Información de Contacto. Experiencia Laboral Previa. Experiencia Docente. Educación & Entrenamiento

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1 Prof. Dr. Alcides Chaux Director de Investigaciones Científicas Director de la Revista UniNorte de Medicina Director del Policlínico UniNorte Catedrático de Metodología de la Investigación, Facultad de Medicina UNIVERSIDAD DEL NORTE Paraguay Actualizado: 28 de mayo de 2014 Información de Contacto DIRECCIÓN DE INVESTIGACIONES CIENTÍFICAS Universidad del Norte Gral. Santos 2409 e/ 25 de Mayo Código Postal 1614 Asunción, Paraguay Oficina: +595 (021) interno 142 Fax: +595 (021) interno 102 Experiencia Laboral Previa Post Doctoral Research Fellow: The Johns Hopkins University School of Medicine, 401 North Broadway / Weinberg Bldg #2268, Baltimore, MD (08/2010 a 12/2011). Investigador Asociado: Instituto de Patología e Investigación, Brizuela 325, Asunción, Paraguay. Código Postal 1817 (11/2008 a 07/2010). Experiencia Docente Jefe de Cátedra de Metodología de la Investigación: Facultad de Medicina, Universidad del Norte, Asunción, Paraguay (03/2012 a actual), para las carreras de Medicina, Periodismo, y Odontología. Instructor de la Cátedra de Histología, Embriología y Biología: Facultad de Medicina, Universidad del Norte, Asunción, Paraguay (03/2003 a 07/2010). Instructor de la Cátedra de Anatomía Patológica: Facultad de Medicina, Universidad del Norte, Asunción, Paraguay (03/2002 a 07/2010). Educación & Entrenamiento Jefe de Médicos Residentes: Instituto de Anatomía Patológica, Hospital de Clínicas, Tte. Rodi e/ Guillermo Arias, Asunción, Paraguay (03/2004 a 03/2005). Página 1 de 21

2 Médico Residente: Instituto de Anatomía Patológica, Hospital de Clínicas, Tte. Rodi e/ Guillermo Arias, Asunción, Paraguay (03/2001 a 03/2004). Doctor en Medicina: Universidad Nacional de Asunción, Paraguay (02/1995 a 12/2000). Líneas de Investigaciones en Curso 1. Significancia Pronóstica de la Expresión Inmunohistoquímica de la proteína p16 INK4a y la Presencia del Virus del Papiloma Humano en los Carcinomas Escamosos del Pene. Función: Investigador Asociado. Proyecto colaborativo con la Johns Hopkins University (Estados Unidos). 2. Significancia Pronóstica y Expresión Inmunohistoquímica de la proteína ARID1A (ATrich interactive domain-containing protein 1A, dominio de interacción rico en AT de la proteína 1) en el carcinoma urotelial de vías urinarias altas. Función: Investigador Asociado. Proyecto colaborativo con la Johns Hopkins University (Estados Unidos). 3. Significancia Pronóstica y Patrones de 5-hidroxi-metilación de la Citosina en carcinomas de células renales del riñón. Función: Investigador Asociado. Proyecto colaborativo con la Johns Hopkins University (Estados Unidos). 4. Significancia Pronóstica y Patrones de 5-hidroxi-metilación de la Citosina en carcinomas uroteliales de la vejiga urinaria. Función: Investigador Asociado. Proyecto colaborativo con la Johns Hopkins University (Estados Unidos). 5. Patrones de 5-hidroxi-metilación de la Citosina en neoplasias prostáticas intraepiteliales. Función: Investigador Asociado. Proyecto colaborativo con la Johns Hopkins University (Estados Unidos). 6. Expresión inmunohistoquímica de la proteína ARID1A (AT-rich interactive domaincontaining protein 1A, dominio de interacción rico en AT de la proteína 1) en el carcinoma escamoso del pene. Función: Investigador Principal. Proyecto colaborativo con la Johns Hopkins University (Estados Unidos). 7. Expresión inmunohistoquímica del receptor del factor de crecimiento similar a la insulina 1 (Insulin-Like Growth Factor 1 Receptor, IGF1R) en el carcinoma escamoso del pene. Función: Investigador Principal. Proyecto colaborativo con la Johns Hopkins University (Estados Unidos). 8. Patrones de 5-hidroxi-metilación de la Citosina en carcinomas escamosos del pene. Función: Investigador Principal. Proyecto colaborativo con la Johns Hopkins University (Estados Unidos). 9. Expresión de proteínas relacionadas al ciclo celular (vías del p53 y del prb) en el carcinoma escamoso del pene. Función: Investigador Principal. Proyecto colaborativo con la Johns Hopkins University (Estados Unidos). 10. Expresión inmunohistoquímica de AIM-1 en el epitelio normal y tumoral de la próstata. Función: Investigador Asociado. Proyecto colaborativo con la Johns Hopkins University (Estados Unidos). 11. Alteraciones genéticas en los carcinomas escamosos del pene y su relación con la infección por el virus del papiloma humano. Función: Investigador Principal. Proyecto colaborativo con los National Health Institutes (Estados Unidos) y la International Agency for Research on Cancer (Francia). 12. Expresión inmunohistoquímica de ERG en la predicción del riesgo de recurrencia tumoral tras prostatectomía por cáncer de próstata clínicamente localizado. Función: Página 2 de 21

3 Investigador Asociado. Proyecto colaborativo con la Johns Hopkins University (Estados Unidos). Artículos Científicos Publicados (Revistas Internacionales) 1. Gonzalez-Roibon N, Kim JJ, Faraj SF, Chaux A, Bezerra SM, Munari E, Ellis C, Sharma R, Keizman D, Bivalacqua TJ, Schoenberg M, Eisenberger M, Carducci M, Netto GJ. Insulinlike growth factor-1 receptor overexpression is associated with outcome in invasive urothelial carcinoma of urinary bladder: A retrospective study of patients treated using radical cystectomy. Urology. 2014;83(6):1444.e1-6. PMID: DOI: /j.urology Amin A, Griffith RC, Chaux A. Penile intraepithelial neoplasia with pagetoid features: Report of an unusual variant mimicking Paget disease. Hum Pathol. 2014;45(4): PMID: DOI: /j.humpath Chaux A, Munari E, Cubilla AL, Hicks J, Lecksell K, Burnett AL, Netto GJ. Immunohistochemical expression of the mammalian target of rapamycin pathway in penile squamous cell carcinomas: A tissue microarray study of 112 cases. Histopathology. 2014;64(6): PMID: DOI: /his Chaux A, Han JS, Lee S, Gonzalez-Roibon N, Sharma R, Burnett AL, Cubilla AL, Netto GJ. Immunohistochemical profile of the penile urethra and differential expression of GATA3 in urothelial versus squamous cell carcinomas of the penile urethra. Hum Pathol. 2013;44(12): PMID: DOI: /j.humpath Chaux A, Munari E, Katz B, Sharma R, Lecksell K, Cubilla AL, Burnett AL, Netto GJ. The epidermal growth factor receptor is frequently overexpressed in penile squamous cell carcinomas: a tissue microarray and digital image analysis study of 112 cases. Hum Pathol. 2013;44(12): PMID: DOI: /j.humpath Munari E, Fujita K, Faraj S, Chaux A, Gonzalez-Roibon N, Hicks J, Meeker A, Nonomura N, Netto GJ. Dysregulation of mammalian target of rapamycin pathway in upper tract urothelial carcinoma. Human Pathol. 2013;44(12): PMID: DOI: /j.humpath Faraj SF, Albadine R, Chaux A, Gonzalez-Roibon N, Hicks J, Humphreys E, Partin A, Netto GJ. Activation of Mammalian Target of Rapamycin Signaling Pathway Markers in Minute Adenocarcinoma of the Prostate. Urology. 2013;82(5): PMID: DOI: /j.urology Página 3 de 21

