Pontificial Universida Catolica de Chile

Transcripción

1 Juan Carlos Roa Strauch Portal del Investigador Antecedentes del Investigador Cargo Institución Ciudad/País Chair Pontificial Universida Catolica de Chile SAntiago, Chile Resumen Biobank national network in Chile; Translational research in digestive tumor, with special emphasys in gallbladder cancer; Research on HPV and its role in cervix preneoplastic and neoplastic lesions. Información Educacional Título Institución País Medical Doctor UNIVERSIDAD DE LA FRONTERA Chile Año de obtención 1991 Título Institución País Oncologia molecular Centro de estudios sanitarios de Europa España Año de obtención 2012 Título Institución País Especialista en Anatomia patologica PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE Chile Año de obtención 1995 Título Institución País Fellowship in molecular biology LOUANA STATE UNIVERSITY Estados Unidos Año de obtención of 33

2 Experiencia Académica Jerarquía Jornada Institution profile Facultad Ciudad País Assistant Professor Part Time UNIVERSIDAD DE LA FRONTERA Medicine Temuco Chile Fecha Enero Enero Jerarquía Jornada Institution profile Facultad Ciudad País Associate Professor Part Time UNIVERSIDAD DE LA FRONTERA Medicine Temuco Chile Fecha Enero - Enero 2009 Jerarquía Jornada Institution profile Facultad Ciudad País Full Professor Full Time UNIVERSIDAD DE LA FRONTERA Medicine Temuco Chile Fecha Enero - Enero Jerarquía Jornada Institution profile Facultad Ciudad País Fecha Full professor Full Time PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE Medicine Santiago Chile Enero A la fecha Experiencia Profesional 2 of 33

3 Cargo Jornada Institución Ciudad País Professor Part Time Universidad de la Frontera Temuco Chile Fecha Enero Enero Cargo Jornada Institución Ciudad País Surgical Pathologist Full Time Hospital Regional Temuco Temuco Chile Fecha Enero Enero 2012 Cargo Jornada Institución Ciudad País Fecha Surgical Pathologist Full Time Pontificia Universidad Catolica de Chile SAntiago Chile Enero A la fecha Premios y Distinciones Name Scientific Productivity Award Institution UNIVERSIDAD DE LA FRONTERA Country Chile Year Description Scientific Productivity Award of 33

4 Name Chilean Gastroenterology Congress Award Institution SOCIEDAD CHILENA DE GASTROENTEROLOGIA Country Chile Year 2003 Description Best Presentation Award Name Chilean Academy of Medicine Award Institution ACADEMIA CHILENA DE MEDICINA Country Chile Year 2001 Description Chilean Academy of Medicine Award, collaborator. Name Scientific Productivity Award Institution UNIVERSIDAD DE LA FRONTERA Country 4 of 33

5 Chile Year 2001 Description Best Scientific Productivity Name Gonzalo Tolosa Award Institution Gonzalo Tolosa Award Country Chile Year 1991 Description The best medicine graduate student Name Cautin Medical Society Award Institution Cautin Medical Society Award Country Chile Year 1989 Description For Investigative Pathology 5 of 33

6 Productividad Microsatellite instability, prognosis and metastasis in gastric cancers from a low-risk population SCOPUS Schneider, BG; Bravo, JC; Roa JC; Roa, I; Kim, MC; Lee, KM; Plaisance, KT; McBride, CM; Mera, R 2000 p53 gene mutation in colorectal carcinoma Roa JC; Roa, I; Melo, A; Araya, JC; Villaseca, MA; Flores, M; Schneider, B 2000 Helicobacter pylori and chronic gastritis: Relationship between infection and inflammatory activity in a high risk population for gastric cancer Araya, JC; Villaseca, MA; Roa, I; Roa JC 2000 Gastric cancer and tumor growth regulation. Study of cell proliferation markers and protein complex p53/p21(waf1/cip1)/mdm-2 Villaseca, M; Araya, JC; Roa, I; Roa JC 2000 Detection of BCR-ABL gene sequences using polymerase chain reaction-reverse transcriptase in patients with leukemia Artigas, CG; Melo, A; Roa JC; Paez, E; de Vittini, C; Arriagada, M; Gonzalez, L; Pflaumer, E; Roa, I 2002 Microsatellite instability and loss of heterozygosity in chronic gastritis Roa JC; Villaseca, MA; Roa L.; Araya, JC 2003 Microsatellite instability and allelic imbalance in neoplastic and preneoplastic gastric lesions 6 of 33

7 Roa JC; Araya, JC; Villaseca, MA; Roa, I; Correa, P 2003 Hypothyroidism after the excision of a Struma ovarii. Report of one case Sapunar, J; Roa JC; Meissner, A 2003 Mutations of TP53 suppressor gene in pre-neoplastic and neoplastic lesions of the stomach: crosssectional study in a high risk region Araya, JC; Roa JC; Villaseca, MA; Roa, I; Guzman, P; Alvarado, C; Melo, A 2003 Detection of bone marrow micrometastases in patients with gallbladder cancer Roa JC; de Aretxabala, X; Melo, A; Faria, G; Araya, JC; Villaseca, MA; Guzman, P; Roa, I Association between Helicobacter pylori genotype and the severity of gastritis in infected adults Araya, JC; Anabalon, L; Roa, I; Bravo M; Villaseca, MA; Guzman, P; Roa JC Promoter methylation profile in breast cancer Roa JC; Anabalon, L; Tapia, O; Martínez J; Araya, JC; Villaseca, M; Guzman, P; Roa, I K-ras gene mutation in gallbladder carcinoma Roa JC; Roa, I; de Aretxabala, X; Melo, A; Faria, G; Tapia, O Management of gallbladder cancer with invasion of the muscular layer 7 of 33

