CURRICULUM VITAE. Manuel Nieto-Sampedro, Ph.D. Cajal Institute, 37 Doctor Arce, Madrid, Spain. (34) FAX: (34)

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1 Manuel Nieto Sampedro, scientific head of he Research Unit of the Hospital of Paraplegics of Toledo. The Unit, that began to function in the year 2000, already has an excellent record of original publications. CURRICULUM VITAE Manuel Nieto-Sampedro, Ph.D. Personal Data: Birthdate: January 6, 1944 Place of Birth: Nationality: Present address: Education: Madrid, Spain Spanish Cajal Institute, 37 Doctor Arce, Madrid, Spain. (34) FAX: (34) B.Sc., University of Madrid, June Majors: Organic Chemistry, Biochemistry and Physical Chemistry. M.Sc., University of Madrid, October MSci work on: "Solid Phase Peptidolipid Synthesis", carried out at the National Institute for Organic Chemistry, CSIC, Madrid. Ph.D. in Biochemistry, Council for National Academic Awards, London, England. Thesis on: "Synthesis of peptides related to precursors of bacterial cell wall and their use in the study of the mode of action of vancomycin and ristocetin", carried out at the National Institute for Medical Research, Mill Hill, London. Supervisor: Harold R. Perkins, PhD. Research Positions: Jan Oct 1967: Nov Sept. 1972: Research Student, Department of Biochemistry, National Institute for Organic Chemistry, Madrid. Scientific guest, then Junior Member of the Scientific Staff of the

2 Oct Feb. 1978: Feb Jun 1978: July July l979: July July l989: April 1986-Sept Sept present 2000-present National Institute for Medical Research, Mill Hill, London, U.K.. Assistant, then Associate and full Research Professor, at the Center for Biological Research, Madrid. Professor (tenured), Center for Biological Research, Madrid. Sabbatical at the Department of Psychobiology, University of California, Irvine, CA, USA. Succesively: Assistant Research Psychobiologist, Associate Researcher, Associate Adjunct Professor, and then Associate Professor in Residence at the Department of Psychobiology, University of California, Irvine, California,, USA. Research Professor (on leave of absence), Cajal Institute for Neuroscience, Madrid, Spain. Research Professor and Head of the Neural Plasticity Group at the Cajal Institute for Neuroscience, Madrid, Spain. Algo en el Hospital, Preguntale a Eduardo y/o al gerente Sept February 1996 Head of Cajal Institute Neural Plasticity Department Nov Sept.1992 Deputy Director of Cajal Institute Sept April 1993 Acting Director of the Cajal Institute USA Neurotrauma Society, (founding member), since Academic Teaching: Ph.D. Courses: : Mode of action of antibiotics on bacterial membranes and cell walls. School of Biological Sciences, Universidad Autónoma de Madrid (UAM) 1977: Molecular Bases of Differentiation and Morphogenesis. School of Medicine, UAM. BSc. courses: 1978: "Conformation of Macromolecules", Dept. de Biophysics, School of. Medicine, UAM 1984, 1987 y 1988 General Psychobiology, Department of Psychobiology, University of California, Irvine Summer Courses International University "Menendez Pelayo", Santander, 1985 Madrid Complutense University., El Escorial, 1991, 1992, 1993 B.SC. THESIS DIRECTED: J.A.Ayala (1976): B.Sci.Thesis "Parámetros de activación de la ATPasa de las Membranas de M. lysodeikticus", Complutense University of Madrid, School of Chemistry. R. Martin Díez (1978): B.Sci.Thesis "Efecto de la 2-bromodeoxiuridina sobre la biosíntesis y conformación de las moléculas de adhesion intercelular de Dyctiostelium discoideum". University of Salamanca, School of Biological Sciences. Doctoral Thesis Supervised:

3 TITLE: "Parámetros de activación y desnaturalización térmica de cuatro formas moleculares de la ATPasa transductora de energía de la membrana de M. lysodeikticus". STUDENT: J.A. Ayala Serrano UNIVERSITY: Complutense University of Madrid SCHOOL: School of Chemistry AÑO: 1978 QUALIFICATION: Sobresaliente cum laude (A+) TITLE: "Caracterización, purificación and clonaje de la PSD-95, una proteina específica de las densidades postsinápticas". STUDENT: M.S. Carrión UNIVERSITY: University Autónoma of Madrid SCHOOL: School of Biological Sciences AÑO: 1991 QUALIFICATION: Apto TITLE: "Glia envolvente: Caracterización y papel como promotora de la regeneración en el sistema nervioso central". STUDENT: A. Ramón Cueto UNIVERSITY: University Autónoma de Madrid SCHOOL: School of Medicine. AÑO: 1993 QUALIFICATION: Sobresaliente