Supplemental Table 1. Significant genes and their values necessary for computing multi-factorial L value in the prediction model.

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1 Supplemental Table 1. Significant genes and their values necessary for computing multi-factorial L value in the prediction model. UG cluster Symbol Description t-value Midpoint p-value Unique id Hs LIMK1 LIM domain kinase Hs CENPE centromere protein E (312kD) Hs FZD2 frizzled (Drosophila) homolog Hs ENO2 enolase 2, (gamma, neuronal) Hs.222 ITGA9 integrin, alpha Hs COPA coatomer protein complex, subunit alpha Hs.6727 KIAA0660 Ras-GTPase activating protein SH3 domain Hs GTF2H1 general transcription factor IIH, polypeptide Hs VPS41 vacuolar protein sorting 41 (yeast homolog) Hs RGS20 regulator of G-protein signalling Hs.274 MATK megakaryocyte-associated tyrosine kinase Hs STOML1 stomatin (EBP72)-like Hs BASP1 membrane attached signal protein Hs.733 EPB42 erythrocyte membrane protein band Hs ALDH3B2 aldehyde dehydrogenase 3 family, member B Hs.5947 MEL mel transforming oncogene Hs CAT56 CAT56 protein Hs RAB3A RAB3A, member RAS oncogene family Hs.7984 PSCD3 pleckstrin homology Hs PLD2 phospholipase D Hs.4748 ADCYAP1R1 adenylate cyclase activating polypeptide Hs ALDH3B1 aldehyde dehydrogenase 3 family, member B Hs RHD Rhesus blood group, D antigen Hs.2175 CSF3R colony stimulating factor 3 receptor Hs.3094 KIAA0063 KIAA0063 gene product Hs KIAA0296 KIAA0296 gene product Hs LRP6 low density lipoprotein receptor-related protein Hs ENO3 enolase 3, (beta, muscle) Hs CTRB1 chymotrypsinogen B Hs YES1 v-yes-1 Yamaguchi sarcoma viral oncogene Unknown (IncytePD: ) Hs.772 GYS1 glycogen synthase 1 (muscle) Hs MDFI MyoD family inhibitor Hs ADD2 adducin 2 (beta)

2 Hs GABRE gamma-aminobutyric acid (GABA) A receptor Unknown (IncytePD: ) Hs CD3Z CD3Z antigen, zeta polypeptide (TiT3 complex) Hs DTYMK deoxythymidylate kinase (thymidylate kinase) Hs SPTBN2 spectrin, beta, non-erythrocytic Unknown (IncytePD: ) Hs HSD3B1 hydroxy-delta-5-steroid dehydrogenase Hs GUCA2B guanylate cyclase activator 2B (uroguanylin) Hs ACOX3 acyl-coenzyme A oxidase 3, pristanoyl Hs.2281 CHGB chromogranin B (secretogranin 1) Hs STUB1 STIP1 homology and U-Box containing protein Hs RHAG Rhesus blood group-associated glycoprotein Hs.96 PMAIP1 PMA-induced protein Hs CD37 CD37 antigen Hs EPHB4 EphB Hs PITX2 paired-like homeodomain transcription factor Hs KIAA0084 KIAA0084 protein Hs LPL lipoprotein lipase Hs PYGB phosphorylase, glycogen; brain Hs MN7 D15F37 (pseudogene) Hs AP1S1 adaptor-related protein complex Hs ESTs Hs IDS iduronate 2-sulfatase (Hunter syndrome) Hs CLCN7 chloride channel Hs SLC20A2 solute carrier family 20, member Hs HMMR hyaluronan-mediated motility receptor (RHAMM) Unknown (IncytePD: ) Hs DGKI diacylglycerol kinase, iota Hs KIAA0406 KIAA0406 gene product Hs INPP5B inositol polyphosphate-5-phosphatase, 75kD Hs EFNA3 ephrin-a Hs SELENBP1 selenium binding protein Hs KHK ketohexokinase (fructokinase) Hs KIAA0225 KIAA0225 protein Hs LILRA2 leukocyte immunoglobulin-like receptor Hs GCLC glutamate-cysteine ligase, catalytic subunit