8 de Aretxabala, X; Roa, I; Mora, J; Pincheira, O; Burgos, L; Silva J; Roa JC Neoadjuvant chemoradiotherapy in gallbladder cancer de Aretxabala, X; Losada, H; Mora, J; Roa, I; Burgos, L; Yanez, E; Quijada, I; Roa JC Frequency of K-ras mutation in biliary and pancreatic tumors Roa JC; Anabalon, L; Tapia, O; Melo, A; de Aretxabala, X; Roa, I 2005 Promoter methylation profile in gastric cancer Roa JC; Anabalon, L; Roa, I; Tapia, O; Melo, A; Villaseca, M; Araya, JC 2005 Detection of human papilloma virus in cytologic samples or biopsies of the cervix Melo, A; Roa, I; Montenegro, S; Capurro, I; Roa JC 2005 Microsatellite instability in preneoplastic and neoplastic lesions of the gallbladder Roa JC; Roa, I; Correa, P; Vo, Q; Araya, JC; Villaseca, M; Guzman, P; Schneider, BG 2005 Frequency of TEL/AML1 and BCR/ABL fusion genes in children with acute lymphoblastic leukemia Artigas, CG; Cabrera, ME; Melo, A; Paez, E; Arriagada, M; Astete, C; Roa, I; Roa JC Chemoradiotherapy in gallbladder cancer de Aretxabala, X; Roa, I; Berrios, M; Hepp, J; Gallardo, J; Cordova, A; Roa JC; Leon J.; Maluenda, F 8 of 33

9 Prognostic factors of phyllodes tumor of the breast SCOPUS Roa JC; Tapia, O; Carrasco, P; Contreras E; Araya, JC; Munoz, S; Roa, I Promoter methylation profile in gallbladder cancer SCOPUS Roa JC; Anabalon, L; Roa, I; Melo, A; Araya, JC; Tapia, O; de Aretxabala, X; Munoz, S; Schneider, B Gallbladder cancer: An analysis of a series of 139 patients with invasion restricted to the subserosal layer SCOPUS de Aretxabala, X; Roa, I; Burgos, L; Losada, H; Roa JC; Mora, J; Hepp, J; Leon J.; Maluenda, F Hepatocarcinoma with sarcomatoid transformation. Case report Losada, HM; Roa JC; Garcia, DM; Araya, JC; Burgos, LSJ; Silva, JA 2007 Detection and typification of human papilloma virus in pre cancerous cervical lesions Aedo, S; Melo, A; Garcia, P; Guzman, P; Capurro, I; Roa JC 2007 Microsatellite instability and human papilloma virus genotypes in preneoplastic and neoplastic uterine cervix lesions Roa JC; Martínez R; Montenegro, S; Roa, I; Capurro, I; Ibacache, G; Melo, A 2007 Prevalence of human papillomavirus genital infection among male university students Guzman, P; Ili, C; Rifo, P; Bricenno, G; Araya, J; Villaseca, M; Roa JC of 33

10 Review Surface enhanced laser desorption/ionization (SELDI): proteomics technology and its application in oncology Espejel, F; Roa JC 2008 Description of Echinococcus granulosus genotypes in human hydatidosis in a region of southern Chile SCOPUS Manterola, C; Benavente, F; Melo, A; Vial, M; Roa JC 2008 Serial analysis of gene expression identifies connective tissue growth factor expression as a prognostic biomarker in gallbladder cancer SCOPUS Alvarez, H; Corvalan, A; Roa JC; Argani, P; Murillo, F; Edwards, J; Beaty, R; Feldmann, G; Hong, SM; Mullendore, M; Roa, I; Ibanez, L; Pimente, F; Diaz, A; Riggins, GJ; Maitra, A 2008 Gene methylation patterns in digestive tumors Roa JC; Garcia, P; Melo, A; Tapia, O; Villaseca, M; Araya, JC; Guzman, P 2008 Early Gallbladder Cancer: Is Further Treatment Necessary? SCOPUS de Aretxabala, X; Roa, I; Hepp, J; Maluenda, F; Mordojovich, G; Leon J.; Roa JC 2009 Diagnostic value of frozen section biopsy during surgery for breast lesions or neoplasms Bellolio, E; Guzman, P; Orellana, J; Roa JC; Villaseca, M; Araya, JC; Tapia, O; Pineda, V 2009 Review Gallbladder cancer: a morphological and molecular update Goldin, RD; Roa JC of 33

11 HPV genotyping from invasive cervical cancer in Chile SCOPUS Roa JC; Garcia, P; Gomez, J; Fernandez, W; Gaete F; Espinoza, A; Lepetic, A; Suarez, E 2009 Detection and genotyping of human papillomavirus in biopsies of uterine cervical adenocarcinoma Brebi, P; Ili, CG; Lopez J; Garcia, P; Melo, A; Montenegro, S; Leal, P; Guzman, P; Roa JC 2009 Promoter Methylation Profile in Preneoplastic and Neoplastic Gallbladder Lesions SCOPUS Garcia, P; Manterola, C; Araya, JC; Villaseca, M; Guzman, P; Sanhueza, A; Thomas, M; Alvarez, H; Roa JC 2009 The Axl receptor tyrosine kinase is an adverse prognostic factor and a therapeutic target in esophageal adenocarcinoma Alvarez, H; Montgomery, EA; Karikari, C; Canto, M; Dunbar, KB; Wang, JS; Feldmann, G; Hong, SM; Haffner, MC; Meeker, AK; Holland, SJ; Yu, JX; Heckrodt, TJ; Zhang J.; Ding, PY; Goff, D; Singh, R; Roa JC; Marimuthu, A; Riggins, GJ; Eshleman, JR; Nelkin, BD; Pandey, A; Maitra, A Human papillomavirus genotyping of cervical uterine preneoplastic lesions in a high risk area Lopez J; Ili, CG; Brebi, P; Garcia, P; Capurro, I; Guzman, P; Suarez, E; Ojeda, JM; Roa JC Bone hydatidosis. Report of five patients Tapia, O; Vidal, A; Bellolio, E; Roa JC Prognosis of signet ring cell carcinoma of the stomach Tapia, O; Gutierrez, V; Roa JC; Manterola, C; Villaseca, M; Araya, JC 11 of 33

