Peripheral Neuropathy Caused by Cancer Treatment
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- Consuelo Velázquez Blanco
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1 Peripheral Neuropathy Caused by Cancer Treatment What is Peripheral Neuropathy? Peripheral neuropathy (nerve changes) happens when there is an injury to peripheral nerves. Symptoms are caused by damage to the nerves that are further away from the brain and spinal cord. These distant nerves are called peripheral nerves. These changes most often happen to the nerves in your fingers, hands, arms, toes, feet, and legs. There are two dierent types of peripheral nerves, sensory and motor. Sensory nerves help you feel pain, touch, temperature, position, and vibration. Motor nerves help you move and maintain muscle tone. Anti-cancer and chemotherapy medicines are one of the causes of these nerve changes. More on next page Learn more about your health care. Copyright January 23, James Cancer Hospital & Solove Research Institute, The Ohio State University Wexner Medical Center - Upon request all patient education handouts are available in other formats for people with special hearing, vision and language needs, call (614)
2 Neuropatía periférica causada por el tratamiento contra el cáncer Qué es la neuropatía periférica? La neuropatía periférica (cambios en los nervios) sucede cuando existe una lesión en los nervios periféricos. Los síntomas son causados por los daños a los nervios que están más alejados del cerebro y la columna vertebral. Estos nervios distantes se llaman nervios periféricos. Estos cambios se producen con más frecuencia en los nervios de los dedos de las manos, las manos, los brazos, los dedos de los pies, los pies y las piernas. Existen dos tipos diferentes de nervios periféricos: sensoriales y motores. Los nervios sensoriales ayudan a sentir el dolor, el tacto, la temperatura, la posición y la vibración. Los nervios motores lo ayudan a moverse y a mantener el tono muscular. Los medicamentos contra el cáncer y la quimioterapia son una de las causas de estos cambios en los nervios. Sigue en la próxima página Aprenda más sobre los cuidados de su salud. Peripheral Neuropathy Caused by Cancer Treatment. Spanish. Copyright January 23, James Cancer Hospital & Solove Research Institute, The Ohio State University Wexner Medical Center - Upon request all patient education handouts are available in other formats for people with special hearing, vision and language needs, call (614)
3 2 Symptoms of Peripheral Neuropathy The symptoms of peripheral neuropathy depend on the nerves that are aected. Tell your doctor or nurse right away if you notice any of these changes: Pain (it may be there all the time, come and go or feel like a stabbing pain) Numbness, loss of feeling or tingling (pins and needles) in your hands and feet Cold, prickly, pinching or burning feeling Trouble using your fingers to button shirts or tie shoes Changes in your ability to walk, such as having trouble picking up your feet Stomach pain or cramps Constipation Problems with urinating Jaw or throat pain Chemotherapy Drugs and Peripheral Neuropathy Chemotherapy drugs that can cause peripheral neuropathy are listed below. There are no proven ways to prevent nerve changes caused by chemotherapy treatment. Peripheral neuropathy caused by chemotherapy may or may not improve over time after treatment ends. Chemotherapy drugs that can cause peripheral neuropathy include: Cisplatin Eribulin (Halaven ) Carboplatin Vincristine (Oncovin ) Paclitaxel (Taxol ) Vinblastine (Velban ) Docetaxel (Taxotere ) Bortezomib (Velcade ) Paclitaxel-Albumin-bound Thalidomide (Thalomid ) (Abraxane ) Oxaliplatin (Eloxatin ) Ixabepilone (Ixempra ) Lenalidomide (Revlimid )
4 2 Síntomas de la neuropatía periférica Los síntomas de la neuropatía periférica dependen de los nervios que se vean afectados. Infórmele a su médico o enfermera de inmediato si nota alguno de estos cambios: Dolor (puede ser permanente o ir y venir o sentirse como una puñalada) Adormecimiento, pérdida de la sensibilidad o cosquilleo (hormigueo) en las manos y pies Sensación de frío, pinchazos o ardor Problemas para usar sus dedos para abotonarse camisas o atarse los zapatos Cambios en su capacidad para caminar, como tener problemas para levantar los pies Dolor de estómago o calambres Estreñimiento Problemas al orinar Dolor en la mandíbula o la garganta Medicamentos administrados en la quimioterapia y neuropatía periférica Los fármacos de quimioterapia que pueden causar neuropatía periférica se indican a continuación. No existen formas comprobadas de evitar los cambios en los nervios causados por el tratamiento con quimioterapia. La neuropatía periférica causada por la quimioterapia podría o no mejorar con el tiempo después de finalizado el tratamiento. Los medicamentos administrados en la quimioterapia que pueden causar neuropatía periférica incluyen: Cisplatino Eribulina (Halaven ) Carboplatino Vincristina (Oncovin ) Paclitaxel (Taxol ) Vinblastina (Velban ) Docetaxel (Taxotere ) Bortezomib (Velcade ) Paclitaxel unido a albúmina Talidomida (Thalomid ) (Abraxane ) Oxaliplatino (Eloxatin ) Ixabepilona (Ixempra ) Lenalidomida (Revlimid )
