FRANCISCO JAVIER OLIVER POZO

Transcripción

1 Ficha de investigador FRANCISCO JAVIER OLIVER POZO Grupo de Investigación: ONCOLOGIA E INMUNOLOGIA MOLECULAR (Cod.: CTS434) Departamento: Centro Andaluz de Biología Molecular y Medicina Regenerativa (CSIC-CABIMER). Biología Molecular Código: Ficha del Directorio Producción 77 Artículos (68) Libros (0) s de Libros (4) dirigidas (5) Evolución producción Capítu Libros Artículos Año Proyectos dirigidos 8 Proyectos (8) Contratos (0) Convenios (0) Proyectos en curso por año 4 3 Conve Contr Proye Año Actividades 0

2 Titulo publicación Fuente Tipo Fecha Interaction between parp-1 and hif-2 alpha in the hypoxic response. Growth and spontaneous differentiation of umbilicalcord stromal stem cells on activated carbon cloth Parp inhibition attenuates histopathological lesion in ischemia/reperfusion renal mouse model after cold prolonged ischemia Parp-1 regulates metastatic melanoma through modulation of vimentin-induced malignant transformation. Parp-1 participates in metastasic melanoma through regulation of vascular plasticity and vimentin-induced malignant transformation Parp-1 regulates metastatic melanoma through modulation of vimentin-induced malignant transformation. Oncogene Articulo 2014 Journal of materials chemistry b Articulo 2013 The scientific world journal Articulo 2013 Plos genetics Articulo 2013 Plos genetics Articulo 2013 Plos genetics Articulo 2013 Poly(adp-ribose) signaling in cell death. Molecular aspects of medicine (online) Articulo 2013 Targeting parp-1 in breast cancer: the paradigm of a dna repair-based Umbilical-cord stromal stem cells grown and differentiation on an activated-carbon cloth: the importance of surface porosity. nitric oxide modulates hypoxia-inducible factor-1 and poly(adp-ribose) polymerase-1 cross-talk in response to hypobaric hypoxia Efecto de la inhibición de parp-1 sobre angiogénesis, metástasis y mimetismo vasculogénico en melanoma Ros-induced dna damage and parp-1 are required for optimal induction of starvation-induced autophagy Targeting parp-1 in breast cancer: the paradigm of a dna repair-based therapeutic strategy Targeting parp-1 in breast cancer: the paradigm of a dna repair-based therapeutic strategy The importance of bystander effects in radiation therapy in melanoma skin-cancer cells and umbilical-cord stromal stem cells Human umbilical cord stromal stem cell express cd10 and exert contractile properties Inhibition of poly (adp-ribose) polymerase-1 enhances doxorubicin activity against liver cancer cells Nitric oxide modulates hypoxia-inducible factor-1 and poly(adp-ribose) polymerase-1 cross-talk in response to hypobaric hypoxia. Poly(adp-ribose)-dependent regulation of snail1 protein stability Poly(adp-ribose)-dependent regulation of snail1 protein stability. Tela de carbón activo: biomateriales para la proliferación de células mesenquimales Inhibition of poly (adp-ribose) polymerase decreases hepatocellular carcinoma growth by modulation of tumour-related gene expression Inhibition of poly (adp-ribose) polymerase-1 enhances Cancer biomarkers 2013 Journal of materials chemistry b Articulo 2013 Journal of applied physiology Articulo Cell research Articulo Cancer biomarkers Cancer biomarkers Radiotherapy and oncology Articulo Placenta Articulo 2011 Cancer letters Articulo 2011 J appl physiol. Articulo 2011 Oncogene Articulo 2011 Oncogene Articulo 2011 Boletín del grupo español del carbón Articulo 2011 Journal of hepatology Articulo 2010