4 8. Chaux A, Albadine R, Schultz L, Hicks J, Carducci MA, Argani P, Allaf M, Netto GJ. Dysregulation of the mammalian target of rapamycin pathway in chromophobe renal cell carcinomas. Hum Pathol. 2013;44(10): PMID: DOI: /j.humpath Chaux A, Cubilla AL, Haffner MC, Lecksell KL, Sharma R, Burnett AL, Netto GJ. Combining routine morphology, p16ink4a immunohistochemistry, and in situ hybridization for the detection of human papillomavirus infection in penile carcinomas: A tissue microarray study using classifier performance analyses. Urol Oncol. 2014;32(2): PMID: DOI: /j.urolonc Gonzalez-Roibon N, Katz B, Chaux A, Sharma R, Munari E, Faraj SF, Illei PB, Torbenson M, Netto GJ. Immunohistochemical expression of SALL4 in hepatocellular carcinoma, a potential pitfall in the differential diagnosis of yolk sac tumors. Hum Pathol. 2013;44(7): PMID: DOI: /j.humpath Chaux A, Compérat E, Varinot J, Hicks J, Lecksell K, Solus J, Netto GJ. High levels of phosphatase and tensin homolog expression are associated with tumor progression, tumor recurrence, and systemic metastases in pt1 urothelial carcinoma of the bladder: A tissue microarray study of 156 patients treated by transurethral resection. Urology. 2013;81(1): PMID: DOI: /j.urology Chaux A, Cubilla AL. Penile cancer: Optimal management of T1G2 penile cancer remains unclear. Nat Rev Urol. 2013;10(1):9-11. PMID: DOI: /nrurol Gonzalez-Roibon ND, Chaux A, Al-Hussain T, Osunkoya AO, Bezerra SM, Hicks J, Epstein JI, Netto GJ. Dysregulation of mammalian target of rapamycin pathway in plasmacytoid variant of urothelial carcinoma of the urinary bladder. Hum Pathol. 2013;44(4): PMID: DOI: /j.humpath Georgiades C, Rodriguez R, Azene E, Weiss C, Chaux A, Gonzalez-Roibon N, Netto G. Determination of the nonlethal margin inside the visible "ice-ball" during percutaneous cryoablation of renal tissue. Cardiovasc Intervent Radiol. 2013;36(3): PMID: DOI: /s Kasamatsu E, Cubilla AL, Alemany L, Chaux A, Tous S, Mendoza L, Paez M, Klaustermeier JE, Quint W, Lloveras B, de Sanjose S, Muñoz N, Bosch FX. Type-specific human papillomavirus distribution in invasive cervical carcinomas in Paraguay. A study of 432 cases. J Med Virol. 2012;84(10): PMID: DOI: /jmv Página 4 de 21

5 16. Zheng G, Chaux A, Sharma R, Netto G, Caturegli P. LMP2, a novel immunohistochemical marker to distinguish renal oncocytoma from the eosinophilic variant of chromophobe renal cell carcinoma. Exp Mol Pathol. 2013;94(1): PMID: DOI: /j.yexmp Chaux A, Brimo F, Gonzalez-Roibon N, Shah S, Schultz L, Rizk JM, Argani P, Hicks J, Netto GJ. Immunohistochemical evidence of dysregulation of the mammalian target of rapamycin pathway in primary and metastatic pheochromocytomas. Urology. 2012;80(3):736.e7-e12. PMID: DOI: /j.urology Chaux A, Peskoe SB, Gonzalez-Roibon N, Schultz L, Albadine R, Hicks J, De Marzo AM, Platz EA, Netto GJ. Loss of PTEN expression is associated with increased risk of recurrence after prostatectomy for clinically localized prostate cancer. Mod Pathol. 2012;25(11): PMID: DOI: /modpathol Meza Britez ME, Caballero Llano C, Chaux A. Periprosthetic breast capsules and immunophenotypes of inflammatory cells. Eur J Plast Surg. 2012;35(9): PMID: DOI: /s Velazquez EF, Chaux A, Cubilla AL. Histologic classification of penile intraepithelial neoplasia. Semin Diagn Pathol. 2012;29(2): PMID: Chaux A, Cubilla AL. Stratification systems as prognostic tools for defining risk of lymph node metastasis in penile squamous cell carcinomas. Semin Diagn Pathol. 2012;29(2):83-9. PMID: Chaux A, Cubilla AL. Diagnostic problems in precancerous lesions and invasive carcinomas of the penis. Semin Diagn Pathol. 2012;29(2): PMID: Chaux A, Cubilla AL. The role of human papillomavirus infection in the pathogenesis of penile squamous cell carcinomas. Semin Diagn Pathol. 2012;29(2): PMID: Chaux A, Velazquez EF, Barreto JE, Ayala GE, Cubilla AL. New pathologic entities in penile carcinomas: An update of the 2004 World Health Organization (WHO) classification. Semin Diagn Pathol. 2012;29(2): PMID: Chaux A, Cubilla AL. Penile Cancer: Introduction. Semin Diagn Pathol. 2012;29(2): PMID: Chaux A, Cubilla AL. Advances in the Pathology of Penile Carcinomas. Hum Pathol. 2012;43(6): PMID: DOI: /j.humpath Chaux A, Toubaji A, Sutcliffe S, Lecksell K, Hicks J, De Marzo A, Platz EA, Netto GJ. Immunohistochemical expression of minichromosome maintenance complex protein 2 predicts biochemical recurrence in prostate cancer: A tissue microarray and digital imaging analysis-based study of 428 cases. Hum Pathol. 2012;43(11): Página 5 de 21

6 PMID: DOI: /j.humpath Chaux A, Schultz L, Albadine R, Hicks J, Kim JJ, Allaf ME, Carducci MA, Rodriguez R, Hammers H, Argani P, Reuter VE, Netto GJ. Immunoexpression status and prognostic value of mammalian target of rapamycin and hypoxia-induced pathway members in papillary cell renal cell carcinomas. Hum Pathol. 2012;43(12): PMID: DOI: /j.humpath Haffner MC, Laimer J, Chaux A, Schäfer G, Obrist P, Brunner A, Kronberger IE, Laimer K, Gurel B, Koller JB, Seifarth C, Zelger B, Klocker H, Rasse M, Doppler W, Bander NH. High expression of prostate-specific membrane antigen in the tumor-associated neo-vasculature is associated with worse prognosis in squamous cell carcinoma of the oral cavity. Mod Pathol. 2012;25(8): PMID: DOI: /modpathol Chaux A, Cohen JS, Schultz L, Albadine R, Jadallah S, Murphy KM, Sharma R, Schoenberg MP, Netto GJ. High epidermal growth factor receptor immunohistochemical expression in urothelial carcinoma of the bladder is not associated with EGFR mutations in exons 19 and 21: a study using formalin-fixed, paraffin-embedded archival tissues. Human Pathol. 2012;43(19): PMID: DOI: /j.humpath Cubilla AL, Lloveras B, Alemany L, Alejo M, Vidal A, Kasamatsu E, Clavero O, Alvarado- Cabrero I, Lynch C, Velasco-Alonso J, Ferrera A, Chaux A, Klaustermeier J, Quint W, Muñoz N, Bosch FX. Basaloid squamous cell carcinoma of the penis with papillary features: A clinicopathologic study of 12 cases. Am J Surg Pathol. 2012;36(6): PMID: DOI: /PAS.0b013e318249c6f Miyamoto H, Yao JL, Chaux A, Zheng Y, Hsu I, Izumi K, Chang C, Messing EM, Netto GJ, Yeh S. Expression of androgen and oestrogen receptors and its prognostic significance in urothelial neoplasm of the urinary bladder. BJU Int. 2012;109(11): PMID: DOI: /j X x. 33. Woo S, Goldberg M, Bankoti J, Selby M, Nirschl C, Bettini M, Vogel P, Liu CL, Tangsombatvisit S, Grosso J, Netto G, Smeltzer M, Chaux A, Utz PJ, Workman C, Pardoll D, Korman A, Drake C, Vignali D. Inhibitory molecules LAG-3 and PD-1 synergistically regulate T cell function to promote tumoral immune escape. Cancer Res. 2012;72(4): PMID: DOI: / CAN Chaux A, Fajardo DA, Gonzalez-Roibon N, Partin AW, Eisenberger M, DeWeese TL, Netto GJ. High grade prostatic adenocarcinoma present in a single biopsy core is associated with increased extraprostatic extension, seminal vesicle invasion, and positive surgical margins at prostatectomy. Urology. 2012;79(4): PMID: DOI: /j.urology Página 6 de 21