Cum Laude (A+) TITLE: "Purificación y caracterización de inhibidores de la mitosis en células neurales en cerebro de mamíferos". STUDENT: J. Abad Rodríguez, School of Biological Sciences. YEAR: 1995 QUALIFICATION: Sobresaliente Cum Laude (A+) TITULO: Glía del Sistema Nervioso Central promotora de la regeneración. STUDENT: G. Gudiño Cabrera, School of Biological Sciences. YEAR: 1998 QUALIFICATION: Sobresaliente Cum Laude TITLE: Propiedades Electrofisiológicas de la Glía Envolvente de la Rata Adulta. STUDENT: D. Rosado Chacón SCHOOL: School of Medicine YEAR: 1999 QUALIFICATION: Sobresaliente Cum Laude TITLE: Células de origen y expresión de la neurostatina durante el desarrollo del encéfalo de la rata. STUDENT: M.T. Vallejo Cremades SCHOOL: School of Biological Sciences YEAR: 2001 QUALIFICATION: Sobresaliente Cum Laude TITLE: Actividad y estructura-función de la neurostatina y moduladores glicolipidicos de la división de astrocitomas. STUDENT: Lorenzo Romero Ramírez

4 SCHOOL: : School of Biological Sciences YEAR: 2001 QUALIFICATION: Sobresaliente Cum Laude TITLE: Reparación de Lesiones por Avulsión del Plexo Braquial mediante el Transplante de Glía Envolvente del Bulbo Olfatorio en Ratas. STUDENT: Vilma Muñetún Gómez SCHOOL: YEAR 2003 School of Biological Sciences QUALIFICATION: Sobresaliente Cum Laude TITLE: Producción de células similares a la glía de Schwann a partir de células madre neurales para la reparación de lesions medulares en rata. STUDENT: Sara del Carmen Caballero Chacón SCHOOL: School of Veterinary Medicine YEAR: 2003 QUALIFICATION: Sobresaliente Cum Laude TITLE: Lesión Experimental de la Médula Espinal: Fisiopatologia de los Trastornos Locomotores y Estrategias de Reparación. STUDENT: Jorge E. Collazos Castro SCHOOL: School of Medicine YEAR: 2003 QUALIFICATION: Sobresaliente Cum Laude TITLE: Papel de la Interleuquina 15 en la regulación de la inflamación en el sistema nervioso central. STUDENT: Diego Gómez Nicola SCHOOL: School of Biological Sciences YEAR: 2008 QUALIFICATION: Sobresaliente Cum Laude TITLE: Biomateriales de quitosano y sus modificaciones mediante mezcla con gelatina y poli-llisina para su aplicación en la reparación de lesiones medulares. DOCTORANDO: Eduardo Martin López SCHOOL: School of Medicine AÑO: 2008 QUALIFICATION: Sobresaliente Cum Laude TITULO: Síntesis Química, actividad antitumoral y modo de acción de la Neurostatina y sus análogos sobre el crecimiento de gliomas. STUDENT: Beatriz Valle Argos SCHOOL: School of Biological Sciences YEAR: 2010 QUALIFICATION: Sobresaliente Cum Laude Theses in process of execution:

5 -Natalia Yanguas Casás (2013 ) Ph:D. -Mª Asunción de la Barreda Manso (2013) Ph.D. -Estela Dámaso Riquelme (2013?) MSc Books, book chapters and publications in Spanish Nieto-Sampedro, M. (1990) Fundamentos Neurobiológicos de la Plasticidad Sináptica. Anuario Psiquiátrico 1: Manuel Nieto Sampedro Scientific Policy (1991) Press Cabinet Secretary of State of Universities and Research El Equipo de Plasticidad Neural del Instituto Cajal: Plasticidad y Reparación del Sistema Nervioso Central Nieto Sampedro, M. (1988) PLASTICIDAD SINÁPTICA, Investigación y Ciencia (Spanish Edition of Scientific Scientific American) ) 138: Nieto-Sampedro, M., ed. (1991) Función Cerebral. Investigación y Ciencia, Barcelona Nieto Sampedro, M., ed.(1991) Investigación y Ciencia ( ) El Cerebro, vol.2. Nieto Sampedro, M. (1997) Plasticidad: Una Propiedad Básica de los Conjuntos Neurona-Glia. En "Daño cerebral, calidad de vida y demencias", Editorial Mapfre Medicina, Madrid, pp Nieto-Sampedro, M., J. Abad and P. Bovolenta. (1995) Reguladores negativos del crecimiento en el cerebro. In (Miñano, F.J. and Armengol, J.A., eds.) Bases experimentales para el estudio del sistema nervioso, Vol.22, pp Universidad de Sevilla, Secretariado de Publicaciones, serie Ciencias. Nieto-Sampedro, M. (1996) Plasticidad Neural : del Aprendizaje a la Reparación de Lesiones. Arbor, 153 (602): Nieto-Sampedro, M. (1996) Plasticidad Neural : Una Propiedad Básica que subyace desde el Aprendizaje a la Reparación de Lesiones. En "El Cerebro Intimo" (F. Mora, ed.) Capítulo 4, Editorial Ariel S.A., pp Nieto-Sampedro, M. (1996) Destrucción de Tumores Cerebrales. Investigación y Ciencia (edición española de Scientific American) 232: 32. Nieto-Sampedro, M. y Verdú, E. (1998) Lesiones del Sistema Nervioso: Respuesta Neural y Reparación. "Manual de Neurociencias", Capítulo 37 (J.M.Delgado, A.Ferrús, F. Mora, F.J.Rubia, eds), Editorial Síntesis, Madrid, pp Nieto-Sampedro, M. (2000) Transplantes de glía y reparación del sistema nervioso central. Investigación y Ciencia (edición española de Scientific American) 281: Muñetón, V.C., Taylor, J.S. and Nieto-Sampedro, M.