By the present I would like to bring more Aloe Vera Whole Leaf Extract knowledge to enrich Prop 65.

Transcripción

1 From: To: Subject: Date: Attachments: P65Public Comments Proposition 65, Aloe Vera Whole Leaf Extract Thursday, May 14, :37:24 AM Efectividad Serobiologiques.pdf Estudio capacidad antioxidante de Aloveria Tecnova.PDF By the present I would like to bring more Aloe Vera Whole Leaf Extract knowledge to enrich Prop 65. We are a Pharmaceutical Laboratory established in Canary Islands, Spain from We are specialized in R&D, manufacturing and commercialization of Canary medicinal plants. We manufacture Aloe Vera Pure raw material for cosmetic, alimentary, textile, etc industries under our brand Aloveria. We have developed a exclusive formula to preserve all the elements inside the plant are. Our R&D works from years have been developed in collaboration with worldwide institutions. Canary Islands is the richest biodiversity area into Europe territory. Here Aloe Vera uses are well known from centuries SOME HISTORY. When Spanish colons comes before America discovering, Franciscans monks wrote about Aloe Vera and others medicinal plants that Ancient Canaries knew. Then Franciscans carry on Aloe Vera to America. Aloe Vera also grown in North Africa and South Asia, in a latitude close to parallel 28. Since Egyptian Ebers Papyrus times until now there are lots of writings which talks about wonderful properties of Aloe Vera and its uses, internal (drink juice) and external (skin care). More recently, between centuries VIII and XV, Muslims extend in South Europe (Spain) Aloe Vera plantations to obtain latex to drink as a powerful laxant. That is why today in the Aloe Monography of European Pharmacopeia, only Anthraquinones identification is done. Due to this monography, Aloe Barbadensis (Aloe Vera) is identify in European Pharmacopeia by Anthraquinones content, expressed in Barbaloine. Otherwise, other products without Barbaloine content is not Aloe Barbadensis. Today, several civilizations in Africa, South America and South Asia eats Aloe Vera dried leafs as a natural laxant. I try to explain that traditional uses of Aloe Vera Whole Leaf internal and external and its properties are well known since thousands years ago, until now RESEARCH AND STUDIES. Since the middle of century XX researcher have been studied Aloe Vera content trying to find which elements cause health benefits. They found that Aloe Vera Leaves contain 96% water and a lot of elements in the other 4%. It has been identified more than 200 elements among vitamins, mono and polysaccharides, enzymes, minerals, amino-acids and anthraquinones. All of them in a small quantity. No one significant. So, there are many opinions, but where most researchers agree is that it is the combination of all these elements which produce a synergistic effect. Certainly empiric properties of Aloe Vera Whole Leaf are well known. However in most of the studies conducted researchers have used derivative content of the plant (dry extracts, solutions, ), processed in different ways that alter the delicate balance of natural chemicals. Since 1995 we have made more than 40 qualitative and quantitative studies about our Aloe Vera Pure (Whole Leaf) Aloveria. If you are interested we can send you some of them about anti-oxidant properties of Aloveria in human and animals cells, in-vitro and in-vivo In case of Proposition 65 about INTERNAL USE of Aloe Vera Whole Leaf Extract, it would be very important that you

2 consider: Exposure data do not identify the type of product used by the many consumer : Really there is a identification problem in the most of the products in the market due to inadequate regulation for the declaration of purity of the Aloe Vera products. So, there are lots of derivate and adulterate Aloe Vera products in the market, but all of them use the Aloe Vera Whole Leaf properties. So, the problem is the labeling norm for raw materials for industry and for finished products for consumers, because the most of finished products are manufactured with Aloe Vera extracts, not with Aloe Vera Whole Leaf. So, they are Aloe Vera derivates. increased incidences of adenoma and carcinoma of the large intestine. There are lots of studies which demonstrate some healthy properties of Aloe Vera Whole Leaf with Athraquinones. See attached: ALOVERIA Efficacy Test: anti-inflammatory and immunostimulant properties, made in Laboratoires Serobiologiques, France ALOVERIA anti-oxidant properties Studie. UE Tecnova Planning. ULPGC I hope be useful. Please, do not hesitate to ask us any question about Aloe Vera. Probably Aloveria is the most studied Aloe Vera Pure (Whole Leaf) product worldwide. I m sure in Europe is. So, we can help you to complete your Proposition. Project Manager & co-owner CONFIDENTIALITY NOTICE: This message is intended only for the person to whom it is addressed and may contain