7 35. Chaux A, Velazquez EF, Amin A, Soskin A, Pfannl R, Rodriguez IM, Barreto JE, Lezcano C, Ayala GE, Netto GJ, Cubilla AL. Distribution and characterization of subtypes of penile intraepithelial neoplasia and their association with invasive carcinomas: A pathological study of 139 lesions in 121 patients. Hum Pathol. 2012;43(7): PMID: DOI: /j.humpath Chaux A, Netto GJ, Rodriguez IM, Barreto JE, Oertell J, Ocampos S, Boggino H, Codas R, Bosch FX, de Sanjose S, Muñoz N, Hildesheim A, Cubilla AL. Epidemiologic profile, sexual history, pathologic features, and human papillomavirus status of 103 patients with penile carcinoma. W J Urol. 2013;31(4): PMID: DOI: /s Haffner MC, Chaux A, Meeker AK, Esopi DM, Gerber J, Pellakuru L, Toubaji Am Argani P, Iacobuzio-Donahue C, Nelson WG, Netto GH, De Marzo A, Yegnasubramanian S. Global 5-hydroxymethilcytosine content is significantly reduced in tissue stem/progenitor cell compartments and in human cancer. Oncotarget. 2011;2(8): PMID: Chaux A, Schultz L, Albadine R, Hicks J, Kim JJ, De Marzo AM, Allaf ME, Carducci MA, Rodriguez R, Hammers H, Argani P, Reuter VE, Netto GJ. Immunoexpression status and prognostic value of mtor and hypoxia-induced pathway members in primary and metastatic clear cell renal cell carcinomas. Am J Surg Pathol. 2011;35(10): PMID: DOI: /PAS.0b013e e Soskin A, Vieillefond A, Carlotti A, Plantier F, Chaux A, Ayala G, Velazquez EF, Cubilla AL. Warty/basaloid penile intraepithelial neoplasia is more prevalent than differentiated PeIN in nonendemic regions for penile cancer when compared with endemic areas: A comparative study between pathologic series from Paris and Paraguay. Hum Pathol. 2012;43(2): PMID: DOI: /j.humpath Albadine R, Hyndman ME, Chaux A, Jeong JY, Saab S, Tavora F, Epstein JI, Gonzalgo ML, Pavlovich CP, Netto GJ. Characteristics of positive surgical margins in robotic assisted radical prostatectomy, open retropubic radical prostatectomy, and laparoscopic radical prostatectomy: A comparative histopathologic study from a single academic center. Hum Pathol. 2012;43(2): PMID: DOI: /j.humpath Chaux A, Karram S, Miller JS, Fajardo DA, Lee TK, Miyamoto H, Netto GJ. High-grade papillary urothelial carcinoma of the urinary tract: A clinicopathologic analysis of a post World Health Organization/International Society of Urological Pathology classification cohort from a single academic center. Hum Pathol. 2012;43(1): PMID: DOI: /j.humpath Chaux A, Lee TK, Karram S, Miyamoto H, Miller JS, Fajardo DA, Epstein JI, Netto GJ. Papillary urothelial neoplasm of low malignant potential of the urinary bladder: Página 7 de 21

8 Clinicopathologic and outcome analysis from a single academic center. Hum Pathol. 2011;42(11): PMID: DOI: /j.humpath Toubaji A, Albadine R, Meeker AK, Isaacs WB, Lotan T, Haffner MC, Chaux A, Epstein JI, Han M, Walsh PC, Partin AW, De Marzo AM, Platz EA, Netto GJ. Increased gene copy number of ERG on chromosome 21 but not TMPRSS2 ERG fusion predicts outcome in prostatic adenocarcinomas. Mod Pathol. 2011;24(11): PMID: DOI: /modpathol Chaux A, Elwood H, Schultz L, Illei PB, Baydar DE, Billis A, Sharma R, Argani P, Epstein JI, Netto GJ. Immunohistochemical analysis of SMARCB1/INI-1 expression in collecting duct carcinomas. Urology. 2011;78(2):474.e1-5. PMID: DOI: /j.urology Chaux A, Albadine R, Toubaji A, Hicks J, Meeker A, Plazt EA, De Marzo AM, Netto GJ. Immunohistochemistry for ERG expression as a surrogate for TMPRSS2-ERG fusion detection in prostatic adenocarcinomas. Am J Surg Pathol. 2011;35(7): PMID: DOI: /PAS.0b013e31821e Chaux A, Eifler J, Karram S, Al-Hussain T, Faraj S, Pomper M, Rodriguez R, Netto GJ. Focal positive prostate-specific membrane antigen (PSMA) expression in ganglionic tissues associated with prostate neurovascular bundle: Implications for novel intraoperative PSMAbased fluorescent imaging techniques. Urol Oncol. 2013;31(5): PMID: DOI: /j.urolonc Oertell J, Caballero C, Iglesias M, Chaux A, Amat L, Ayala E, Rodriguez IM, Velazquez EF, Barreto BE, Ayala G, Cubilla AL. Differentiated precursor lesions and low-grade variants of squamous cell carcinomas are frequent findings in foreskins of patients from a region of high penile cancer incidence. Histopathology. 2011;56(6): PMID: DOI: /j x. 48. Ling S, Chang X, Schultz L, Lee TK, Chaux A, Marchionni L, Netto GJ, Sidransky S, Berman DM. An EGFR-ERK1/2-Sox9 signaling cascade links urothelial development, regeneration, and cancer. Cancer Res. 2011;71(11): PMID: DOI: / CAN Chaux A, Pfannl R, Rodríguez IM, Barreto JE, Velazquez EF, Lezcano C, Piris A, Netto GJ, Cubilla AL. Distinctive immunohistochemical profile of penile intraepithelial lesions: A study of 74 cases. Am J Surg Pathol. 2011;35(4): PMID: DOI: /PAS.0b013e Lotan TL, Gupta NS, Wang W, Toubaji A, Haffner MC, Chaux A, Hicks JL, Meeker AK, Bieberich CJ, De Marzo AM, Epstein JI, Netto GJ. ERG gene rearrangements are common in prostatic small cell carcinomas. Mod Pathol. 2011;24(6): PMID: Página 8 de 21

9 DOI: /modpathol Carney EM, Banerjee P, Ellis CL, Albadine R, Sharma R, Chaux AM, Burger PC, Netto GJ. PAX2(-)/PAX8(-)/inhibin A(+) immunoprofile in hemangioblastoma: A helpful combination in the differential diagnosis with metastatic clear cell renal cell carcinoma to the central nervous system. Am J Surg Pathol. 2011;35(2): PMID: DOI: /PAS.0b013e d Cubilla AL, Lloveras B, Alejo M, Clavero O, Chaux A, Kasamatsu E, Monfulleda N, Tous S, Alemany L, Klaustermeier J, Muñoz N, Quint W, de Sanjose S, Bosch FX. Value of p16 INK4a in the pathology of invasive penile squamous cell carcinomas: A report of 202 cases. Am J Surg Pathol. 2011;35(2): PMID: DOI: /PAS.0b013e318203cdba. 53. Chaux A, Velazquez EF, Algaba F, Ayala G, Cubilla AL. Developments in the pathology of penile squamous cell carcinomas. Urology. 2010;76(2 Suppl 1):S7-S14. PMID: DOI: /j.urology Chaux A, Tamboli P, Ayala A, Soares F, Rodríguez I, Barreto J, Cubilla AL. Warty-basaloid carcinoma: Clinicopathological features of a distinctive penile neoplasm. Report of 45 cases. Mod Pathol. 2010;23(6): PMID: DOI: /modpathol Chaux A, Pfannl R, Lloveras B, Alejo M, Clavero O, Lezcano C, Muñoz N, de Sanjosé S, Bosch FX, Hernández-Pérez M, Velazquez EF, Cubilla AL. Distinctive association of p16 INK4a overexpression with penile intraepithelial neoplasia depicting warty and/or basaloid features: A study of 141 cases evaluating a new nomenclature. Am J Surg Pathol. 2010;34(3): PMID: DOI: /PAS.0b013e3181cdad Chaux A, Amin M, Cubilla AL, Young R. Metastatic tumors to the penis: A report of 17 cases and review of the literature. Int J Surg Pathol. 2011;19(5): PMID: DOI: / Chaux A, Soares F, Rodríguez I, Barreto J, Lezcano C, Torres J, Velazquez EF, Cubilla AL. Papillary squamous cell carcinoma, not otherwise specified (NOS) of the penis: Clinicopathologic features, differential diagnosis, and outcome of 35 cases. Am J Surg Pathol. 2010;34(2): PMID: DOI: /PAS.0b013e3181c7666e. 58. Cubilla AL, Lloveras B, Alejo M, Clavero O, Chaux A, Kasamatsu E, Velazquez EF, Lezcano C, Monfulleda N, Tous S, Alemany L, Klaustermeier J, Muñoz N, Quint W, de Sanjose S, Bosch FX. The basaloid cell is the best tissue marker for human papillomavirus in invasive penile squamous cell carcinoma: A study of 202 cases from Paraguay. Am J Surg Pathol. 2010;34(1): PMID: DOI: /PAS.0b013e3181c76a49. Página 9 de 21