12 Breast hydatidosis. Report of one case Tapia, O; Pineda, V; Roa JC Prognostic factors for survival of malignant melanomas Bellolio, E; San-Martin, A; Quininir, L; Orellana, J; Tapia, O; Rifo, P; Roa JC; Villaseca, M Human papillomavirus genotyping in cervical adenocarcinoma in the Region of La Araucania-Chile Melo, A; Garcia, P; Capurro, I; Guzmán G; Brebi, P; Ili, C; Lopez J; Roa JC Survival of a cohort of patients with Intermediate and advanced gall bladder cancer treated with a prospective therapeutic protocol Manterola, C; Vial, M; Roa JC Duodenal villous atrophy associated with Mycophenolate mofetil. Report of one case Tapia, O; Villaseca, M; Sierralta, A; Roa JC Changes in morphological an clinical characteristics of gastric cancer from 1986 to 2005 Tapia, O; Roa JC; Manterola, C; Villaseca, M; Gutierrez, V; Flores, P; Araya, JC; Guzman, P Colon and Rectum Cancer: Morphological and Clinical Description of 322 Cases Tapia, O; Roa JC; Manterola, C; Bellolio, E 12 of 33

13 Clinical and public health research using methylated DNA immunoprecipitation (MeDIP) A comparison of commercially available kits to examine differential DNA methylation across the genome Brebi-Mieville, P; Ili-Gangas, C; Leal-Rojas, P; Noordhuis M.G.; Soudry, E; Perez, J; Roa C.J.; Sidransky, D; Guerrero-Preston, R 2012 Diverticular disease of the appendix in appendectomies Muñoz C; Mansilla, J; Roa JC; Heider, C Prognostic value of extracapsular lymph node involvement among patients with gastric cancer Tapia, O; Villaseca, M; Araya, JC; Roa JC Hyalinizing Cholecystitis and Associated Carcinomas: Clinicopathologic Analysis of a Distinctive Variant of Cholecystitis With Porcelain-like Features and Accompanying Diagnostically Challenging Carcinomas Patel, S; Roa JC; Tapia, O; Dursun, N; Bagci, P; Basturk, O; Cakir, A; Losada, H; Sarmiento, J; Adsay, V Squamous cell and adenosquamous carcinomas of the gallbladder: clinicopathological analysis of 34 cases identified in 606 carcinomas Roa JC; Tapia, O; Cakir, A; Basturk, O; Dursun, N; Akdemir, D; Saka, B; Losada, H; Bagci, P; Adsay, NV Genotyping of Human Papillomavirus in Cervical Intraepithelial Neoplasia in a High-Risk Population Ili, CG; Brebi, P; Lopez J; Garcia, P; Leal, P; Suarez, E; Roa JC Prognostic factors for gastric cancer without lymph node involvement 13 of 33

14 Tapia, O; Villaseca, M; Bellolio, E; Araya, JC; Roa JC Pathological features associated with survival in early gastric cancer Tapia, O; Garcia, P; Manterola, C; Villaseca, M; Araya, JC; Roa JC Pericytes: New Approaches in Regenerative Therapy, Cerebrovascular Pathology and Cancer Montiel-Eulefi, E; Diaz, LB; Leal, P; Roa JC; Risopatron, J; Salazar, LA; Romero, F; Sanchez, R P53 Gene mutation in gallbladder cancer Roa, I; Melo, A; Roa J; Araya, J; Villaseca, M; de Aretxabala, X 2000 Clinical and pathological features of early gallbladder carcinoma Roa, I; de Aretxabala, X; Araya, JC; Villaseca, M; Roa J; Guzman, P 2001 Pathological findings in surgical reinterventions for gallbladder cancer in patients with and without preoperative chemo and radiotherapy Roa, I; de Aretxabala, X; Araya, JC; Villaseca, M; Roa J; Burgos, L; Guzman, P 2001 CD44 (HCAM) expression in subserous gallbladder carcinoma Roa, I; Villaseca, M; Araya, J; Roa J; de Aretxabala, X; Ibacache, G; García M 2001 Expression of cadherine-catenine complex in subserous gallbladder carcinoma Roa, I; Ibacache, G; Melo, A; Morales, E; Villaseca, M; Araya, J; Roa J; Guzman, P; de Aretxabala, X 14 of 33

15 2002 Is gallbladder cancer a tumor with bad prognosis? Roa, I; de Aretxabala, X; Roa J; Araya, JC; Villaseca, M; Guzman, P; Burgos, L 2002 Morphological prognostic factors in gallbladder cancer Roa, I; de Aretxabala, X; Araya, JC; Villaseca, M; Roa J; Ibacache, TMG; Burgos, L; Munoz, S 2002 DNA content and survival in subserous gallbladder carcinoma Roa, I; de Aretxabala, X; Fuentealba, P; Cabrera, ME; Araya, JC; Roa J Clinicopathological features of gallbladder polyps and adenomas Roa, I; de Aretxabala, X; Morgan, R; Molina, R; Araya, JC; Roa J; Ibacahe, G Aneurysmal bone cyst of the maxilla. Report of one case Guzman, P; Baeza, A; Araya, J; Roa J; Brevis, L; Torres, P 2005 Immunohistochemical expression of the E-cadherin-catenin complex in gastric cancer Guzman, P; Araya, J; Villaseca, M; Roa, I; Melo, A; Munoz, S; Roa J Preneoplastic lesions in gallbladder cancer Roa, I; de Aretxabala, X; Araya, JC; Roa J 15 of 33

