACM 2013). From to Sapporo, Japan Niso G., Pereda E., Carrasco S., Gudín M., del-pozo F., Maestú F. Complex network analysis of connectivity patterns from MEG data of epileptic patients. XXXIII Dynamics Days Europe. From to Madrid, Spain Pineda-Pardo J, Garcés P, López ME, Aurtenexte S, Delgado M, Montenegro M, Marcos A, Yus M, Arrazola J, Barabash A, Martín Buldú J, del Pozo F, Maestú F. White Matter Integrity Predicts Resting State Network Organization in Mild Cognitive Impairment. Alzheimer s Association International Conference (AAIC). Boston, 2013 (Estados Unidos). Pineda-Pardo JA, Garcés P, López ME, Aurtenexte S, Cuesta P, Montejo P, Marcos A, Yus M, Tamames JA, del Pozo F, Maestú F. MEG networks organization is related to white matter integrity. European Society for Magnetic Resonance in Medicine and Biology (ESMRMB). Toulouse, 2013 (Francia) Pineda-Pardo JA, Martinez K, Solana AB, Molina E, Colom R, Buldú JM, Hernández- Tamames JA, Del Pozo F. Anatomo-functional Organization in Brain Networks. XXXIII Dynamic Days Europe. Madrid, 2013 Van Straaten ECW, De Waal H, Lansberg MM, Maestu F, Scheltens Ph. Brain Network analysis as an outcome measure in Alzheimer s Disease clinical trials. The Networked Brain: Cell Symposium, 7-8 nov San Diego, 2013 Invited talks Maestu F. Brain Network Organization in the early stages of Alzheimer Disease. ISACM, Saporo, Japan, august 28-30, 2013 Maestu F. Potential Clinical Utility of MEG in traumatic Brain Injury and Alzheimer s Disease. ISACM, Saporo, Japan, august 28-30, 2013 Maestú F. Organización de las redes funcionales en las etapas tempranas de la Enfermedad de Alzheimer. Congreso de la Asociación de Familiares de enfermos de Alzheimer y parkinson y otras demencias del corredor del Henares. 19 septiembre, Maestú F. Utilidad clínica de la Conectividad Funcional. Sociedad Española de neurología, Seminario-Comida Nutricia. Barcelona 20 Noviembre 2013 Maestú F. Organización de las redes cerebrales en las fases iniciales de la Enfermedad de lzheimer. Dia Mundial del Alzheimer, Pozuelo de Alarcçon, 21 de septiembre de 2013.

6 Maestú F. El papel del Psicólogo en la investigación de las enfermedadesneurodegenerativas. X jornadas informativas sobre salidas profesionales. Universidad Complutebnse de Madrid, facultad de Psicología 12 Noviembre, Maestú F. Networks in the brain. Sant Luois University. 5 noviembre, 2013 Moratti S; Baillet S; Tadel F. Advanced EEG MEG Data Analysis: Cortical Source Imaging Using Brainstorm and SPM8; A Hands-On Training. 53rd Annual Meeting of the Society for Psychophysiological Research. Florencia, Italia, 01/10/2013 Niso G. CTB-Scientific Session. HERMES: hacia software integrado para la caracterización de la conectividad funcional y efectiva en el cerebro Center for Biomedical Technology, Madrid, Spain Niso G. Madrid M+VISION Open House: NeuroImaging, Neurosciences & Brain Diseases. Characterizing functional brain activity: MEG signals, connectivity patterns and complex networks Centro Alzheimer Fundación Reina Sofía, Madrid, Spain Pereda E and Maestú F. Clinical aplications of MEG to dementia. European MEG Society, Chiemse, September 11 th, ew Research projects - Elekta Neuromag funding. Development clinical protocols with MEG 60k - Human Brain Project. European Union Flagship project. Neuroinformatic Pilar, workpackage of tools for data analysis Task Leader: Fernando Maestú. 1.5ME - Alicia Koplovitch Foundation. Del autismo la esquizofrenia. Estudio del sustrato neurofisiológico subyacente a la disfunción cerebral en la esquizofrenia y los trastornos del espectro autista mediante magnetoencefaloagrafía 50k