5 3 Symptoms with Common Chemotherapy Drugs Here is information about common chemotherapy drugs and the nerve changes they may cause. Cisplatin can cause the following symptoms: Unable tell where your hands and feet are located (this is called position sense). Feet slip out of shoes or slippers that are not tied or do not come up over the top of your foot. Unable to feel the floor under your feet when you walk. Feel as if your bare feet have socks on them. Paclitaxel, Vincristine, Vinblastine and Oxaliplatin can decrease your ability to feel the shape of an object in your hand. Paclitaxel and Vincristine may decrease your ability to tell the dierence between hot or cold temperatures. Oxaliplatin can make your jaw to feel tight or make you feel like you are unable to catch your breath. These signs can be worse when you come in contact with cold air or drink cold liquids. Bortezomib and Thalidomide can cause changes in the feeling you have in your toes, feet, fingers and hands. If you are going to take a chemotherapy drug that can cause peripheral neuropathy, your doctor or nurse will ask you questions about your past and current illnesses. This is done to find out if you have had symptoms of peripheral neuropathy in the past. If you have had peripheral neuropathy before, you may find that symptoms start sooner and are more severe during chemotherapy treatment.
6 3 Síntomas con medicamentos administrados con la quimioterapia comunes Esta es información sobre fármacos comunes de quimioterapia y los cambios en los nervios que podrían causar. El cisplatino puede causar los siguientes síntomas: No ser capaz de decir en dónde están sus pies y manos (esto se llama sentido de la posición). Se le salen los zapatos o zapatillas que no están atados o no llegan hasta la parte de arriba de su pie. No puede sentir el piso bajo sus pies cuando camina. Siente como si al andar descalzo tuviera calcetines. Paclitaxel, vincristina, vinblastina y oxaliplatino pueden disminuir su capacidad para sentir la forma de un objeto en su mano. Paclitaxel y vincristina podrían disminuir su capacidad para indicar la diferencia entre temperatura caliente o fría. Oxaliplatino podría hacer que sienta que la mandíbula está rígida o hacerlo sentir como si no pudiera respirar. Estos signos pueden ser peores cuando entra en contacto con el aire frío o bebe líquidos fríos. Bortezomib y talidomida pueden causar cambios en las sensaciones que tiene en los dedos de los pies, los pies, los dedos de las manos y las manos. Si va a tomar un medicamento para la quimioterapia que podría causar neuropatía periférica, su médico o enfermera le harán preguntas sobre sus enfermedades pasadas y actuales. Esto se hace para saber si ha tenido síntomas de neuropatía periférica en el pasado. Si ha tenido neuropatía periférica antes, podría descubrir que los síntomas comienzan antes y que son más graves durante el tratamiento de quimioterapia.
7 4 Treatment for Peripheral Neuropathy Medicines may help reduce pain in the feet, legs and arms. They usually do not bring back loss of feeling. Talk to your doctor about your pain and ways to manage it. To reduce your risk of infection, check your feet each day for any cuts and sores. Call your doctor for directions on how to take care of your feet if this happens. To lower you chance of injury, there are ways to make your environment safer. For tips on how to make your home and place of work safe, ask for the patient education handout on Safety Tips for Peripheral Neuropathy Caused by Cancer Treatment.
8 4 Tratamiento para la neuropatía periférica Los medicamentos podrían ayudar a reducir el dolor en los pies, las piernas y los brazos. Generalmente, los medicamentos no recuperan la pérdida de sensibilidad. Hable con su médico sobre su dolor y las formas de controlarlo. Para reducir su riesgo de infección, inspeccione sus pies todos los días para ver si tiene cortes o llagas. Llame a su médico para que le dé indicaciones sobre cómo cuidar sus pies si esto sucediera. Para disminuir sus posibilidades de lesión, hay formas de hacer su entorno más seguro. Para obtener consejos sobre cómo hacer que su hogar y su lugar de trabajo sean seguros, pida el folleto de educación para los pacientes en Safety Tips for Peripheral Neuropathy Caused by Cancer Treatment.
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