10 59. Chaux A, Lezcano C, Cubilla AL, Tamboli P, Ro J, Ayala A. Comparison of subtypes of penile squamous cell carcinoma from high and low incidence geographical regions. Int J Surg Pathol. 2010;18(4): PMID: DOI: / Guimarães GC, Cunha IW, Soares FA, Lopes A, Torres J, Chaux A, Velazquez EF, Ayala G, Cubilla AL. Penile squamous cell carcinoma clinicopathological features, nodal metastasis and outcome in 333 cases. J Urol. 2009;182(2): PMID: DOI: /j.juro Chaux A, Reuter V, Lezcano C, Velazquez EF, Torres J, Cubilla AL. Comparison of morphologic features and outcome of resected recurrent and nonrecurrent squamous cell carcinoma of the penis: A study of 81 cases. Am J Surg Pathol. 2009;33(9): PMID: DOI: /PAS.0b013e3181a418ae. 62. Chaux A, Reuter V, Lezcano C, Velazquez E, Codas R, Cubilla AL. Autopsy findings in 14 patients with penile squamous cell carcinoma. Int J Surg Pathol. 2011;19(2): PMID: DOI: / Chaux A, Torres J, Pfannl R, Barreto J, Rodriguez I, Velazquez EF, Cubilla AL. Histologic grade in penile squamous cell carcinoma: Visual estimation versus digital measurement of proportions of grades, adverse prognosis with any proportion of grade 3 and correlation of a Gleason-like system with nodal metastasis. Am J Surg Pathol. 2009;33(7): PMID: DOI: /PAS.0b013e31819aa4c Chaux A, Caballero C, Soares F, Guimarães GC, Cunha IW, Reuter V, Barreto J, Rodríguez I, Cubilla AL. The prognostic index: A useful pathologic guide for prediction of nodal metastases and survival in penile squamous cell carcinoma. Am J Surg Pathol. 2009;33(7): PMID: DOI: /PAS.0b013e31819d17eb. 65. Cunha IW, Guimaraes GC, Soares F, Velazquez E, Torres JJ, Chaux A, Ayala G, Cubilla AL. Pseudoglandular (adenoid, acantholytic) penile squamous cell carcinoma: A clinicopathologic and outcome study of 7 patients. Am J Surg Pathol. 2009;33(4): PMID: DOI: /PAS.0b013e31818a01d Velazquez EF, Ayala G, Liu H, Chaux A, Zanotti M, Torres J, Cho SI, Barreto BE, Soares F, Cubilla AL. Histologic grade and perineural invasion are more important than tumor thickness as predictor of nodal metastasis in penile squamous cell carcinoma invading 5 to 10 mm. Am J Surg Pathol. 2008;32(7): PMID: DOI: /PAS.0b013e Cubilla AL, Velazquez EF, Ayala GE, Chaux A, Torres J, Reuter VE. Identification of prognostic pathologic parameters in squamous cell carcinoma of the penis: Significance and difficulties. Path Case Reviews. 2005;10(1):3-13. DOI: /01.pcr Página 10 de 21

11 Capítulos de Libros Publicados (Editoriales Internacionales) 1. Chaux A. Ovarian epithelial-like testicular tumors. In: Zhou M, Netto GJ, Epstein JI (Eds). Uropathology: High-Yield Pathology. Elsevier Saunders: Philadelphia, 2012: ISBN-13: ISBN-10: Chaux A. Tumors of the rete testis. In: Zhou M, Netto GJ, Epstein JI (Eds). Uropathology: High-Yield Pathology. Elsevier Saunders: Philadelphia, 2012: ISBN-13: ISBN-10: Chaux A. Giant cell cystitis. In: Zhou M, Netto GJ, Epstein JI (Eds). Uropathology: High- Yield Pathology. Elsevier Saunders: Philadelphia, 2012: 147. ISBN-13: ISBN-10: Chaux A. Granulomatous cystitis after BCG therapy. In: Zhou M, Netto GJ, Epstein JI (Eds). Uropathology: High-Yield Pathology. Elsevier Saunders: Philadelphia, 2012: 154. ISBN-13: ISBN-10: Chaux A. Inverted papilloma. In: Zhou M, Netto GJ, Epstein JI (Eds). Uropathology: High- Yield Pathology. Elsevier Saunders: Philadelphia, 2012: ISBN-13: ISBN-10: Chaux A. Clear cell adenocarcinoma. In: Zhou M, Netto GJ, Epstein JI (Eds). Uropathology: High-Yield Pathology. Elsevier Saunders: Philadelphia, 2012: ISBN-13: ISBN-10: Chaux A. Spermatic cord torsion and testicular infarctions. In: Zhou M, Netto GJ, Epstein JI (Eds). Uropathology: High-Yield Pathology. Elsevier Saunders: Philadelphia, 2012: 358. ISBN-13: ISBN-10: Chaux A. Granulomatous orchidoepididymitis. In: Zhou M, Netto GJ, Epstein JI (Eds). Uropathology: High-Yield Pathology. Elsevier Saunders: Philadelphia, 2012: ISBN-13: ISBN-10: Chaux A. Mixed germ cell tumor. In: Zhou M, Netto GJ, Epstein JI (Eds). Uropathology: High-Yield Pathology. Elsevier Saunders: Philadelphia, 2012: ISBN-13: ISBN-10: Chaux A. Gastrointestinal stromal tumor of the urinary tract. In: Zhou M, Netto GJ, Epstein JI (Eds). Uropathology: High-Yield Pathology. Elsevier Saunders: Philadelphia, 2012: ISBN-13: ISBN-10: Chaux A. Metanephric adenoma. In: Zhou M, Netto GJ, Epstein JI (Eds). Uropathology: High-Yield Pathology. Elsevier Saunders: Philadelphia, 2012: ISBN-13: ISBN-10: Chaux A. Staging for urethral carcinoma. In: Zhou M, Netto GJ, Epstein JI (Eds). Uropathology: High-Yield Pathology. Elsevier Saunders: Philadelphia, 2012: 511. ISBN-13: ISBN-10: Chaux A. Solitary fibrous tumor. In: Zhou M, Netto GJ, Epstein JI (Eds). Uropathology: High-Yield Pathology. Elsevier Saunders: Philadelphia, 2012: 519. ISBN-13: ISBN-10: Chaux A. Clear cell adenocarcinoma of the urethra. In: Zhou M, Netto GJ, Epstein JI (Eds). Uropathology: High-Yield Pathology. Elsevier Saunders: Philadelphia, 2012: 476. ISBN-13: ISBN-10: Página 11 de 21

