Date: 8 March Curriculum vitae Thomas Brioche

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1 Date: 8 March 2013 Curriculum vitae Thomas Brioche

2 PERSONAL DATA Family name: Brioche Nacionality: French Forename: Thomas Date of birth : 12 March 1987 Gender: M PRESENT PROFESIONAL POSITION Phd Student of Physiology Institution: University of Valencia Faculty, School or Institute: Medicine Department: Physiology Address: Avda. Blasco Ibanez, Valencia. Country: Spain Telephone (indicate prefix, number and extension): Fax: thomas.brioche@gmail.com Field of study (UNESCO codes): (Physiology) Professional status: Phd Student Start date: April 2010 Administrative status Permanent Staff Hired on contracts Acting Fellowship holder Others specify: Full-time Part-time PRESENT RESEARCH AREA Brief summary (key words). Physiology of Exercise Anti-oxidant Anti-Aging Sarcopenia Longevity ACADEMIC BACKGROUND Bachelor Centre Date International Master s degree (Hons) in Physical Activity and Sport Sciences in Europe specialty «Movement Sport Healt BSc Science and Technology of Sport and Physical Activity (STAPS)- Specialty University of Rennes 2 in collaboration with University of Valencia 2010 University of Rennes

3 Physical Activity for the Disabled - BSc (Hons) in Science and Technology of Sport and Physical Activity (STAPS) Specialty Physical Training University of Rennes PAST SCIENTIFIC EXPERIENCE (*) Position R&D Centre Institution (**) Start date End date Laboratory University of Fellowship Movement, Sport, Rennes Health (*) The information contained in this chart will be used to verify the placement requirements, according to the section 42.1.c) of the Call. (**) If the Institution is a joint centre, you should specify all the centres involved in running it. LANGUAGES (N = NORMAL, G = GOOD, P = PERFECTLY) Language Speaking Reading Writing Inglish Good Good Good Spanish Perfectly Perfectly Perfectly

4 PARTICIPATION IN RESEARCH PROJECTS PUBLICATIONS BOOKS Fabian Sanchis-Gomar, Vladimir Martinez-Bello, Helios Pareja-Galeano, Brioche T, Mari Carmen Gómez-Cabrera. Chapter title: An overview of doping in sports. In Nutrition and Enhanced Sports Performance: Recommendations for Muscle Building. Being published by ELSEVIER ARTICLES Brioche T*, Cuesta S*, Gomez-Cabrera MC, Gratas-Delamarche A, Tresguerres JA, and Viña J. Growth hormone replacement therapy prevents sarcopenia by a dual mechanism: stimulation of protein synthesis and of antioxidant defenses. (Manuscript Submitted to the Journals of Gerontology Series A Biological Sciences) Helios Pareja-Galeano; Thomas Brioche; Fabián Sanchis-Gomar; Consuelo Escrivá; Mar Dromant; Mari Carmen Gómez-Cabrera; José Viña. Effects of physical exercise on cognitive alterations and oxidative stress in an APP/PSN1 transgenic model of Alzheimer's disease. Rev Esp Geriatr Gerontol Sep;47(5): Helios Pareja-Galeano*, Thomas Brioche*, Fabian Sanchis-Gomar, Angeles Montal, Carmen Jovaní3, Cecilia Martínez-Costa4, Mari Carmen Gomez-Cabrera, and Jose Viña. Impact of exercise training on neuroplasticity-related growth factors in adolescents. Accepted in Journal of Musculoskeletal and Neuronal Interactions, 2013 Mari Carmen Gomez-Cabrera, Beatriz Ferrando, Thomas Brioche, Fabian Sanchis- Gomar, and Jose Viña. Exercise and antioxidant supplements in the elderly. Accepted in Journal of Sport and Health Science Fabian Sanchis-Gomar, Helios Pareja Galeano, Thomas Brioche, Giuseppe Lippi. Addressing altitude exposure in the Athlete s Biological Passport. Submitted to Journal of Strength and Conditioning Research,2013 Fabian Sanchis-Gomar, Vladimir E. Martinez-Bello, Frédéric Derbré, Ernesto Garcia- Lopez, Rebeca Garcia-Valles, Thomas Brioche, Beatriz Ferrando, Sandra Ibanez- Sania, Helios Paleja-Galeano, Mari Carmen Gomez-Cabrera, José Viña. Rapid hemodilution induced by desmopressin after erythropoietin administration in humans. JOURNAL OF HUMAN SPORT & EXERCISE, 2011; 6 (2) Sanchis-Gomar, F ; Martinez-Bello, V. E. ; Martinez-Bello, D. A. ; Nascimento, A. L. ; García-Vallés, R. ; Brioche, T. ; Ferrando, B. ; Ibáñez-Sania, S. ; Pareja-Galeano, H. ;