3 Hs MMP9 matrix metalloproteinase Hs HCGII-7 HCGII-7 protein Hs FZD5 frizzled (Drosophila) homolog Unknown (IncytePD: ) Hs PDK1 pyruvate dehydrogenase kinase, isoenzyme Hs HOXB13 homeo box B Hs MKI67 antigen identified by monoclonal antibody Ki Hs ASPH aspartate beta-hydroxylase Hs CES1 carboxylesterase Hs NDP52 nuclear domain 10 protein Hs IL2RB interleukin 2 receptor, beta Hs.4756 FEN1 flap structure-specific endonuclease Hs.673 IL12A interleukin 12A Hs KCNN3 potassium calcium-activated channel Hs.799 DTR diphtheria toxin receptor Hs PLA2G6 phospholipase A2, group VI Hs RFC5 replication factor C (activator 1) 5 (36.5kD) Hs TNFSF7 tumor necrosis factor superfamily, member Hs.9605 CPSF5 cleavage and polyadenylation specific factor Hs NFRKB nuclear factor related to kappa B binding protein Hs SCNN1B sodium channel, nonvoltage-gated Hs RAB28 RAB28, member RAS oncogene family Hs IRF2 interferon regulatory factor Hs LTBP4 latent TGF-beta binding protein Hs CGI-85 CGI-85 protein Hs ABL2 v-abl murine leukemia viral oncogene homolog Hs CRSP8 cofactor for Sp1 transcriptional activation Hs GAB1 GRB2-associated binding protein Hs AKR1C4 aldo-keto reductase family 1, member C Hs TNFRSF5 TNF receptor superfamily, member Hs.858 RELB v-rel viral oncogene homolog B Hs KIAA0095 KIAA0095 gene product Hs.8358 FLJ20366 hypothetical protein FLJ Hs ESTs Hs ESTs, Highly similar to A38712 fibrillarin Hs DDEF1 development and differentiation enhancing factor

4 Hs ESTs, similar to ALU Hs GRTH gonadotropin-regulated testicular RNA helicase Hs Homo sapiens cdna: FLJ22049 fis Hs ESTs Hs FLJ20764 hypothetical protein FLJ Hs.3686 KIAA0978 KIAA0978 protein Hs ESTs Hs KIAA0185 KIAA0185 protein Hs HTPAP HTPAP protein Hs KIAA0974 KIAA0974 protein Hs.2969 SKI v-ski avian sarcoma viral oncogene homolog Hs FLJ20015 hypothetical protein Hs SH3GLB1 SH3-domain, GRB2-like, endophilin B Hs Homo sapiens mrna; cdna DKFZp761G Hs UBN1 ubinuclein Hs SRP46 Splicing factor, arginine/serine-rich, 46kD Hs RPS6KA4 ribosomal protein S6 kinase, 90kD, polypeptide Hs RANBP9 RAN binding protein Hs NS1-BP NS1-binding protein Unknown (IncytePD: ) Hs FLJ23188 hypothetical protein FLJ Hs ESTs Hs HTCD37 TcD37 homolog Hs.2301 DBH dopamine beta-hydroxylase Hs FLJ10008 hypothetical protein FLJ Hs Homo sapiens, clone IMAGE: Hs.4988 Homo sapiens clone mrna sequence Hs FLJ21439 hypothetical protein FLJ Hs KIAA0615 KIAA0615 gene product Hs Homo sapiens mrna; cdna DKFZp434A Hs Similar to bromodomain-containing Hs ESTs, similar to CASPASE-4 PRECURSOR Hs ESTs Hs DKFZP564G092 DKFZP564G092 protein Hs cdna: FLJ21913 fis, clone HEP Hs UBXD2 UBX domain-containing

5 Hs TAZ transcriptional co-activator with PDZ-binding motif Hs ESTs Hs DKFZP434B044 hypothetical protein DKFZp434B Hs Homo sapiens cdna FLJ12366 fis Hs UCP2 uncoupling protein Hs FLJ14225 hypothetical protein FLJ Hs GALK1 galactokinase Hs ESTs Hs HBG1 hemoglobin, gamma A Hs ESTs Hs FLJ21065 hypothetical protein FLJ

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