16 Gallstones and gallbladder cancer-volume and weight of gallstones are associated with gallbladder cancer: A case-control study Roa, I; Ibacache, G; Roa J; Araya, J; de Aretxabala, X; Munoz, S Malignant melanoma in Chile: an unusual distribution of primary sites in men from low socioeconomic strata Zemelman, V; Roa J; Tagle, SR; Valenzuela, CY Papillary carcinoma in a thyroglossal duct cyst. Report of two cases Guzman, P; Baeza, A; Cabello, A; Montecinos A.; Leal, C; Roa J 2008 Concomitant presence of a gastric adenocarcinoma and gastrointestinal stromal tumor. Report of one case Antonio, L; Guzman, P; Villaseca, M; Araya, J; de Toro, G; Roa J 2009 Morphological findings in fatal cases of hantavirus cardiopulmonary syndrome. Report of 7 autopsies Guzman, P; Tapia, O; Villaseca, M; Araya, J; Antonio, L; Lee, B; Roa J Oral and oropharingeal squamous cells carcinoma. Clinico-pathological study Guzman, P; Villaseca, M; Antonio, L; Araya, J; Aravena, P; Cravero, C; Pino, P; Roa J Gallstones and gallbladder cancer-volume and weight of gallstones are associated with gallbladder cancer: A case-control study Roa, I; Ibacache, G; Roa J; Araya, J; de Aretxabala, X; Munoz, S 16 of 33

17 Preneoplastic lesions in gallbladder cancer Roa, I; de Aretxabala, X; Araya, JC; Roa J Early Gallbladder Cancer: Is Further Treatment Necessary? SCOPUS de Aretxabala, X; Roa, I; Hepp, J; Maluenda, F; Mordojovich, G; Leon J.; Roa JC 2009 Gallstones and gallbladder cancer-volume and weight of gallstones are associated with gallbladder cancer: A case-control study Roa, I; Ibacache, G; Roa J; Araya, J; de Aretxabala, X; Munoz, S Gallstones and gallbladder cancer-volume and weight of gallstones are associated with gallbladder cancer: A case-control study Roa, I; Ibacache, G; Roa J; Araya, J; de Aretxabala, X; Munoz, S Preneoplastic lesions in gallbladder cancer Roa, I; de Aretxabala, X; Araya, JC; Roa J Chemoradiotherapy in gallbladder cancer de Aretxabala, X; Roa, I; Berrios, M; Hepp, J; Gallardo, J; Cordova, A; Roa JC; Leon J.; Maluenda, F Microsatellite instability, prognosis and metastasis in gastric cancers from a low-risk population SCOPUS Schneider, BG; Bravo, JC; Roa JC; Roa, I; Kim, MC; Lee, KM; Plaisance, KT; McBride, CM; Mera, R 17 of 33

18 2000 Microsatellite instability in preneoplastic and neoplastic lesions of the gallbladder Roa JC; Roa, I; Correa, P; Vo, Q; Araya, JC; Villaseca, M; Guzman, P; Schneider, BG 2005 Gallbladder cancer: An analysis of a series of 139 patients with invasion restricted to the subserosal layer SCOPUS de Aretxabala, X; Roa, I; Burgos, L; Losada, H; Roa JC; Mora, J; Hepp, J; Leon J.; Maluenda, F Prognostic factors of phyllodes tumor of the breast SCOPUS Roa JC; Tapia, O; Carrasco, P; Contreras E; Araya, JC; Munoz, S; Roa, I Chemoradiotherapy in gallbladder cancer de Aretxabala, X; Roa, I; Berrios, M; Hepp, J; Gallardo, J; Cordova, A; Roa JC; Leon J.; Maluenda, F Promoter methylation profile in gallbladder cancer SCOPUS Roa JC; Anabalon, L; Roa, I; Melo, A; Araya, JC; Tapia, O; de Aretxabala, X; Munoz, S; Schneider, B Description of Echinococcus granulosus genotypes in human hydatidosis in a region of southern Chile SCOPUS Manterola, C; Benavente, F; Melo, A; Vial, M; Roa JC 2008 Serial analysis of gene expression identifies connective tissue growth factor expression as a prognostic biomarker in gallbladder cancer SCOPUS Alvarez, H; Corvalan, A; Roa JC; Argani, P; Murillo, F; Edwards, J; Beaty, R; Feldmann, G; Hong, SM; Mullendore, M; Roa, I; Ibanez, L; Pimente, F; Diaz, A; Riggins, GJ; Maitra, A 18 of 33