(2001) Mecanismos involucrados en la promoción de crecimiento axonal por la glía envolvente del bulbo olfatorio. Biomédica 21 (2): Nieto-Sampedro, M (2003) Plasticidad Neural. Mente y Cerebro 4: Nieto-Sampedro, M (2003) Reparación de las lesions del sistema nervioso central. Mente y Cerebro 5: Nieto Sampedro, M., E. Martín López, D.W. Pita Thomas y M. Nieto Díaz (2004) Plasticidad Neural: Aprendizaje y Reparación de Lesiones. Simposio sobre Plasticidad y Desarrollo del Sistema Nervioso con motivo del Año Cajal (150 Aniversario). Colección Actas, pp Gobierno de Aragón, Departamento de Educación, Cultura y Deporte. Nieto Sampedro, M., Gómez-Nicola, D. and Taylor, J.S. (2004) Perspectivas futuras en la reparación del plexo braquial. Momento Médico IberoAmericano.Capítulo X, pp Nieto-Sampedro, M. (2005) Reparación del traumatismo medular. Rehabilitación (Madrid) 39(3). Nieto-Sampedro, M., Doncel-Pérez, E., Martín-López, E. y Nieto-Diaz, M. (2006) Desarrollo de

6 instrumentos de reparación del trauma del sistema nervioso central, pp En: La olfacción en España (Alonso, JR,de Castro, F y López-Mascaraque, eds.) Ediciones SBI, Salamanca. Doncel-Pérez, E., Caballero-Chacón, Sara y Nieto-Sampedro, M.(2006) Diferenciación de células de neuroesfera a células con fenotipo de aldainoglía. Cuadernos FEDACE sobre Daño Cerebral Adquirido, Pamplona. Gómez-Nicola, D. and Nieto-Sampedro, M. (2008). Glia Reactiva. Mente y Cerebro 32: Nieto-Sampedro, M. and Doncel-Pérez, E. (2012) Glía promotora del crecimiento derivada de células madre neurales: un instrumento de reparación del trauma medular. EditorialAcadémicaEspañola (EAE) editores. Scientific Research Published research papers 176 total to date, published in Journals with impact index high (12 or higher), medium (3-5) and low (1-3). List of more recent (since 1995) Coterón, J.M., Singh, K., Asensio, J.L., Domínguez-Dalda, M., Fernández-Mayoralas, A., Jiménez-Barbero, J., Martín-Lomas, M., Abad-Rodríguez, J., and Nieto-Sampedro, M.(1995) Oligosaccharides structurally related to E-selectin ligands are inhibitors of neural cell division: Synthesis, conformational analysis and biological activity. J. Org. Chem. 60: Nieto-Sampedro, M. (1995) CNS transplant usefulness may survive even their hasty clinical use. Behav. Brain Sci. 18: Nieto-Sampedro, M., Bailón, C., Fernández-Mayoralas, A., Martín-Lomas, M., Mellström, B. and Naranjo, J.R., (1996). Experimental brain glioma: growth arrest and destruction by a blood group-related tetrasaccharide. J. Neuropathol. Exper. Neurol. 55: Nieto-Sampedro and Abad, J. (1995) Inhibidores de la división glial. Rev.Neurol. 23: Martínez-Murillo, R, Bentura, M.L., Fernández, A.M., Nieto-Sampedro, M. and Rodrigo, J. (1995) Chemical heterogeneity in adult rat cerebellar Purkinje cells as revealed by zebrin I and low-affinity NGF receptor immunocytochemical expression following injury. J. Neurocytol. 24, Fernaud-Espinosa, I., Nieto-Sampedro, M. and Bovolenta, P. (1996) Developmental distribution of glycosaminoglycans in the embryonic rat brain: implications for axon tracts formation. J. Neurobiol. 30: Gudiño-Cabrera, G. and Nieto-Sampedro, M. (1996) Ensheathing cells: Large scale purification from adult olfactory bulb, freeze-preservation and migration of transplanted cells in adult brain. Restor.Neurol.Neurosci.: 10: Bovolenta, P., Fernaud-Espinosa, I., Rosalía Méndez-Otero and Nieto-Sampedro, M. (1997) Neurite outgrowth inhibitor of gliotic brain tissue. Mode of action and cellular localization, studied with specific monoclonal antibodies.eur.j. Neurosci. 9: Abad-Rodríguez J., Vallejo-Cremades M. and Nieto-Sampedro M. (1998) Control of glial number: Purification from mammalian brain extracts of an inhibitor of astrocyte division. Glia 22: Fernaud-Espinosa, I., Nieto-Sampedro, M. and Bovolenta, P. (1998) A neurite outgrowth inhibitory proteoglycan expressed during development is similar to that isolated from adult brain after isomorphic injury. J. Neurobiol., 36: Carrión-Vazquez, M., Fernández, A.M., Chowen, J. and Nieto-Sampedro, M. (1999) Brain Ac39/Physophilin: cloning, coexpression and colocalization with synaptophysin. Eur.J.