12 15. Cubilla AL, Chaux A, Velazquez EF, Algaba F, Ayala G. Developments in the Pathology of Penile Cancer. In: Pompeo CA, Heyns C, Abrams P (Eds). Penile Cancer. 1 st Edition. Société Internationale d Urologie: Montreal, 2009: ISBN-10: ISBN-13: Cubilla AL, Chaux A, Velazquez EF. Penis & Scrotum: HPV-associated lesions. In: MB Amin (Ed). Diagnostic Pathology: Genitourinary. Amirsys: Salt Lake City, 2010: ISBN-13: ISBN-10: Cubilla AL, Chaux A, Velazquez EF. Penis & Scrotum: Squamous Hyperplasia. In: MB Amin (Ed). Diagnostic Pathology: Genitourinary. Amirsys: Salt Lake City, 2010: ISBN-13: ISBN-10: Cubilla AL, Chaux A, Velazquez EF. Penis & Scrotum: Squamous Cell Carcinoma, General Concepts. In: MB Amin (Ed). Diagnostic Pathology: Genitourinary. Amirsys: Salt Lake City, 2010: ISBN-13: ISBN-10: Cubilla AL, Chaux A, Velazquez EF. Penis & Scrotum: Squamous Cell Carcinoma, Usual Type. In: MB Amin (Ed). Diagnostic Pathology: Genitourinary. Amirsys: Salt Lake City, 2010: ISBN-13: ISBN-10: Cubilla AL, Chaux A, Velazquez EF. Penis & Scrotum: Pseudohyperplastic Carcinoma. In: MB Amin (Ed). Diagnostic Pathology: Genitourinary. Amirsys: Salt Lake City, 2010: ISBN-13: ISBN-10: Cubilla AL, Chaux A, Velazquez EF. Penis & Scrotum: Basaloid Carcinoma. In: MB Amin (Ed). Diagnostic Pathology: Genitourinary. Amirsys: Salt Lake City, 2010: ISBN- 13: ISBN-10: Cubilla AL, Chaux A, Velazquez EF. Penis & Scrotum: Carcinoma Cuniculatum. In: MB Amin (Ed). Diagnostic Pathology: Genitourinary. Amirsys: Salt Lake City, 2010: ISBN-13: ISBN-10: Cubilla AL, Chaux A, Velazquez EF. Penis & Scrotum: Papillary Carcinoma. In: MB Amin (Ed). Diagnostic Pathology: Genitourinary. Amirsys: Salt Lake City, 2010: ISBN- 13: ISBN-10: Cubilla AL, Chaux A, Velazquez EF. Penis & Scrotum: Metastatic Tumors, Penis. In: MB Amin (Ed). Diagnostic Pathology: Genitourinary. Amirsys: Salt Lake City, 2010: ISBN-13: ISBN-10: Chaux A, Ayala G, Cubilla AL. Chapter 40: The Penis. In: Cheng L, Bostwick DG (Eds). Essentials of Anatomic Pathology. Third Edition. Springer Science Business Media, LLC: New York, 2011: ISBN-13: ISBN-10: Chaux A, Cubilla AL. Diagnosis, Epidemiology and Pathology of Penile Cancer. In: Vogelzang NJ, Scardino PT, Zelefsky MJ, Linehan WM. Comprehensive Textbook of Genitourinary Oncology. Fourth Edition. Lippincott Williams & Wilkins: Philadelphia. 2011: ISBN-13: ISBN-10: Chaux A, Cubilla AL. Chapter 3: Diagnosis and Pathology of Penile Cancer. In: Muneer A, Arya M, Horenblas S (Eds). Textbook of Penile Cancer. Springer Science Business Media, LLC: New York, 2011: ISBN-13: ISBN-10: Calonje E, Neill S, Bunker C, Francis N, Chaux A, Cubilla AL. Chapter 12: Diseases of the Anogenital Skin. In: Calonje E, Brenn T, Lazar AJ, McKee PH. McKee s Pathology of the Skin. Fourth Edition. Saunders: Philadelphia. 2011: ISBN-13: ISBN-10: Página 12 de 21

13 Ponencias Presentadas en Reuniones Internacionales 1. Bezerra SM, Ball M, Gonzalez-Roibon N, Faraj SF, Chaux A, Munari E, Burnett A, Netto GJ. Human Papillomavirus Infection and Immunohistochemical p16ink4a Expression in Penile Squamous Cell Carcinomas. Mod Pathol. 2014;27(S2):217A. 2. Netto GJ, Bezerra SM, Gonzalez-Roibon N, Chaux A, Munari E, Ball M, Shih IM, Burnett AL, Faraj SF. Low ARID1A Immunoexpression in Penile Squamous Cell Carcinoma. Mod Pathol. 2014;27(S2):252A. 3. Chaux A, Gonzalez-Roibon N, Faraj S, Munari E, Shih IE, Cubilla AL, Netto GJ. Immunohistochemical Expression of ARID1a in Penile Squamous Cell Carcinomas. J Urol. 2013;189(4):e Chaux A, Munari E, Faraj S, Gonzalez-Roibon N, Sharma R, Cubilla AL, Netto GJ. Strong Association of Insulin-Like Growth Factor 1 Receptor (IGR1R) Expression and Histologic Grade in Penile Squamous Cell Carcinomas. J Urol. 2013;189(4):e Munari E, Chaux A, Faraj S, Gonzalez-Roibon N, Sharma R, GJ Netto. Decreased BRG1 Expression in Primary and Metastatic Clear Cell Renal Cell Carcinoma: A Potential Role for a Tumor Suppressor Gene Inactivation in Oncogenesis. J Urol. 2013;189(4):e Gonzalez-Roibon N, Kim J, Chaux A, Munari E, Faraj S, Ellis C, Sharma R, Bivalacqua T, Schoenberg M, Carducci M, Netto GJ. Overexpression of IGF1R Predicts Outcome in Invasive Urothelial Carcinoma of Urinary Bladder. J Urol. 2013;189(4):e Fujita K, Faraj S, Munari E, Chaux A, Gonzalez-Roibon N, Hicks J, Meeker A, Nonomura N, Netto GJ. Immunoexpression Status and Prognostic Significance of mtor Pathway Members in Upper Tract Urothelial Carcinoma. J Urol. 2013;189(4):e Poling J, Munari E, Gonzalez-Roibon N, Faraj S, Doucet M, Chaux A, Kominsky S, Weber K, Netto GJ. Macrophage Inflammatory Protein-3 is Downregulated in Clear Cell Renal Cell Carcinomas and Correlates with Stage and Grade. J Urol. 2013;189(4):e Chaux A, Gonzalez-Roibon N, Faraj SF, Munari E, Shih IM, Cubilla AL, Netto GJ. Immunohistochemical Expression of ARID1A in Penile Squamous Cell Carcinomas. Mod Pathol. 2013;26(S2):200A. 10. Chaux A, Munari E, Faraj SF, Gonzalez-Roibon N, Sharma R, Cubilla AL, Netto GJ. Strong Association of Insulin-Like Growth Factor 1 Receptor (IGF1R) Expression and Histologic Grade in Penile Squamous Cell Carcinomas. Mod Pathol. 2013;26(S2):200A. 11. Faraj SF, Fujita K, Munari E, Chaux A, Gonzalez-Roibon N, Hicks J, Meeker A, Netto GJ. Immunoexpression Status and Prognostic Significance of mtor Pathway Members in Upper Tract Urothelial Carcinoma. Mod Pathol. 2013;26(S2):209A. 12. Faraj SF, Gonzalez-Roibon N, Chaux A, Munari E, Ellis C, Driscoll T, Schoenberg MP, Bivalacqua T, Shih IM, Netto GJ. Immunohistochemical Expression and Prognostic Value of ARID1A in Invasive Urothelial Carcinoma of Urinary Bladder. Mod Pathol. 2013;26(S2):209A 13. Gonzalez-Roibon N, Chaux A, Sharma R, Allaf ME, Netto GJ. The Role of GATA3 in the Differential Diagnosis of Upper Tract Urothelial and Collecting Duct Carcinomas. Mod Pathol. 2013;26(S2):213A. 14. Gonzalez-Roibon N, Kim J, Chaux A, Munari E, Faraj SF, Ellis C, Sharma R, Bivalacqua T, Schoemberg M, Carducci M, Netto GJ. Overexpression of IGF1R Predicts Outcome in Invasive Urothelial Carcinoma of Urinary Bladder. Mod Pathol. 2013;26(S2):213A. Página 13 de 21