19 2008 Promoter Methylation Profile in Preneoplastic and Neoplastic Gallbladder Lesions SCOPUS Garcia, P; Manterola, C; Araya, JC; Villaseca, M; Guzman, P; Sanhueza, A; Thomas, M; Alvarez, H; Roa JC 2009 HPV genotyping from invasive cervical cancer in Chile SCOPUS Roa JC; Garcia, P; Gomez, J; Fernandez, W; Gaete F; Espinoza, A; Lepetic, A; Suarez, E 2009 Review Gallbladder cancer: a morphological and molecular update Goldin, RD; Roa JC 2009 Early Gallbladder Cancer: Is Further Treatment Necessary? SCOPUS de Aretxabala, X; Roa, I; Hepp, J; Maluenda, F; Mordojovich, G; Leon J.; Roa JC 2009 The Axl receptor tyrosine kinase is an adverse prognostic factor and a therapeutic target in esophageal adenocarcinoma Alvarez, H; Montgomery, EA; Karikari, C; Canto, M; Dunbar, KB; Wang, JS; Feldmann, G; Hong, SM; Haffner, MC; Meeker, AK; Holland, SJ; Yu, JX; Heckrodt, TJ; Zhang J.; Ding, PY; Goff, D; Singh, R; Roa JC; Marimuthu, A; Riggins, GJ; Eshleman, JR; Nelkin, BD; Pandey, A; Maitra, A Genotyping of Human Papillomavirus in Cervical Intraepithelial Neoplasia in a High-Risk Population Ili, CG; Brebi, P; Lopez J; Garcia, P; Leal, P; Suarez, E; Roa JC Widespread Hypomethylation Occurs Early and Synergizes with Gene Amplification during Esophageal Carcinogenesis 19 of 33

20 Alvarez, H; Montgomery E.A.; Maitra, A; Opalinska J.; Zhou, L; Sohal D.; Yu, Y; Montagna C.; Mo Y.; Bhagat T.; Cannizzaro L.; Thompson R.F.; Suzuki, M; Greally J.M.; Verma, A; Fazzari M.J.; Canto, M; Dunbar K.B.; Wang, J; Meltzer, S; Roa J.C.; Ramesh, K. H.; Mollenhauer J.; Melnick A. Hyalinizing Cholecystitis and Associated Carcinomas: Clinicopathologic Analysis of a Distinctive Variant of Cholecystitis With Porcelain-like Features and Accompanying Diagnostically Challenging Carcinomas Patel, S; Roa JC; Tapia, O; Dursun, N; Bagci, P; Basturk, O; Cakir, A; Losada, H; Sarmiento, J; Adsay, V Squamous cell and adenosquamous carcinomas of the gallbladder: clinicopathological analysis of 34 cases identified in 606 carcinomas Roa JC; Tapia, O; Cakir, A; Basturk, O; Dursun, N; Akdemir, D; Saka, B; Losada, H; Bagci, P; Adsay, NV Intracholecystic Papillary-Tubular Neoplasms (ICPN) of the Gallbladder (Neoplastic Polyps, Adenomas, and Papillary Neoplasms That Are >= 1.0 cm) Clinicopathologic and Immunohistochemical Analysis of 123 Cases Adsay, V; Jang K.-T.; Roa J.C.; Escalona O.T.; Dursun, N; Ohike, N; Bagci, P; Basturk, O; Bandyopadhyay, S; Cheng J.D.; Sarmiento J.M.; Goodman, M; Kong S.Y.; Terry, P 2012 Mucinous Carcinomas of the Gallbladder Clinicopathologic Analysis of 15 Cases Identified in 606 Carcinomas Dursun, N; Escalona O.T.; Roa J.C.; Basturk, O; Bagci, P; Cakir, A; Cheng, J; Sarmiento, J; Losada, H; Kong S.Y.; Ducato, L; Goodman, M; Volkan Adsay N Pathologic staging of pancreatic, ampullary, biliary, and gallbladder cancers: pitfalls and practical limitations of the current AJCC/UICC TNM staging system and opportunities for improvement Adsay N.V.; Bagci, P; Tajiri, T; Oliva, I; Ohike, N; Balci, S; Gonzalez R.S.; Basturk, O; Jang K.-T.; Roa J.C of 33

21 Clinical relevance of ErbB-2/HER2 nuclear expression in breast cancer Schillaci, R; Guzman, P; Cayrol F.; Beguelin, W; Diaz Flaque M.C.; Proietti C.J.; Pineda, V; Palazzi J.; Frahm I.; Charreau E.H.; Maronna, E; Roa J.C.; Elizalde P.V TRANSCRIPTOS DE FUSIÓN DEL GEN BCR/ABL EN PACIENTES CON LEUCEMIA MIELOIDE CRÓNICA Artigas, Carmen Gloria; Melo, Angelica; Roa, Juan Carlos; Roa, Ivan; Quijada, Ingrid; Vittini, Cecilia; Cabrera, María Elena; Risueño, Concepción 2003 Case Report Hepatocarcinoma con componente sarcomatoide: Caso clínico 2007 Descripción de genotipos de Echinococcus granulosus obtenidos de especímenes de hidatidosis humana Manterola, Carlos; Melo, Angelica; Vial, Manuel; Roa, Juan Carlos; MORA, JAVIER Prevalencia de la infección genital por virus papiloma humano en hombres universitarios voluntarios de la IX Región, Chile Guzmán, Pablo; Ili, Carmen; Rifo, Patricio; Briceño, Gastón; Araya, Juan; Villaseca, Miguel; Roa, Juan Carlos 2008 Los Pericitos: Nuevos Enfoques en la Terapia Regenerativa, Patología Cerebrovascular y Cáncer Montiel-Eulefi, Enrique; Barrientos Díaz, Leticia; Leal, Pamela; Roa, Juan Carlos; Risopatrón, Jennie; Salazar, Luis A; Romero, Fernando; Sánchez, Raúl Carcinoma incipiente de la vesícula biliar: Estudio clínico-patológico y pronóstico de 196 casos ROA E, IVÁN; DE ARETXABALA U, XABIER; Araya O, Juan C; VILLASECA H, MIGUEL; Roa S, Juan; GUZMÁN G, PABLO of 33