7 Neurosci. 10: Aguilera, B, Romero-Ramírez, L., Abad-Rodríguez, J., Corrales, G., Nieto-Sampedro, M.and Fernández-Mayoralas, A. (1998) Novel disaccharides inhibitors of human glioma cell division. J. Med. Chem. 41: Navarro X, Valero A. Gudiño-Cabrera G., Forès J., Rodriguez F.J., Verdu E., Pascual R., Cuadras J., Nieto-Sampedro M. (1999) Ensheathing glia transplants promote dorsal root regeneration and spinal reflex restitution after multiple lumbar rhizotomy. Ann Neurol 45: Nieto-Sampedro M. (1999) Neurite outgrowth inhibitors in gliotic tissue. Adv Exp Med Biol. 468: Gudiño-Cabrera, G. and Nieto-Sampedro, M. (1999) Estrogen receptor immunoreactivity in Schwann-like brain macroglia. J. Neurobiol., 40: Verdú, E., Navarro, X., Gudiño-Cabrera, G., Rodríguez, F.J., Ceballos, D., Valero, A., and Nieto- Sampedro, M. (1999) Olfactory bulb ensheathing cells enhance peripheral nerve regeneration. NeuroReport 10: Gudiño-Cabrera, G. and Nieto-Sampedro, M. (2000) Schwann-like growth-promoting macroglia in adult rat brain. Glia 30: Gudiño-Cabrera, G., Pastor, A.M., de la Cruz, R.R., Delgado-García, J.M. and Nieto-Sampedro, M. (2000) Limits to the capacity of olfactory ensheathing glia to promote axonal regrowth in the CNS. NeuroReport : 11(3), Keynes, R., Kirik, D. and Nieto-Sampedro, M.(2000) European Neuroscience meets the snow. TINS 23: Nieto-Sampedro, M.(2000) Transplantes de Glia. Reparación del sistema nervioso central. Invest. Ciencia 281: Abad-Rodríguez, J., Bernabe, M., Romero-Ramírez, L., Vallejo-Cremades M., Fernández- Mayoralas, A. and Nieto-Sampedro, M. (2000) Purification and structure of neurostatin, an inhibitor of astrocyte division from mammalian brain. J. Neurochem. 74: Verdú,E., García-Alías, G., Forés, J., Gudiño-Cabrera, G., Nieto-Sampedro, M., and Navarro, X. (2001) Effects of ensheathing cells transplanted into photochemically damaged spinal cord. NeuroReport, 12: Pascual, J.I., Gudiño-Cabrera, G., Insausti, R. and Nieto-Sampedro, M. (2002) Spinal implants of olfactory ensheathing cells promote axon regeneration and bladder activity after bilateral lumbosacral dorsal rhizotomy in the adult rat. J. Urol. 167: Collazos-Castro, J.E. and Nieto-Sampedro, M. (2002). Developmental and Reactive Growth of Dentate Gyrus afferents: cellular and molecular interactions. Restor.Neurol.Neurosci., 19: Nieto-Sampedro, M., Collazos-Castro, J.E., Taylor, J.S.,Gudiño-Cabrera, G., Verdú-Navarro, E., Pascual-Piédrola, J.I., Insausti-Serrano, R. (2002) Trauma en el Sistema Nervioso Central y su Reparación. Rev. Neurol. 35: Collazos-Castro, J.E, de Castro, F., Gudiño-Cabrera, G., Herreras, O., Insausti-Serrano, R., Navarro, X., Pascual-Piédrola, J.I., Taylor, J.S., Vidal, J., Nieto-Sampedro, M. (2003) Reparación del Truma Medular. Boletín SENC 12: Muñetón Gómez, VC Taylor, J S, Averill, SA, Vallejo-Cremades, MT, King, VR, Priestley, JV, Nieto-Sampedro M (2003) Trasplantation of Olfactory Ensheathing Cells in a Model of Brachial Plexus Avulsion. Increase Spinal Cord Permissivity to Dorsal Root Ingrowth. J. Neurocytol. 32: Fernández-Mayoralas, A., de la Figuera, N., Zurita, M., Vaquero, J., Abraham, G.A., San Román, J., and Nieto-Sampedro, M. (2003) Central Neural Tumor Destruction by Controlled Release of a Synthetic Glycoside Dispersed in a Biodegradable Polymeric Matrix. J. Med. Chemistry 46: Nieto-Sampedro, M (2003) Plasticidad Neural. Mente y Cerebro 4: Nieto-Sampedro, M (2003) Reparación de las lesions del sistema nervioso central. Mente y

