JOSE CRISTOBAL MARTINEZ HERRERIAS

Transcripción

1 Ficha de investigador JOSE CRISTOBAL MARTINEZ HERRERIAS Grupo de Investigación: BIOFISICA Y BIOTECNOLOGIA MOLECULAR (Cod.: FQM171) Departamento: Universidad de Granada. Química Física Citas en Google Scholar: Correo electronico: jcmh@ugr.es Código: Ficha del Directorio Producción 50 Artículos (41) Libros (0) Capítulos de Libros (2) dirigidas (7) Evolución producción 4 3 Capítu Libros Artículos 2 1 Proyectos dirigidos Año Proyectos (1) Contratos (0) Convenios (0) Proyectos en curso por año Conve Contr Proye Año Actividades 0

2 Titulo publicación Fuente Tipo Fecha Towards the improvement in stability of an anti-abeta single-chain variable fragment, scfv-h3d6, as a way to enhance its therapeutic potential Understanding the contribution of disulfide bridges to the folding and misfolding of an anti-abeta scfv Búsqueda de inhibidores de la interacción entre los dominios l víricos y sus dianas celulares de interés como antivirales de amplio espectro Búsqueda de inhibidores de la interacción entre los dominios l víricos y sus dianas celulares de interés como antivirales de amplio espectro Common features in the folding and misfolding of pdz domains and beyond: the modulatory effect of domain swapping and extra-elements A thermodynamic study of the third pdz domain of maguk neuronal protein psd-95 reveals a complex three-state folding behavior Alteration of the c-terminal ligand specificity of the erbin pdz domain by allosteric mutational effects Post translational modifications modulate ligand recognition by the third pdz domain of maguk protein psd 95 The impact of extra-domain structures and posttranslational modifications in the folding/misfolding behaviour of the third pdz domain of maguk neuronal protein psd-95 Isothermal titration calorimetry: thermodynamic analysis of the binding thermograms of molecular recognition events by using equilibrium models Aspectos dinámicos de reconocimiento de ligandos y regulación funcional de dominios sh3: hidratación, cooperatividad y equilibrio conformacional The interconversion between a flexible ß-sheet and a fibril ß-arrangement constitutes the main conformational event during misfolding of psd95-pdz3 domain Thermodynamic impact of embedded water molecules in the unfolding of human cd2bp2-gyf domain A comparative analysis of the folding and misfolding pathways of the third pdz domain of psd95 investigated under different ph conditions Caracterización termodinámico-estructural de la estabilidad de dominios pdz y análisis de su especificidad de unión mediante librerías de expresión en fagos Understanding the polymorphic behaviour of a mutant of the alpha-spectrin sh3 domain by means of two 1.1 a resolution structures An oligomeric equilibrium intermediate as the precursory nucleus of globular and fibrillar supramacromolecular assemblies in a pdz domain Differential scanning calorimetry: thermodynamic analysis of the unfolding transitions of proteins, Amyloid: the journal of protein folding disorders Articulo 2017 Protein science Articulo 2017 Facultad de ciencias, universidad de granada Facultad de ciencias Scientific reports Articulo 2016 Biophysical chemistry Articulo 2014 Journal of molecular biology Articulo 2014 Plos one Articulo 2014 Plos one Articulo 2014 Applications of calorimetry in a wide context - differential scanning calorimetry, isothermal titration calorimetry and microcalorimetry Facultad de ciencias. universidad de granada Capítulo de libro Articulo 2012 Articulo 2012 Biophysical chemistry Articulo Articulo 2011 Biophysical journal Articulo 2010 Protein folding (edited by eric c. walters) Capítulo 2010

