FRANCISCO JAVIER OLIVER POZO

Transcripción

1 Ficha de investigador FRANCISCO JAVIER OLIVER POZO Grupo de Investigación: ONCOLOGIA E INMUNOLOGIA MOLECULAR (Cod.: CTS434) Departamento: Instituto de Parasitología y Biomedicina López-Neyra (CSIC-IPBLN). Biología Celular e Inmunología Código: Ficha del Directorio Producción 85 Artículos (74) Libros (0) Capítulos de Libros (4) dirigidas (7) Evolución producción Capítu Libros Artículos Proyectos dirigidos Proyectos (9) Contratos (0) Convenios (0) 2004 Año Proyectos en curso por año 4 3 Conve Contr Proye Año Actividades 0

2 Titulo publicación Fuente Tipo Fecha Allogeneic adipose-derived mesenchymal stromal cells ameliorate experimental autoimmune encephalomyelitis by regulating self-reactive t cell responses and dendritic cell function. Vasculogenic mimicry signaling revisited: focus on nonvascular ve-cadherin. Autophagy requires poly(adp-ribosyl)altion dependent ampk nuclear export Effect of poly adp(ribose) polymerase inhibition on glioblastoma Functional consequences for apoptosis by transcription elongation regulator 1 (tcerg1)-mediated bcl-x and fas/cd95 alternative splicing Parp targeting counteracts gliomagenesis through induction of mitotic catastrophe and aggravation of deficiency in homologous recombination in pten mutant glioma Interaction between parp-1 and hif-2 alpha in the hypoxic response. Parp targeting counteracts gliomagenesis through induction of mitotic catastrophe and aggravation of deficiency in homologous recombination in pten-mutant glioma Targeting parp-1 in breast cancer: the paradigm of a dna repair-based therapeutic strategy Growth and spontaneous differentiation of umbilical-cord stromal stem cells on activated carbon cloth Parp inhibition attenuates histopathological lesion in ischemia/reperfusion renal mouse model after cold prolonged ischemia Parp-1 regulates metastatic melanoma through modulation of vimentin-induced malignant transformation. Parp-1 participates in metastasic melanoma through regulation of vascular plasticity and vimentin-induced malignant transformation Parp-1 regulates metastatic melanoma through modulation of vimentin-induced malignant transformation. Papel de parp1 y del procesamiento de poli(adpribosilación) en autofagia: regulaci on sobre la ruta de ampk/mtorc1 Stem cells international Articulo 2017 Molecular cancer Articulo 2017 Cell death and differentiation Articulo Plos one Articulo 2015 Oncotarget Articulo 2015 Oncogene Articulo 2014 Oncotarget Articulo 2014 Descoberta, desenho e desenvolvimento no âmbito do programa iberoamericano-cyted Capítulo de libro 2014 Journal of materials chemistry b Articulo 2013 The scientific world journal Articulo 2013 Plos genetics Articulo 2013 Plos genetics Articulo 2013 Plos genetics Articulo 2013 Instituto de parasitología y biomedicina lópez-neyra (csic-ipbln). biología celular e inmunología Poly(adp-ribose) signaling in cell death. Molecular aspects of medicine Articulo 2013 Targeting parp-1 in breast cancer: the paradigm of a dna repair-based Umbilical-cord stromal stem cells grown and differentiation on an activated-carbon cloth: the importance of surface porosity. nitric oxide modulates hypoxia-inducible factor-1 and poly(adp-ribose) polymerase-1 cross-talk in response to hypobaric hypoxia Efecto de la inhibición de parp-1 sobre angiogénesis, metástasis y mimetismo vasculogénico en melanoma Cancer biomarkers Capítulo de libro Journal of materials chemistry b Articulo 2013 Journal of applied physiology Articulo