8 Cerebro 5: Taylor J, Muñetón-Gómez V, Averill S, Priestley J, Nieto-Sampedro M (2003) Olfactory ensheathing cell transplantation into the dorsal horn of adult rat cervical spinal cord. Brain Res. Bull Muñetón-Gómez, V.C., Averill, S., Robson, L., Collazos-Castro, J., Doncel-Pérez, E., Caballero-Chacón. S., Merino, J., Rodríguez-Rodriguez, R., Nieto-Sampedro, M., Priestley J.V., Taylor, J.S. Reparación de lesiones por avulsión del plexo braquial mediante el transplante de glia envolvente en ratas. Revista de Neurología, 2003, 37: Polentes, J., Stamegna, J.C, Nieto-Sampedro, M. and Gauthier, P. (2004) Phrenic rehabilitation and diaphragm recovery after cervical injury and transplantation of olfactory ensheathing cells. Neurobiol.Dis. 16: Romero-Ramírez, L. and Nieto-Sampedro, M. (2004) Inhibiting human astrocytoma growth: Structure-activity relationships in neurostatin related glycolipids. J. Med. Chem. 47(21): Nieto-Sampedro, M., Doncel-Pérez, E., Fernández-Mayoralas, A. (2004). Natural, synthetic and semisynthetic glycolipid inhibitors of glioma growth. Expert Opin. Ther.Patents 14: Collazos-Castro J, Muñetón-Gómez V., Nieto-Sampedro M. (2005) Olfactory glia transplantation into cervical spinal cord contusion injuries. J. Neurosurgery Spine 3: Nieto-Sampedro, M., Nieto-Diaz, M. (2005) Neural plasticity: Changes with Age. Journal of Neural Transmission, Volume 112 (1): Dr. Manuel Nieto-Sampedro Articulos en Revistas Página Collazos-Castro J., Soto, V.M., Gutiérrez-Dávila, M., Nieto-Sampedro, M. (2005) Motoneuron Loss Associated with Chronic Locomotion Impairments after Spinal Cord Contusion in the Rat. Journal of Neurotrauma 22 : Collazos-Castro, J.E., López-Dolado, E and Nieto-Sampedro, M. (2005) Locomotor Deficits and Adaptive Mechanisms after Thoracic Spinal Cord Contusion in the Adult Rat. J. Neurotrauma 23: Doncel-Pérez, E., Darder, M., Martín-López, E., Vázquez, L., Nieto-Sampedro, M., Ruiz-Hitzky, E. (2006) Gelation under dynamic conditions: a strategy for in vitro cell ordering. J. Mat. Sci. in Medic.17: Vallejo-Cremades, M.T. and Nieto-Sampedro, M. (2005) Neurostatin: cellular sources and cellular targets of the inhibitor. Neuron Glia Biology 2(2): Mingorance1, A., Sole, M., Munetón, V., Martínez,A., Nieto-Sampedro, M., Soriano,E. and del Río, J.A. (2006) Regeneration of lesioned entorhino-hippocampal axons in vitro by combined degradation of inhibitory proteoglycans and blockade of Nogo-66/NgR signaling. FASEBJ Express 20(3): Online, January 11, páginas Gómez-Nicola, D, Doncel-Pérez, E., and Nieto-Sampedro, M. (2006) Regulation by GD3 of the proinflammatory response of murine microglia mediated by Interleukin-15. J.Neurosci.Res. 83: García-Álvarez, I. Corrales, G., Doncel-Pérez, E. Muñoz, A., Nieto-Sampedro, M. and Fernández-Mayoralas, A. (2007) Design and Synthesis of Glycoside Inhibitors of Glioma and Melanoma Growth. J. Med. Chemistry, 50(2): Nieto-Díaz, M., Pita-Thomas, D.W. y Nieto-Sampedro, M., (2007) Cross-species analysis of gene expression in non-model mammals: repruducibility of hybridization on high density oligonucleotide microarrays. BioMed Central Genomics. 8: Gómez-Nicola, D, Martin-Lopez E, Nieto-Sampedro, M. (2007) Expression of IL-15 in the spinal cord after chronic constriction injury. Eur J Pain. 11 (1) Sup 1: 154.