3 analysis of the unfolding transitions of proteins, domains and peptidic fragments by using equilibrium models Novel conformational aspects of the third pdz domain of the neuronal post-synaptic density-95 protein revealed from two 1.4a x-ray structures. Role of interfacial water molecules in proline-rich ligand recognition by the src homology 3 domain of abl Evaluation of folding co-operativity of a chimeric protein based on the molecular recognition between polyproline ligands and sh3 domains Thermodynamic characterization of the folding equilibrium of the human nedd4-ww4 domain: at the frontiers of cooperative folding An error analysis for two-state protein-folding kinetic parameters and phi-values: progress toward precision by exploring ph dependencies on leffler plots Analysis of the thermodynamics of binding of an sh3 domain to proline-rich peptides using a chimeric fusion protein Diseño y caracterizacion de proteinas quimericas para el estudio del reconocimiento molecular entre ligandos peptidicos y dominios sh3 Reconocimiento de secuencias ricas en prolina por dominios modulares de interacción proteína-proteína Crystallization by capillary counter-diffusion and structure determination of the n114a mutant of the sh3 domain of abl tyrosine kinase complexed with a highaffinity peptide ligand The high-resolution nmr structure of a single-chain chimeric protein mimicking a sh3-peptide complex. Kinetic analysis and modelling of the allosteric behaviour of liver and muscle glycogen phosphorylases Structure of human tsg101 uev domain. Binding curves by continuous gradient flow-mix calorimetry A miniprotein scaffold used to assemble the polyproline ii binding epitope recognized by sh3 domains Thermodynamic dissection of the binding energetics of proline-rich peptides to the abl-sh3 domain: implications for rational ligand design Protein folding (edited by eric c. walters) Capítulo de libro 2010 Journal of structural biology Articulo 2010 Journal of biological chemistry Articulo 2010 Protein engineering, design & selection Articulo 2009 Biochemistry (easton) Articulo 2009 Biophysical journal Articulo 2008 Journal of molecular biology Articulo Articulo 2007 Febs letters Articulo 2007 Journal of molecular recognition Articulo 2006 Articulo 2006 Thermochimica acta Articulo 2005 Journal of molecular biology Articulo 2004 Journal of molecular biology Articulo 2004 A binding event converted into a folding event Febs letters Articulo 2003 A thermodynamic and kinetic analysis of the folding pathway of an sh3 domain entropically stabilised by a redesigned hydrophobic core Structural cooperativity in the sh3 domain studied by site- directed mutagenesis and amide hydrogen exchange Estabilidad, plegamiento y estructura de la proteína circular as-48 y de mutantes del dominio sh3 Ph dependence of the hydrogen exchange in the sh3 domain of [alpha]-spectrin The denaturation of circular enterocin as-48 by urea and guanidinium hydrochloride Journal of molecular biology Articulo 2003 Febs letters Articulo Febs letters Articulo 2002 Biochimica et biophysica acta. proteins and proteomics Articulo 2002

4 and guanidinium hydrochloride As-48: a circular protein with an extremely stable globular structure Thermodynamic analysis of helix-engineered forms of the activation domain of human procarboxypeptidase a2 Thermodynamic and structural characterization of asn and ala residues in the disallowed ii ' region of the ramachandran plot The folding transition state between sh3 domains is conformationally restricted and evolutionarily conserved Thermodynamic analysis of alpha-spectrin sh3 and two of its circular permutants with different loop lengths: discerning the reasons for rapid folding in proteins Obligatory steps in protein folding and the conformational diversity of the transition state Structure of the transition state in the folding process of human procarboxypeptidase a2 activation domain The dsc data analysis for small, single-domain proteins. application to the sh3 domain A calorimetric study of the thermal-stability of barstar and its interaction with barnaset A calorimetric study of the thermal-stability of barnase and its interaction with 3'gmp Thermodynamic and kinetic-analysis of the sh3 domain of spectrin shows a 2-state folding transition and proteomics Febs letters Articulo 2001 European journal of biochemistry (print) Articulo 2000 Protein science Articulo 2000 Nature structural biology Articulo 1999 Biochemistry (easton) Articulo 1999 Nature structural biology Articulo 1998 Journal of molecular biology Articulo 1998 Reactive & functional polymers Articulo 1998 Biochemistry (easton) Articulo 1995 Biochemistry (easton) Articulo 1994 Biochemistry (easton) Articulo 1994

5 1 Titulo proyecto Tipo Inicio Fin Analisis termodinámico y estructural de dominios pdz. estudio de los aspectos moleculares que determinan la influencia del equilibrio conformacional e interacciones con ligandos en la regulación de re Proyecto 3/15/11 4/30/16 Actividades 0 Titulo actividad Fuente Tipo Fecha Colaboradores EVA SANCHEZ COBOS (18) PEDRO LUIS MATEO ALARCON (16) IRENE LUQUE FERNÁNDEZ (13) JAVIER MURCIANO CALLES (11) FRANCISCO CONEJERO LARA (9) ADELA MARÍA CANDEL RAMÓN (7) JAVIER RUIZ SANZ (5) JOSE ANTONIO GAVIRA GALLARDO (4) SALVADOR CASARES ATIENZA (4) OBDULIO LÓPEZ MAYORGA (3) ANTONIO PARODY MORREALE (2) JUAN MANUEL GARCIA RUIZ (2) MARIA DOLORES EVA VALDIVIA MARTÍNEZ (2) MERCEDES MAQUEDA ABREU (2) BEATRIZ IBARRA MOLERO (1) ISABEL MARIA PLAZA DEL PINO (1) JOSÉ ANTONIO PAREJA FDEZ. DE LA REGUERA (1)