22 Elementos morfológicos pronósticos en el cáncer de la vesícula biliar ROA E, IVÁN; DE ARETXABALA U, XABIER; Araya O, Juan C; VILLASECA H, MIGUEL; Roa S, Juan; Ibacache S, TM Gilda; BURGOS S, LUIS; Muñoz N, Sergio 2002 Es el cáncer de la vesícula biliar una enfermedad de mal pronóstico en Chile? ROA E, IVÁN; DE ARETXABALA U, XABIER; Roa S, Juan; Araya O, Juan C; VILLASECA H, MIGUEL; GUZMÁN G, PABLO; BURGOS S, LUIS 2002 Carcinoma subseroso de la vesícula biliar: expresión del complejo caderina-catenina ROA E, IVÁN; IBACACHE S, GILDA; Melo A, Angélica; Morales M, Erick; VILLASECA H, MIGUEL; Araya O, Juan; Roa S, Juan; GUZMÁN G, PABLO; DE ARETXABALA U, XABIER 2002 Carcinoma epidermoide oral y orofaríngeo: Estudio clínico-patológico GUZMÁN G, PABLO; VILLASECA H, MIGUEL; Antonio P, Lilia; Araya O, Juan; Aravena M, Paola; Cravero P, Carla; Pino M, Pilar; Roa S, Juan Pólipos y adenomas de la vesícula biliar: consideraciones clínico-patológicas ROA E, IVÁN; Aretxabala U, Xabier de; Morgan F, René; Molina U, Ricardo; Araya O, Juan C; Roa S, Juan; Ibacahe S, Gilda Contenido de ADN y sobrevida en el carcinoma subseroso de la vesícula biliar ROA E, IVÁN; Aretxabala U, Xabier de; Fuentealba A, Patricia; Cabrera C, María Elena; Araya O, Juan C; Roa S, Juan Case Report 22 of 33

23 Quiste aneurismático del maxilar superior: Reporte de un caso 2005 Expresión inmunohistoquímica del complejo E-caderina-catenina en cáncer gástrico: Relación con variables clínico-morfológicas y sobrevida de pacientes GUZMÁN G, PABLO; Araya O, Juan; VILLASECA H, MIGUEL; ROA E, IVÁN; Melo A, Angélica; Muñoz N, Sergio; Roa S, Juan Case Report ADENOCARCINOMA ENDOMETRIAL CONCOMITANTE CON TUMOR ESTROMAL BENIGNO DEL ENDOMETRIO 2008 Case Report Carcinoma papilar en quiste del conducto tirogloso: Reporte de dos casos 2008 Case Report Adenocarcinoma gástrico primario concomitante con tumor estromal gastrointestinal: Reporte de un caso y revisión de literatura 2009 Hallazgos morfológicos en casos fatales de síndrome cardiopulmonar por hantavirus: Estudio de 7 autopsias GUZMÁN G, PABLO; TAPIA E, OSCAR; VILLASECA H, MIGUEL; Araya O, Juan; Antonio P, Lilia; Lee O, Bolívar; Roa S, Juan Detección de micrometástasis en médula ósea de pacientes con cáncer de vesícula biliar Roa S, Juan C; DE ARETXABALA U, XABIER; Melo A, Angélica; Faria, Gaspar; Araya O, Juan C; Villaseca H, 23 of 33

24 Miguel A; GUZMÁN G, PABLO; ROA E, IVÁN Genotipificación del virus papiloma humano en mujeres con adenocarcinoma cervical de la Región de La Araucanía-Chile Melo A, Angélica; GARCÍA M, PATRICIA; CAPURRO V, ITALO; GUZMÁN G, PABLO; Brebi M, Priscila; Ili G, Carmen; LÓPEZ M, JAIME; Roa S, Juan C Detección de secuencias del gen BCR-ABL mediante RT-PCR en pacientes con leucemia en la IX Región: Chile Artigas A, Carmen Gloria; Melo A, Angélica; Roa S, Juan Carlos; Páez F, Eduardo; Vittini de R, Cecilia; Arriagada M, Mónica; González O, Luis; Pflaumer F, Erna; ROA E, IVÁN 2002 Tumores del Estroma Gastrointestinal (GIST): Características Clinico-Morfológicas y Perfil Inmunohistoquímico TAPIA E, OSCAR; Roa S, Juan Carlos Case Report Carcinosarcoma de la vesícula biliar: Caso clínico Prevalencia de enfermedad diverticular del apéndice cecal en pacientes apendicectomizados por apendicitis aguda Muñoz C, César; MANSILLA E, JUAN; Roa S, Juan Carlos; Heider C, Claudia Factores asociados al pronóstico de pacientes operados por cáncer gástrico avanzado TAPIA E, OSCAR; Roa S, Juan Carlos; Manterola D, Carlos; PUGA A, VALENTINA; VILLASECA H, MIGUEL; ARAYA O, JUAN CARLOS 24 of 33

25 Factores morfológicos asociados al pronóstico de pacientes operados por cáncer gástrico incipiente TAPIA E, OSCAR; GARCÍA M, PATRICIA; Manterola D, Carlos; VILLASECA H, MIGUEL; ARAYA O, JUAN CARLOS; Roa S, Juan Carlos Puntaje de Gleason en cáncer de próstata: Correlación de la biopsia por punción y prostatectomía radical TAPIA E, OSCAR; BELLOLIO J, ENRIQUE; Roa S, Juan Carlos; GUZMÁN G, PABLO; VILLASECA H, MIGUEL; ARAYA O, JUAN CARLOS Cáncer gástrico sin compromiso ganglionar linfático (pn0): características demográfico-patológicas y factores pronósticos TAPIA E, OSCAR; VILLASECA H, MIGUEL; BELLOLIO J, ENRIQUE; ARAYA O, JUAN CARLOS; Roa S, Juan Carlos Compromiso ganglionar extracapsular en pacientes con cáncer gástrico: determinación del valor pronóstico TAPIA E, OSCAR; VILLASECA H, MIGUEL; ARAYA O, JUAN CARLOS; Roa S, Juan Carlos Mutación puntual del gen supresor de tumores TP53 en lesiones preneoplásicas y neoplásicas del estómago: cross- sectional study in a high risk region ARAYA O, JUAN CARLOS; Roa S, Juan Carlos; Villaseca H, Miguel Ángel; ROA E, IVÁN; GUZMÁN G, PABLO; Alvarado C, César 2003 Case Report Hipotiroidismo primario luego de la resección de un Struma ovarii: Report of one case 2003 Case Report 25 of 33