9 146. Gómez-Nicola, D, Valle-Argos, B, Pita-Thomas, DW, Nieto-Sampedro, M. (2008). Interleukin 15 expression in the mouse CNS: a key signal for glial activation after an inflammatory injury. Glia 56(5): Nieto-Sampedro, M (2003) Central Nervous System lesions that can and those that cannot be repaired with the help of olfactory bulb ensheathing cell transplants. Neurochem. Res. 28: Gómez-Nicola, D. and Nieto-Sampedro, M. (2008). Glia Reactiva. Mente y Cerebro 32: Gómez-Nicola, D., Valle-Argos, B., Suardíaz, M., Taylor, J.S. and Nieto-Sampedro, M.(2008) Role of IL-15 in spinal cord and sciatic nerve after chronic constriction injury: regulation of macrophage and T-cell infiltration. J.Neurochem. 107: Doncel-Pérez, E., Caballero-Chacón, S. and Nieto-Sampedro, M (2009) Neurosphere cell differentiation to aldynoglia promoted by olfactory ensheathing cell conditioned medium. Glia 53: García-Álvarez, I., Garrido, L., Doncel-Pérez, E. Nieto-Sampedro, M.and Fernández- Mayoralas, A.(2009) Detection of Metabolite Changes in C6 Glioma Cells Cultured with Antimitotic OleylGlycoside by 1H MAS NMR. J. Med. Chemistry 52: Gómez-Nicola, D., Valle-Argos, B. and Nieto-Sampedro, M. (2010) Blockade of IL-15 activity inhibits microglial activation through the NFκB, p38 and ERK1/2 pathways, reducing cytokine and chemokine release. Glia 58(3) : Gómez-Nicola, D, Spagnolo, A, Guaza, C, Nieto-Sampedro, M. (2010). Aggravated experimental autoimmune encephalomyelitis in IL-15 knockout mice. Exper. Neurol. 222: Valle-Argos, B., Gomez-Nicola, D. and Nieto-Sampedro, M. (2010b) Glioma growth inhibition by neurostatin and O-But GD1b. Neuro-Oncology, 12: Yr impact factor: Valle-Argos B, Gomez-Nicola D, Nieto-Sampedro M. (2010a) Synthesis and characterization of neurostatin-related compounds with high inhibitory activity of glioma growth. Eur J Med Chem. 45(5), IF= 156. Pita-Thomas, W., Nieto-Sampedro, M., Martínez-Maza, R. and Nieto-Diaz. M. (2010). Factors promoting neurite outgrowth during deer antler regeneration J.Neurosci. Res. 88: Gomez-Nicola, D., Pallas-Bazarra, N., Valle-Argos, B. and Nieto-Sampedro, M. (2010) CCR7 is expressed in astrocytes and upregulated after an inflammatory injury. J. Neuroimmunol. 227: Pita-Thomas, W., Nieto-Sampedro, M., Maza, R. and Nieto-Diaz. M. (2010) Gene expression of axon growth promoting factors in the deer antler. BMC Genomics, in press García-Álvarez I, Egido-Gabás M, Romero-Ramírez L, Doncel-Pérez E., Nieto-Sampedro M, Casas J, Fernández-Mayoralas A. (2011) Lipid and ganglioside alterations in tumor cells treated with antimitotic oleyl glycoside. Mol. BioSyst. 7: Martín-López E, Nieto-Díaz M, Nieto-Sampedro M.(2012) Differential Adhesiveness and Neurite-promoting Activity for Neural Cells of Chitosan, Gelatin, and Poly-L-Lysine Films. J Biomater Appl. 26(7): Pita-Thomas, W.,Carmen Fernández-Martos, Mónica Yunta, Rodrigo M. Maza, Rosa Navarro- Ruiz, Marcos Javier Lopez-Rodrıguez, David Reigada, Nieto-Sampedro, Manuel, and Nieto- Diaz, Manuel. (2011) PLOS one. 5(12): e15706, 13 pages Valle-Argos B., Gómez-Nicola D., Nieto-Sampedro M. (2011) Neurostatin blocks glioma cell