3 metástasis y mimetismo vasculogénico en melanoma Ros-induced dna damage and parp-1 are required for optimal induction of starvation-induced autophagy The importance of bystander effects in radiation therapy in melanoma skin-cancer cells and umbilical-cord stromal stem cells Human umbilical cord stromal stem cell express cd10 and exert contractile properties Inhibition of poly (adp-ribose) polymerase-1 enhances doxorubicin activity against liver cancer cells Nitric oxide modulates hypoxia-inducible factor-1 and poly(adp-ribose) polymerase-1 cross-talk in response to hypobaric hypoxia. Poly(adp-ribose)-dependent regulation of snail1 protein stability Poly(adp-ribose)-dependent regulation of snail1 protein stability. Tela de carbón activo: biomateriales para la proliferación de células mesenquimales Inhibition of poly (adp-ribose) polymerase decreases hepatocellular carcinoma growth by modulation of tumour-related gene expression Inhibition of poly (adp-ribose) polymerase-1 enhances doxorubicin activity against liver cancer cells Inhibition of poly (adp-ribose) polymerase decreases hepatocellular carcinoma growth by modulation of tumour-related gene expression. Parp-1 modulation of brain hif-1 in vivo response to hypoxia/reoxygenation is mediated by nitric oxide and fih Activated carbon cloth as support for mesenchymal stem cell growth and differentiation to osteocytes 2012 Cell research Articulo 2012 Radiotherapy and oncology Articulo 2012 Placenta Articulo 2011 Cancer letters Articulo 2011 Journal of applied physiology Articulo 2011 Oncogene Articulo 2011 Oncogene Articulo 2011 Boletín del grupo español del carbón Articulo 2011 Journal of hepatology Articulo 2010 Cancer letters Articulo 2010 Hepatology Articulo 2010 Neurochemistry Articulo 2010 Carbon Articulo 2009 Parp-1 is involved in autophagy induced by dna damage Autophagy Articulo 2009 Poly(adp-ribose) polymerase-1 modulation of in vivo response of brain hypoxia-inducible factor-1 to hypoxia/reoxygenation is mediated by nitric oxide and factor inhibiting hif Poly[adp-ribose] polymerase-1 expression is related to cold ischemia, acute tubular necrosis, and delayed renal function in kidney transplantation Poly[adp-ribose] polymerase-1 expression is directly related to acute tubular necrosis, cold ischemia, and delayed renal function in kidney transplantation Función de parp-1 en rutas de inestabilidad genómica e hipoxia: implicaciones en el control tumoral Parp-1 modulates deferoxamine-induced hif-1alpha accumulation through the regulation of nitric oxide and oxidative stress. Parp-1, nueva diana el el tratamiento del carcinoma hepatocelular Poly(adp-ribose)polymerase-1 (parp-1) in carcinogenesis: potential role of parp inhibitors in cancer treatment Journal of neurochemistry Articulo 2009 Plos one Articulo 2009 Plos one Articulo 2009 Instituto de parasitologia y biomedicina lopez neyra (ipbln)(delegación del c.s.i.c.en andalucía). biología celular e inmunología 2008 Journal of cellular biochemistry Articulo 2008 Instituto de parasitologia y biomedicina lopez neyra (ipbln)(delegación del c.s.i.c.en andalucía). biología celular e inmunología 2008 Clinical & translational oncology Articulo 2008

4 potential role of parp inhibitors in cancer treatment Quantitative detection of methylated esr1 and ? gene promoters in serum as candidate biomarkers for diagnosis of breast cancer and evaluation of treatment efficacy Interaction between atm and parp-1 in response to dna damage and sensitization of atm deficient cells through parp inhibition Modulation of transcription by parp-1: consequences in carcinogenesis and inflammation. Therapeutic effect of a poly(adp-ribose) polymerase-1 inhibitor on experimental arthritis by downregulating inflammation and th1 response. Inhibition of poly(adp-ribose) polymerase modulates tumor-related gene expression, including hypoxiainducible factor-1 activation, during skin carcinogenesis Papel de parp-1 en procesos de muerte celular inducida por el tratamiento con el antineoplásico doxorrubicina Early and late skin reactions to radiotherapy for breast cancer and their correlation with radiation-induced dna damage in lymphocytes. Involvement of poly (adp-ribose) polymerase in the cellular response to dna damage Modulación por poli(adp-ribosa) polimerasa1- de la expresión génica durante la carcinogénesis epidérmica Parp inhibition sensitizes p53-deficient breast cancer cells to doxorubicin-induced apoptosis Parp-1-dependent 3-nitrotyrosine protein modification after dna damage Role of poly (adp-ribose) polymerase in kidney transplant and its relationship with delayed renal function. multivariate analysis. Correlation of morphological findings with functional reserve in the aging donor: role of the poly (adp-ribose) polymerase Crosstalk between parp-1 and nf-kappa b modulates the promotion of skin neoplasia Transcription regulation of tnf-alpha-early response genes poly (adp-ribose) polymerae-1 in murine hearth endotelial cells Parp-1 modifies the effectiveness of p53-mediated dna damage response Radiación, adn, cromatina y respuesta a la terapéutica Role of poly(adp-ribose) polymerase in the inflammatory response Apoptosis of haematopoietic cells upon thymidylate synthase inhibition is independent of p53 accumulation and cd95-cd95 ligand interaction Interplay of parp-1 and p53 in cell cycles checkpoints and tumorigenesis A dual approach in the study of poly (adp-ribose) polymerase: in vitro random mutagenesis and generation of deficient mice. Clinical & translational oncology Articulo 2008 Cancer biology & therapy Articulo 2008 Bmc molecular biology Articulo 2007 Current medicinal chemistry Articulo 2007 Plos one Articulo 2007 Cancer research Articulo 2006 Universidad de granada. radiología y medicina física 2006 Breast cancer research Articulo 2005 Poly (adp-ribose) polymerase and apoptosis Capítulo de libro Biochemical journal Articulo 2005 Journal of cellular biochemistry Articulo 2005 Transplantation proceedings Articulo 2005 Transplantation proceedings Articulo 2004 Oncogene Articulo 2004 Nucleic acids research Articulo 2003 Oncogene Articulo 2002 Oncología molecular Capítulo de libro 2002 Inmunologia Articulo 2002 Biochemical journal Articulo 2001 Embo journal Articulo 2001 Molecular and cellular biochemistry Articulo 1999

