Pre-cancer treatment by Innate Acquired Immunoactivation with Viscum Helixor DR J.C. BOTERO MEDICO ONCÓLOGO BARCELONA, SPAIN

Transcripción

1 Pre-cancer treatment by Innate Acquired Immunoactivation with Viscum Helixor DR J.C. BOTERO MEDICO ONCÓLOGO BARCELONA, SPAIN

2 2030 In the world will be diagnosed 22 millons new patients of cancer PRECANCER The hidden disease of the twenty-first century 2

3 Patologia organica precancerosa. Leucoplasias orales y vaginales. Poliposis intestinal CIN de cervix. Mastopatia fibrosa quistica. Gastritis cronica atrofica. VHC Hiperplasia endometrial Poliposis de intestino delgado. S. Peutz Jager 3

4 Sintomas de precancerosis clínica de evolución lenta, progresiva...invisible Perdida de vitalidad, agotamiento, desanimo, tendencia depresiva. PESADEZ. Perdida de la temperatura corporal y del Calor. Psique: ruptura Yo - mundo 4

5 Precancerosis: contraccion del organismo calórico Disminución del sistema inmune, expresado en leucopenia o déficit de subpoblaciones linfocitarias. Perfil térmico por debajo de 36 grados. Síndrome anémico por deficiencia de hierro. Tendencias depresivas. 5

6 Immunological Microbioma Tumoral Micro Enviroment 6 Extra Cell Matrix Form Principle PRECANCER CONDITIONS

7 Immunological: L T 8, NK, Dendritic cell, Macrophagues. 7 Microbioma : immunomodulator functions Tumoral Micro Enviroment: Hipoxia, H 2 O 2, T reg, TAM. Extra Cell Matrix: Fibroblasts, Colagens, Cytokines. Form principle: Morphogenesis activity. PRECANCER CONDITIONS

8 Immunological 8 Microbioma Tumoral Micro Enviroment Extra cell Matrix Form principle PRECANCER CONDITIONS

9 9

10 10 IMMUNOEDITION (2004 Schreiber R.) Clinic Diagnosis HEALTH / PRE CANCER / CANCER

11 11

12 12 PRECANCEROSIS

13 13 CANCER PATHWAY

14 FROM PRECANCER UNTIL METASTASIS = 30 YEARS (Volgestein B. NEJM,2015) 14 HEALTH PRE CANCER CANCER Pre Cancer------until Metastasic = 30 years

15 15

16 16 immunity CANCER CELL cancer

17 PRECANCER: Equilibrium 17 Imm Cancer

18 18

19 PRECANCER - NEXT STEP : Immuno-inhibition 19

20 Microbioma 20 Immune Micro Environment. IME Matrix Extra Cell. MEC Form principle Precancer Conditions

21 Microbioma and precancer 21 HOLOGENOMA

22 Microbiota and pre cancer 22 P R E C A N C E R

23 Microbiota, Inflamationand and precancer 2321

24 24 DENDRITIC CELL DC MICROBIOMA and IMMUNIDAD PROGRAMATION Th17 and Treg (Immunoinhibition)

25 25 COLON POLYPOSIS LYNFOCIT Th17 Activated secondary by Disbiosis

26 Microbioma 26 Immune Micro Environment. Matrix Extra Cell. MEC Form principle Precancer Conditions

27 Microenviroment in precancer: Immunoinhibition 27 Depletion Lymphocitos Infiltrating Tumor CD 8 Increment Lymphocits T REG Increment MDSC: cell supresive myeloderived Expression PDL1 by tumor cell. CANCER IMMUNITY

28 Enviroment factors: Hypoxia, H 2 O 2 and cancer 28 In tumor microenvironment it found HYPOXIA. Tumor activate of Hypoxic-responsive genes in tumor cell ( Denko 2003) Macrophagues 1 and Granulocytes survival in hypoxia, BUT < ROS (Reactive Oxigen Species) H 2 O 2

29 29 Hipoxia and NK

30 30 Microbioma Immune Micro Environment Form principle Matrix Extra Cell Precancer conditions

31 ECM and remodeling structure 31

32 MEC 32 Architecture organic s ExtraCell Matrix Tissue especific mor Myoepithelial cells Tissue Macrophagues Fibroblasts Antioxidants Oxigenation

33 EXTRACELULAR MATRIX 33 ECM Factors Biophysical, Geometrical, Anatomics ECM contains Cytokines, Growth factors, ECM. Collagen, Laminims, fibronectins, proteoglycans, hyaluronic ECM Architectur tridimensional = FORM Principle

34 Microbioma 34 Immune Micro Environment Matrix Extra Cell Form principle= morphogenesis Precancer conditions

35 Morphogenesis 37 Cell = C E N T R I F U G A L S F O R C E S CENTRIPETAL= FORMATIVE FORCES

36 ORGANISMS = FORM & CELL. 38 TWO Basics PRINCIPLES building our Organism: FORM CENTRIPETAL CELL CENTRIFUGAL CELL

37 FRACTAL MORPHOLOGICAL FORCES 39

38 Organogenesis Vs Tumorgenesis 40 FORM FORM CELL CELL ANATOMY LIMITED LOSS ANATOMY UNLIMITED

39 PRECANCER: LOSS OF ARCHITECTURE 42

40 FORM PRINCIPLE = ARCHITECTURE 43 FORM CELL

41 Fractals pathway : Form and Geometry 44 FORM

42 45 I C C I MORPHOGENESIS PRE CANCEROSIS

43 46 PRECANCEROSIS: REVERSIBLE CONDITION

44 Morphogenesis, cáncer and Viscum 47

45 48

46 49

47 50 The antitumor immune response cycle I C

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49 I 52 C

50 53

51 Hypotermia 54

52 IMMUNOEDITION-PRECANCER- Temperature 55 T < 36ªC No Fever T > 36 ºC Febril reaction HEALTH / PRE CANCER / CANCER

53 IMMUNOEDITION PRECANCER - VISCUM 56 HEALTH PRE CANCER CANCER V I S C U M H E L I X O R

54 Thermic graph in Celsius am 7 pm 365 days.

55 VISCUM HELIXOR 58

56 Immunoedition: Elimination, Equilibrium 64 Immune Micro Environment Matrix Extra Cell Form principle Precancer conditions should be overcome by Viscum Helixor

57 Immunoedition & VISCUM REACTIVITY IMMUNE UNREACTIVITY HEALTHY VISCUM A. HELIXOR PRECANCER VISCUM A. HElIXOR CANCER

58 1901, P. Erlich Immune system could figth again cancer 66 Lymphocit T8 Nobel Prize Medicine 2018 Immunotherapy Allison J. Cancer cell

59 67 Thank you for your attention Dr J.C.Botero Integrative Oncology