10 cycle progression by inhibiting EGFR activation. Mol Cell Neurosci. 46, Gómez-Nicola, D., Valle-Argos, B, Pallas-Bazarra, N. and Nieto-Sampedro, M. (2011) IL-15 regulates proliferation and self-renewal of adult neural stem cells. Mol.Biol. Cell 22: Nieto-Diaz, M., Daniel Wolfgang Pita-Thomas, Rodrigo M Maza, Monica Yunta-Gonzalez, Marcos J Lopez-Rodriguez, Rosa Navarro-Ruiz, David Reigada, Carmen Fernandez-Martos, Manuel Nieto-Sampedro (2011): Factors promoting axon growth in the deer antler. Animal Prod Science 51, García-Álvarez, I., Groult, H.Casas, J., Nieto-Sampedro, M, L. Romero Ramírez and Fernández-Mayoralas, A. (2011) Synthesis of Antimitotic Thioglycosides: in vitro and in vivo Evaluation of their Anticancer Activity. J.Med.Chem. 54: Nieto-Sampedro, M., Valle Argos, B., Gómez-Nicola, D., Fernández-Mayoralas, A., Nieto- Diaz, M. (2011) Inhibitors of Glioma Growth that Reveal the Tumour to the Immune System. Clin. Med. Insights Oncol. 5: Martín-López, E., Darder-Colom, M., Nieto-Diaz, M., Ruiz-Hitzky, E., and Nieto- Sampedro, M. (2011) Spinal cord transections: neurite outgrowth and Schwann cell invasion through grafted agar bridges. J. Biomed. Mat. Res. Part A. Submitted 168. Martín-López, E., Rubio Alonso, F., Nieto-Díaz, M. and Manuel Nieto-Sampedro (2012) Chitosan, Gelatin and Poly(L-Lysine) Polyelectrolyte-Based Scaffolds and Films for Neural Tissue Engineering. J Biomater Sci Polymer Ed. 23: Nieto-Sampedro, M. (2005) Reparación del traumatismo medular. Rehabilitación (Madrid) 39(3) : 170. Nieto-Diaz M, Pita-Thomas W, Maza RM, Yunta-Gonzalez M, Lopez-Rodríguez MJ, Navarro-Ruiz R, Reigada D, Fernández-Martos C, Nieto-Sampedro M. (2011) Factors promoting axon growth in the deer antler. Animal Production Science 51: Nieto-Diaz, Manuel, Pita-Thomas, Daniel Wolfgang, Muñoz-Galdeano, T., Martinez-Maza, C., Navarro-Ruiz, R., Reigada, D., Yunta, M., Lopez-Rodriguez, M.J., Nieto-Sampedro, M. and Martinez-Maza, R. (2012). Deer antler innervation and regeneration. Frontiers in Bioscience 17: Burgos, E., Gómez-Nicola, D., Pascual, D., Martín, M.I., Nieto-Sampedro, M., Goicoechea, C. (2012). Cannabinoid agonist WIN 55,212-2 prevents the development of paclitaxelinduced peripheral neuropathy in rats. possible involvement of spinal glial cells. European J. Pharmacol. Feb Muñeton Gomez, V.C., Doncel Perez, E., Fernandez Fernandez, A.P., Serrano Masa, J., Pozo-Rodrigalvarez, A., Vellosillo-Huerta, L., Scott Taylor, J., Cardona-Gomez, G.P., Nieto- Sampedro, M. and Martinez-Murillo, R. (2012) Neural differentiation of transplanted neural stem cells in a rat model of striatal lacunar infarction: light and electron microscopic observations. Frontiers Cell. Neurosci. 6 (30): Romero-Ramírez, L., García-Álvarez, I., Campos-Olivas, R., Gilbert, M., Goneau, M.F., Fernández-Mayoralas, A., and Nieto-Sampedro, M. (2012) Specific synthesis of Neurostatin and gangliosides O-acetylated in the outer sialic acids using a sialate transferase. PLoS One 7(12): e Doncel-Pérez, E. García-Álvarez,I., Fernández-Mayoralas, A., Nieto-Sampedro, M.(2013) Synthetic glycolipids for glioma growth inhibition developed from neurostatin and NF115 compound. Bioorganic & Medicinal Chemistry Letters 23: Martín-López, E., Ruiz-Hitzky, E., and Nieto- Sampedro, M. (2013) Agar-based bridges as biocompatible candidares to provide guide cues in spinal cord injury repair. Bio-Med. Mater. Engineer., in press. Book Chapters

11 (Since 1998, total: 52) 34. Nieto-Sampedro, M. (1998) Neuron-Glia Ensembles and Mammalian CNS Lesion Repair (en "Understanding Glial Cells", B.Castellano, B.González de Mingo and M. Nieto-Sampedro, eds.), Kluwer Acad.Pub., Norwell, Mass.pp Nieto-Sampedro, M. y Verdú, E. (1998) Lesiones del Sistema Nervioso: Respuesta Neural y Reparación. "Manual de Neurociencias", Capítulo 37 (J.M.Delgado, A.Ferrús, F. Mora, F.J.Rubia, eds), Editorial Síntesis, Madrid, pp Nieto-Sampedro, M. (1999) Neurite outgrowth inhibitors in gliotic tissue. En "The function of glial cells in health and disease: Dialogue between glia and neurons" (R. Matsas and M. Tsacopoulos, eds.) serie