3 Inhibition of poly (adp-ribose) polymerase-1 enhances doxorubicin activity against liver cancer cells Inhibition of poly (adp-ribose) polymerase decreases hepatocellular carcinoma growth by modulation of tumour-related gene expression. Parp-1 modulation of brain hif-1 in vivo response to hypoxia/reoxygenation is mediated by nitric oxide and fih Activated carbon cloth as support for mesenchymal stem cell growth and differentiation to osteocytes Cancer letters Articulo 2010 Hepatology Articulo 2010 Neurochemistry Articulo 2010 Carbon Articulo 2009 Parp-1 is involved in autophagy induced by dna damage Autophagy Articulo 2009 Poly(adp-ribose) polymerase-1 modulation of in vivo response of brain hypoxia-inducible factor-1 to hypoxia/reoxygenation is mediated by nitric oxide and factor inhibiting hif Poly[adp-ribose] polymerase-1 expression is related to cold ischemia, acute tubular necrosis, and delayed renal function in kidney transplantation Poly[adp-ribose] polymerase-1 expression is directly related to acute tubular necrosis, cold ischemia, and delayed renal function in kidney transplantation Función de parp-1 en rutas de inestabilidad genómica e hipoxia: implicaciones en el control tumoral Parp-1 modulates deferoxamine-induced hif-1alpha accumulation through the regulation of nitric oxide and oxidative stress. Parp-1, nueva diana el el tratamiento del carcinoma hepatocelular Poly(adp-ribose)polymerase-1 (parp-1) in carcinogenesis: potential role of parp inhibitors in cancer treatment Quantitative detection of methylated esr1 and ? gene promoters in serum as candidate biomarkers for diagnosis of breast cancer and evaluation of treatment efficacy Interaction between atm and parp-1 in response to dna damage and sensitization of atm deficient cells through parp inhibition Modulation of transcription by parp-1: consequences in carcinogenesis and inflammation. Therapeutic effect of a poly(adp-ribose) polymerase-1 inhibitor on experimental arthritis by downregulating inflammation and th1 response. Inhibition of poly(adp-ribose) polymerase modulates tumor-related gene expression, including hypoxiainducible factor-1 activation, during skin carcinogenesis Papel de parp-1 en procesos de muerte celular inducida por el tratamiento con el antineoplásico doxorrubicina Early and late skin reactions to radiotherapy for breast cancer and their correlation with radiation-induced dna damage in lymphocytes. Journal of neurochemistry Articulo 2009 Plos one Articulo 2009 Pl o s one Articulo 2009 Instituto de parasitologia y biomedicina lopez neyra (ipbln)(delegación del c.s.i.c.en andalucía). biología celular e inmunología 2008 Journal of cellular biochemistry Articulo 2008 Instituto de parasitologia y biomedicina lopez neyra (ipbln)(delegación del c.s.i.c.en andalucía). biología celular e inmunología Clinical & translational oncology : official publication of the federation of spanish oncology societies and of the 2008 Articulo 2008 Cancer biology & therapy Articulo 2008 Bmc molecular biology Articulo 2007 Current medicinal chemistry Articulo 2007 Plos one Articulo 2007 Cancer research Articulo 2006 Universidad de granada. radiología y medicina física 2006 Breast cancer research Articulo 2005

