Algunas aportaciones de patólogos mexicanos a la Anatomía Patológica actual.

Algunas aportaciones de patólogos mexicanos a la Anatomía Patológica actual. Reynaldo Falcón Escobedo Facultad de Medicina, Universidad Autónoma de San Luis Potosí Hospital Central Dr. Ignacio Morones Prieto San Luis Potosí, S.L.P. MÉXICO

Dr. Isaac Costero Tudanca

Dr. Ruy Pérez Tamayo

Dr. Jorge Albores Saavedra

CARCINOMAS DEL CUELLO UTERINO CON PATRÓN PAPILAR Carcinoma de células transicionales, puro Carcinoma de células transicionales con carcinoma epidermoide Carcinoma de células transicionales con adenocarcinoma Carcinoma epidermoide Carcinoma verrucoso

CARCINOMA DE CÉLULAS TRANSICIONALES DEL CUELLO UTERINO Afecta a mujeres cuyas edades oscilan entre 34 y 81 años El cuadro clínico es similar al del carcinoma epidermoide Puede ser exofítico o polipoide Su tamaño es variable (2 a 6 cm) Metástasis: 3/8 casos

CK7 CK20

Carcinoma neuroendocrino de células grandes de vesícula biliar.

Carcinoma neuroendocrino de células grandes de la ampolla de Vater.

Carcinoma de células pequeñas de la vesícula biliar.

Carcinoma de células pequeñas de la vesícula biliar.

The American Journal of Surgical Pathology 19(1):91-9, 1995 Clear cell carcinomas of the gallbladder and extrahepatic bile ducts. Celeste Vardam, M.D., Jorge Albores-Saavdera, M.D.

Carcinoma cribiforme de vesícula biliar

Adenocarcinoma foveolar de vías biliares extrahepáticas

Hiperplasia fisiológica de células C

Células de Cajal en vesícula biliar

Neoplasia Intraepitelial Pancreática de tipo Espumoso

Papiloma urotelial invertido con estructuras papilares

Senos de Aschoff-Rokitansky asociados con abundante moco extracelular simulando carcinoma mucinoso.

Int J Gynecol Pathol, 1997;16(3):291-3.

Dr. Alberto G. Ayala

Honorary member of the Mexican Association of Pathologists Honorary member of the Spanish Society of Pathologists Received the Harlan J. Spjut award given by the Houston Society of Clinical Pathologists, 1992-1993. This award is given annually to individuals who have demonstrated to be true scholars and teachers. Received the Ashbel Smith Professorship Award, from M D. Anderson Cancer Center, 1996. Received the Charlie Lemaistre Oustanding Achievement Award from The University of Texas, M.D. Anderson Cancer Center in September 1997. Award, Annual meeting of The Radiological Society of North America: Cum Laude 0682MK Giant Cell Containing Lesions of Bone. K.W. McEnery, M.D., A. Yasko, M.D., A.K. Raymond, M.D., A.G. Ayala, M.D. November 29 to December 4, 1998. Professor Emeritus Ashbel-Smith, given by The University of Texas M.D. Anderson Cancer retirement, 2,000 Center, upon Award, Texas Society of Pathologist Annual Meeting, Galveston, Texas. Prestigious "Caldwell Award." February 10, 2001. The Distinguished Alumnus Award conferred by the University of Texas M.D. Anderson Cancer Center, Houston Texas in December 18, 2012 Award on Excellence in the Professional Development Distinguidhed ( A la excelencia en el Profesional) conferred by the University of Nuevo Leon, Monterrey Mexico, September 18, 2013. Desarrollo

The Arthur Purdy Stout Recognition Award conferred by the Arthur Purdy Stout Society. USCAP March 2013, Baltimore, Marylan

403.

Artículos predilectos Entre otras publicaciones la descripción de la cápsula de la próstata y el artículo sobre Clear cell cribriform hyperplasia of the prostate gland son publicaciones predilectas. Asi como tambien hay otro artíiculo publicado en Cáncer sobre Osteosarcoma de células pequeñas. Otra publcacion muy apreciada es la descripción de la Muscularis Mucosae en la vejiga urinaria. Hay muchas otras más de las cuales tambien estoy muy orgulloso. Otro ejemplo es el articulo Chest wall hamartoma.

Am J Surg Pathol 1986 Oct;10(10):665-71. Clear cell cribriform hyperplasia of prostate. Report of 10 cases. Ayala AG,, Srigley JR, Ro JY, Abdul-Karim FW, Johnson DE. Abstract We report 10 patients with clear cell cribriform hyperplasia of the prostate. Their ages ranged from 62 to 87 years, with a mean of 72 years. The clinical diagnosis in all patients was benign nodular hyperplasia; all the patients are alive and have shown no evidence of recurrent disease. Follow-ups ranged from 1 month to 7 years (median: 12.5 months; mean: 24.6 months). Pathologically, this lesion has a cribriform arrangement of clear cells with a complex papillary growth simulating the cribriform pattern of prostatic carcinoma. In fact, in five of the 10 cases, the referring diagnosis was either carcinoma or possible carcinoma. Cytologically, however, there is no nuclear atypia, mitosis, or prominent nucleoli, and typically there is a double epithelial cell layer at the periphery of the involved acini. In summary, clear cell cribriform hyperplasia is a benign hyperplastic process with a complex papillary-cribriform structure and should not be confused with prostatic carcinoma. The key feature for the diagnosis is the preservation of nodular configuration with a bland cytology and double cell layer lining the involved acini.

Cancer. 1989 Nov 15;64(10):2162-73. Small cell osteosarcoma. A clinicopathologic study of 27 cases. Ayala AG, Ro JY, Raymond AK, Jaffe N, Chawla S, Carrasco H, Link M, Jimenez J, Edeiken J, Wallace S, et al. Department of Pathology, University of Texas M. D. Anderson Cancer Center, Houston 77030. Abstract We report a study of 27 patients with small cell osteosarcoma (SCO), 17 from the M. D. Anderson Cancer Center (MDAH) and ten from the Pediatric Oncology Group (POG). There were 12 male patients and 15 female patients; 19 were white, five were black, and three were Hispanic. They ranged from 6 to 28 years of age with a median of 14 years. Histologically there were three patterns: Ewing's-like, lymphoma-like, and spindle cell. All cases showed osteoid formation and a few had chondroid areas. There was cytoplasmic glycogen in ten cases. Initial treatment for MDAH patients included intraarterial infusion of cisplatin in ten, amputation in four, partial mandibulectomies in two, and biopsy with local radiotherapy and systemic chemotherapy in one. All POG patients had resection or amputation followed by adjuvant chemotherapy. Twelve patients are alive, of whom nine have had significant follow-ups for 25 to 90 months. Fourteen patients are dead of lung, spine, and brain metastases from 1 to 23 months after initial diagnosis. One patient is alive with lung relapse at 4 months. In summary, SCO is a high-grade variant of osteosarcoma, with an incidence of up to 4% of all osteosarcomas, that affects patients of the same age group and has the same anatomic location as conventional osteosarcoma. Currently, SCO appears to have a prognosis that is the same as or slightly worse than that of conventional osteosarcoma. Furthermore, although intraarterial infusion is effective for the primary tumors in the bone, distant metastases are difficult to control.

Dr. Mario A. Luna

Dr. José Jessurun

Dra. Leticia Quintanilla-Martínez