26 Hipofosfatemia revertida al extirpar hemangioendotelioma compuesto del dedo mayor del pie 2003 Inestabilidad microsatelital y pérdida de la heterocigocidad en lesiones neoplásicas y preneoplásicas gástricas Roa S, Juan Carlos; ARAYA O, JUAN CARLOS; Villaseca H, Miguel Ángel; ROA E, IVÁN; Correa, Pelayo 2003 Alteraciones genéticas en gastritis crónica: Estudio de inestabilidad microsatelital y pérdida de la heterocigocidad Roa S, Juan Carlos; Villaseca V, Miguel Angel; ROA E, IVÁN; ARAYA O, JUAN CARLOS 2003 Tipificación del virus papiloma humano (VPH) en lesiones preneoplásicas y carcinoma del cuello uterino en mujeres de la IX Región-Chile Melo A, Angélica; Montenegro H, Sonia; Hooper, Terryl; CAPURRO V, ITALO; Roa S, Juan Carlos; ROA E, IVÁN 2003 Quimiorradioterapia de neoadyuvancia en cáncer de vesícula biliar DE ARETXABALA U, XABIER; LOSADA M, HÉCTOR; MORA P, JAVIER; ROA E, IVÁN; BURGOS S, LUIS; Yáñez R, Eduardo; Quijada P, Ingrid; Roa S, Juan Carlos Cáncer de la vesícula biliar: Manejo de pacientes con invasión de la túnica muscular DE ARETXABALA U, XABIER; ROA E, IVÁN; MORA P, JAVIER; Pincheira S, Oscar; BURGOS SJ, LUIS; SILVA A, JORGE; Roa S, Juan Carlos Mutación del gen K-ras en el cáncer de la vesícula biliar Roa S, Juan Carlos; ROA E, IVÁN; Aretxabala U, Xabier de; Melo A, Angélica; Faría O, Gaspar; TAPIA E, 26 of 33

27 OSCAR Patrón de metilación génico en el cáncer de mama Roa S, Juan Carlos; Anabalón R, Leonardo; TAPIA E, OSCAR; Martínez S, Javier; ARAYA O, JUAN CARLOS; VILLASECA H, MIGUEL; GUZMÁN G, PABLO; ROA E, IVÁN Relación de la genotipificación de Helicobacter pylori con la forma e intensidad de la gastritis en población adulta portadora de patología gástrica benigna ARAYA O, JUAN CARLOS; Anabalón R, Leonardo; ROA E, IVÁN; Bravo E, María; Villaseca H, Miguel Ángel; GUZMÁN G, PABLO; Roa S, Juan Carlos Inactivación del gen CDKN2A (p16) en cáncer de la vesícula biliar Roa S, Juan Carlos; Vo, Quynh; ARAYA O, JUAN CARLOS; VILLASECA H, MIGUEL; GUZMÁN G, PABLO; IBACACHE S, GILDA; DE ARETXABALA U, XABIER; ROA E, IVÁN Inestabilidad microsatelital en lesiones preneoplásicas y neoplásicas del cuello uterino: Correlación con el genotipo del virus papiloma humano Roa S, Juan Carlos; Martínez S, Ricardo; Montenegro, Sonia; ROA E, IVÁN; CAPURRO V, ITALO; IBACACHE S, GILDA; Melo A, Angélica 2007 Detección y tipificación de virus papiloma humano en lesiones preneoplásicas del cuello uterino mediante PCR-RFLP Aedo A, Susana; Melo A, Angélica; García, Patricia; GUZMÁN G, PABLO; CAPURRO V, ITALO; Roa S, Juan Carlos 2007 Case Report Colitis quística profunda posradioterapia: Caso clínico 27 of 33

28 2007 Estudio comparativo de detección del virus papiloma humano (VPH) en muestras citológicas y biopsias de cuello uterino Melo A, Angélica; ROA E, IVÁN; Montenegro H, Sonia; CAPURRO V, ITALO; Roa S, Juan Carlos 2005 Estudio del patrón de metilación génico en el cáncer gástrico en Chile Roa S, Juan Carlos; Anabalón R, Leonardo; ROA E, IVÁN; TAPIA E, OSCAR; Melo, Angelica; VILLASECA H, MIGUEL; ARAYA O, JUAN CARLOS 2005 Mutación del gen K-ras en tumores pancreático-biliares Roa S, Juan Carlos; Anabalón R, Leonardo; TAPIA E, OSCAR; Melo A, Angélica; DE ARETXABALA U, XABIER; ROA E, IVÁN 2005 Frecuencia de los genes de fusión TEL/AML1 y BCR/ABL en pacientes pediátricos con leucemia linfoblástica aguda Artigas A, Carmen Gloria; Cabrera C, María Elena; Melo A, Angélica; Páez F, Eduardo; Arriagada M, Mónica; Astete A, Carmen; ROA E, IVÁN; Roa S, Juan Carlos Estudio de patrones de metilación génica en tumores del tubo digestivo Roa S, Juan Carlos; GARCÍA M, PATRICIA; Melo A, Angélica; TAPIA E, OSCAR; VILLASECA H, MIGUEL; ARAYA O, JUAN CARLOS; GUZMÁN G, PABLO 2008 Detección y tipificación de virus papiloma humano en adenocarcinoma de cuello uterino mediante reverse line blot, Región de La Araucanía, Chile Brebi M, Priscilla; ILI G, CARMEN GLORIA; LÓPEZ M, JAIME; GARCÍA M, PATRICIA; Melo A, Angélica; Montenegro H, Sonia; Leal R, Pamela; GUZMÁN G, PABLO; Roa S, Juan Carlos of 33