14 15. Haffner MC, Yegnasubramanian S, Netto GJ, Chaux A. Immunohistochemical Expression of AIM1 in Normal Prostate and in Primary and Metastatic Prostate Carcinoma. Mod Pathol. 2013;26(S2):214A. 16. Lotan TL, Chaux A, Peskoe S, Hicks J, Platz EA, Netto GJ, De Marzo AM. PTEN Protein Loss Is More Frequent in ERG-Positive Prostate Tumors. Mod Pathol. 2013;26(S2):231A. 17. Munari E, Chaux A, Faraj SF, Gonzalez-Roibon N, Sharma R, Netto GJ. Decreased BRG1 Expression in Primary and Metastatic Clear Cell Renal Cell Carcinoma, a Potential Role for a Tumor Suprressor Gene Inactivation in Oncogenesis. Mod Pathol. 2013;26(S2):236A. 18. Munari E, Poling JS, Gonzalez-Roibon N, Faraj SF, Doucet M, Chaux A, Kominsky S, Weber WL, Netto GJ. Macrophage Inflammatory Protein-3a Is Downregulated in Clear Cell Renal Cell Carcinomas and Correlates with Stage and Grade. Mod Pathol. 2013;26(S2):236A. 19. Munari E, Gonzalez-Roibon N, Faraj SF, Chaux A, Allaf ME, Sharma R, Netto GJ. GATA- 3 Immunohistochemical Expression in Primary and Metastatic Renal Cell Carcinomas. Mod Pathol. 2013;26(S2):236A. 20. Chaux A, Haffner MC, Nelson WG, Lecksell KL, Yegnasubramanian S, Cubilla AL, Netto GJ. 5-hydroxy-methyl-cytosine content is strongly associated with degree of histologic differentiation in penile squamous cell carcinomas. Mod Pathol. 2012;25(S2):197A. 21. Chaux A, Peskoe S, Gonzalez-Roibon N, Hicks J, De Marzo AM, Platz EA, Netto GJ. Loss of PTEN immunoexpression is associated with increased risk of recurrence after prostatectomy for clinically-localized prostate cancer. Mod Pathol. 2012;25(S2):197A. 22. Chaux A, Cubilla AL, Hicks J, Lecksell KL, Burnett AL, Netto GJ. Immunohistochemical expression of phosphorylated S6 is associated with degree of differentiation in penile squamous cell carcinoma. Mod Pathol. 2012;25(S2):197A. 23. Gonzalez-Roibon N, Chaux A, Osunkoya AO, Al-Hussain T, Hicks J, Epstein JI, Netto GJ. Dysregulation of mtor pathway in plasmacytoid variant of urothelial carcinoma of the urinary bladder. Mod Pathol. 2012;25(S2):208A. 24. Gonzalez-Roibon N, Peskoe S, Chaux A, Albadine R, Hicks J, De Marzo A, Platz EA, Netto GJ. ERG immunoexpression does not predict risk of recurrence after prostatectomy for clinically-localized prostate cancer. Mod Pathol. 2012;25(S2):209A. 25. Han JS, Netto GJ, Lee S, Gonzalez-Roibon N, Ross H, Sharma R, Cubilla AL, Chaux A. Potential utility of GATA3 immunoexpression and HPV status in the differential diagnosis of urothelial vs squamous cell carcinomas of distal penile urethra. Mod Pathol. 2012;25(S2):211A. 26. Han JS, Netto GJ, Cubilla AL, Lee S, Gonzalez-Roibon N, Sharma R, Chaux A. Distinctive immunohistochemical profile of the penile distal urethra. Mod Pathol. 2012;25(S2):212A. 27. Katz B, Gonzalez-Roibon N, Chaux A, Sharma R, Netto GJ, Torbenson M. Immunohistochemical expression of SALL4 in hepatocellular carcinoma, a potential pitfall in the differential diagnosis of yolk sac tumors. Mod Pathol. 2012;25(S2):217A. 28. Miyamoto H, Yao JL, Chaux A, Yang Q, McMahon LA, Zheng Y, Izumi K, Netto GJ. Expression of androgen and estrogen receptors and its prognostic significance in urothelial neoplasm of the urinary bladder. Mod Pathol. 2012;25(S2):228A. 29. Miyamoto H, Izumi K, Yao JL, Yang Q, McMahon LA, Gonzalez-Roibon N, Chaux A, Hicks DG, Netto GJ, Tacha D. GATA3 is down-regulated in bladder cancer yet strong expression is an independent predictor of poor prognosis in invasive tumor. Mod Pathol. 2012;25(S2):228A. Página 14 de 21

15 30. Netto GJ, Cubilla AL, Sharma R, Hicks J, Lecksell KL, Chaux A. Intercorrelation of cell cycle markers in squamous cell carcinomas of the penis. Mod Pathol. 2012;25(S2):230A. 31. Netto GJ, Cubilla AL, Katz B, Lecksell KL, Sharma R, Chaux A. The epidermal growth factor receptor (EGFR) is frequently overexpressed in penile squamous carcinomas. Mod Pathol. 2012;25(S2):231A. 32. Netto GJ, Cubilla AL, Sharma R, Hicks J, Lecksell KL, Chaux A. Combined in situ hybridization and immunohistochemistry for the detection of human papillomavirus (HPV) infection in penile carcinomas. Mod Pathol. 2012;25(S2):231A. 33. Toubaji A, Sutcliffe S, Chaux A, Lecksell K, Hicks J, De Marzo AM, Platz EA, Netto GJ. Immunohistochemical expression of MCM2 predicts biochemical recurrence in prostate cancer: A tissue microarray and digital imaging analysis-based study of 428 cases. Mod Pathol. 2012;25(S2):245A. 34. Zheng G, Chaux A, Sharma R, Netto G, Caturegli P. LMP2: An immunohistochemical marker for the differential diagnosis of renal oncocytoma and chromophobe renal cell carcinoma eosinophilic variant. Mod Pathol. 2012;25(S2):255A. 35. Chaux A, Peskoe S, Gonzalez-Roibon N, Hicks J, De Marzo AM, Platz EA, Netto G. Loss of PTEN immunoexpression is associated with risk of recurrence after prostatectomy for clinically-localized prostate cancer: A nested case-control study update. J Urol. 2012;187(4 S):e Chaux A, Cubilla AL, Hicks J, Lecksell K, Netto G. Decrease or loss of PTEN expression is frequent in penile squamous cell carcinomas. J Urol. 2012;187(4 S):e Gonzalez-Roibon N, Chaux A, Osunkoya AO, Al-Hussain T, Hicks J, Epstein JI, Netto G. Dysregulation of mtor pathway in plasmacytoid variant of urothelial carcinoma of the urinary bladder. J Urol. 2012;187(4 S):e Miyamoto H, Yao J, Chaux A, Zheng Y, Hsu I, Izumi K, Chang C, Messing E, Netto G, Yeh S. Expression of androgen and estrogen receptors and its prognostic significance in urothelial neoplasm of the urinary bladder. J Urol. 2012;187(4 S):e159-e Gonzalez-Roibon N, Peskoe S, Chaux A, Albadine R, Hicks J, De Marzo AM, Platz EA, Netto G. ERG immunoexpression is not associated with increased risk of recurrence after prostatectomy for clinically-localized prostate cancer: A nested case-control study. J Urol. 2012;187(4 S):e Miyamoto H, Izumi K, Yao J, Gonzalez-Roibon N, Chaux A, Hicks D, Netto G, Tacha D. GATA3 is down-regulated in bladder cancer yet strong expression is an independent predictor of poor prognosis in invasive tumor. J Urol. 2012;187(4 S):e Netto G, Cubilla AL, Sharma R, Lecksell K, Katz B, Chaux A. The epidermal growth factor receptor (EGFR) is frequently overexpressed in penile squamous carcinomas. J Urol. 2012;187(4 S):e Netto G, Cubilla AL, Sharma R, Hicks J, Lecksell KL, Chaux A. Combined in situ hybridization and immunohistochemistry for the diagnosis of human papillomavirus (HPV) infection in penile carcinomas. J Urol. 2012;187(4 S):e Brimo F, Chaux A, Schultz L, Epstein JI, De Marzo A, Argani P, Netto GJ. Higher Expression of mtor Pathway Members in Association with Malignant Behavior in Pheochromocytomas. J Urol. 2011;185(4 S):e Chaux A, Albadine R, Toubaji A, Haffner M, Hicks J, Meeker A, De Marzo A, Platz A, Netto GJ. Immunohistochemistry for ERG Expression as a Surrogate for TMPRSS2-ERG Fusion Detection in Prostatic Adenocarcinoma. J Urol. 2011;185(4 S):e249. Página 15 de 21