4 Modulación por la poli-adp-ribosa polimerasa-1 de la expresión génica durante la carcinigénesis epidérmica Parp inhibition sensitizes p53-deficient breast cancer cells to doxorubicin-induced apoptosis Parp-1-dependent 3-nitrotyrosine protein modification after dna damage Role of poly (adp-ribose) polymerase in kidney transplant and its relationship with delayed renal function. multivariate analysis. Correlation of morphological findings with functional reserve in the aging donor: role of the poly (adp-ribose) polymerase Crosstalk between parp-1 and nf-kappa b modulates the promotion of skin neoplasia Transcription regulation of tnf-alpha-early response genes poly (adp-ribose) polymerae-1 in murine hearth endotelial cells Parp-1 modifies the effectiveness of p53-mediated dna damage response Radiación, adn, cromatina y respuesta a la terapéutica Role of poly(adp-ribose) polymerase in the inflammatory response Apoptosis of haematopoietic cells upon thymidylate synthase inhibition is independent of p53 accumulation and cd95-cd95 ligand interaction Interplay of parp-1 and p53 in cell cycles checkpoints and tumorigenesis A dual approach in the study of poly (adp-ribose) polymerase: in vitro random mutagenesis and generation of deficient mice. Defective nf-kb activation and resistance to septic shock in poly (adp-ribose) polymerase (parp) deficient mice Involvement of poly(adp-ribose) polymerase in base excision repair. Poly (adp-ribose) polymerase in dna damage response, apoptosis and disease Deficient dna repair in poly (adp-ribose) polymerase null mice Universidad de granada. radiología y medicina física 2005 Biochemical journal (london. 1984) Articulo 2005 Journal of cellular biochemistry Articulo 2005 Transplantation proceedings Articulo 2005 Transplantation proceedings Articulo 2004 Oncogene Articulo 2004 Nucleic acids research Articulo 2003 Oncogene Articulo 2002 Oncología molecular 2002 Inmunologia Articulo 2002 Biochemical journal (london. 1984) Articulo 2001 Embo journal (print) Articulo 2001 Molecular and cellular biochemistry Articulo 1999 Embo journal (print) Articulo 1999 Biochimie (print) Articulo 1999 American journal of human genetics Articulo 1999 Nucleic acids research Articulo 1998 La poly (adp-ribose) polymerase : un facteur de survie Medicine et science Articulo 1998 Poly (adp-ribose) polymerase is required for the maintenance of genomic integrity during base excision repair Role of parp and parp cleavage in apoptosis: lesson from an uncleavable mutant. Overexpression of a heterologous thymidine kinase delays apoptosis induced by factor deprivation and inhibitors of deoxynucleotide metabolism Requirement of poly (adp-ribose) polymerase in recovery from dna damage in mice and in cells. An apoptotic endonuclease activated either by decreasing ph or by increasing calcium Effects of starvation, diabetes and carbon tetrachloride Nucleic acids and molecular biology Articulo 1998 Journal of biological chemistry (print) Articulo 1998 Journal of biological chemistry (print) Articulo 1997 Proceedings of the national academy of sciences of the united states of america Articulo 1997 Journal of cell science Articulo 1996

5 Effects of starvation, diabetes and carbon tetrachloride intoxication on rat kidney cortex and liver pyruvate carboxylase levels Regulation of the salvage pathway of deoxynucleotides synthesis in apoptosis induced by growth factor deprivation Citrate inhibition of rat-kidney cortex phosphofructokinase Citrate inhibition of rat-kidney cortex phosphofructokinase Effects of amp and fructose 2,6-bisphosphate on fluxes between glucose-6-phosphate and triose-phosphate in renal cortical extracts Regulation of rat-kidney cortex fructose-1,6- bisphosphatase activity. i. effects of fructose-2,6- bisphosphate and divalent cations. Regulation of rat-kidney cortex fructose-1,6- bisphosphatase activity. ii. effects of adenine nucleotides. Distribution of pyruvate carboxylase along the rat nephron: an immunological and enzymatic study Efecto de los cationes divalentes sobre la actividad fructosa 1,6-bisfosfatasa purificada de corteza renal de rata. Kinetic characterization of phosphofructokinase isolated from rat kidney cortex Determinación de los coeficientes de control de flujo en un tramo acotado de la ruta glucolítica Purification and characterization of pyruvate carboxylase from rat-kidney cortex Stimulation of mitochondrial pyruvate transport in rat renal cortex by phenylephrine Archives of physiology and biochemistry Articulo 1996 Biochemical journal (london. 1984) Articulo 1996 Molecular and cellular biochemistry Articulo 1994 Molecular and cellular biochemistry Articulo 1993 Journal of biological chemistry (print) Articulo 1993 The international journal of biochemistry & cell biology The international journal of biochemistry & cell biology Articulo 1993 Articulo 1993 Kidney international Articulo 1991 Ars pharmaceutica Articulo 1991 Comparative biochemistry and physiology. part b, biochemistry & molecular biology Articulo 1991 Ars pharmaceutica Articulo 1990 Biochemical archives Articulo 1990 Life sciences Articulo 1990