5 Defective nf-kb activation and resistance to septic shock in poly (adp-ribose) polymerase (parp) deficient mice Involvement of poly(adp-ribose) polymerase in base excision repair. Poly (adp-ribose) polymerase in dna damage response, apoptosis and disease Deficient dna repair in poly (adp-ribose) polymerase null mice Embo journal Articulo 1999 Biochimie Articulo 1999 American journal of human genetics Articulo 1999 Nucleic acids research Articulo 1998 La poly (adp-ribose) polymerase : un facteur de survie Medicine et science Articulo 1998 Poly (adp-ribose) polymerase is required for the maintenance of genomic integrity during base excision repair Role of parp and parp cleavage in apoptosis: lesson from an uncleavable mutant. Overexpression of a heterologous thymidine kinase delays apoptosis induced by factor deprivation and inhibitors of deoxynucleotide metabolism Requirement of poly (adp-ribose) polymerase in recovery from dna damage in mice and in cells. An apoptotic endonuclease activated either by decreasing ph or by increasing calcium Effects of starvation, diabetes and carbon tetrachloride intoxication on rat kidney cortex and liver pyruvate carboxylase levels Regulation of the salvage pathway of deoxynucleotides synthesis in apoptosis induced by growth factor deprivation Citrate inhibition of rat-kidney cortex phosphofructokinase Citrate inhibition of rat-kidney cortex phosphofructokinase Effects of amp and fructose 2,6-bisphosphate on fluxes between glucose-6-phosphate and triose-phosphate in renal cortical extracts Regulation of rat-kidney cortex fructose-1,6- bisphosphatase activity. i. effects of fructose-2,6- bisphosphate and divalent cations. Regulation of rat-kidney cortex fructose-1,6- bisphosphatase activity. ii. effects of adenine nucleotides. Distribution of pyruvate carboxylase along the rat nephron: an immunological and enzymatic study Efecto de los cationes divalentes sobre la actividad fructosa 1,6-bisfosfatasa purificada de corteza renal de rata. Kinetic characterization of phosphofructokinase isolated from rat kidney cortex Determinación de los coeficientes de control de flujo en un tramo acotado de la ruta glucolítica Purification and characterization of pyruvate carboxylase from rat-kidney cortex Stimulation of mitochondrial pyruvate transport in rat Nucleic acids and molecular biology Articulo 1998 Journal of biological chemistry Articulo 1998 Journal of biological chemistry Articulo 1997 Proceedings of the national academy of sciences of the united states of america Articulo 1997 Journal of cell science Articulo 1996 Archives of physiology and biochemistry Articulo 1996 Biochemical journal Articulo 1996 Molecular and cellular biochemistry Articulo 1994 Molecular and cellular biochemistry Articulo 1993 Journal of biological chemistry Articulo 1993 The international journal of biochemistry & cell biology The international journal of biochemistry & cell biology Articulo 1993 Articulo 1993 Kidney international Articulo 1991 Ars pharmaceutica Articulo 1991 Comparative biochemistry and physiology. part b, biochemistry & molecular biology Articulo 1991 Ars pharmaceutica Articulo 1990 Biochemical archives Articulo 1990