16 45. Chaux A, Netto GJ, Lloveras B, Muñoz N, de Sanjose S, Bosch FX, Cubilla AL. High- Grade Squamous Cell Carcinomas of the Penis Usually Show Evidence of Human Papillomavirus Infection. J Urol. 2011;185(4 S):e Amin A, Faraj S, Chaux A, Al-Hussain T, Cox R, Nagar M, Netto GJ. Recurrence and Progression Rates of Urothelial Papillomas of the Urinary Bladder. J Urol. 2011;185(4 S):e Albadine R, Chaux A, Hicks J, De Marzo AM, Netto GJ. Increased Phosphorylated 4EBP1 Expression in Minute Prostatic Adenocarcinoma. Mod Pathol. 2011;24(Suppl 1):175A. 48. Albadine R, Chaux A, Hicks J, De Marzo A, Netto GJ. PTEN and Phosphorylated S6 Expression in Clinically insignificant Prostate Adenocarcinoma: Correlation with ERG Fusion Status. Mod Pathol. 2011;24(Suppl 1):175A. 49. Amin A, Faraj SF, Chaux A, Al-Hussain T, Cox R, Nagar M, Netto GJ. Long-Term Clinical Outcome in Urothelial Papillomas of the Urinary Bladder. Mod Pathol. 2011;24(Suppl 1):177A. 50. Brimo F, Chaux A, Schultz L, Epstein JI, De Marzo A, Argani P, Netto GJ. Activation of mtor Pathway in Malignant Pheochromocytoma: A Potential Therapeutic Target. Mod Pathol. 2011;24(Suppl 1):182A. 51. Chaux A, Guimaraes-Cardozo G, Soares F, da Cunha I, Netto GJ, Cubilla AL. A Pathology- Based Mathematical Model Predicts Nodal Metastasis in Squamous Cell Carcinoma of the Penis. Mod Pathol. 2011;24(Suppl 1):184A. 52. Chaux A, Soares F, da Cunha Wernecke I, Netto GJ, Lloveras B, Munoz N, de Sanjose S, Bosch FX, Cubilla AL. Penile Squamous Cell Carcinomas: Preferential Association of Human Papillomavirus with High Histological Grade. Mod Pathol. 2011;24(Suppl 1):184A. 53. Chaux A, Pfannl R, Rodriguez IM, Barreto JE, Velazquez EF, Netto GJ, Cubilla AL. Distinctive Immunohistochemical Profiles of Penile Intraepithelial Lesions A Study of 74 Cases. Mod Pathol. 2011;24(Suppl 1):184A. 54. Cox R, Chaux A, Solus J, Schultz L, De Marzo A, Comperat E, Netto GJ. mtor Pathway Activation in pt1 Urothelial Cell Carcinomas of the Bladder: A Potential Target of Therapy. Mod Pathol. 2011;24(Suppl 1):186A. 55. Cubilla AL, Chaux A, Rodriguez IM, Barreto JE, Netto GJ, Bosch FX, de Sanjose S, Munoz N, Hildesheim A. Phimosis, Lichen Sclerosus, Smoking, Poverty, Sexually Related Epidemiological Factors and Late Diagnosis Are Prevalent among Patients with Penile Cancer in Paraguay. Mod Pathol. 2011;24(Suppl 1):186A. 56. Cubilla AL, Chaux A, Rodriguez IM, Barreto JE, Netto GJ, Bosch FX, de Sanjose S, Munoz N, Hildesheim A. Sexual History and Distinctive Pathological Features in HPV-Related Penile Carcinomas. Mod Pathol. 2011;24(Suppl 1):187A. 57. Lotan T, Chaux A, Wang W, Gupta N, Epstein J, De Marzo A, Netto GJ. ERG Protein Expression in Prostatic Small Cell Carcinoma Cases with Known ERG Gene Rearrangement Status. Mod Pathol. 2011;24(Suppl 1):208A. 58. Netto GJ, Albadine R, Chaux A, Toubaji A, Hicks J, Meeker A, De Marzo AM. ERG Protein IHC Expression as an Alternative Methodology for Evaluation of ERG Fusion Status in Prostate Adenocarcinoma. Mod Pathol. 2011;24(Suppl 1):213A. 59. Faraj SF, Solus J, Eifler J, Al-Hussain T, Chaux A, Pomper M, Rodriguez R, Netto GJ. Focal Positive PSMA Expression in Ganglionic Tissues Associated with Prostate Neurovascular Bundle: Implications for Novel Intraoperative PSMA Based Fluorescent Imaging Techniques. Mod Pathol. 2011;24(Suppl 1):192A. Página 16 de 21

17 60. Cubilla AL, Alejo M, Lloveras B, Clavero O, Kasamatsu E, Chaux A, Velazquez EF, Monfulleda N, Tous S, Alemany L, Klaustermeier J, Munoz N, Quint W, de San Jose S, Bosch FX. The Value of P16NK4a as a Histomarker for HPV in Subtypes of Penile Squamous Cell Carcinoma (SCC). A Study of 158 Tumors. Mod Pathol. 2009;22(Suppl 1):164A. 61. Cubilla AL, Lloveras B, Alejo M, Clavero O, Kasamatsu E, Velazquez EF, Chaux A, Monfulleda N, Tous S, Alemany L, Klaustermeier J, Munoz N, Quint W, de San Jose S, Bosch FX. Distinctive Association of HPV with Special Types of Penile Squamous Cell Carcinoma (SCC) and Giant Condyloma. A Study of 211 Cases. Mod Pathol. 2009;22(Suppl 1):164A. 62. Soskin A, Vieillefond A, Carlotti A, Plantier F, Chaux A, Ayala G, Velazquez EF, Torres JJ, Cubilla AL. Warty/Basaloid (Undifferentiated) Penile Intraepithelial Neoplasia (PeIN) Is More Prevalent Than Differentiated PeIN in a Non-Endemic Region for Penile Cancer When Compared with an Endemic Area. A Comparative Study between France and Paraguay. Mod Pathol. 2009;22(Suppl 1):194A. 63. Guimaraes GC, Werneck da Cunha I, Soares FA, Lopes A, Torres JJ, Chaux C, Velazquez EF, Cubilla AL. WHO Histological Classification, Regional Metastasis and Outcome in 372 Surgically Treated Patients with Penile Squamous Cell Carcinomas. Mod Pathol. 2007;20(Suppl 2):150A. 64. Soares FA, Werneck da Cunha I, Oliveria ML, Guimaraes GC, Velazquez EF, Torres JJ, Chaux A, Cubilla AL. Grade Is More Influential on Prognosis Than Depth of Invasion in Penile Squamous Cell Carcinoma. An Outcome Study Comparing Paradoxical Superficial High Grade and Deeply Invasive Low Grade Tumors. Mod Pathol. 2007;20(Suppl 2):177A. 65. Werneck da Cunha I, Soares FA, Souza AM, Velazquez EF, Torres JJ, Chaux A, Cubilla AL. Pseudoglandular (Acantholytic) Squamous Cell Carcinomas of the Penis. A Report of 7 Cases. Mod Pathol. 2007;20(Suppl 2):183A. 66. Cubilla AL, Chaux A, Zanotti M, Acevedo M, Knofelmacher A, Torres J, Barreto JE, Velazquez EF. Histologic Grade is More Important Than Tumor Thickness as Predictor of Nodal Metastasis in Squamous Cell Carcinoma (SCC) of the Penis Invading 5-10 mm. Mod Pathol. 2006;19(Suppl 1):134A. 67. Cubilla AL, Velazquez EF, Barreto JE, Chaux A, Caballero C. Prognostic Index in 110 Invasive Squamous Cell Carcinoma of the Penis. A Useful Guide for the Management of Inguinal Lymph Node Dissections. Mod Pathol. 2006;19(Suppl 1):134A. 68. Velazquez EF, Zanotti M, Acevedo M, Knofelmacher A, Barreto JE, Torres J, Chaux A, Cubilla AL. Anatomical Levels of Invasion and Tumor Thickness in Invasive Penile Squamous Cell Carcinoma (SCC) of the Glans. A Proposal of Modification of the TNM System. Mod Pathol. 2006;19(Suppl 1):167A. 69. Chaux A, Velazquez EF, Torres J, Cubilla AL. Papillary Squamous Cell Carcinoma of the Penis. A Report of 18 Cases. Mod Pathol. 2005;18(Suppl 1):132A. 70. Cubilla AL, Chaux A, Pfannl R, Torres J, Barreto JE, Velazquez EF. Any Proportion of Histological Grade 3 Is Related to Metastasis in SCC of Penis. An Electronically Quantified Study of Proportions of Grades. Mod Pathol. 2005;18(Suppl 1):135A. 71. Cubilla AL, Chaux A, Torres J, Pfannl R, Velazquez EF. Intuitive vs Electronic Quantification of Proportions of Grades in Squamous Cell Carcinomas of the Penis. Mod Pathol. 2005;18(Suppl 1):132A. Página 17 de 21