3 From: To: Subject: Date: P65Public Comments RE: Proposition 65, Aloe Vera Whole Leaf Extract Monday, May 18, :18:21 AM Additionally to my dated 05/14/2015 I send you some two interesting references about the uses of Aloe anthraquinones. No one scientific study confirm the genotoxic effect of ALOE VERA WHOLE LEAF. In contrast, numerous studies conclude positive results on the antibacterial, anti-inflammatory, immunostimulant and antioxidant activity of Aloe anthraquinones. Only in some cases where mice or rats were treated with overdose of some isolated and concentrated hydroxyanthracene derivatives were found a toxic effect. This effect is possible to achieve with many other isolated and concentrated chemical elements, meanwhile they are healthy in its normal status while on a daily food. ALOE VERA WHOLE LEAF: it is a natural product with more than 200 elements content in a very few quantity, well balanced and safe. I send you some references about this: EMEA HMPC - COMMUNITY HERBAL MONOGRAPH ON ALOE BARBADENSIS MILLER AND ON ALOE _Community_herbal_monograph/2009/12/WC pdf ULPGC - Estudio sobre el Aloe Vera Barbadensis cultivado en Gran Canaria. Contenido de barbaloina en distintas partes de sus hojas. Estabilidad y algunos efectos farmacológicos. Please, observe the lots of very interesting references of this Doctoral Thesis Hope to be useful. Jefe de Proyectos Project Manager

4 CONFIDENTIALITY NOTICE: This message is intended only for the person to whom it is addressed and may contain De: Enviado el: jueves, 14 de mayo de :37 Para: Asunto: Proposition 65, Aloe Vera Whole Leaf Extract By the present I would like to bring more Aloe Vera Whole Leaf Extract knowledge to enrich Prop 65. We are a Pharmaceutical Laboratory established in Canary Islands, Spain from We are specialized in R&D, manufacturing and commercialization of Canary medicinal plants. We manufacture Aloe Vera Pure raw material for cosmetic, alimentary, textile, etc industries under our brand Aloveria. We have developed a exclusive formula to preserve all the elements inside the plant are. Our R&D works from years have been developed in collaboration with worldwide institutions. Canary Islands is the richest biodiversity area into Europe territory. Here Aloe Vera uses are well known from centuries SOME HISTORY. When Spanish colons comes before America discovering, Franciscans monks wrote about Aloe Vera and others medicinal plants that Ancient Canaries knew. Then Franciscans carry on Aloe Vera to America. Aloe Vera also grown in North Africa and South Asia, in a latitude close to parallel 28. Since Egyptian Ebers Papyrus times until now there are lots of writings which talks about wonderful properties of Aloe Vera and its uses, internal (drink juice) and external (skin care). More recently, between centuries VIII and XV, Muslims extend in South Europe (Spain) Aloe Vera plantations to obtain latex to drink as a powerful laxant. That is why today in the Aloe Monography of European Pharmacopeia, only Anthraquinones identification is done. Due to this monography, Aloe Barbadensis (Aloe Vera) is identify in European Pharmacopeia by Anthraquinones content, expressed in Barbaloine. Otherwise, other products without Barbaloine content is not Aloe Barbadensis. Today, several civilizations in Africa, South America and South Asia eats Aloe Vera dried leafs as a natural laxant. I try to explain that traditional uses of Aloe Vera Whole Leaf internal and external and its properties are well known since thousands years ago, until now RESEARCH AND STUDIES. Since the middle of century XX researcher have been studied Aloe Vera content trying to find which elements cause health benefits. They found that Aloe Vera Leaves contain 96% water and a lot of elements in the other 4%. It has been identified more than 200 elements among vitamins, mono and polysaccharides, enzymes, minerals, amino-acids and anthraquinones. All of them in a small quantity. No one significant. So, there are many opinions, but where most researchers agree is that it is the combination of all these elements which produce a synergistic effect. Certainly empiric properties of Aloe Vera Whole Leaf are well known. However in most of the studies conducted researchers have used derivative content of the plant (dry extracts, solutions, ), processed in different ways that alter the delicate balance of natural chemicals. Since 1995 we have made more than 40 qualitative and quantitative studies about our Aloe Vera Pure (Whole Leaf) Aloveria. If you are interested we can send you some of them about anti-oxidant properties of Aloveria in human and animals cells, in-vitro and in-vivo.

5 In case of Proposition 65 about INTERNAL USE of Aloe Vera Whole Leaf Extract, it would be very important that you consider: Exposure data do not identify the type of product used by the many consumer : Really there is a identification problem in the most of the products in the market due to inadequate regulation for the declaration of purity of the Aloe Vera products. So, there are lots of derivate and adulterate Aloe Vera products in the market, but all of them use the Aloe Vera Whole Leaf properties. So, the problem is the labeling norm for raw materials for industry and for finished products for consumers, because the most of finished products are manufactured with Aloe Vera extracts, not with Aloe Vera Whole Leaf. So, they are Aloe Vera derivates. increased incidences of adenoma and carcinoma of the large intestine. There are lots of studies which demonstrate some healthy properties of Aloe Vera Whole Leaf with Athraquinones. See attached: ALOVERIA Efficacy Test: anti-inflammatory and immunostimulant properties, made in Laboratoires Serobiologiques, France ALOVERIA anti-oxidant properties Studie. UE Tecnova Planning. ULPGC I hope be useful. Please, do not hesitate to ask us any question about Aloe Vera. Probably Aloveria is the most studied Aloe Vera Pure (Whole Leaf) product worldwide. I m sure in Europe is. So, we can help you to complete your Proposition. Project Manager & co-owner CONFIDENTIALITY NOTICE: This message is intended only for the person to whom it is addressed and may contain