6 Stimulation of mitochondrial pyruvate transport in rat renal cortex by phenylephrine Life sciences Articulo 1990

7 Efecto de vecindad (bystander) tras radioterapia de modelos de tumor experimental y de tejido sano Modulación por parp-1 de la agresividad tumoral: papel en la respuesta hipóxica y en la transición epitelio mesénquima (emt). Melanoma maligno: estudio molecular y preclínico de la función de parp en el control de la angiogénesis tumoral durante la hipoxia Poli(adp-ribosa)polimerasa-1: una nueva diana anti-angiogénica en la terapia antineoplásica Nuevas funciones de poli(adp-ribosa) polimerasa-1 en la señalización y en el control de la respuesta celular durante el daño genotóxico Regulación de la respuesta inflamatoria por poli(adp-ribosa) polimerasa-1: efectos sobre la expresión génica y el daño oxidativo Actividades 0 Proyecto 1/1/13 12/31/15 Proyecto 1/1/10 12/31/12 Proyecto 1/1/08 12/31/11 Proyecto 11/30/06 9/30/09 Proyecto 1/1/04 12/31/06 Proyecto 3/1/05 12/31/05 7 Inflamación y daño articular. Proyecto 1/1/03 12/31/05 8 Interacción entre parp y atm en la respuesta a daños genotóxicos Proyecto 1/1/02 12/31/03 9 Titulo proyecto Tipo Inicio Fin Poli(adp-ribosa)polimerasa-1: una nueva diana anti-angiogénica en la terapia antineoplásica Proyecto 10/1/07 Titulo actividad Fuente Tipo Fecha Colaboradores JOSÉ MARIANO RUIZ DE ALMODOVAR RIVERA (28) FRANCISCO DAVID MARTÍN OLIVA (14) JOSÉ ANTONIO MUÑOZ GÁMEZ (13) MARIA DEL MAR SOLA ZAPATA (12) RAFAEL SALTO GONZALEZ (12) ALBERTO MANUEL VARGAS MORALES (11) FRANCISCO J. O'VALLE RAVASSA (11) MARÍA ISABEL RODRÍGUEZ LARA (11) ANDREINA CECILIA PERALTA LEAL (9) ARIANNYS GONZALEZ FLORES (8) JOSE MANUEL RODRIGUEZ VARGAS (8) JARA MAJUELOS MELGUIZO (7) MARIA ISABEL NUÑEZ TORRES (7) ROSA QUILES PEREZ (6) VIRGÍNEA DE ARAUJO FARIAS (6) LAURA MARÍA LÓPEZ JIMÉNEZ (5) JOSE LUIS LINARES FERNÁNDEZ (4) Santiago Serrano Sáenz (4) ANGELES RUIZ EXTREMERA (3) CARLOS MORENO CASTILLA (3) MERCEDES VILLALOBOS TORRES (3) ANA BELÉN MARTIN ÁLVAREZ (2) ANTONIO OSUNA ORTEGA (2) DAVID AGUILAR PEÑA (2) FRANCISCO JAVIER SALMERON ESCOBAR (2)

8 GUSTAVO ORTIZ FERRON (2) Julia Sirés Campos (2) LAURA SANJUAN NÚÑEZ (2) M. ESCARLATA LOPEZ RAMIREZ (2) MARIA DEL CARMEN RUIZ RUIZ (2) PEDRO HERNÁNDEZ CORTÉS (2) ANGEL CARAZO GALLEGO (1) ANTONIO MANUEL ALMENDROS GALLEGO (1) ANTONIO OSUNA CARRILLO DE ALBORNOZ (1) BLANCA TORRES TORRES (1) DAMIÁN GUIRADO LLORENTE (1) ENRIQUE GARCÍA OLIVARES (1) ESTER LENO DURÁN (1) JOSEFA LEÓN LÓPEZ (1) M. DOLORES RODRÍGUEZ MARTÍNEZ (1) MARIA JOSE RUIZ MAGAÑA (1) MARIANO AGUILAR PEÑA (1) MOHAMED TASSI Mzamzi (1) PABLO ANTONIO GALINDO MORENO (1) RAQUEL MUÑOZ FERNÁNDEZ (1)