29 Cáncer de Colon y Recto: Descripción Morfológica y Clínica de 322 Casos TAPIA E, OSCAR; Roa S, Juan Carlos; Manterola D, Carlos; BELLOLIO J, ENRIQUE Cáncer gástrico en una región de Chile: Comparación de variables clínicas y morfológicas en dos períodos ( y ) TAPIA E, OSCAR; Roa S, Juan Carlos; Manterola D, Carlos; VILLASECA H, MIGUEL; GUTIÉRREZ M, VALENTINA; FLORES O, PLÁCIDO; ARAYA O, JUAN CARLOS; GUZMÁN G, PABLO Descripción clínico-morfológica y factores pronósticos en carcinomas de apéndice cecal: Estudio de cohorte TAPIA E, OSCAR; Manterola D, Carlos; VILLASECA H, MIGUEL; ARAYA O, JUAN CARLOS; GUZMÁN G, PABLO; Roa S, Juan Carlos Evaluación de factores histológicos pronósticos de sobrevida en melanoma maligno cutáneo, seguimiento de 13 años BELLOLIO J, ENRIQUE; SAN MARTÍN L, ALVARO; Quiñiñir S, Luis; ORELLANA C, JUAN; TAPIA E, OSCAR; RIFO L, PATRICIO; Roa S, Juan Carlos; VILLASECA H, MIGUEL Carcinoma de células en anillo de sello gástrico: Descripción clínico-morfológica y valor pronóstico TAPIA E, OSCAR; GUTIÉRREZ M, VALENTINA; Roa S, Juan Carlos; Manterola D, Carlos; VILLASECA H, MIGUEL; ARAYA O, JUAN CARLOS Case Report Hidatidosis de la mama: Reporte de un caso Case Report 29 of 33

30 Atrofia vellositaria duodenal inducida por micofenolato mofetil: Caso clínico Review Alteraciones genéticas en lesiones preneoplásicas y neoplásicas de la vesícula biliar CASTILLO A, JONATHAN; GARCÍA M, PATRICIA; Roa S, Juan Carlos Detección y tipificación de virus papiloma humano en lesiones preneoplásicas de cuello uterino LÓPEZ M, JAIME; ILI G, CARMEN GLORIA; Brebi M, Priscilla; GARCÍA M, PATRICIA; CAPURRO V, ITALO; GUZMÁN G, PABLO; SUÁREZ P, EUGENIO; OJEDA F, JOSÉ MANUEL; Roa S, Juan Carlos Case Report Hidatidosis ósea: Reporte de 5 casos y revisión de la literatura Early gallbladder carcinoma has a favorable outcome but Rokitansky-Aschoff sinus involvement is an adverse prognostic factor User Generated SILAC-based quantitative proteomic analysis of gastric cancer secretome User Generated Treatment of the residual cavity during hepatic hydatidosis surgery: a cohort study of capitonnage vs. omentoplasty User Generated 30 of 33

31 Neoadjuvant chemoradiation therapy for borderline pancreatic adenocarcinoma: report of two cases User Generated Connective Tissue Growth Factor Immunohistochemical Expression Is Associated With Gallbladder Cancer Progression User Generated Inhibition of connective tissue growth factor (CTGF/CCN2) in gallbladder cancer cells leads to decreased growth in vitro User Generated CMS: A Web-Based System for Visualization and Analysis of Genome-Wide Methylation Data of Human Cancers User Generated Cellular FLICE-like Inhibitory Protein Long Form (c-flipl) Overexpression is Related to Cervical Cancer Progression User Generated Immunohistochemical Expression of Phospho-mTOR Is Associated With Poor Prognosis in Patients With Gallbladder Adenocarcinoma User Generated AKT/mTOR substrate P70S6K is frequently phosphorylated in gallbladder cancer tissue and cell lines User Generated 31 of 33

32 Leal, P; Garcia, P; Sandoval, A; Buchegger, K; Weber, H; Tapia, O; Roa J.C. Promoter methylation profile in gallbladder cancer SCOPUS Roa JC; Anabalon, L; Roa, I; Melo, A; Araya, JC; Tapia, O; de Aretxabala, X; Munoz, S; Schneider, B Actualizacion Diagnóstico de la infección por virus papiloma humano en el hombre Genome-wide methylation profiling reveals Zinc finger protein 516 (ZNF516) and FK-506binding protein 6 (FKBP6) promoters frequently methylated in cervical neoplasia, associated with HPV status and ethnicity in a Chilean population 2014 Frequency of Chlamydia trachomatis infection in a group of women from Region of Araucania, Chile Exome sequencing identifies frequent inactivating mutations in BAP1, ARID1A and PBRM1 in intrahepatic cholangiocarcinomas Errata Early gallbladder carcinoma has a favorable outcome but Rokitansky-Aschoff sinus involvement is an adverse prognostic factor (vol 463, pg 651, ) 32 of 33

33 Detection of Hypermethylation in Tumor Suppressor Genes APAF1, ASSP1, p73 and FHIT in Childhood Acute Lymphoblastic Leukemia Letter Criteria for Pathologic Sampling of Gallbladder Specimens Detection of human papilloma virus infection in men Review Human papillomavirus infection in men and its relation with cancer: Current status and prospectics 33 of 33