6 Modulación por parp-1 de la agresividad tumoral: papel en la respuesta hipóxica y en la transición epitelio mesénquima (emt). Melanoma maligno: estudio molecular y preclínico de la función de parp en el control de la angiogénesis tumoral durante la hipoxia Poli(adp-ribosa)polimerasa-1: una nueva diana anti-angiogénica en la terapia antineoplásica Nuevas funciones de poli(adp-ribosa) polimerasa-1 en la señalización y en el control de la respuesta celular durante el daño genotóxico Actividades 0 Proyecto 1/1/10 12/31/12 Proyecto 1/1/08 12/31/11 Proyecto 11/30/06 9/30/09 Proyecto 1/1/04 12/31/06 5 Inflamación y daño articular. Proyecto 1/1/03 12/31/05 6 Regulación de la respuesta inflamatoria por poli(adp-ribosa) polimerasa-1: efectos sobre la expresión génica y el daño oxidativo Proyecto 3/1/05 12/31/05 7 Interacción entre parp y atm en la respuesta a daños genotóxicos Proyecto 1/1/02 12/31/03 8 Titulo proyecto Tipo Inicio Fin Poli(adp-ribosa)polimerasa-1: una nueva diana anti-angiogénica en la terapia antineoplásica Proyecto 10/1/07 Titulo actividad Fuente Tipo Fecha Colaboradores JOSÉ MARIANO RUIZ DE ALMODOVAR RIVERA (25) FRANCISCO DAVID MARTÍN OLIVA (14) JOSÉ ANTONIO MUÑOZ GÁMEZ (13) FRANCISCO J. O'VALLE RAVASSA (12) MARIA DEL MAR SOLA ZAPATA (12) RAFAEL SALTO GONZALEZ (12) ALBERTO MANUEL VARGAS MORALES (11) MARÍA ISABEL RODRÍGUEZ LARA (10) ANDREINA CECILIA PERALTA LEAL (9) ARIANNYS GONZALEZ FLORES (8) MARIA ISABEL NUÑEZ TORRES (7) JARA MAJUELOS MELGUIZO (6) JOSE MANUEL RODRIGUEZ VARGAS (6) LAURA MARÍA LÓPEZ JIMÉNEZ (6) ROSA QUILES PEREZ (6) VIRGÍNEA DE ARAUJO FARIAS (6) JOSE LUIS LINARES FERNÁNDEZ (4) ANGELES RUIZ EXTREMERA (3) CARLOS MORENO CASTILLA (3) MERCEDES VILLALOBOS TORRES (3) ANA BELÉN MARTIN ÁLVAREZ (2) ANTONIO OSUNA ORTEGA (2) DAVID AGUILAR PEÑA (2) FRANCISCO JAVIER SALMERON ESCOBAR (2) GUSTAVO ORTIZ FERRON (2) Julia Sirés Campos (2) LAURA SANJUAN NÚÑEZ (2)

7 M. ESCARLATA LOPEZ RAMIREZ (2) MARIA DEL CARMEN RUIZ RUIZ (2) PEDRO HERNÁNDEZ CORTÉS (2) TRINIDAD CABALLERO MORALES (2) ANGEL CARAZO GALLEGO (1) ANTONIO MANUEL ALMENDROS GALLEGO (1) ANTONIO OSUNA CARRILLO DE ALBORNOZ (1) DAMIÁN GUIRADO LLORENTE (1) ENRIQUE GARCÍA OLIVARES (1) ESTER LENO DURÁN (1) JORGE AARÓN PAYÁ COLMENERO (1) JOSEFA LEÓN LÓPEZ (1) M. DOLORES RODRÍGUEZ MARTÍNEZ (1) MARIA JOSE RUIZ MAGAÑA (1) MARIANO AGUILAR PEÑA (1) MOHAMED TASSI Mzamzi (1) PABLO ANTONIO GALINDO MORENO (1) RAQUEL MUÑOZ FERNÁNDEZ (1)