5 Gómez-Cabrera, M.C. ; Viña, J. Modificaciones hematologicas inducidas por eritropoyentina frente a hypoxia normobarica intermitente. Motricidad. European Journal of Human Movement, 2010: 25, STAYS IN INTERNATIONALLY RECOGNIZED CENTRES Centre: Laboratory Movement, Sport, Health: Research area: Obesity and Adolescence and exercise: Effect of endurance training on plasma volume changes induced by the carrying out of incremental exhaustive exercise Supervisor : Pr Sophie Lemoine-Morrel, 2009 Centre: University of Valencia, Alzheimer's Disease and Physical Activity: Impact of training on aerobic physical skills, memory and behavior. Study in a transgenic mouse model (Supervisor : Pr Mari-Carmen Gomez), 2010, 4 meses PRESENTATIONS IN CONGRESSES Oral communications T Brioche. Mecanismo de prevención de la sarcopenia con hormona de crecimiento. Máster en Fisiología Envejecimiento saludable y ejercicio físico Mayo de Valencia, Spain Jovani Casano, C.; Brioche, T.; Pareja-Galeano, H.; Gómez-Cabrera, MC.; Montal, MA.; Viña, J.; Martínez Costa, C. RELACIÓN ENTRE EJERCICIO FÍSICO Y EL INCREMENTO DE FACTORES NEUROTRÓFICOS (BDNF E IGF- I)RELACIONADOS CONLA FUNCIÓN COGNITIVA EN ADOLESCENTES. XIX Congreso de la Sociedad Española de Gastroenterología, Hepatología y Nutrición Pediátrica. Las Palmas de Gran Canaria, España Mayo Pareja-Galeano, Helios, Brioche Thomas. EFFECTS OF EXERCISE TRAINING ON COGNITIVE DEFICITS AND BIOLOGICAL ALTERATIONS IN AN APP/PSN1 TRANSGENIC MICE MODEL FOR ALZHEIMER S DISEASE. The 20 th International Congress on Sport Science for Students. Semmelweis University. Budapest, Hungría Abril Pareja-GaleanoH., Brioche T., Jovani C., Montal MA, Sanchis-Gomar F., Gomez- Cabrera MC, Martinez-Costa C. and Viña J. El Entrenamiento físico esta asociado con un incremento periférico de factores neurotroficos en adolescentes. Posibles implicaciones en la function cognitiviva. IV Jornadas Nacionales de medicina del deporte de la federación española de medicina del deporte, November 2011, Reus, Spain POSTERS