7 Doctoral Thesis Title: Brain Oscillations Underlying Memory Retention and Forgetting, in the Presence and Absence of Interference, in Mild Cognitive Impairment Student: Sara Aurtenetxe Vicandi Advisors: Fernando Maestú, Nazareth Castellanos, Garikoitz Beitia Program: Neuroscience UCM University: Universidad Complutense, European Doctorate Year: 2013 Qualification: Sobresaliente Cum Laude Title: Functional and effective connectivity in MEG: Application to the study of epilepsy Student: Guiomar Niso Galan Advisors: Francisco del Pozo, Ernesto Pereda Program: Biomedical Engeneering University: Technical University of Madrid, European Doctorate Year: 2013 Qualification: Sobresaliente Cum Laude Organization of educational courses - Maestú F and del Pozo F. Curso de Verano del Escorial: Desde la especialización funcional al conectoma humano Julio, 2013, El Escorial, Madrid. Directores Fernando Maestú y Francisco del Pozo - Guiomar Niso and Ricardo Bruña. HERMES hacia una herramienta para el análisis de la conectividad funcional. Centro de Tecnología Biomédica 31 de Mayo del Pereda E. Hands on HERMES. European MEG Society. Germany September Stephan moratti; Silvain Baillet; Francois Tadel. Advanced EEG MEG Data Analysis: Cortical Source Imaging Using Brainstorm and SPM8; A Hands-On Training. 53rd Annual Meeting of the Society for Psychophysiological Research. Florencia, Italia, 01/10/2013 Patents SOFTWARE REGISTRATION Scientific software package (HERMES, for the analysis of functional and effective brain connectivity from neurological data, publicly available for the scientific community under license GNU. Guiomar Niso, Ricardo Bruña, Ernesto Pereda, Ricardo Gutiérrez, Ricardo Bajo, Fernando Maestú, Francisco del-pozo Oficina de Transferencia de Resultados de Investigación (OTRI-UPM). Submitted for Intellectual property registration

8 Awards X competición de creación de empresas actúaupm HERMES selected as one of the best business idea at the actúaupm X entrepreneurship competition. March, 2013 Guiomar Niso, Ricardo Bruña, Ernesto Pereda, Francisco del-pozo Honorable Mention at Idea2 Madrid competition of the Madrid-MIT M+Vision Consortiom 2013 program, with the project WEEG wireless EEG on the go! Guiomar Niso, Gererdo Gálvez. Finalists at Venture Day 2013 competition by the IE Business School, with the project Mindzilla, mind your mind. Guiomar Niso, Gererdo Gálvez, Caleb Forbes. Participation in the organization of international conferences - XXXIII Dynamics Days Europe, 3-7 June 2013 Madrid - International Society for the Clinical Advances of MEG, Saporo, Hokaido, Japan, Agoust 2013

9 Students scientific visits abroad - Pablo Cuesta. June 15th to October 20th University of California at San Francisco (UCSF). Department of Neurology and biomedical Imaging and the Memory and Aging Center - Pablo Cuesta. January 21th to March 31 National Centre for Geriatrics and Gerontologic. Obu-Shi, Aichi Japan. - Jose Angel Pineda. January to April University of Nottingham, UK, Matt Brookes. Scholar activities for the UCM and UPM universities - Direction of Master thesis Psicogerontología, Facultad de Psicología UCM - Direction of Master Thesis of the Master de Ingeniería Biomédica UPM - Training courses for one month to students of the Master de Psicogerontología, Facultad de Psicología UCM - Training courses for one month to students of the Master - Students from the faculty of Medicine, department of Psychiatry UCM - Students from the Faculty of Psychology, UCM - Students from the faculty of Physics UCM - Students from the faculty of Informatics UPM - Students from the Faculty of Telecomunications UPM - Training courses on MEG to teachers of the UCM and UPM Visitors - Maria Grazzia Vaccaro. Neuroimaging Research Unit of the National Research Centre. Lamezia-Terme, Italy. Faculty of Medicina,"Magna Graecia"University of Catanzaro With convention With research national counsil CNR learning clinical uses of MEG in stroke patients. - Teodoro Pascual. Camilo Jose Cela University, Department of Psychology

10 Members Lab Director: Fernando Maestú Senior researchers: Ricardo Bajo Leonides Canuet Alberto Fernandez Stephan Moratti Angel Nevado Ernesto Pereda David del Río Francisco de Vicente PhD Students: Guillermo Alemany Sara Aurtenetxe Ricardo Bruña Angeles Correas Pablo Cuesta Gemma Díaz Maria Eugenia López Gerardo Galvez Javier García-Pacios Juan García Prieto Pilar Garcés Tamara Jiménez David López Mari Carmen Martín-Buro Constantino Méndez Bértolo Guiomar Niso Teodoro Pascual José Pineda Sandra Pusil Ignacio de Ramón Noelia Serrano Maria Grazzia Vaccaro

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