Advances in Exper. Med. Biol. 468: , Plenum Pub. Corp., New York. 37. Nieto-Sampedro, M. (2000) Transplantes de glía y reparación del sistema nervioso central. Investigación y Ciencia (edición española de Scientific American) 281: Taylor, J.S., Muñetón-Gómez, V.C., Eguía-Recuero, R. and Nieto-Sampedro, M. (2001) Transplants of olfactory bulb ensheathing cells promote functional repair of multiple dorsal rhizotomy. Prog. Brain Res. 132: M. Nieto-Sampedro. (2002) Cajal Club Meeting on "Changing Views of Cajal s Neuron". CNS Schwann-like glia and functional restoration of damaged spinal cord. Prog. Brain Res. 136: Muñetón, V.C., Taylor, J.S. and Nieto-Sampedro, M.(2001) Mecanismos involucrados en la promoción de crecimiento axonal por la glía envolvente del bulbo olfatorio. Biomédica 21 (2): Collazos-Castro, J.E. and Nieto-Sampedro, M. (2002). Developmental and Reactive Growth of Dentate Gyrus afferents: cellular and molecular interactions. Restor.Neurol.Neurosci., 19: Nieto-Sampedro, M, Gudiño-Cabrera, G. and Taylor, J. S. Schwann-like Macroglia of the CNSand Spinal Cord Lesion Repair. Eur. J. Anat. en prensa (revisión invitada). 43. Nieto Sampedro, M., E. Martín López, D.W. Pita Thomas y M. Nieto Díaz (2004) Plasticidad Neural: Aprendizaje y Reparación de Lesiones. Simposio sobre Plasticidad y Desarrollo del Sistema Nervioso con motivo del Año Cajal (150 Aniversario). Colección Actas, pp Gobierno de Aragón, Departamento de Educación, Cultura y Deporte. 44. Nieto Sampedro, M., Gómez-Nicola, D. and Taylor, J.S. (2004) Perspectivas futuras en la reparación del plexo braquial. Momento Médico IberoAmericano.Capítulo X, pp Nieto-Sampedro, M. (2004). Neural plasticity and CNS lesion repair. In Brain Damage and Repair. From molecular research to clinical therapy Chapter 21. J.M. Delgado-García, T. Herdegen and A. Privat, eds. Kluwer Academic Publishers, Dordrecht/Boston/ London, pp Nieto-Sampedro, M. (2004). Neural plasticity and the cell biology of learning. In Brain Damage and Repair. From molecular research to clinical therapy Chapter 20. J.M. Delgado-García, T. Herdegen and A. Privat, eds. Kluwer Academic Publishers, Dordrecht/Boston/ London, pp Nieto-Sampedro, M., Doncel-Pérez, E., Martín-López, E. y Nieto-Diaz, M. (2006) Desarrollo de instrumentos de reparación del trauma del sistema nervioso central, pp En: La olfacción en España (Alonso, JR,de Castro, F y López-Mascaraque, eds.) Ediciones SBI,Salamanca. 48. Doncel-Pérez, E., Caballero-Chacón, Sara y Nieto-Sampedro, M.(2006) Diferenciación de células de neuroesfera a células con fenotipo de aldainoglía. Cuadernos FEDACE sobre Daño Cerebral Adquirido, Pamplona. 49. Nieto-Sampedro, M. (2007). New Encyclopledia of Neuroscience (L.Squire, Albright, T., Bloom, F., Gage,F., and Spitzer, N. eds.) Neural repair: regeneration and functional recovery: Regeneration after spinal cord damage: olfactory ensheathing cells (MS number: 20),

12 Bjórklund, A., asoc.editor.(invited) 50. Nieto-Díaz, M., Pita-Thomas,W.D., Martínez-Maza, R. and Nieto-Sampedro, M. (2008) Quality control methods for oligonucleotyde microarrays. In Oligonucleotide Array Sequence Analysis, Frank Columbus, Editor, Nova Science Publishers, Inc., Hauppauge, N.Y. 51. Nieto-Sampedro, M. and Doncel-Pérez, E. (2012) Glía promotora del crecimiento derivada de células madre neurales: un instrumento de reparación del trauma medular. EditorialAcadémicaEspañola (EAE) editores, pp. 52. Nieto-Sampedro, M. and Romero-Ramírez, L.(20113) Negative Regulation in the Brain: Neurons Control Astrocyte Division, Astrocytes Regulate Neurite Outgrowth., in preparation.