6 T Brioche, S Cuesta, H Pareja-Galeano, H Cabo, MC Gomez-Cabrera, A Gratas Delamarche, JA Tresguerres, and J Viña. Beneficial Effects of Growth Hormone in the Treatment of Skeletal Muscle Aging. Role in Sarcopenia. Redox Signaling and Oxidative stress in Health and disease. IV Spanish and Portuguese meeting on Free radicals. June Valencia Spain Brioche T., Pareja-GaleanoH., Jovani C., Montal MA, Sanchis-Gomar F., Gomez- Cabrera MC, Martinez-Costa C. and Viña J., Blood concentrations of neurotrophic factors at differents times during the season of Young high level cyclists. A possible marker of overtraining? International Symposium on learning, Memory and cognitive function. Mechanisms, Pathology and therapeutics. 2011, Valencia, Spain Galeano, Helios. Brioche Thomas. EXERCISE TRAINING IS ASSOCIATED WITH A PERIPHERAL INCREASE IN IGF-I AND BDNF IN TEENAGERS. POSSIBLE ROLE OF CREB. Pareja- The 20 th International Congress on Sport Science for Students. Semmelweis University. Budapest, Hungría Abril Pareja-Galeano, H.; Brioche T.; Sanchis-Gomar, F.; Martínez-Bello, V.; Ferrando, B.; Garcia-Valles, R.; Gomez-Cabrera, MC. and Viña, J. EFFECTS OF EXERCISE TRAINING ON COGNITIVE DEFICITS AND BIOLOGICAL ALTERATIONS IN AN APP/PSN1 TRANSGENIC MICE MODEL FOR ALZHEIMER S DISEASE. SFRR-Europe Summer School Dietary factors and redox signalling. Spetses. Grecia Septiembre H Pareja-Galeano, T Brioche, VE Martínez-Bello, B Ferrando, R García-Vallés, E García-López, S Ibáñez-Sania, F Sanchis-Gomar, I Noguera, MC Gómez-Cabrera and J Viña EXERCISE TRAINING AS A THERAPEUTIC STRATEGY FOR ALZHEIMER S DISEASE IN A APPSWE,PSEN1DE9-TRANSGENIC MICE MODEL.VI Congreso International de la Asociacion Española de Ciensias Del Deporte, Elche, 2010 Pareja-GaleanoH., Brioche T., Jovani C., Montal MA, Sanchis-Gomar F., Gomez- Cabrera MC, Martinez-Costa C. and Viña J., Exercice Training is associated with a peripheral increase in neurotrophic factors in teenagers. Possible Role of CREB. International Symposium on learning, Memory and cognitive function. Mechanisms, Pathology and therapeutics. 2011, Valencia, Spain Mari Carmen Gomez Cabrera, H. Pareja-Galeano, T. Brioche, V.E. Martinez-Bello, B. Ferrando, Rebeca Garcia Valles, Jose Viña Ribes, Effects of exercise on cognitive alterations and oxidative stress in a double transgenic mice model for alzheimer s disease. 53 Congreso de la Socidedad Espanola de Geriatria y Gerontologia 2011, Malaga (Spain), (Best Poster Award) Ferrando B., Puchades C., Derbre F., Brioche T., Pareja-Galeano H., Garcia- Valles R., Cabo H., Diaz A., Cerda-Nicolas M., Comez-Cabrera Mc., Vina J. ROLE OF IKK-Α IN SKELETAL MUSCLE ATROPHY CAUSED BY HINDLIMB UNLOADING IN MICE.REDOX SIGNALING AND OXIDATIVE STRESS IN HEALTH AND DISEASE. International symposium. Valencia 2012 G. Olaso, B. Ferrando, F. Derbre, R. García, V.E. Martínez-Vello, F. Sanchis- Gomar, H. Pareja-Galeano, T. Brioche y J. Viña. BENEFICIOS DE LA ADMINISTRACIÓN DE ALOPURINOL EN LA PÉRDIDA DE MASA MUSCULAR CAUSADA POR INMOVILIZACIÓN. 5ª Reunión Nacional de la Sociedad Española de Medicina Geriátrica. Toledo, España Abril 2012.

7 R. García, D. Monleón, J.M. Morales, H. Pareja-Galeano, T. Brioche, B. Ferrando, A. Díaz, I. Noguera, M.C. Gómez-Cabrera y J. Viña.EL EJERCICIO ESPONTANEO DURANTE 20 MESES INDUCE CAMBIOS METABÓLICOS EN RATONES C57BL/6J. 5ª Reunión Nacional de la Sociedad Española de Medicina Geriátrica. Toledo, España Abril Ferrando,B., Derbre,F., Martinez-Bello, V.E., Sanchis-Gomar,F., Garcia-Valles,R., Romagnoli,M., Garcia-Lopez, E., Ibañez-Sania,S,. Brioche,T., Escriva,C., Sebastia,V., Diaz,A., Pareja-Galeano,H., Gomez-Cabrera,M.C., y Viña, J. Allopurinol prevents the loss of muscle mass induced by hindlimb unloading.molecular mechanisms. VI Congreso International de la Asociacion Española de Ciensias Del Deporte, Elche, 2010 Mari Carmen Gomez Cabrera, Frédéric Derbré, Vladimir Essau Martinez Bello, Fabian Sanchiz Gomar, Rebecca Garcia Valles, Sandra Ibanez Sania, Thomas Brioche, Beatriz Ferrando, Gloria Olaso Gonzales, Helios Pareja Galeano, Arlette Gratas Delamarche, Jose Vina. Age associated low mitocondrial biogénesis may be explained by a lack of reponse of PGC-1α to exercise. SFRR - Europe 2011 Meeting, Istanbul. Turkey Gomez-Cabrera MC, Ibanez-Sania S, Sanchiz-Gomar F, Martinez-Bello VE, Diaz A, Olaso-Gonzalez G, Ferrando B, Brioche T, Pareja-Galeano H, Garcia-Valles R, Vina J, Regulation of the p53 Protein levels by aerobic training. Protective effect of exercise on paraquat-induced toxicity.second International Conference on Environmental Stressors in Biology and Medicine, October 2011, Siena, Italy RESEARCH AWARDS Best Poster Award of the 53 Congreso de la Socidedad Espanola de Geriatria y Gerontologia 2011, Malaga (Spain), OTHER ACHIEVEMENTS Degree in animal experiments. Level 1. Veterinary School of Nantes. (2011)