18 Artículos Publicados en Revistas Nacionales 1. Chaux A. Pathological Risk-Group Stratification Systems for Penile Cancer Management: A Study of 198 Patients with Invasive Squamous Cell Carcinoma. Rev UniNorte Med. 2013;2: Chaux A, Cohen JS, Katz B, Schultz L, Albadine R, Jadallah S, Murphy KM, Schoenberg MP, Netto GJ. PIK3A Mutational Analysis in Formalin-Fixed, Paraffin- Embedded Archival Tissues of Urothelial Carcinoma of Urinary Bladder. Rev UniNorte Med. 2013;2: Sánchez DF, Grillón F, Chaux A, Rodriguez I, Barreto JE, Cubilla AL. Características Demográficas, Patológicas y Detección del Virus del Papiloma Humano en el Carcinoma Peneal: Revisión de Estudios Realizados en el Paraguay. Rev UniNorte Med. 2012;1: Chaux A. Evaluation of p53 Immunohistochemical Expression Using Open-Source Software for Digital Image Analysis: A Tissue Microarray Study of Penile Squamous Cell Carcinomas. Rev UniNorte Med. 2012;1: Documentos Técnicos 1. Chaux A. Manual de Organización y Funciones de la Dirección de Investigaciones Científicas. Universidad del Norte: Asunción, 2013: pp Disponible en 2. Chaux A. Manual de Procedimientos del Comité de Bioética de la Dirección de Investigaciones Científicas. Universidad del Norte: Asunción, 2013: pp Disponible en 3. Chaux A. Manual de Procedimientos del Comité Científico de la Dirección de Investigaciones Científicas. Universidad del Norte: Asunción, 2013: pp Disponible en 4. Armele A, Vuyk I, Chaux A. Reglamento del Concurso para el Escalafonamiento Docente. Universidad del Norte: Asunción, 2013: pp Disponible en 5. Chaux A. Guía para la Elaboración del Análisis DAFO de los Contenidos Programáticos de la Carrera de Medicina de la Facultad de Medicina. Universidad del Norte: Asunción, 2013: pp Disponible en 6. Chaux A. Programa de Iniciación Científica & Incentivo a la Investigación (PRICILA), Dirección de Investigaciones Científicas. Universidad del Norte: Asunción, 2013: pp Disponible en 7. Chaux A. Reglamento General del Programa de Ayudantía e Incentivo a la Investigación Científica (PANIC), Dirección de Investigaciones Científicas. Universidad del Norte: Asunción, 2013: pp Disponible en 8. Chaux A. Reglamento del Premio UniNorte a la Investigación Científica. Universidad del Norte: Asunción, 2013: pp Disponible en Página 18 de 21

19 9. Chaux A. Proyecto Prevención del Cáncer de Cuello Uterino, Dirección de Investigaciones Científicas. Universidad del Norte: Asunción, 2013: pp Disponible en Chaux A, Miranda J. Proyecto Autoevaluación de la Carrera de Medicina. Universidad del Norte: Asunción, 2013: pp Disponible en Chaux A, Armele A, Vuyk I. Proyecto Ajuste Curricular de la Carrera de Medicina. Universidad del Norte: Asunción, 2013: pp Disponible en Chaux A, Malek L. Proyecto Tutorías para la Carrera de Medicina. Universidad del Norte. Asunción, 2013: pp Disponible en Conferencias Dictadas (Nacionales) 1. Chaux A. Los Límites de la Ciencia: Cómo Distinguir Ciencia, Pseudociencia, y No-Ciencia. Evento: Charla de Divulgación, Sociedad Científica de Estudiantes de Medicina de la Universidad del Norte (SOCEM-UN). Fecha: 12 de Julio de Lugar: Facultad de Medicina, Universidad del Norte, Asunción, Paraguay. 2. Chaux A. Estrategias para la Investigación Científica en el Paraguay: Una Experiencia Personal. Evento: II Jornada de Introducción a la Investigación Científica. Fecha: 4 de Agosto de Lugar: Facultad de Medicina, Universidad Nacional del Este, Minga Guazú, Paraguay. 3. Chaux A. Fundamentos de Metodología de la Investigación. Evento: 1º Jornada de Actualización Científica 2012, Programa de Iniciación Científica & Incentivo a la Investigación (PRICILA), Dirección de Investigaciones Científicas. Fecha: 16 de Agosto de Lugar: Facultad de Medicina, Universidad del Norte, Asunción, Paraguay. 4. Chaux A. Los Límites de la Ciencia: Cómo Distinguir Ciencia, Pseudociencia, y No-Ciencia. Evento: Charla de Divulgación, Programa de Iniciación Científica & Incentivo a la Investigación (PRICILA), Dirección de Investigaciones Científicas. Fecha: 16 de Agosto de Lugar: Facultad de Medicina, Universidad del Norte, Asunción, Paraguay. 5. Chaux A. Redacción de Artículos Científicos de Investigación, Programa de Iniciación Científica & Incentivo a la Investigación (PRICILA), Dirección de Investigaciones Científicas. Evento: 2º Jornada de Actualización Científica Fecha: 13 de Septiembre de Lugar: Facultad de Medicina, Universidad del Norte, Asunción, Paraguay. 6. Chaux A. Diseño y Exposición Efectivas de Presentaciones Científicas. Evento: 3º Jornada de Actualización Científica 2012, Programa de Iniciación Científica & Incentivo a la Investigación (PRICILA), Dirección de Investigaciones Científicas. Fecha: 18 de Octubre de Lugar: Facultad de Medicina, Universidad del Norte, Asunción, Paraguay. Página 19 de 21

20 7. Chaux A. Utilidad Potencial de la Expresión Inmunohistoquímica de GATA3 y la Presencia del Virus del Papiloma Humano en el Diagnóstico Diferencial de Carcinomas Uroteliales vs. Carcinomas Escamosos de la Uretra Peneana. Evento: I Encuentro de Investigadores en las Áreas de Salud y Educación, VI Foro Internacional de Educación. Fecha: 3 de Noviembre de Lugar: Universidad Iberoamericana, Asunción, Paraguay. 8. Chaux A. Uso de Bibliotecas Virtuales. Evento: 1º Taller de Capacitación, Dirección de Investigaciones Científicas. Fecha: 7 de Junio de Lugar: Aula Magna de la Facultad de Medicina, Universidad del Norte, Asunción, Paraguay. 9. Chaux A. Estrategias de Investigación Científica a través de un Policlínico Universitario Evento: II Foro de Extensión Universitaria y Responsabilidad Social Universitaria, Universidad del Pacífico Privada. Fecha: 11 de Octubre de Lugar: Laboratorios Catedral, Asunción, Paraguay. 10. Chaux A. Fundamentos Epistemológicos de la Investigación Científica Fundamentos Metodológicos de la Investigación Científica El Planteamiento Inicial de Proyectos de Investigación. Evento: II Jornadas de Iniciación Científica Fecha: 18 de Octubre de Lugar: Facultad de Medicina, Universidad del Norte, Asunción, Paraguay. 11. Chaux A. El Diseño de Proyectos de Investigación La Gestión de Datos y el Análisis Estadístico de Proyectos de Investigación Estrategias para la Investigación Científica. Evento: II Jornadas de Iniciación Científica Fecha: 25 de Octubre de Lugar: Facultad de Medicina, Universidad del Norte, Asunción, Paraguay. Revistas y Páginas de Divulgación 1. Cubilla AL, Chaux A. Research in Progress: Diagnostic Utility of p16ink4a Overexpression in Penile Carcinomas. HPV Today No. 21, June 2010: 7. ISSN: Disponible 2. Chaux A. Beyond the Abstract Metastatic tumors to the penis: A report of 17 cases and review of the literature. July 7, Disponible en Conferencias Virtuales (online) 1. Netto GJ, Chaux A. Surgical Pathology Unknown Conference, Week 476, April 18, Available at 2. Netto GJ, Chaux A. Surgical Pathology Unknown Conference, Week 475, April 11, Available at 3. Netto GJ, Chaux A. Surgical Pathology Unknown Conference, Week 455, October 18, Available at Página 20 de 21